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Items: 48

1.

Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus.

Maness NJ, Schouest B, Singapuri A, Dennis M, Gilbert MH, Bohm RP, Schiro F, Aye PP, Baker K, Van Rompay KKA, Lackner AA, Bonaldo MC, Blair RV, Permar SR, Coffey LL, Panganiban AT, Magnani D.

Sci Rep. 2019 Sep 5;9(1):12802. doi: 10.1038/s41598-019-49209-7.

2.

Lung Computational Models and the Role of the Small Airways in Asthma.

Foy BH, Soares M, Bordas R, Richardson M, Bell A, Singapuri A, Hargadon B, Brightling C, Burrowes K, Kay D, Owers-Bradley J, Siddiqui S.

Am J Respir Crit Care Med. 2019 Oct 15;200(8):982-991. doi: 10.1164/rccm.201812-2322OC.

PMID:
31106566
3.

Assessment of breath volatile organic compounds in acute cardiorespiratory breathlessness: a protocol describing a prospective real-world observational study.

Ibrahim W, Wilde M, Cordell R, Salman D, Ruszkiewicz D, Bryant L, Richardson M, Free RC, Zhao B, Yousuf A, White C, Russell R, Jones S, Patel B, Awal A, Phillips R, Fowkes G, McNally T, Foxon C, Bhatt H, Peltrini R, Singapuri A, Hargadon B, Suzuki T, Ng LL, Gaillard E, Beardsmore C, Ryanna K, Pandya H, Coates T, Monks PS, Greening N, Brightling CE, Thomas P, Siddiqui S.

BMJ Open. 2019 Mar 8;9(3):e025486. doi: 10.1136/bmjopen-2018-025486.

4.

DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.

Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaao6451. doi: 10.1126/scitranslmed.aao6451.

5.

Breath analysis by two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection - Method optimisation and integration within a large-scale clinical study.

Wilde MJ, Cordell RL, Salman D, Zhao B, Ibrahim W, Bryant L, Ruszkiewicz D, Singapuri A, Free RC, Gaillard EA, Beardsmore C, Thomas CLP, Brightling CE, Siddiqui S, Monks PS.

J Chromatogr A. 2019 Jun 7;1594:160-172. doi: 10.1016/j.chroma.2019.02.001. Epub 2019 Feb 5.

6.

Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma.

Bell AJ, Foy BH, Richardson M, Singapuri A, Mirkes E, van den Berge M, Kay D, Brightling C, Gorban AN, Galbán CJ, Siddiqui S.

J Allergy Clin Immunol. 2019 Jul;144(1):83-93. doi: 10.1016/j.jaci.2019.01.014. Epub 2019 Jan 22.

PMID:
30682455
7.

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D, Pogson ZEK, Fogarty A, McKeever TM, Singapuri A, Heaney LG, Mansur AH, Chaudhuri R, Thomson NC, Holloway JW, Lockett GA, Howarth PH, Djukanovic R, Hankinson J, Niven R, Simpson A, Chung KF, Sterk PJ, Blakey JD, Adcock IM, Hu S, Guo Y, Obeidat M, Sin DD, van den Berge M, Nickle DC, Bossé Y, Tobin MD, Hall IP, Brightling CE, Wain LV, Sayers I.

Lancet Respir Med. 2019 Jan;7(1):20-34. doi: 10.1016/S2213-2600(18)30389-8. Epub 2018 Dec 11.

8.

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort.

Thompson GR 3rd, Krois CR, Affolter VK, Everett AD, Varjonen EK, Sharon VR, Singapuri A, Dennis M, McHardy I, Yoo HS, Fedor DM, Wiederhold NP, Aaron PA, Gelli A, Napoli JL, White SD.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01384-18. doi: 10.1128/AAC.01384-18. Print 2019 Feb.

9.

Chikungunya Virus Fidelity Variants Exhibit Differential Attenuation and Population Diversity in Cell Culture and Adult Mice.

Riemersma KK, Steiner C, Singapuri A, Coffey LL.

J Virol. 2019 Jan 17;93(3). pii: e01606-18. doi: 10.1128/JVI.01606-18. Print 2019 Feb 1.

10.

A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.

Keeffe JR, Van Rompay KKA, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC, Robbiani DF.

