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Items: 1 to 50 of 302

1.

Single-mRNA detection in living S. cerevisiae using a re-engineered MS2 system.

Tutucci E, Vera M, Singer RH.

Nat Protoc. 2018 Sep 14. doi: 10.1038/s41596-018-0037-2. [Epub ahead of print]

PMID:
30218101
2.

Fluorescence Imaging Methods to Investigate Translation in Single Cells.

Biswas J, Liu Y, Singer RH, Wu B.

Cold Spring Harb Perspect Biol. 2018 Aug 6. pii: a032722. doi: 10.1101/cshperspect.a032722. [Epub ahead of print]

PMID:
30082468
3.

Imaging cell-type-specific dynamics of mRNAs in living mouse brain.

Nwokafor C, Singer RH, Lim H.

Methods. 2018 Jul 29. pii: S1046-2023(18)30116-6. doi: 10.1016/j.ymeth.2018.07.009. [Epub ahead of print]

PMID:
30067943
4.

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process.

Limi S, Senecal A, Coleman R, Lopez-Jones M, Guo P, Polumbo C, Singer RH, Skoultchi AI, Cvekl A.

J Biol Chem. 2018 Aug 24;293(34):13176-13190. doi: 10.1074/jbc.RA118.001927. Epub 2018 Jun 29.

PMID:
29959226
5.

A transgenic mouse for imaging activity-dependent dynamics of endogenous Arc mRNA in live neurons.

Das S, Moon HC, Singer RH, Park HY.

Sci Adv. 2018 Jun 20;4(6):eaar3448. doi: 10.1126/sciadv.aar3448. eCollection 2018 Jun.

6.

Better-quality diet is associated with lower odds of severe periodontitis in US Hispanics/Latinos.

Salazar CR, Laniado N, Mossavar-Rahmani Y, Borrell LN, Qi Q, Sotres-Alvarez D, Morse DE, Singer RH, Kaplan RC, Badner V, Lamster IB.

J Clin Periodontol. 2018 Jul;45(7):780-790. doi: 10.1111/jcpe.12926. Epub 2018 Jun 11.

PMID:
29779261
7.

Transvection Goes Live-Visualizing Enhancer-Promoter Communication between Chromosomes.

Tsai A, Singer RH, Crocker J.

Mol Cell. 2018 Apr 19;70(2):195-196. doi: 10.1016/j.molcel.2018.04.004.

PMID:
29677489
8.

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia.

Carvajal LA, Neriah DB, Senecal A, Benard L, Thiruthuvanathan V, Yatsenko T, Narayanagari SR, Wheat JC, Todorova TI, Mitchell K, Kenworthy C, Guerlavais V, Annis DA, Bartholdy B, Will B, Anampa JD, Mantzaris I, Aivado M, Singer RH, Coleman RA, Verma A, Steidl U.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaao3003. doi: 10.1126/scitranslmed.aao3003.

9.

The association of periodontal disease and cardiovascular disease risk: Results from the Hispanic Community Health Study/Study of Latinos.

Singer RH, Stoutenberg M, Feaster DJ, Cai J, Hlaing WM, Metsch LR, Salazar CR, Beaver SM, Finlayson TL, Talavera G, Gellman MD, Schneiderman N.

J Periodontol. 2018 Jul;89(7):840-857. doi: 10.1002/JPER.17-0549. Epub 2018 Jul 20.

PMID:
29542123
10.

Imaging mRNA In Vivo, from Birth to Death.

Tutucci E, Livingston NM, Singer RH, Wu B.

Annu Rev Biophys. 2018 May 20;47:85-106. doi: 10.1146/annurev-biophys-070317-033037. Epub 2018 Jan 18.

PMID:
29345990
11.

Unfair Treatment and Periodontitis Among Adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Finlayson TL, Lemus H, Becerra K, Kaste LM, Beaver SM, Salazar CR, Singer RH, Youngblood ME Jr.

J Racial Ethn Health Disparities. 2018 Oct;5(5):1093-1106. doi: 10.1007/s40615-017-0459-5. Epub 2018 Jan 11.

PMID:
29327269
12.

