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Items: 42

1.

Solution NMR Structure and Backbone Dynamics of Partially Disordered Arabidopsis thaliana Phloem Protein 16-1, a Putative mRNA Transporter.

Sashi P, Singarapu KK, Bhuyan AK.

Biochemistry. 2018 Feb 13;57(6):912-924. doi: 10.1021/acs.biochem.7b01071. Epub 2018 Jan 26.

PMID:
29320165
2.

Benzimidazoles from Aryl Alkyl Ketones and 2-Amino Anilines by an Iodine Catalyzed Oxidative C(CO)-C(alkyl) Bond Cleavage.

Ravi O, Shaikh A, Upare A, Singarapu KK, Bathula SR.

J Org Chem. 2017 Apr 21;82(8):4422-4428. doi: 10.1021/acs.joc.7b00165. Epub 2017 Apr 10.

PMID:
28378580
3.

Substitution dependent stereoselective construction of bicyclic lactones and its application to the total synthesis of pyranopyran, tetraketide and polyrhacitide A.

Subba Reddy BV, Biradar DO, Vikram Reddy Y, Yadav JS, Singarapu KK, Sridhar B.

Org Biomol Chem. 2016 Sep 21;14(37):8832-8837.

PMID:
27714240
4.

Solution Nuclear Magnetic Resonance Studies of Sterol Carrier Protein 2 Like 2 (SCP2L2) Reveal the Insecticide Specific Structural Characteristics of SCP2 Proteins in Aedes aegypti Mosquitoes.

Singarapu KK, Ahuja A, Potula PR, Ummanni R.

Biochemistry. 2016 Sep 6;55(35):4919-27. doi: 10.1021/acs.biochem.6b00322. Epub 2016 Aug 23.

PMID:
27508310
5.

The unique functional role of the C-HS hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase.

Reddi R, Singarapu KK, Pal D, Addlagatta A.

Mol Biosyst. 2016 Jul 19;12(8):2408-16. doi: 10.1039/c6mb00259e.

PMID:
27225936
6.

The facile synthesis of 1-benzoazepine derivatives via gold-catalyzed regioselective cycloisomerization reactions of N-(o-alkynylaryl)-N-vinyl sulfonamides.

Undeela S, Ravikumar G, Nanubolu JB, Singarapu KK, Menon RS.

Chem Commun (Camb). 2016 Apr 4;52(26):4824-7. doi: 10.1039/c6cc01061j. Epub 2016 Mar 11.

PMID:
26964664
7.

Nazarov cyclization of divinyl ketones bearing an ester group at the β-position: a remarkable effect of α-substitution and alkene geometry on regioselectivity.

Sudhakar G, Raghavaiah J, Mahesh G, Singarapu KK.

Org Biomol Chem. 2016 Mar 14;14(10):2866-72. doi: 10.1039/c6ob00081a.

PMID:
26864166
8.

Structure-function relationships of brazzein variants with altered interactions with the human sweet taste receptor.

Singarapu KK, Tonelli M, Markley JL, Assadi-Porter FM.

Protein Sci. 2016 Mar;25(3):711-9. doi: 10.1002/pro.2870. Epub 2016 Jan 9.

9.

Sequential aza-Piancatelli rearrangement/Friedel-Crafts alkylation for the synthesis of pyrrolo[1,2-d]benzodiazepine derivatives.

Reddy BV, Reddy YV, Singarapu KK.

Org Biomol Chem. 2016 Jan 21;14(3):1111-6. doi: 10.1039/c5ob01616a. Epub 2015 Dec 8.

PMID:
26646535
10.

Total synthesis of a piperidine alkaloid, microcosamine A.

Raji Reddy C, Latha B, Warudikar K, Singarapu KK.

Org Biomol Chem. 2016 Jan 7;14(1):251-8. doi: 10.1039/c5ob02085a. Epub 2015 Nov 13.

PMID:
26565783
11.

Domino Strategy for the Stereoselective Construction of Angularly Fused Tricyclic Ethers.

Reddy BV, Medaboina D, Reddy SG, Reddy VH, Singarapu KK, Sridhar B.

