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Items: 1 to 50 of 136

1.

Slow-channel myasthenia due to novel mutation in M2 domain of AChR delta subunit.

Shen XM, Milone M, Wang HL, Banwell B, Selcen D, Sine SM, Engel AG.

Ann Clin Transl Neurol. 2019 Oct;6(10):2066-2078. doi: 10.1002/acn3.50902. Epub 2019 Sep 27.

2.

Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors.

Sine SM, Strikwerda JR, Mazzaferro S.

Neuropharmacology. 2019 Dec 1;160:107660. doi: 10.1016/j.neuropharm.2019.05.037. Epub 2019 Jun 1.

PMID:
31163179
3.

Potentiation of a neuronal nicotinic receptor via pseudo-agonist site.

Mazzaferro S, Bermudez I, Sine SM.

Cell Mol Life Sci. 2019 Mar;76(6):1151-1167. doi: 10.1007/s00018-018-2993-7. Epub 2019 Jan 1.

PMID:
30600358
4.

Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors.

Noori HR, Mücksch C, Vengeliene V, Schönig K, Takahashi TT, Mukhtasimova N, Bagher Oskouei M, Mosqueira M, Bartsch D, Fink R, Urbassek HM, Spanagel R, Sine SM.

Commun Biol. 2018 Oct 3;1:159. doi: 10.1038/s42003-018-0157-9. eCollection 2018.

5.

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel.

Mukhtasimova N, Sine SM.

J Gen Physiol. 2018 May 7;150(5):713-729. doi: 10.1085/jgp.201711881. Epub 2018 Apr 21.

6.

Mutations causing congenital myasthenia reveal principal coupling pathway in the acetylcholine receptor ε-subunit.

Shen XM, Brengman JM, Shen S, Durmus H, Preethish-Kumar V, Yuceyar N, Vengalil S, Nalini A, Deymeer F, Sine SM, Engel AG.

JCI Insight. 2018 Jan 25;3(2). pii: 97826. doi: 10.1172/jci.insight.97826. eCollection 2018 Jan 25.

7.

Nicotinic acetylcholine receptors at the single-channel level.

Bouzat C, Sine SM.

Br J Pharmacol. 2018 Jun;175(11):1789-1804. doi: 10.1111/bph.13770. Epub 2017 Apr 8. Review.

8.

α4β2 Nicotinic Acetylcholine Receptors: RELATIONSHIPS BETWEEN SUBUNIT STOICHIOMETRY AND FUNCTION AT THE SINGLE CHANNEL LEVEL.

Mazzaferro S, Bermudez I, Sine SM.

J Biol Chem. 2017 Feb 17;292(7):2729-2740. doi: 10.1074/jbc.M116.764183. Epub 2016 Dec 28.

9.

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR.

Mukhtasimova N, daCosta CJ, Sine SM.

J Gen Physiol. 2016 Jul;148(1):43-63. doi: 10.1085/jgp.201611584.

10.

Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates.

Shen XM, Brengman J, Neubauer D, Sine SM, Engel AG.

J Biol Chem. 2016 Feb 12;291(7):3291-301. doi: 10.1074/jbc.M115.683995. Epub 2015 Dec 23.

11.

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors.

daCosta CJ, Free CR, Sine SM.

Nat Commun. 2015 Aug 18;6:8057. doi: 10.1038/ncomms9057.

12.

Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment.

Engel AG, Shen XM, Selcen D, Sine SM.

Lancet Neurol. 2015 May;14(5):461. doi: 10.1016/S1474-4422(15)00010-1. Epub 2015 Mar 26. No abstract available.

PMID:
25895926
13.

Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment.

Engel AG, Shen XM, Selcen D, Sine SM.

Lancet Neurol. 2015 Apr;14(4):420-34. doi: 10.1016/S1474-4422(14)70201-7. Review. Erratum in: Lancet Neurol. 2015 May;14(5):461.

14.

