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Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers.

Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanović R, Postle AD; U-BIOPRED Study Group.

Metabolomics. 2018 Sep 17;14(10):123. doi: 10.1007/s11306-018-1412-2.


Obstructive Sleep Apnoea in Children and Adolescents with Ehlers-Danlos Syndrome.

Stöberl AS, Gaisl T, Giunta C, Sievi NA, Singer F, Möller A, Rohrbach M, Kohler M.

Respiration. 2019;97(4):284-291. doi: 10.1159/000494328. Epub 2018 Nov 28.


The Swiss Paediatric Airway Cohort (SPAC).

Pedersen ESL, de Jong CCM, Ardura-Garcia C, Barben J, Casaulta C, Frey U, Jochmann A, Latzin P, Moeller A, Regamey N, Singer F, Spycher B, Sutter O, Goutaki M, Kuehni CE.

ERJ Open Res. 2018 Nov 20;4(4). pii: 00050-2018. doi: 10.1183/23120541.00050-2018. eCollection 2018 Oct.


SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics.

Singer F, Irmisch A, Toussaint NC, Grob L, Singer J, Thurnherr T, Beerenwinkel N, Levesque MP, Dummer R, Quagliata L, Rothschild SI, Wicki A, Beisel C, Stekhoven DJ.

BMC Med Inform Decis Mak. 2018 Oct 29;18(1):89. doi: 10.1186/s12911-018-0680-0.


Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride.

Singer F, Ramsey K, Latzin P.

ERJ Open Res. 2018 Oct 19;4(4). pii: 00140-2018. doi: 10.1183/23120541.00140-2018. eCollection 2018 Oct.


Ventilation and perfusion assessed by functional MRI in children with CF: reproducibility in comparison to lung function.

Nyilas S, Bauman G, Pusterla O, Ramsey K, Singer F, Stranzinger E, Yammine S, Casaulta C, Bieri O, Latzin P.

J Cyst Fibros. 2019 Jul;18(4):543-550. doi: 10.1016/j.jcf.2018.10.003. Epub 2018 Oct 20.


Treatable traits in the European U-BIOPRED adult asthma cohorts.

Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group.

Allergy. 2019 Feb;74(2):406-411. doi: 10.1111/all.13629. Epub 2018 Nov 12. No abstract available.


Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women.

Sommer T, Richter K, Singer F, Derntl B, Rune GM, Diekhof E, Bayer J.

Psychopharmacology (Berl). 2018 Dec;235(12):3465-3477. doi: 10.1007/s00213-018-5061-y. Epub 2018 Oct 10.


Structural and Functional Lung Impairment in Primary Ciliary Dyskinesia. Assessment with Magnetic Resonance Imaging and Multiple Breath Washout in Comparison to Spirometry.

Nyilas S, Bauman G, Pusterla O, Sommer G, Singer F, Stranzinger E, Heyer C, Ramsey K, Schlegtendal A, Benzrath S, Casaulta C, Goutaki M, Kuehni CE, Bieri O, Koerner-Rettberg C, Latzin P.

Ann Am Thorac Soc. 2018 Dec;15(12):1434-1442. doi: 10.1513/AnnalsATS.201712-967OC.


Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.


Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease.

Nyilas S, Bigler A, Yammine S, Kieninger E, Rochat I, Ramsey K, Casaulta C, Moeller A, Latzin P, Singer F.

Pediatr Pulmonol. 2018 Nov;53(11):1485-1491. doi: 10.1002/ppul.24149. Epub 2018 Aug 30.


Short-Term Effects of Elastic Chest Wall Restriction on Pulmonary Function in Children with Cystic Fibrosis.

Roethlisberger K, Nyilas S, Riedel T, Wolfensberger J, Singer F, Latzin P.

Respiration. 2018;96(6):535-542. doi: 10.1159/000491094. Epub 2018 Aug 21.


Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth.

Korten I, Kieninger E, Yammine S, Cangiano G, Nyilas S, Anagnostopoulou P, Singer F, Kuehni CE, Regamey N, Frey U, Casaulta C, Spycher BD, Latzin P; SCILD; BILD study group.