J Org Chem. 2015 Dec 18;80(24):12580-7. doi: 10.1021/acs.joc.5b02241. Epub 2015 Nov 20.

PMID:
26562722
12.

Solution Structural Studies of GTP:Adenosylcobinamide-Phosphateguanylyl Transferase (CobY) from Methanocaldococcus jannaschii.

Singarapu KK, Otte MM, Tonelli M, Westler WM, Escalante-Semerena JC, Markley JL.

PLoS One. 2015 Oct 29;10(10):e0141297. doi: 10.1371/journal.pone.0141297. eCollection 2015.

13.

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.

Eller CH, Chao TY, Singarapu KK, Ouerfelli O, Yang G, Markley JL, Danishefsky SJ, Raines RT.

ACS Cent Sci. 2015 Jul 22;1(4):181-190. Epub 2015 Jul 13.

14.

Catalyst-controlled divergence in cycloisomerisation reactions of N-propargyl-N-vinyl sulfonamides: gold-catalysed synthesis of 2-sulfonylmethyl pyrroles and dihydropyridines.

Undeela S, Thadkapally S, Nanubolu JB, Singarapu KK, Menon RS.

Chem Commun (Camb). 2015 Sep 18;51(72):13748-51. doi: 10.1039/c5cc04871k. Epub 2015 Jul 10.

PMID:
26159251
15.

Cu(OAc)2-Et3N mediated oxidative coupling of α-azido ketones with pyridinium ylides: utilizing in situ generated imines for regioselective synthesis of imidazo[1,2-a]pyridines.

Kamal A, Reddy CN, Satyaveni M, Chandrasekhar D, Nanubolu JB, Singarapu KK, Maurya RA.

Chem Commun (Camb). 2015 Jul 4;51(52):10475-8. doi: 10.1039/c5cc00815h.

PMID:
26027651
16.

Chemical shift assignments of zinc finger domain of methionine aminopeptidase 1 (MetAP1) from Homo sapiens.

Rachineni K, Arya T, Singarapu KK, Addlagatta A, Bharatam J.

Biomol NMR Assign. 2015 Oct;9(2):351-3. doi: 10.1007/s12104-015-9608-0. Epub 2015 Apr 29.

PMID:
25921012
17.

One-pot, three-component approach to the synthesis of 3,4,5-trisubstituted pyrazoles.

Kamal A, Sastry KN, Chandrasekhar D, Mani GS, Adiyala PR, Nanubolu JB, Singarapu KK, Maurya RA.

J Org Chem. 2015 May 1;80(9):4325-35. doi: 10.1021/jo502946g. Epub 2015 Apr 17.

PMID:
25849582
18.

Regioselective synthesis of substituted arenes via aerobic oxidative [3 + 3] benzannulation reactions of α,β-unsaturated aldehydes and ketones.

Joshi PR, Undeela S, Reddy DD, Singarapu KK, Menon RS.

Org Lett. 2015 Mar 20;17(6):1449-52. doi: 10.1021/acs.orglett.5b00318. Epub 2015 Feb 27.

PMID:
25723761
19.

Synthesis and determination of absolute configuration of α-pyrones isolated from Penicillium corylophilum.

Yadav JS, Ganganna B, Dutta P, Singarapu KK.

J Org Chem. 2014 Nov 21;79(22):10762-71. doi: 10.1021/jo5015382. Epub 2014 Nov 4.

PMID:
25337961
20.

Sequential allylic substitution/Pauson-Khand reaction: a strategy to bicyclic fused cyclopentenones from MBH-acetates of acetylenic aldehydes.

Raji Reddy C, Kumaraswamy P, Singarapu KK.

J Org Chem. 2014 Sep 5;79(17):7880-8. doi: 10.1021/jo500962d. Epub 2014 Aug 19.

PMID:
25105763
21.

Solution NMR structures of Pyrenophora tritici-repentis ToxB and its inactive homolog reveal potential determinants of toxin activity.

Nyarko A, Singarapu KK, Figueroa M, Manning VA, Pandelova I, Wolpert TJ, Ciuffetti LM, Barbar E.

