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Singanayagam A, Johnston SL.

J Allergy Clin Immunol. 2020 Jan 14. pii: S0091-6749(20)30029-4. doi: 10.1016/j.jaci.2019.12.907. [Epub ahead of print] No abstract available.


Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.

Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C.

Life Sci Alliance. 2019 Dec 10;3(1). pii: e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan.


Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation.

Patel DF, Peiró T, Bruno N, Vuononvirta J, Akthar S, Puttur F, Pyle CJ, Suveizdytė K, Walker SA, Singanayagam A, Carlin LM, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Immunol. 2019 Nov 8;4(41). pii: eaax7006. doi: 10.1126/sciimmunol.aax7006.


CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.

Lebossé F, Gudd C, Tunc E, Singanayagam A, Nathwani R, Triantafyllou E, Pop O, Kumar N, Mukherjee S, Hou TZ, Quaglia A, Zoulim F, Wendon J, Dhar A, Thursz M, Antoniades CG, Khamri W.

EBioMedicine. 2019 Nov;49:258-268. doi: 10.1016/j.ebiom.2019.10.011. Epub 2019 Oct 31.


Antiviral immunity is impaired in COPD patients with frequent exacerbations.

Singanayagam A, Loo SL, Calderazzo M, Finney LJ, Trujillo Torralbo MB, Bakhsoliani E, Girkin J, Veerati P, Pathinayake PS, Nichol KS, Reid A, Footitt J, Wark PAB, Grainge CL, Johnston SL, Bartlett NW, Mallia P.

Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1;317(6):L893-L903. doi: 10.1152/ajplung.00253.2019. Epub 2019 Sep 12.


Less burn, more fat: electronic cigarettes and pulmonary lipid homeostasis.

Singanayagam A, Snelgrove RJ.

J Clin Invest. 2019 Oct 1;129(10):4077-4079. doi: 10.1172/JCI131336.


Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease.

Singanayagam A, Glanville N, Cuthbertson L, Bartlett NW, Finney LJ, Turek E, Bakhsoliani E, Calderazzo MA, Trujillo-Torralbo MB, Footitt J, James PL, Fenwick P, Kemp SV, Clarke TB, Wedzicha JA, Edwards MR, Moffatt M, Cookson WO, Mallia P, Johnston SL.

Sci Transl Med. 2019 Aug 28;11(507). pii: eaav3879. doi: 10.1126/scitranslmed.aav3879.


Review of the British Thoracic Society Winter Meeting 2018, 5-7 December 2018, London, UK.

Goodwin AT, Singanayagam A, Jenkins G.

Thorax. 2019 Dec;74(12):1168-1173. doi: 10.1136/thoraxjnl-2019-213680. Epub 2019 Aug 5.


Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study.

Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K, Tregoning JS, Meijer A, Clarke E, Dong T, Barclay W, Kampmann B, de Silva TI.

Lancet Respir Med. 2019 Aug;7(8):665-676. doi: 10.1016/S2213-2600(19)30086-4. Epub 2019 Jun 21.


Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium.

Singanayagam A, Zambon M, Barclay WS.

J Virol. 2019 Aug 13;93(17). pii: e00058-19. doi: 10.1128/JVI.00058-19. Print 2019 Sep 1.


Inflammation and infections in unreported chronic obstructive pulmonary disease exacerbations.

Calderazzo MA, Trujillo-Torralbo MB, Finney LJ, Singanayagam A, Bakhsoliani E, Padmanaban V, Kebadze T, Aniscenko J, Elkin SL, Johnston SL, Mallia P.

Int J Chron Obstruct Pulmon Dis. 2019 Apr 10;14:823-832. doi: 10.2147/COPD.S191946. eCollection 2019.


Not just the common cold: Rhinovirus infection in lung allograft recipients.

Singanayagam A, Johnston SL.

Respirology. 2019 Dec;24(12):1134-1135. doi: 10.1111/resp.13571. Epub 2019 Apr 19. No abstract available.


Severe Disseminated Infection with Emerging Lineage of Methicillin-Sensitive Staphylococcus aureus.

Jewell P, Dixon L, Singanayagam A, Ghani R, Wong E, Coleman M, Pichon B, Kearns A, Russell G, Hatcher J.

Emerg Infect Dis. 2019 Jan;25(1):187-189. doi: 10.3201/eid2501.180684.


Respiratory infection: insights from assembly 10 of the European Respiratory Society 2018 Annual Congress.

Calarasu C, Singanayagam A.

J Thorac Dis. 2018 Sep;10(Suppl 25):S3017-S3019. doi: 10.21037/jtd.2018.09.20. No abstract available.


Early Career Members at the ERS International Congress 2017: highlights from the Assemblies.

Kahn N, Tomos I, Andrianopoulos V, Arikan H, van der Does A, Almendros I, Bonvivi S, Morgan A, Nenna R, Magouliotis D, Rutter M, De Soomer K, Nyberg A, Lundell S, Leceuvre K, Singanayagam A, Bostantzoglou C, Karmouty-Quintana H, De Brandt J.

Breathe (Sheff). 2017 Dec;13(4):e121-e129. doi: 10.1183/20734735.017617.