J Cyst Fibros. 2019 Jan;18(1):118-126. doi: 10.1016/j.jcf.2018.07.002. Epub 2018 Jul 27.


Comparison of different analysis algorithms to calculate multiple-breath washout outcomes.

Anagnostopoulou P, Kranz N, Wolfensberger J, Guidi M, Nyilas S, Koerner-Rettberg C, Yammine S, Singer F, Latzin P.

ERJ Open Res. 2018 Jul 13;4(3). pii: 00021-2017. doi: 10.1183/23120541.00021-2017. eCollection 2018 Jul.


Monitoring pulmonary health in Swiss childhood cancer survivors.

Kasteler R, Kam LMH, Weiss A, Waespe N, Sommer G, Singer F, von der Weid NX, Ansari M, Kuehni CE; Swiss Pediatric Oncology Group (SPOG).

Pediatr Blood Cancer. 2018 Oct;65(10):e27255. doi: 10.1002/pbc.27255. Epub 2018 Jun 15.


Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome.

Burg D, Schofield JPR, Brandsma J, Staykova D, Folisi C, Bansal A, Nicholas B, Xian Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Fleming L, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Hashimoto S, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Singer F, Sun K, Pandis I, Auffray C, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Djukanović R, Skipp PJ, The U-Biopred Study Group.

J Proteome Res. 2018 Jun 1;17(6):2072-2091. doi: 10.1021/acs.jproteome.8b00018. Epub 2018 May 23.


Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; , on behalf of the U-BIOPRED study group.

Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May.


Multiple breath washout: A new and promising lung function test for patients with idiopathic pulmonary fibrosis.

Nyilas S, Schreder T, Singer F, Poellinger A, Geiser TK, Latzin P, Funke M.

Respirology. 2018 Aug;23(8):764-770. doi: 10.1111/resp.13294. Epub 2018 Mar 24.


Real-time exhaled breath analysis in patients with cystic fibrosis and controls.

Gaisl T, Bregy L, Stebler N, Gaugg MT, Bruderer T, García-Gómez D, Moeller A, Singer F, Schwarz EI, Benden C, M-L Sinues P, Zenobi R, Kohler M.

J Breath Res. 2018 Apr 30;12(3):036013. doi: 10.1088/1752-7163/aab7fd.


Leaks during multiple-breath washout: characterisation and influence on outcomes.

Lenherr N, Ramsey KA, Jost K, Hornwall L, Singer F, Yammine S, Latzin P.

ERJ Open Res. 2018 Feb 23;4(1). pii: 00012-2017. doi: 10.1183/23120541.00012-2017. eCollection 2018 Jan.


Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement.

Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen F; ATS Assembly on Pediatrics.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):e1-e19. doi: 10.1164/rccm.201801-0074ST.


Monitoring of Soft Deposition Layers in Liquid-Filled Tubes with Guided Acoustic Waves Excited by Clamp-on Transducers.

Tietze S, Singer F, Lasota S, Ebert S, Landskron J, Schwuchow K, Drese KS, Lindner G.

Sensors (Basel). 2018 Feb 9;18(2). pii: E526. doi: 10.3390/s18020526.


Infant multiple breath washout using a new commercially available device: Ready to replace the previous setup?

Kentgens AC, Guidi M, Korten I, Kohler L, Binggeli S, Singer F, Latzin P, Anagnostopoulou P.

Pediatr Pulmonol. 2018 May;53(5):628-635. doi: 10.1002/ppul.23959. Epub 2018 Feb 8.


Inert Gas Washout in Bronchiolitis Obliterans Following Hematopoietic Cell Transplantation.

Nyilas S, Baumeler L, Tamm M, Halter JP, Savic S, Korten I, Meyer A, Singer F, Passweg JR, Latzin P, Stolz D.

Chest. 2018 Jul;154(1):157-168. doi: 10.1016/j.chest.2017.12.009. Epub 2017 Dec 21.