J Biol Chem. 2014 Sep 12;289(37):25946-56. doi: 10.1074/jbc.M114.569103. Epub 2014 Jul 26.

22.

Acetal-initiated Prins bicyclization for the synthesis of hexahydrofuro-[3,4-c]furan lignans and octahydropyrano[3,4-c]pyran derivatives.

Reddy BV, Ramana Reddy M, Sridhar B, Singarapu KK.

Org Biomol Chem. 2014 Jul 14;12(26):4754-62. doi: 10.1039/c4ob00305e.

PMID:
24875046
23.

Synthesis of proposed aglycone of mandelalide A.

Reddy KM, Yamini V, Singarapu KK, Ghosh S.

Org Lett. 2014 May 16;16(10):2658-60. doi: 10.1021/ol500875e. Epub 2014 Apr 16.

PMID:
24738830
24.

Assignments of RNase A by ADAPT-NMR and enhancer.

Tonelli M, Eller CH, Singarapu KK, Lee W, Bahrami A, Westler WM, Raines RT, Markley JL.

Biomol NMR Assign. 2015 Apr;9(1):81-8. doi: 10.1007/s12104-014-9549-z. Epub 2014 Mar 12.

25.

Prins cascade cyclization for the synthesis of 1,9-dioxa-4-azaspiro[5.5]undecane derivatives.

Reddy BV, Medaboina D, Sridhar B, Singarapu KK.

J Org Chem. 2014 Mar 7;79(5):2289-95. doi: 10.1021/jo4027534. Epub 2014 Feb 24.

PMID:
24533744
26.

Stereoselective synthesis of hexahydro-1H-pyrano- and thiopyrano[3,4-c]quinoline derivatives through a Prins cascade cyclization.

Reddy BV, Medaboina D, Sridhar B, Singarapu KK.

J Org Chem. 2013 Aug 16;78(16):8161-8. doi: 10.1021/jo4009657. Epub 2013 Jul 31.

PMID:
23859007
27.

Protein conformational space populated in solution probed with aromatic residual dipolar (13) C-(1) H couplings.

Sathyamoorthy B, Singarapu KK, Garcia AE, Szyperski T.

Chembiochem. 2013 Apr 15;14(6):684-8. doi: 10.1002/cbic.201300016. Epub 2013 Mar 12.

PMID:
23494854
28.

Efficient stable isotope labeling and purification of vitamin D receptor from inclusion bodies.

Zhu J, Rao H, Tonelli M, Westler WM, Singarapu KK, Markley JL, DeLuca HF, Assadi-Porter FM.

Protein Expr Purif. 2012 Sep;85(1):25-31. doi: 10.1016/j.pep.2012.06.012. Epub 2012 Jun 29.

29.

Robust, integrated computational control of NMR experiments to achieve optimal assignment by ADAPT-NMR.

Bahrami A, Tonelli M, Sahu SC, Singarapu KK, Eghbalnia HR, Markley JL.

PLoS One. 2012;7(3):e33173. doi: 10.1371/journal.pone.0033173. Epub 2012 Mar 12.

30.

Ligand-specific structural changes in the vitamin D receptor in solution.

Singarapu KK, Zhu J, Tonelli M, Rao H, Assadi-Porter FM, Westler WM, DeLuca HF, Markley JL.

Biochemistry. 2011 Dec 27;50(51):11025-33. doi: 10.1021/bi201637p. Epub 2011 Dec 5.

31.

Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1.

Rajbhandari P, Finn G, Solodin NM, Singarapu KK, Sahu SC, Markley JL, Kadunc KJ, Ellison-Zelski SJ, Kariagina A, Haslam SZ, Lu KP, Alarid ET.

Mol Cell Biol. 2012 Jan;32(2):445-57. doi: 10.1128/MCB.06073-11. Epub 2011 Nov 7.

32.

Structural characterization of Hsp12, the heat shock protein from Saccharomyces cerevisiae, in aqueous solution where it is intrinsically disordered and in detergent micelles where it is locally α-helical.