An improved MS2 system for accurate reporting of the mRNA life cycle.

Tutucci E, Vera M, Biswas J, Garcia J, Parker R, Singer RH.

Nat Methods. 2018 Jan;15(1):81-89. doi: 10.1038/nmeth.4502. Epub 2017 Nov 13.

13.

Occupational Exposures and Metabolic Syndrome Among Hispanics/Latinos: Cross-Sectional Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Bulka CM, Daviglus ML, Persky VW, Durazo-Arvizu RA, Avilés-Santa ML, Gallo LC, Hosgood HD 3rd, Singer RH, Talavera GA, Thyagarajan B, Zeng D, Argos M.

J Occup Environ Med. 2017 Nov;59(11):1047-1055. doi: 10.1097/JOM.0000000000001115.

PMID:
29112602
14.

Nuclear microenvironments modulate transcription from low-affinity enhancers.

Tsai A, Muthusamy AK, Alves MR, Lavis LD, Singer RH, Stern DL, Crocker J.

Elife. 2017 Nov 2;6. pii: e28975. doi: 10.7554/eLife.28975.

15.

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.

Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9873-E9882. doi: 10.1073/pnas.1706365114. Epub 2017 Oct 24.

16.

Localization of TFPI-2 in the nucleus modulates MMP-2 gene expression in breast cancer cells.

Wang G, Zeng Y, Chen S, Li D, Li W, Zhou Y, Singer RH, Gu W.

Sci Rep. 2017 Oct 19;7(1):13575. doi: 10.1038/s41598-017-14148-8.

17.

Quantitative mRNA imaging throughout the entire Drosophila brain.

Long X, Colonell J, Wong AM, Singer RH, Lionnet T.

Nat Methods. 2017 Jul;14(7):703-706. doi: 10.1038/nmeth.4309. Epub 2017 Jun 5.

PMID:
28581495
18.

Binding of DEAD-box helicase Dhh1 to the 5'-untranslated region of ASH1 mRNA represses localized translation of ASH1 in yeast cells.

Zhang Q, Meng X, Li D, Chen S, Luo J, Zhu L, Singer RH, Gu W.

J Biol Chem. 2017 Jun 9;292(23):9787-9800. doi: 10.1074/jbc.M117.776492. Epub 2017 Apr 27.

19.

RNP transport in cell biology: the long and winding road.

Eliscovich C, Singer RH.

Curr Opin Cell Biol. 2017 Apr;45:38-46. doi: 10.1016/j.ceb.2017.02.008. Epub 2017 Mar 1. Review.

20.

Imaging mRNA and protein interactions within neurons.

Eliscovich C, Shenoy SM, Singer RH.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1875-E1884. doi: 10.1073/pnas.1621440114. Epub 2017 Feb 21.

21.

Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/MenaINV-initiated invadopodium formation.

Pignatelli J, Bravo-Cordero JJ, Roh-Johnson M, Gandhi SJ, Wang Y, Chen X, Eddy RJ, Xue A, Singer RH, Hodgson L, Oktay MH, Condeelis JS.

Sci Rep. 2016 Nov 30;6:37874. doi: 10.1038/srep37874.

22.

Single-Cell and Single-Molecule Analysis of Gene Expression Regulation.

Vera M, Biswas J, Senecal A, Singer RH, Park HY.

Annu Rev Genet. 2016 Nov 23;50:267-291. Review.

23.

Glutamate-induced RNA localization and translation in neurons.

Yoon YJ, Wu B, Buxbaum AR, Das S, Tsai A, English BP, Grimm JB, Lavis LD, Singer RH.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6877-E6886. Epub 2016 Oct 17.

24.

IMP1, an mRNA binding protein that reduces the metastatic potential of breast cancer in a mouse model.

Nwokafor CU, Sellers RS, Singer RH.

Oncotarget. 2016 Nov 8;7(45):72662-72671. doi: 10.18632/oncotarget.12083.

25.

Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos.

Sanders AE, Sofer T, Wong Q, Kerr KF, Agler C, Shaffer JR, Beck JD, Offenbacher S, Salazar CR, North KE, Marazita ML, Laurie CC, Singer RH, Cai J, Finlayson TL, Divaris K.