Cell Rep. 2018 Nov 6;25(6):1385-1394.e7. doi: 10.1016/j.celrep.2018.10.031.

11.

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.

Coffey LL, Keesler RI, Pesavento PA, Woolard K, Singapuri A, Watanabe J, Cruzen C, Christe KL, Usachenko J, Yee J, Heng VA, Bliss-Moreau E, Reader JR, von Morgenland W, Gibbons AM, Jackson K, Ardeshir A, Heimsath H, Permar S, Senthamaraikannan P, Presicce P, Kallapur SG, Linnen JM, Gao K, Orr R, MacGill T, McClure M, McFarland R, Morrison JH, Van Rompay KKA.

Nat Commun. 2018 Jun 20;9(1):2414. doi: 10.1038/s41467-018-04777-6.

12.

Scented Sugar Baits Enhance Detection of St. Louis Encephalitis and West Nile Viruses in Mosquitoes in Suburban California.

Steiner CD, Riemersma KK, Stuart JB, Singapuri A, Lothrop HD, Coffey LL.

J Med Entomol. 2018 Aug 29;55(5):1307-1318. doi: 10.1093/jme/tjy064.

13.

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.

Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE.

Eur Respir J. 2018 May 24;51(5). pii: 1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May.

14.

Aspirin and clopidogrel high on-treatment platelet reactivity and genetic predictors in peripheral arterial disease.

Yeo KK, Armstrong EJ, López JE, Chen DC, Westin GG, Li CS, Anderson D, Hua A, Singapuri A, Amsterdam EA, Chiamvimonvat N, Laird JR.

Catheter Cardiovasc Interv. 2018 Jun;91(7):1308-1317. doi: 10.1002/ccd.27453. Epub 2018 Feb 7.

15.

Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.

Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE.

Eur Respir J. 2017 May 1;49(5). pii: 1601507. doi: 10.1183/13993003.01507-2016. Print 2017 May.

16.

Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.

Coffey LL, Pesavento PA, Keesler RI, Singapuri A, Watanabe J, Watanabe R, Yee J, Bliss-Moreau E, Cruzen C, Christe KL, Reader JR, von Morgenland W, Gibbons AM, Allen AM, Linnen J, Gao K, Delwart E, Simmons G, Stone M, Lanteri M, Bakkour S, Busch M, Morrison J, Van Rompay KK.

PLoS One. 2017 Jan 31;12(1):e0171148. doi: 10.1371/journal.pone.0171148. eCollection 2017.

17.

Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics.

Ghebre MA, Desai D, Singapuri A, Woods J, Rapley L, Cohen S, Herath A, Wardlaw AJ, Pashley CH, May R, Brightling CE.

Allergy Asthma Immunol Res. 2017 Mar;9(2):177-181. doi: 10.4168/aair.2017.9.2.177.

18.

A microbiome assessment of medical marijuana.

Thompson GR 3rd, Tuscano JM, Dennis M, Singapuri A, Libertini S, Gaudino R, Torres A, Delisle JM, Gillece JD, Schupp JM, Engelthaler DM.

Clin Microbiol Infect. 2017 Apr;23(4):269-270. doi: 10.1016/j.cmi.2016.12.001. Epub 2016 Dec 9. No abstract available.

19.

Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial.

Gonem S, Berair R, Singapuri A, Hartley R, Laurencin MFM, Bacher G, Holzhauer B, Bourne M, Mistry V, Pavord ID, Mansur AH, Wardlaw AJ, Siddiqui SH, Kay RA, Brightling CE.

Lancet Respir Med. 2016 Sep;4(9):699-707. doi: 10.1016/S2213-2600(16)30179-5. Epub 2016 Aug 5.

PMID:
27503237
20.

Domiciliary exhaled nitric oxide and eosinophilic airway inflammation in adults with asthma.

Nanda CR, Singapuri A, Soares M, Monteiro W, Siddiqui S, Gonem S.

Eur Respir J. 2016 Jul;48(1):242-4. doi: 10.1183/13993003.02060-2015. Epub 2016 Apr 21. No abstract available.

21.

In vivo development of fluconazole resistance in serial Cryptococcus gattii isolates from a cat.

Sykes JE, Hodge G, Singapuri A, Yang ML, Gelli A, Thompson GR 3rd.