Singarapu KK, Tonelli M, Chow DC, Frederick RO, Westler WM, Markley JL.

J Biol Chem. 2011 Dec 16;286(50):43447-53. doi: 10.1074/jbc.M111.306464. Epub 2011 Oct 13.

33.

Hydrogen exchange during cell-free incorporation of deuterated amino acids and an approach to its inhibition.

Tonelli M, Singarapu KK, Makino S, Sahu SC, Matsubara Y, Endo Y, Kainosho M, Markley JL.

J Biomol NMR. 2011 Dec;51(4):467-76. doi: 10.1007/s10858-011-9575-4. Epub 2011 Oct 8.

34.

Differences in the structure and dynamics of the apo- and palmitate-ligated forms of Aedes aegypti sterol carrier protein 2 (AeSCP-2).

Singarapu KK, Radek JT, Tonelli M, Markley JL, Lan Q.

J Biol Chem. 2010 May 28;285(22):17046-53. doi: 10.1074/jbc.M110.101154. Epub 2010 Mar 31.

35.

Solution NMR structures of proteins VPA0419 from Vibrio parahaemolyticus and yiiS from Shigella flexneri provide structural coverage for protein domain family PFAM 04175.

Singarapu KK, Mills JL, Xiao R, Acton T, Punta M, Fischer M, Honig B, Rost B, Montelione GT, Szyperski T.

Proteins. 2010 Feb 15;78(3):779-84. doi: 10.1002/prot.22630. No abstract available.

36.

Nucleic acid folding determined by mesoscale modeling and NMR spectroscopy: solution structure of d(GCGAAAGC).

Santini GP, Cognet JA, Xu D, Singarapu KK, Hervé du Penhoat C.

J Phys Chem B. 2009 May 14;113(19):6881-93. doi: 10.1021/jp8100656.

PMID:
19374420
37.

Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif.

Parish D, Benach J, Liu G, Singarapu KK, Xiao R, Acton T, Su M, Bansal S, Prestegard JH, Hunt J, Montelione GT, Szyperski T.

J Struct Funct Genomics. 2008 Dec;9(1-4):41-9. doi: 10.1007/s10969-008-9050-y. Epub 2008 Nov 26.

38.

Consistent blind protein structure generation from NMR chemical shift data.

Shen Y, Lange O, Delaglio F, Rossi P, Aramini JM, Liu G, Eletsky A, Wu Y, Singarapu KK, Lemak A, Ignatchenko A, Arrowsmith CH, Szyperski T, Montelione GT, Baker D, Bax A.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4685-90. doi: 10.1073/pnas.0800256105. Epub 2008 Mar 7.

39.

NMR structure of the peptidyl-tRNA hydrolase domain from Pseudomonas syringae expands the structural coverage of the hydrolysis domains of class 1 peptide chain release factors.

Singarapu KK, Xiao R, Acton T, Rost B, Montelione GT, Szyperski T.

Proteins. 2008 May 1;71(2):1027-31. doi: 10.1002/prot.21947. No abstract available.

40.

NMR structure of protein Cgl2762 from Corynebacterium glutamicum implicated in DNA transposition reveals a helix-turn-helix motif attached to a flexibly disordered leucine zipper.

Singarapu KK, Xiao R, Sukumaran DK, Acton T, Montelione GT, Szyperski T.

Proteins. 2008 Mar;70(4):1650-4. doi: 10.1002/prot.21840. No abstract available.

PMID:
18175328
41.

Sequence-specific, dynamic covalent crosslinking in aqueous media.

Li M, Yamato K, Ferguson JS, Singarapu KK, Szyperski T, Gong B.

J Am Chem Soc. 2008 Jan 16;130(2):491-500. Epub 2007 Dec 20.

PMID:
18092773
42.

NMR structure of protein yjbR from Escherichia coli reveals 'double-wing' DNA binding motif.

Singarapu KK, Liu G, Xiao R, Bertonati C, Honig B, Montelione GT, Szyperski T.

Proteins. 2007 May 1;67(2):501-4. No abstract available.

PMID:
17266124

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