J Dent Res. 2017 Jan;96(1):64-72. doi: 10.1177/0022034516664509. Epub 2016 Oct 1.

26.

Subnuclear positioning and interchromosomal clustering of the GAL1-10 locus are controlled by separable, interdependent mechanisms.

Brickner DG, Sood V, Tutucci E, Coukos R, Viets K, Singer RH, Brickner JH.

Mol Biol Cell. 2016 Oct 1;27(19):2980-93. doi: 10.1091/mbc.E16-03-0174. Epub 2016 Aug 3.

27.

Translation dynamics of single mRNAs in live cells and neurons.

Wu B, Eliscovich C, Yoon YJ, Singer RH.

Science. 2016 Jun 17;352(6292):1430-5. doi: 10.1126/science.aaf1084. Epub 2016 May 5.

28.

Occupational Physical Activity and Body Mass Index: Results from the Hispanic Community Health Study/Study of Latinos.

Singer RH, Stoutenberg M, Gellman MD, Archer E, Davis SM, Gotman N, Marquez DX, Buelna C, Deng Y, Hosgood HD, Zambrana RE.

PLoS One. 2016 Mar 31;11(3):e0152339. doi: 10.1371/journal.pone.0152339. eCollection 2016.

29.

IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs.

Wang G, Huang Z, Liu X, Huang W, Chen S, Zhou Y, Li D, Singer RH, Gu W.

Oncotarget. 2016 Mar 29;7(13):15690-702. doi: 10.18632/oncotarget.7464.

30.
31.

Imaging Transcription: Past, Present, and Future.

Coleman RA, Liu Z, Darzacq X, Tjian R, Singer RH, Lionnet T.

Cold Spring Harb Symp Quant Biol. 2015;80:1-8. doi: 10.1101/sqb.2015.80.027201. Epub 2016 Jan 13. Review.

32.

Mapping translation 'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes.

Katz ZB, English BP, Lionnet T, Yoon YJ, Monnier N, Ovryn B, Bathe M, Singer RH.

Elife. 2016 Jan 13;5. pii: e10415. doi: 10.7554/eLife.10415.

33.

Cellular Levels of Signaling Factors Are Sensed by β-actin Alleles to Modulate Transcriptional Pulse Intensity.

Kalo A, Kanter I, Shraga A, Sheinberger J, Tzemach H, Kinor N, Singer RH, Lionnet T, Shav-Tal Y.

Cell Rep. 2015 Nov 10;13(6):1284-1285. doi: 10.1016/j.celrep.2015.10.053. Epub 2015 Nov 10. No abstract available.

34.

Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.

LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM.

J Biol Chem. 2015 Dec 18;290(51):30390-405. doi: 10.1074/jbc.M115.689604. Epub 2015 Oct 16.

35.

CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells.

Deng W, Shi X, Tjian R, Lionnet T, Singer RH.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11870-5. doi: 10.1073/pnas.1515692112. Epub 2015 Aug 31.

36.

Inferring transient particle transport dynamics in live cells.

Monnier N, Barry Z, Park HY, Su KC, Katz Z, English BP, Dey A, Pan K, Cheeseman IM, Singer RH, Bathe M.

Nat Methods. 2015 Sep;12(9):838-40. doi: 10.1038/nmeth.3483. Epub 2015 Jul 20.

37.

Quantifying Protein-mRNA Interactions in Single Live Cells.

Wu B, Buxbaum AR, Katz ZB, Yoon YJ, Singer RH.

Cell. 2015 Jul 2;162(1):211-20. doi: 10.1016/j.cell.2015.05.054.

38.

Single-molecule insights into mRNA dynamics in neurons.

Buxbaum AR, Yoon YJ, Singer RH, Park HY.

Trends Cell Biol. 2015 Aug;25(8):468-75. doi: 10.1016/j.tcb.2015.05.005. Epub 2015 Jun 4. Review.

39.

Promoter-Autonomous Functioning in a Controlled Environment using Single Molecule FISH.