Med Mycol. 2017 Jun 1;55(4):396-401. doi: 10.1093/mmy/myw104.

PMID:
28339594
22.

Fluconazole Susceptibility in Cryptococcus gattii Is Dependent on the ABC Transporter Pdr11.

Yang ML, Uhrig J, Vu K, Singapuri A, Dennis M, Gelli A, Thompson GR 3rd.

Antimicrob Agents Chemother. 2015 Dec 7;60(3):1202-7. doi: 10.1128/AAC.01777-15.

23.

Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling.

Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD, Chiamvimonvat N.

Circ Arrhythm Electrophysiol. 2015 Aug;8(4):942-50. doi: 10.1161/CIRCEP.114.002162. Epub 2015 May 20.

24.

Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography.

Gupta S, Hartley R, Singapuri A, Hargadon B, Monteiro W, Pavord ID, Sousa AR, Marshall RP, Subramanian D, Parr D, Entwisle JJ, Siddiqui S, Raj V, Brightling CE.

Am J Respir Crit Care Med. 2015 Jan 1;191(1):107-10. doi: 10.1164/rccm.201406-1128LE. No abstract available.

25.

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel.

Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9989-94. doi: 10.1073/pnas.1323541111. Epub 2014 Jun 20.

26.

Lung clearance index in adults with non-cystic fibrosis bronchiectasis.

Gonem S, Scadding A, Soares M, Singapuri A, Gustafsson P, Ohri C, Range S, Brightling CE, Pavord I, Horsley A, Siddiqui S.

Respir Res. 2014 May 18;15:59. doi: 10.1186/1465-9921-15-59.

27.

Between-visit variability of small airway obstruction markers in patients with asthma.

Gonem S, Corkill S, Singapuri A, Gustafsson P, Costanza R, Brightling CE, Siddiqui S.

Eur Respir J. 2014 Jul;44(1):242-4. doi: 10.1183/09031936.00001814. Epub 2014 Mar 6. No abstract available.

28.

Validation of a photoacoustic gas analyser for the measurement of functional residual capacity using multiple-breath inert gas washout.

Gonem S, Singer F, Corkill S, Singapuri A, Siddiqui S, Gustafsson P.

Respiration. 2014;87(6):462-8. doi: 10.1159/000357786. Epub 2014 Feb 13.

29.

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis.

Haldar P, Brightling CE, Singapuri A, Hargadon B, Gupta S, Monteiro W, Bradding P, Green RH, Wardlaw AJ, Ortega H, Pavord ID.

J Allergy Clin Immunol. 2014 Mar;133(3):921-3. doi: 10.1016/j.jaci.2013.11.026. Epub 2014 Jan 10. No abstract available.

PMID:
24418480
30.

Clinical significance of small airway obstruction markers in patients with asthma.

Gonem S, Natarajan S, Desai D, Corkill S, Singapuri A, Bradding P, Gustafsson P, Costanza R, Kajekar R, Parmar H, Brightling CE, Siddiqui S.

Clin Exp Allergy. 2014 Apr;44(4):499-507. doi: 10.1111/cea.12257.

PMID:
24341600
31.

Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK, Chiamvimonvat N.

Cardiovasc Res. 2014 Feb 1;101(2):317-25. doi: 10.1093/cvr/cvt262. Epub 2013 Nov 26.

32.

Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients.

Gupta S, Hartley R, Khan UT, Singapuri A, Hargadon B, Monteiro W, Pavord ID, Sousa AR, Marshall RP, Subramanian D, Parr D, Entwisle JJ, Siddiqui S, Raj V, Brightling CE.

J Allergy Clin Immunol. 2014 Mar;133(3):729-38.e18. doi: 10.1016/j.jaci.2013.09.039. Epub 2013 Nov 12.

33.

Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.

Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK, Chiamvimonvat N.

Circ Res. 2013 Jun 7;112(12):1567-76. doi: 10.1161/CIRCRESAHA.112.300370. Epub 2013 Apr 22.

34.

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, Herath A, Anderson IK, Bradding P, Green R, Kulkarni N, Pavord I, Marshall RP, Sousa AR, May RD, Wardlaw AJ, Brightling CE.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63. doi: 10.1164/rccm.201208-1470OC.

35.

Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma.

