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Items: 39

1.

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.

Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS.

Bioorg Med Chem. 2017 Feb 15;25(4):1320-1328. doi: 10.1016/j.bmc.2016.11.034. Epub 2016 Dec 7.

2.

Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.

Harshbarger W, Gondi S, Ficarro SB, Hunter J, Udayakumar D, Gurbani D, Singer WD, Liu Y, Li L, Marto JA, Westover KD.

J Biol Chem. 2017 Jan 6;292(1):112-120. doi: 10.1074/jbc.M116.750299. Epub 2016 Nov 21.

3.

Increased dietary cholesterol promotes enhanced mutagenesis in DNA polymerase kappa-deficient mice.

Singer WD, Osimiri LC, Friedberg EC.

DNA Repair (Amst). 2013 Oct;12(10):817-23. doi: 10.1016/j.dnarep.2013.07.010. Epub 2013 Aug 13.

PMID:
23948094
4.

Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.

Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR.

Structure. 2008 Oct 8;16(10):1532-43. doi: 10.1016/j.str.2008.07.009.

5.

Regulation of Rho guanine nucleotide exchange factors by G proteins.

Sternweis PC, Carter AM, Chen Z, Danesh SM, Hsiung YF, Singer WD.

Adv Protein Chem. 2007;74:189-228. Review.

PMID:
17854659
6.

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.

Chen Z, Singer WD, Sternweis PC, Sprang SR.

Nat Struct Mol Biol. 2005 Feb;12(2):191-7. Epub 2005 Jan 16.

PMID:
15665872
7.

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.

Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC.

J Biol Chem. 2003 Mar 14;278(11):9912-9. Epub 2003 Jan 13.

8.

Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D.

Jiang X, Gutowski S, Singer WD, Sternweis PC.

Methods Enzymol. 2002;345:328-34. No abstract available.

PMID:
11665616
9.

Endothelin-B receptors activate Galpha13.

Kitamura K, Shiraishi N, Singer WD, Handlogten ME, Tomita K, Miller RT.

Am J Physiol. 1999 Apr;276(4):C930-7. doi: 10.1152/ajpcell.1999.276.4.C930.

PMID:
10199825
10.

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.

Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G.

Science. 1998 Jun 26;280(5372):2112-4.

11.

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.

Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC.

Science. 1998 Jun 26;280(5372):2109-11.

12.

The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin.

Wilk-Blaszczak MA, Singer WD, Quill T, Miller B, Frost JA, Sternweis PC, Belardetti F.

J Neurosci. 1997 Jun 1;17(11):4094-100.

13.

Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.

Singer WD, Brown HA, Sternweis PC.

Annu Rev Biochem. 1997;66:475-509. Review.

PMID:
9242915
14.

Three distinct G protein pathways mediate inhibition of neuronal calcium current by bradykinin.

Wilk-Blaszczak MA, Singer WD, Belardetti F.

J Neurophysiol. 1996 Nov;76(5):3559-62.

PMID:
8930294
15.

Gq/11 and PLC-beta 1 mediate the substance P-induced inhibition of an inward rectifier K+ channel in brain neurons.

Takano K, Yasufuku-Takano J, Kozasa T, Singer WD, Nakajima S, Nakajima Y.

J Neurophysiol. 1996 Sep;76(3):2131-6.

PMID:
8890327
16.

Induction of inducible nitric-oxide synthase by the heterotrimeric G protein Galpha13.

Kitamura K, Singer WD, Star RA, Muallem S, Miller RT.

J Biol Chem. 1996 Mar 29;271(13):7412-5.

17.
18.

Resolved phospholipase D activity is modulated by cytosolic factors other than Arf.

Singer WD, Brown HA, Bokoch GM, Sternweis PC.

J Biol Chem. 1995 Jun 23;270(25):14944-50.

19.

G alpha q and G alpha 13 regulate NHE-1 and intracellular calcium in epithelial cells.

Kitamura K, Singer WD, Cano A, Miller RT.

Am J Physiol. 1995 Jan;268(1 Pt 1):C101-10.

PMID:
7840138
20.

Polymerization of Antarctic fish tubulins at low temperatures: role of carboxy-terminal domains.

Singer WD, Parker SK, Himes RH, Detrich HW 3rd.

Biochemistry. 1994 Dec 27;33(51):15389-96.

PMID:
7803402
21.

The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin.