Stoichiometry for activation of neuronal α7 nicotinic receptors.

Andersen N, Corradi J, Sine SM, Bouzat C.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20819-24. doi: 10.1073/pnas.1315775110. Epub 2013 Dec 2.

15.

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.

Sine SM, Huang S, Li SX, daCosta CJ, Chen L.

Biochem J. 2013 Sep 1;454(2):311-21. doi: 10.1042/BJ20130638.

16.

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera.

Huang S, Li SX, Bren N, Cheng K, Gomoto R, Chen L, Sine SM.

Biochem J. 2013 Sep 1;454(2):303-310. doi: 10.1042/BJ20130636.

17.

Stoichiometry for drug potentiation of a pentameric ion channel.

daCosta CJ, Sine SM.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6595-600. doi: 10.1073/pnas.1301909110. Epub 2013 Apr 1.

18.

Nicotinic receptor transduction zone: invariant arginine couples to multiple electron-rich residues.

Mukhtasimova N, Sine SM.

Biophys J. 2013 Jan 22;104(2):355-67. doi: 10.1016/j.bpj.2012.12.013.

19.

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease.

Sine SM.

Physiol Rev. 2012 Jul;92(3):1189-234. doi: 10.1152/physrev.00015.2011. Review.

20.

Myasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gating.

Shen XM, Brengman JM, Sine SM, Engel AG.

J Clin Invest. 2012 Jul;122(7):2613-21. doi: 10.1172/JCI63415. Epub 2012 Jun 25.

21.

Highly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding site.

Shen XM, Brengman JM, Edvardson S, Sine SM, Engel AG.

Neurology. 2012 Jul 31;79(5):449-54. doi: 10.1212/WNL.0b013e31825b5bda. Epub 2012 May 16.

22.

Intramembrane proton binding site linked to activation of bacterial pentameric ion channel.

Wang HL, Cheng X, Sine SM.

J Biol Chem. 2012 Feb 24;287(9):6482-9. doi: 10.1074/jbc.M111.305839. Epub 2011 Nov 14.

23.

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.

daCosta CJ, Free CR, Corradi J, Bouzat C, Sine SM.

J Neurosci. 2011 Sep 28;31(39):13870-9. doi: 10.1523/JNEUROSCI.2652-11.2011.

24.

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist.

Li SX, Huang S, Bren N, Noridomi K, Dellisanti CD, Sine SM, Chen L.

Nat Neurosci. 2011 Sep 11;14(10):1253-9. doi: 10.1038/nn.2908.

25.

Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptors.

Andersen N, Corradi J, Bartos M, Sine SM, Bouzat C.

J Neurosci. 2011 Mar 9;31(10):3662-9. doi: 10.1523/JNEUROSCI.5940-10.2011.

26.

On the origin of ion selectivity in the Cys-loop receptor family.

Sine SM, Wang HL, Hansen S, Taylor P.

J Mol Neurosci. 2010 Jan;40(1-2):70-6. doi: 10.1007/s12031-009-9260-1. Review.

27.

What have we learned from the congenital myasthenic syndromes.

Engel AG, Shen XM, Selcen D, Sine SM.

J Mol Neurosci. 2010 Jan;40(1-2):143-53. doi: 10.1007/s12031-009-9229-0. Epub 2009 Aug 18. Review.

28.

Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor.

Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA.

Biophys J. 2009 Jun 3;96(11):4502-13. doi: 10.1016/j.bpj.2009.03.018.

29.

Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors.

Rayes D, De Rosa MJ, Sine SM, Bouzat C.

J Neurosci. 2009 May 6;29(18):6022-32. doi: 10.1523/JNEUROSCI.0627-09.2009.

30.

Single-channel current through nicotinic receptor produced by closure of binding site C-loop.

Wang HL, Toghraee R, Papke D, Cheng XL, McCammon JA, Ravaioli U, Sine SM.