Review of the British Thoracic Society Winter Meeting 2017, 6-8 December 2017, London, UK.

Singanayagam A, Woodcock HV, Molyneaux PL, Jenkins G.

Thorax. 2018 Sep;73(9):872-876. doi: 10.1136/thoraxjnl-2018-212012. Epub 2018 Jun 14. Review.


Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations.

Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, Toussaint M, Walton RP, Finney LJ, Aniscenko J, Zhu J, Trujillo-Torralbo MB, Calderazzo MA, Grainge C, Loo SL, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, James PL, Solari R, Wark PAB, Knight DA, Moffatt MF, Cookson WO, Edwards MR, Mallia P, Bartlett NW, Johnston SL.

Nat Commun. 2018 Jun 8;9(1):2229. doi: 10.1038/s41467-018-04574-1.


In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis.

Lisman T, Kleiss S, Patel VC, Fisher C, Adelmeijer J, Bos S, Singanayagam A, Stoy SH, Shawcross DL, Bernal W.

Liver Int. 2018 Nov;38(11):1988-1996. doi: 10.1111/liv.13882. Epub 2018 May 30.


Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease.

Mallia P, Webber J, Gill SK, Trujillo-Torralbo MB, Calderazzo MA, Finney L, Bakhsoliani E, Farne H, Singanayagam A, Footitt J, Hewitt R, Kebadze T, Aniscenko J, Padmanaban V, Molyneaux PL, Adcock IM, Barnes PJ, Ito K, Elkin SL, Kon OM, Cookson WO, Moffat MF, Johnston SL, Tregoning JS.

J Allergy Clin Immunol. 2018 Sep;142(3):815-823.e6. doi: 10.1016/j.jaci.2017.10.017. Epub 2018 Jan 5.


β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells.

Ritchie AI, Singanayagam A, Wiater E, Edwards MR, Montminy M, Johnston SL.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):128-132. doi: 10.1165/rcmb.2017-0315LE. No abstract available.


Respiratory infection: insights from Assembly 10 of the European Respiratory Society 2017 Annual Congress.

Garcia-Basteiro AL, Wong E, Van Oort PM, Cilloniz C, Migliori GB, Singanayagam A.

J Thorac Dis. 2017 Nov;9(Suppl 16):S1559-S1562. doi: 10.21037/jtd.2017.11.39. No abstract available.


Can defective interfering RNAs affect the live attenuated influenza vaccine? - Authors' reply.

Singanayagam A, Zambon M, Lalvani A, Barclay W.

Lancet Infect Dis. 2017 Dec;17(12):1235-1236. doi: 10.1016/S1473-3099(17)30638-2. No abstract available.


Review article: the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease.

Woodhouse CA, Patel VC, Singanayagam A, Shawcross DL.

Aliment Pharmacol Ther. 2018 Jan;47(2):192-202. doi: 10.1111/apt.14397. Epub 2017 Oct 30. Review.


Evaluation of severity score-guided approaches to macrolide use in community-acquired pneumonia.

Singanayagam A, Aliberti S, Cillóniz C, Torres A, Blasi F, Chalmers JD.

Eur Respir J. 2017 Sep 10;50(3). pii: 1602306. doi: 10.1183/13993003.02306-2016. Print 2017 Sep.


Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure.

Fisher C, Patel VC, Stoy SH, Singanayagam A, Adelmeijer J, Wendon J, Shawcross DL, Lisman T, Bernal W.

J Crit Care. 2018 Feb;43:54-60. doi: 10.1016/j.jcrc.2017.07.053. Epub 2017 Aug 17.


Urgent challenges in implementing live attenuated influenza vaccine.

Singanayagam A, Zambon M, Lalvani A, Barclay W.

Lancet Infect Dis. 2018 Jan;18(1):e25-e32. doi: 10.1016/S1473-3099(17)30360-2. Epub 2017 Aug 2. Review.


Oral versus intravenous clarithromycin in moderate to severe community-acquired pneumonia: an observational study.

Rae N, Singanayagam A, Schembri S, Chalmers JD.

Pneumonia (Nathan). 2017 Feb 5;9:2. doi: 10.1186/s41479-017-0025-2. eCollection 2017.


CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure.

Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CG.

Gut. 2018 Jun;67(6):1155-1167. doi: 10.1136/gutjnl-2017-314184. Epub 2017 Jun 7.


MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.

Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG.

Gut. 2018 Feb;67(2):333-347. doi: 10.1136/gutjnl-2016-313615. Epub 2017 Apr 27.


Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.

Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG.

Gastroenterology. 2017 Jul;153(1):263-276.e8. doi: 10.1053/j.gastro.2017.03.023. Epub 2017 Mar 28.


Early Career Members at the ERS International Congress London 2016: Early Career Forum.

Bos LD, Bartel S, Ojanguren Arranz I, Kahn NC, Mathioudakis AG, Flood E, Petrarca L, Singanayagam A, Hardavella G.

Breathe (Sheff). 2016 Dec;12(4):364-368. doi: 10.1183/20734735.017216.