Bioinformatics for precision oncology.

Singer J, Irmisch A, Ruscheweyh HJ, Singer F, Toussaint NC, Levesque MP, Stekhoven DJ, Beerenwinkel N.

Brief Bioinform. 2019 May 21;20(3):778-788. doi: 10.1093/bib/bbx143.


Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease.

Nyilas S, Bauman G, Sommer G, Stranzinger E, Pusterla O, Frey U, Korten I, Singer F, Casaulta C, Bieri O, Latzin P.

Eur Respir J. 2017 Dec 7;50(6). pii: 1701464. doi: 10.1183/13993003.01464-2017. Print 2017 Dec.


An innovative lung model for multiple breath washout testing in health and disease.

Anagnostopoulou P, Vomsattel S, Kentgens AC, Guidi M, Binggeli S, Kohler L, Singer F, Latzin P, Obrist D.

Clin Biomech (Bristol, Avon). 2019 Jun;66:74-80. doi: 10.1016/j.clinbiomech.2017.11.002. Epub 2017 Nov 10.


Elevated lung clearance index in infants with cystic fibrosis shortly after birth.

Kieninger E, Yammine S, Korten I, Anagnostopoulou P, Singer F, Frey U, Mornand A, Zanolari M, Rochat I, Trachsel D, Mueller-Suter D, Moeller A, Casaulta C, Latzin P; SCILD study group; BILD study group.

Eur Respir J. 2017 Nov 9;50(5). pii: 1700580. doi: 10.1183/13993003.00580-2017. Print 2017 Nov.


NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.


Inert gas washout: background and application in various lung diseases.

Usemann J, Yammine S, Singer F, Latzin P.

Swiss Med Wkly. 2017 Aug 16;147:w14483. doi: 10.4414/smw.2017.14483. eCollection 2017. Review.


Multiple breath washout in pediatric patients after lung transplantation.

Nyilas S, Carlens J, Price T, Singer F, Müller C, Hansen G, Warnecke G, Latzin P, Schwerk N.

Am J Transplant. 2018 Jan;18(1):145-153. doi: 10.1111/ajt.14432. Epub 2017 Aug 21.


Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.

Korten I, Liechti M, Singer F, Hafen G, Rochat I, Anagnostopoulou P, Müller-Suter D, Usemann J, Moeller A, Frey U, Latzin P, Casaulta C; SCILD and BILD study group.

J Cyst Fibros. 2018 Jan;17(1):105-108. doi: 10.1016/j.jcf.2017.05.005. Epub 2017 Jul 14.


Unexpected results in infant multiple breath washout: Is the truth hidden in the washin?

Kentgens AC, Anagnostopoulou P, Singer F, Latzin P.

Pediatr Pulmonol. 2017 Jun;52(6):717-719. doi: 10.1002/ppul.23655. Epub 2017 May 5. No abstract available.


A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.

Port J, Tao Z, Junger A, Joppek C, Tempel P, Husemann K, Singer F, Latzin P, Yammine S, Nagel JH, Kohlhäufl M.

Med Biol Eng Comput. 2017 Nov;55(11):1975-1987. doi: 10.1007/s11517-017-1633-y. Epub 2017 Mar 29.


Alternative inert gas washout outcomes in patients with primary ciliary dyskinesia.

Nyilas S, Schlegtendal A, Singer F, Goutaki M, Kuehni CE, Casaulta C, Latzin P, Koerner-Rettberg C.

Eur Respir J. 2017 Jan 25;49(1). pii: 1600466. doi: 10.1183/13993003.00466-2016. Print 2017 Jan.


Genomic variant annotation workflow for clinical applications.

Thurnherr T, Singer F, Stekhoven DJ, Beerenwinkel N.

Version 2. F1000Res. 2016 Aug 12 [revised 2016 Jan 1];5:1963. eCollection 2016.


Agreement between multiple-breath nitrogen washout systems in children and adults.

Poncin W, Singer F, Aubriot AS, Lebecque P.

