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Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E.

Davidge B, Rebola KGO, Agbor LN, Sigmund CD, Singer JD.

J Cell Sci. 2019 Nov 6;132(21). pii: jcs233049. doi: 10.1242/jcs.233049.


Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.

Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD.

JCI Insight. 2019 Jun 11;5. pii: 129793. doi: 10.1172/jci.insight.129793.


Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon.

Dombrowski JG, Souza RM, Lima FA, Bandeira CL, Murillo O, Costa DS, Peixoto EPM, Cunha MDP, Zanotto PMA, Bevilacqua E, Grisotto MAG, Pedroso de Lima AC, Singer JDM, Campino S, Clark TG, Epiphanio S, Gonçalves LA, Marinho CRF.

JAMA Netw Open. 2019 May 3;2(5):e193300. doi: 10.1001/jamanetworkopen.2019.3300.


Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy.

Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S.

JCI Insight. 2019 Apr 16;5. pii: 125665. doi: 10.1172/jci.insight.125665.


Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis.

Saritas T, Cuevas CA, Ferdaus MZ, Kuppe C, Kramann R, Moeller MJ, Floege J, Singer JD, McCormick JA.

Sci Rep. 2019 Mar 14;9(1):4596. doi: 10.1038/s41598-019-40795-0.


Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.

Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1006-F1018. doi: 10.1152/ajprenal.00602.2017. Epub 2018 Jun 13.


Testing international education assessments.

Singer JD, Braun HI.

Science. 2018 Apr 6;360(6384):38-40. doi: 10.1126/science.aar4952. No abstract available.


Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.

Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA.

JCI Insight. 2017 Dec 21;2(24). pii: 96700. doi: 10.1172/jci.insight.96700.


Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.

Li X, Zhang Z, Li L, Gong W, Lazenby AJ, Swanson BJ, Herring LE, Asara JM, Singer JD, Wen H.

J Exp Med. 2017 Apr 3;214(4):1093-1109. doi: 10.1084/jem.20161105. Epub 2017 Mar 9.


Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.

Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P.

Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. Epub 2016 Mar 21.


Association between Traffic Air Pollution and Reduced Forced Vital Capacity: A Study Using Personal Monitors for Outdoor Workers.

Santos UP, Garcia ML, Braga AL, Pereira LA, Lin CA, de André PA, de André CD, Singer JD, Saldiva PH.

PLoS One. 2016 Oct 6;11(10):e0163225. doi: 10.1371/journal.pone.0163225. eCollection 2016.


Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.

Zhang C, Meermeier NP, Terker AS, Blankenstein KI, Singer JD, Hadchouel J, Ellison DH, Yang CL.

Biochem Biophys Res Commun. 2016 Jan 1;469(1):44-48. doi: 10.1016/j.bbrc.2015.11.067. Epub 2015 Nov 23.


"Menaced Rationality": Husserl and Merleau-Ponty on the Crisis and Promise of Science.

Singer JD.

Prog Biophys Mol Biol. 2015 Dec;119(3):245-56. doi: 10.1016/j.pbiomolbio.2015.06.007. Epub 2015 Jul 2. Review.


Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.

McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH.

J Clin Invest. 2014 Nov;124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24.


Novel Cul3 binding proteins function to remodel E3 ligase complexes.

Wimuttisuk W, West M, Davidge B, Yu K, Salomon A, Singer JD.

BMC Cell Biol. 2014 Jul 10;15:28. doi: 10.1186/1471-2121-15-28.


A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.

Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent AL, Dinner AR, Bendelac A.

J Exp Med. 2014 Jun 2;211(6):1137-51. doi: 10.1084/jem.20132267. Epub 2014 May 26.


Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.

Lampert L, Timonen B, Smith S, Davidge B, Li H, Conley JF Jr, Singer JD, Jiao J.

Chem Commun (Camb). 2014 Feb 7;50(10):1234-7. doi: 10.1039/c3cc48088g.


BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.

Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.

Nature. 2012 Nov 22;491(7425):618-21. doi: 10.1038/nature11548. Epub 2012 Oct 21.


B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).

Werwein E, Schmedt T, Hoffmann H, Usadel C, Obermann N, Singer JD, Klempnauer KH.

Cell Cycle. 2012 Nov 1;11(21):4047-58. doi: 10.4161/cc.22386. Epub 2012 Oct 3.


Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1.

Ye Y, Yaeger D, Owen LJ, Escobedo JO, Wang J, Singer JD, Strongin RM, Abramson JJ.

Mol Pharmacol. 2012 Jan;81(1):53-62. doi: 10.1124/mol.111.074740. Epub 2011 Oct 11.


BTB-Kelch proteins and ubiquitination of kainate receptors.

Marshall J, Blair LA, Singer JD.

Adv Exp Med Biol. 2011;717:115-25. doi: 10.1007/978-1-4419-9557-5_10. Review.


The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells.