Evaluation of prediagnosis emergency department presentations in patients with active tuberculosis: the role of chest radiography, risk factors and symptoms.

Appleton SC, Connell DW, Singanayagam A, Bradley P, Pan D, Sanderson F, Cleaver B, Rahman A, Kon OM.

BMJ Open Respir Res. 2017 Jan 17;4(1):e000154. doi: 10.1136/bmjresp-2016-000154. eCollection 2017.


Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis.

Singanayagam A, Manalan K, Connell DW, Chalmers JD, Sridhar S, Ritchie AI, Lalvani A, Wickremasinghe M, Kon OM.

Int J Tuberc Lung Dis. 2016 Dec;20(12):1653-1660.


Role of microbiome in the pathophysiology and disease course of asthma.

Singanayagam A, Ritchie AI, Johnston SL.

Curr Opin Pulm Med. 2017 Jan;23(1):41-47. Review.


Smoke and viruses-a hindrance to relaxing the airways?

Singanayagam A, Johnston SL.

Clin Sci (Lond). 2016 May 1;130(10):839-41. doi: 10.1042/CS20160139.


Risk factors for Clostridium difficile infection in hospitalized patients with community-acquired pneumonia.

Chalmers JD, Akram AR, Singanayagam A, Wilcox MH, Hill AT.

J Infect. 2016 Jul;73(1):45-53. doi: 10.1016/j.jinf.2016.04.008. Epub 2016 Apr 19.


Juniors' voice at the ERS International Congress, Amsterdam 2015: Juniors' voice.

Polverino F, Longhini F, Vanaudenaerde B, Bikov A, Aamli A, Singanayagam A, Kahn N, Boots A, Skoczynski S.

Breathe (Sheff). 2015 Dec;11(4):303-5. doi: 10.1183/20734735.010815.


Pathogenesis of Viral Infection in Exacerbations of Airway Disease.

Ritchie AI, Farne HA, Singanayagam A, Jackson DJ, Mallia P, Johnston SL.

Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S115-32. doi: 10.1513/AnnalsATS.201503-151AW. Review.


Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice.

Singanayagam A, Glanville N, Bartlett N, Johnston S.

Lancet. 2015 Feb 26;385 Suppl 1:S88. doi: 10.1016/S0140-6736(15)60403-2.


Immunotherapy in the treatment and prevention of infection in acute-on-chronic liver failure.

Bernsmeier C, Singanayagam A, Patel VC, Wendon J, Antoniades CG.

Immunotherapy. 2015;7(6):641-54. doi: 10.2217/imt.15.27. Epub 2015 Jun 12. Review.


Screening for latent tuberculosis before tumour necrosis factor antagonist therapy.

Hewitt RJ, Singanayagam A, Sridhar S, Wickremasinghe M, Min Kon O.

Eur Respir J. 2015 May;45(5):1510-2. doi: 10.1183/09031936.00194314. No abstract available.


A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.

Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, Horvat JC, Hansbro PM, Bartlett NW, Johnston SL.

Clin Sci (Lond). 2015 Aug;129(3):245-58. doi: 10.1042/CS20140654.


Screening tests for tuberculosis before starting biological therapy.

Hewitt RJ, Francis M, Singanayagam A, Kon OM.

BMJ. 2015 Mar 5;350:h1060. doi: 10.1136/bmj.h1060. No abstract available.


Systemic cytokine storm in severe eosinophilic dermatitis.

Singanayagam A, Lamb L, Makinde JE, Teo I, Shaunak S.

QJM. 2015 Nov;108(11):907-8. doi: 10.1093/qjmed/hcv056. Epub 2015 Feb 28. No abstract available.


Update on acute liver failure.

Singanayagam A, Bernal W.

Curr Opin Crit Care. 2015 Apr;21(2):134-41. doi: 10.1097/MCC.0000000000000187. Review.


Inhaled glucocorticoids and COPD exacerbations.

Singanayagam A, Johnston SL, Mallia P.

N Engl J Med. 2015 Jan 1;372(1):92-3. doi: 10.1056/NEJMc1413308. No abstract available.


Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK.

Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J, Antoniades CG.

Gastroenterology. 2015 Mar;148(3):603-615.e14. doi: 10.1053/j.gastro.2014.11.045. Epub 2014 Dec 3.


Letter in response to TB during TNF-α inhibitor therapy, despite screening.

Manalan K, Singanayagam A, Wickremasinghe M, Kon OM.

Thorax. 2015 Apr;70(4):373. doi: 10.1136/thoraxjnl-2014-206239. Epub 2014 Oct 29. No abstract available.


Mouse models of rhinovirus infection and airways disease.

Bartlett NW, Singanayagam A, Johnston SL.

Methods Mol Biol. 2015;1221:181-8. doi: 10.1007/978-1-4939-1571-2_14.


Inhaled corticosteroids and pneumonia in chronic obstructive pulmonary disease.

Finney L, Berry M, Singanayagam A, Elkin SL, Johnston SL, Mallia P.

Lancet Respir Med. 2014 Nov;2(11):919-932. doi: 10.1016/S2213-2600(14)70169-9. Epub 2014 Sep 17. Review.


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