Wilk-Blaszczak MA, Singer WD, Gutowski S, Sternweis PC, Belardetti F.

Neuron. 1994 Nov;13(5):1215-24.

PMID:
7946358
22.

Purification and characterization of the alpha subunit of G13.

Singer WD, Miller RT, Sternweis PC.

J Biol Chem. 1994 Aug 5;269(31):19796-802.

23.

Cellular uptake and tubulin binding properties of four Vinca alkaloids.

Singer WD, Himes RH.

Biochem Pharmacol. 1992 Feb 4;43(3):545-51.

PMID:
1540212
24.

The incidence of seizures during tricyclic antidepressant drug treatment in a brain-injured population.

Wroblewski BA, McColgan K, Smith K, Whyte J, Singer WD.

J Clin Psychopharmacol. 1990 Apr;10(2):124-8.

PMID:
2341586
25.

Binding of vinblastine to stabilized microtubules.

Singer WD, Jordan MA, Wilson L, Himes RH.

Mol Pharmacol. 1989 Sep;36(3):366-70.

PMID:
2571072
26.

Carbamazepine replacement of phenytoin, phenobarbital and primidone in a rehabilitation setting: effects on seizure control.

Wroblewski BA, Glenn MB, Whyte J, Singer WD.

Brain Inj. 1989 Apr-Jun;3(2):149-56.

PMID:
2499396
27.

Effect of solution variables on the binding of vinblastine to tubulin.

Singer WD, Hersh RT, Himes RH.

Biochem Pharmacol. 1988 Jul 1;37(13):2691-6.

PMID:
3390227
28.

Effect of pyridoxine deficiency in the neuronally mature rat.

Dakshinamurti K, Singer WD, Paterson JA.

Int J Vitam Nutr Res. 1987;57(2):161-7.

PMID:
3654110
29.

Lorazepam therapy of status epilepticus in children and adolescents.

Lacey DJ, Singer WD, Horwitz SJ, Gilmore H.

J Pediatr. 1986 May;108(5 Pt 1):771-4. No abstract available.

PMID:
3084747
30.

Carbamazepine-erythromycin interaction. Case studies and clinical significance.

Wroblewski BA, Singer WD, Whyte J.

JAMA. 1986 Mar 7;255(9):1165-7.

PMID:
3945037
31.

Human serum teratogenicity studied by rat embryo culture: epilepsy, anticonvulsant drugs, and nutrition.

Chatot CL, Klein NW, Clapper ML, Resor SR, Singer WD, Russman BS, Holmes GL, Mattson RH, Cramer JA.

Epilepsia. 1984 Apr;25(2):205-16.

PMID:
6705751
32.

Malignant hyperthermia in a child with Duchenne muscular dystrophy.

Kelfer HM, Singer WD, Reynolds RN.

Pediatrics. 1983 Jan;71(1):118-9. No abstract available.

PMID:
6848959
33.

Infantile spasms.

Haller JS, Singer WD.

Dev Med Child Neurol. 1982 Feb;24(1):91-2. No abstract available.

PMID:
7106411
34.

Trauma from toy boxes.

Singer WD, Lutner L.

J Pediatr. 1982 Feb;100(2):242-3. No abstract available.

PMID:
7057333
35.

The value of neuroradiology in infantile spasms.

Singer WD, Haller JS, Sullivan LR, Wolpert S, Mills C, Rabe EF.

J Pediatr. 1982 Jan;100(1):47-50.

PMID:
6276522
36.

Transient Gilles de la Tourette syndrome after chronic neuroleptic withdrawal.

Singer WD.

Dev Med Child Neurol. 1981 Aug;23(4):518-21.

PMID:
6944239
37.

The effect of ACTH therapy upon infantile spasms.

Singer WD, Rabe EF, Haller JS.

J Pediatr. 1980 Mar;96(3 Pt 1):485-9.

PMID:
6244378
38.

Nocturnal head banging as a sleep disorder: a case report.

Freidin MR, Jankowski JJ, Singer WD.

Am J Psychiatry. 1979 Nov;136(11):1469-70. No abstract available.

PMID:
495804
39.

Occlusive vertebrobasilar artery disease associated with cervical spine anomaly.

Singer WD, Haller JS, Wolpert SM.

Am J Dis Child. 1975 Apr;129(4):492-5.

PMID:
1130356

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