Kossatz U, Breuhahn K, Wolf B, Hardtke-Wolenski M, Wilkens L, Steinemann D, Singer S, Brass F, Kubicka S, Schlegelberger B, Schirmacher P, Manns MP, Singer JD, Malek NP.

J Clin Invest. 2010 Nov;120(11):3820-33. doi: 10.1172/JCI41959. Epub 2010 Oct 11.


Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.

Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA.

J Clin Invest. 2010 Oct;120(10):3713-21. doi: 10.1172/JCI40440. Epub 2010 Sep 1.


The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.

Cummings CM, Bentley CA, Perdue SA, Baas PW, Singer JD.

J Biol Chem. 2009 Apr 24;284(17):11663-75. doi: 10.1074/jbc.M809374200. Epub 2009 Mar 4.


The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases.

Plafker KS, Singer JD, Plafker SM.

Biochemistry. 2009 Apr 21;48(15):3527-37. doi: 10.1021/bi801971m.


Subcellular localization and cytoplasmic complex status of endogenous Keap1.

Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, Yamamoto M.

Genes Cells. 2007 Oct;12(10):1163-78.


Constitutive turnover of cyclin E by Cul3 maintains quiescence.

McEvoy JD, Kossatz U, Malek N, Singer JD.

Mol Cell Biol. 2007 May;27(10):3651-66. Epub 2007 Mar 5.


The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.

Wimuttisuk W, Singer JD.

Mol Biol Cell. 2007 Mar;18(3):899-909. Epub 2006 Dec 27.


Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway.

Salinas GD, Blair LA, Needleman LA, Gonzales JD, Chen Y, Li M, Singer JD, Marshall J.

J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.


Maternal correlates of growth in toddler vocabulary production in low-income families.

Pan BA, Rowe ML, Singer JD, Snow CE.

Child Dev. 2005 Jul-Aug;76(4):763-82.


Two novel mutations in severe factor VII deficiency.

Gomez K, Laffan MA, Kemball-Cook G, Pasi J, Layton M, Singer JD, Tuddenham EG, McVey JH.

Br J Haematol. 2004 Jul;126(1):105-10.


Variation in predictors of primary care career choice by year and stage of training.

Connelly MT, Sullivan AM, Peters AS, Clark-Chiarelli N, Zotov N, Martin N, Simon SR, Singer JD, Block SD.

J Gen Intern Med. 2003 Mar;18(3):159-69.


The effect of medical education on primary care orientation: results of two national surveys of students' and residents' perspectives.

Zinn WM, Sullivan AM, Zotov N, Peters AS, Connelly MT, Singer JD, Block SD.

Acad Med. 2001 Apr;76(4):355-65.


Recent developments in products, general liability, and consumer law.

Simpson WK, Singer JD, Singhal V, Sterchi TN, Landherr CC, Mischke PE, Brundige J, Hinrichs P, Baer LG, Bertschi E, Kelley SD, Lepore M, Gieger EP, Corrigan ML.

Tort Insur Law J. 2000 Winter;35(2):553-79. No abstract available.


Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE.

Mol Cell. 2000 Feb;5(2):403-10.


Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

Singer JD, Gurian-West M, Clurman B, Roberts JM.

Genes Dev. 1999 Sep 15;13(18):2375-87.


Views of managed care--a survey of students, residents, faculty, and deans at medical schools in the United States.

Simon SR, Pan RJ, Sullivan AM, Clark-Chiarelli N, Connelly MT, Peters AS, Singer JD, Inui TS, Block SD.

N Engl J Med. 1999 Mar 25;340(12):928-36.


Mixed messages about primary care in the culture of U.S. medical schools.

Block SD, Clark-Chiarelli N, Singer JD.

Acad Med. 1998 Oct;73(10):1087-94.


Early child-care selection: variation by geographic location, maternal characteristics, and family structure.

Singer JD, Fuller B, Keiley MK, Wolf A.

Dev Psychol. 1998 Sep;34(5):1129-44.


Physician retention in community and migrant health centers: who stays and for how long?

Singer JD, Davidson SM, Graham S, Davidson HS.

Med Care. 1998 Aug;36(8):1198-213.


Academia's chilly climate for primary care.

Block SD, Clark-Chiarelli N, Peters AS, Singer JD.

JAMA. 1996 Sep 4;276(9):677-82.


Binding properties of newly identified Xenopus proteins containing dsRNA-binding motifs.

Bass BL, Hurst SR, Singer JD.

Curr Biol. 1994 Apr 1;4(4):301-14.


Job experiences over time, multiple roles, and women's mental health: a longitudinal study.

Barnett RC, Marshall NL, Singer JD.

J Pers Soc Psychol. 1992 Apr;62(4):634-44.


Technology's children: report of a statewide census of children dependent on medical supports.

Palfrey JS, Walker DK, Haynie M, Singer JD, Porter S, Bushey B, Cooperman P.

Pediatrics. 1991 May;87(5):611-8.


Applications of survival analysis to aging research.

Willett JB, Singer JD.

Exp Aging Res. 1991 Winter;17(4):243-50. Review.


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