J Cyst Fibros. 2017 Mar;16(2):258-266. doi: 10.1016/j.jcf.2016.11.004. Epub 2016 Dec 3.


U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.

Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2017 Jun;139(6):1797-1807. doi: 10.1016/j.jaci.2016.08.048. Epub 2016 Oct 20.


Feasibility of nitrogen multiple-breath washout in inexperienced children younger than 7 years.

Yammine S, Summermatter S, Singer F, Lauener R, Latzin P.

Pediatr Pulmonol. 2016 Nov;51(11):1183-1190. doi: 10.1002/ppul.23431. Epub 2016 May 1.


Recurrent primary hyperparathyroidism due to Type 1 parathyromatosis.

Jain M, Krasne DL, Singer FR, Giuliano AE.

Endocrine. 2017 Feb;55(2):643-650. doi: 10.1007/s12020-016-1139-7. Epub 2016 Oct 14.


Erratum to: Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria.

Rintelen B, Zwerina J, Herold M, Singer F, Hitzelhammer J, Halder W, Eichbauer-Sturm G, Puchner R, Stetter M, Leeb BF; BIOREG investigator group.

BMC Musculoskelet Disord. 2016 Oct 3;17(1):412. No abstract available.


Changes in minute ventilation after exposure to 4% sulfur hexafluoride (SF6 ) in infants.

Jost K, Egger B, Kieninger E, Singer F, Frey U, Latzin P.

Pediatr Pulmonol. 2017 Feb;52(2):151-153. doi: 10.1002/ppul.23557. Epub 2016 Sep 2. No abstract available.


Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria.

Rintelen B, Zwerina J, Herold M, Singer F, Hitzelhammer J, Halder W, Eichbauer-Sturm G, Puchner R, Stetter M, Leeb BF; BIOREG investigator group.

BMC Musculoskelet Disord. 2016 Aug 22;17(1):358. doi: 10.1186/s12891-016-1207-4. Erratum in: BMC Musculoskelet Disord. 2016 Oct 3;17 (1):412.


Physiological phenotyping of pediatric chronic obstructive airway diseases.

Nyilas S, Singer F, Kumar N, Yammine S, Meier-Girard D, Koerner-Rettberg C, Casaulta C, Frey U, Latzin P.

J Appl Physiol (1985). 2016 Jul 1;121(1):324-32. doi: 10.1152/japplphysiol.00086.2016. Epub 2016 May 26.


Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurements.

Egger B, Jost K, Anagnostopoulou P, Yammine S, Singer F, Casaulta C, Frey U, Latzin P.

Pediatr Pulmonol. 2016 Dec;51(12):1373-1381. doi: 10.1002/ppul.23483. Epub 2016 May 23.


Changes in breathing pattern upon 100% oxygen in children at early school age.

Jost K, Lenherr N, Singer F, Schulzke SM, Frey U, Latzin P, Yammine S.

Respir Physiol Neurobiol. 2016 Jul;228:9-15. doi: 10.1016/j.resp.2016.03.006. Epub 2016 Mar 10.


Bone Quality in Paget's Disease of Bone.

Singer FR.

Curr Osteoporos Rep. 2016 Apr;14(2):39-42. doi: 10.1007/s11914-016-0303-6. Review.


CFTR modulation for young children with cystic fibrosis.

Yammine S, Singer F, Latzin P.

Lancet Respir Med. 2016 Feb;4(2):84-5. doi: 10.1016/S2213-2600(16)00009-6. Epub 2016 Jan 21. No abstract available.


How to Monitor Early Cystic Fibrosis Lung Disease. By Multiple-Breath Washout, Chest Computed Tomography, or Both?

Singer F, Casaulta C, Latzin P.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):7-8. doi: 10.1164/rccm.201509-1862ED. No abstract available.


Last Word on Viewpoint: Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate.

Yammine S, Lenherr N, Nyilas S, Singer F, Latzin P.

J Appl Physiol (1985). 2015 Dec 15;119(12):1515. doi: 10.1152/japplphysiol.00764.2015. No abstract available.

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