Desai D, Gupta S, Siddiqui S, Singapuri A, Monteiro W, Entwisle J, Visvanathan S, Parmar H, Kajekar R, Brightling CE.

Respir Res. 2013 Feb 11;14:17. doi: 10.1186/1465-9921-14-17.

36.

Genome-wide association study to identify genetic determinants of severe asthma.

Wan YI, Shrine NR, Soler Artigas M, Wain LV, Blakey JD, Moffatt MF, Bush A, Chung KF, Cookson WO, Strachan DP, Heaney L, Al-Momani BA, Mansur AH, Manney S, Thomson NC, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Hui J, Musk AW, James AL; Australian Asthma Genetics Consortium, Brown MA, Baltic S, Ferreira MA, Thompson PJ, Tobin MD, Sayers I, Hall IP.

Thorax. 2012 Sep;67(9):762-8. Epub 2012 May 5.

37.

Body mass and fat mass in refractory asthma: an observational 1 year follow-up study.

Bafadhel M, Singapuri A, Terry S, Hargadon B, Monteiro W, Green RH, Bradding PH, Wardlaw AJ, Pavord ID, Brightling CE.

J Allergy (Cairo). 2010;2010:251758. doi: 10.1155/2010/251758. Epub 2010 Dec 1.

38.

Expression and roles of Cav1.3 (α1D) L-type Ca²+ channel in atrioventricular node automaticity.

Zhang Q, Timofeyev V, Qiu H, Lu L, Li N, Singapuri A, Torado CL, Shin HS, Chiamvimonvat N.

J Mol Cell Cardiol. 2011 Jan;50(1):194-202. doi: 10.1016/j.yjmcc.2010.10.002. Epub 2010 Oct 14.

39.

Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy.

Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK, Chiamvimonvat N.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1459-67. doi: 10.1152/ajpheart.01208.2009. Epub 2010 Aug 13.

40.

Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.

Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, Mateo RK, Singapuri A, Young JN, Knowlton AA, Chiamvimonvat N.

Circ Res. 2010 Oct 1;107(7):851-9. doi: 10.1161/CIRCRESAHA.109.215269. Epub 2010 Aug 5.

41.

Mannitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness.

Singapuri A, McKenna S, Brightling CE, Bradding P.

Respirology. 2010 Apr;15(3):510-5. doi: 10.1111/j.1440-1843.2010.01712.x. Epub 2010 Feb 24.

PMID:
20210888
42.

Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel).

Lu L, Timofeyev V, Li N, Rafizadeh S, Singapuri A, Harris TR, Chiamvimonvat N.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18402-7. doi: 10.1073/pnas.0908207106. Epub 2009 Oct 8.

43.

Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.

Li N, Timofeyev V, Tuteja D, Xu D, Lu L, Zhang Q, Zhang Z, Singapuri A, Albert TR, Rajagopal AV, Bond CT, Periasamy M, Adelman J, Chiamvimonvat N.

J Physiol. 2009 Mar 1;587(Pt 5):1087-100. doi: 10.1113/jphysiol.2008.167718. Epub 2009 Jan 12.

44.

The utility of the mannitol challenge in the assessment of chronic cough: a pilot study.

Singapuri A, McKenna S, Brightling CE.

Cough. 2008 Nov 18;4:10. doi: 10.1186/1745-9974-4-10.

45.

Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes.

Zhang Q, Timofeyev V, Lu L, Li N, Singapuri A, Long MK, Bond CT, Adelman JP, Chiamvimonvat N.

Circ Res. 2008 Feb 29;102(4):465-71. Epub 2007 Dec 20.

46.

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors.

Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai HJ, Kim IH, Tuteja D, Mateo RK, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18733-8. Epub 2006 Nov 27.

47.

Calmodulin concentrates at the apex of growing hyphae and localizes to the Spitzenkörper in Aspergillus nidulans.

Wang G, Lu L, Zhang CY, Singapuri A, Yuan S.

Protoplasma. 2006 Sep;228(4):159-66. Epub 2006 Sep 20.

PMID:
16983484
48.

Timing of retroviral infection influences anamnestic immune response in vaccinated primates.

Anderson DE, Singapuri A, Kang KH, Montefiori DC, Torres JV.

Viral Immunol. 2005;18(4):689-94.

PMID:
16359235

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