Hocine S, Vera M, Zenklusen D, Singer RH.

Sci Rep. 2015 May 28;5:9934. doi: 10.1038/srep09934.

40.

Nuclear accessibility of β-actin mRNA is measured by 3D single-molecule real-time tracking.

Smith CS, Preibisch S, Joseph A, Abrahamsson S, Rieger B, Myers E, Singer RH, Grunwald D.

J Cell Biol. 2015 May 25;209(4):609-19. doi: 10.1083/jcb.201411032.

41.

Synonymous modification results in high-fidelity gene expression of repetitive protein and nucleotide sequences.

Wu B, Miskolci V, Sato H, Tutucci E, Kenworthy CA, Donnelly SK, Yoon YJ, Cox D, Singer RH, Hodgson L.

Genes Dev. 2015 Apr 15;29(8):876-86. doi: 10.1101/gad.259358.115. Epub 2015 Apr 15.

42.

Cellular Levels of Signaling Factors Are Sensed by β-actin Alleles to Modulate Transcriptional Pulse Intensity.

Kalo A, Kanter I, Shraga A, Sheinberger J, Tzemach H, Kinor N, Singer RH, Lionnet T, Shav-Tal Y.

Cell Rep. 2015 Apr 21;11(3):419-32. doi: 10.1016/j.celrep.2015.03.039. Epub 2015 Apr 9.

43.

Translation. An RNA biosensor for imaging the first round of translation from single cells to living animals.

Halstead JM, Lionnet T, Wilbertz JH, Wippich F, Ephrussi A, Singer RH, Chao JA.

Science. 2015 Mar 20;347(6228):1367-671. doi: 10.1126/science.aaa3380.

44.

Reminiscences on my life with RNA: a self-indulgent perspective.

Singer RH.

RNA. 2015 Apr;21(4):508-9. doi: 10.1261/rna.050922.115. No abstract available.

45.

Dynamic visualization of transcription and RNA subcellular localization in zebrafish.

Campbell PD, Chao JA, Singer RH, Marlow FL.

Development. 2015 Apr 1;142(7):1368-74. doi: 10.1242/dev.118968. Epub 2015 Mar 10.

46.

Periodontitis and Sleep Disordered Breathing in the Hispanic Community Health Study/Study of Latinos.

Sanders AE, Essick GK, Beck JD, Cai J, Beaver S, Finlayson TL, Zee PC, Loredo JS, Ramos AR, Singer RH, Jimenez MC, Barnhart JM, Redline S.

Sleep. 2015 Aug 1;38(8):1195-203. doi: 10.5665/sleep.4890.

47.

A general method to improve fluorophores for live-cell and single-molecule microscopy.

Grimm JB, English BP, Chen J, Slaughter JP, Zhang Z, Revyakin A, Patel R, Macklin JJ, Normanno D, Singer RH, Lionnet T, Lavis LD.

Nat Methods. 2015 Mar;12(3):244-50, 3 p following 250. doi: 10.1038/nmeth.3256. Epub 2015 Jan 19.

48.

Specific interaction of KIF11 with ZBP1 regulates the transport of β-actin mRNA and cell motility.

Song T, Zheng Y, Wang Y, Katz Z, Liu X, Chen S, Singer RH, Gu W.

J Cell Sci. 2015 Mar 1;128(5):1001-10. doi: 10.1242/jcs.161679. Epub 2015 Jan 14.

49.

In the right place at the right time: visualizing and understanding mRNA localization.

Buxbaum AR, Haimovich G, Singer RH.

Nat Rev Mol Cell Biol. 2015 Feb;16(2):95-109. doi: 10.1038/nrm3918. Epub 2014 Dec 30. Review. Erratum in: Nat Rev Mol Cell Biol. 2015 Aug;16(8):513.

50.

Photoswitchable red fluorescent protein with a large Stokes shift.

Piatkevich KD, English BP, Malashkevich VN, Xiao H, Almo SC, Singer RH, Verkhusha VV.

Chem Biol. 2014 Oct 23;21(10):1402-1414. doi: 10.1016/j.chembiol.2014.08.010. Epub 2014 Sep 18.

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