Biophys J. 2009 May 6;96(9):3582-90. doi: 10.1016/j.bpj.2009.02.020.

31.

Detection and trapping of intermediate states priming nicotinic receptor channel opening.

Mukhtasimova N, Lee WY, Wang HL, Sine SM.

Nature. 2009 May 21;459(7245):451-4. doi: 10.1038/nature07923. Epub 2009 Apr 1.

32.

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions.

Lee WY, Free CR, Sine SM.

J Neurosci. 2009 Mar 11;29(10):3189-99. doi: 10.1523/JNEUROSCI.6185-08.2009.

33.

An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance.

Hansen SB, Wang HL, Taylor P, Sine SM.

J Biol Chem. 2008 Dec 26;283(52):36066-70. doi: 10.1074/jbc.C800194200. Epub 2008 Oct 21.

34.

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.

Bouzat C, Bartos M, Corradi J, Sine SM.

J Neurosci. 2008 Jul 30;28(31):7808-19. doi: 10.1523/JNEUROSCI.0448-08.2008.

35.

Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating.

Lee WY, Free CR, Sine SM.

J Gen Physiol. 2008 Aug;132(2):265-78. doi: 10.1085/jgp.200810014.

36.

Further observations in congenital myasthenic syndromes.

Engel AG, Shen XM, Selcen D, Sine SM.

Ann N Y Acad Sci. 2008;1132:104-13. doi: 10.1196/annals.1405.039. Review.

37.

Recent structural and mechanistic insights into endplate acetylcholine receptors.

Sine SM, Gao F, Lee WY, Mukhtasimova N, Wang HL, Engel AG.

Ann N Y Acad Sci. 2008;1132:53-60. doi: 10.1196/annals.1405.041.

38.

Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors.

Wu TY, Smith CM, Sine SM, Levandoski MM.

Mol Pharmacol. 2008 Aug;74(2):466-75. doi: 10.1124/mol.107.044388. Epub 2008 May 5.

39.

Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating.

Shen XM, Fukuda T, Ohno K, Sine SM, Engel AG.

J Clin Invest. 2008 May;118(5):1867-76. doi: 10.1172/JCI34527.

40.

Control of cation permeation through the nicotinic receptor channel.

Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM.

PLoS Comput Biol. 2008 Feb;4(2):e41. doi: 10.1371/journal.pcbi.0040041.

41.

Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor.

Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA.

Biophys J. 2007 Oct 15;93(8):2622-34. Epub 2007 Jun 15.

42.

Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family.

Ivanov I, Cheng X, Sine SM, McCammon JA.

J Am Chem Soc. 2007 Jul 4;129(26):8217-24. Epub 2007 Jun 7.

PMID:
17552523
43.

An intersubunit trigger of channel gating in the muscle nicotinic receptor.

Mukhtasimova N, Sine SM.

J Neurosci. 2007 Apr 11;27(15):4110-9.

44.

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors.

Cheng X, Wang H, Grant B, Sine SM, McCammon JA.

PLoS Comput Biol. 2006 Sep 29;2(9):e134. Epub 2006 Aug 23.

45.

Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop.

Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM.

Mol Pharmacol. 2006 Oct;70(4):1230-5. Epub 2006 Jul 17.

PMID:
16847142
46.

Slow-channel mutation in acetylcholine receptor alphaM4 domain and its efficient knockdown.

Shen XM, Deymeer F, Sine SM, Engel AG.

Ann Neurol. 2006 Jul;60(1):128-36.

PMID:
16685696
47.

Recent advances in Cys-loop receptor structure and function.

Sine SM, Engel AG.

Nature. 2006 Mar 23;440(7083):448-55. Review.

PMID:
16554804
48.

Principal pathway coupling agonist binding to channel gating in nicotinic receptors.

Lee WY, Sine SM.

Nature. 2005 Nov 10;438(7065):243-7.

PMID:
16281039
49.

Single-channel kinetic analysis of chimeric alpha7-5HT3A receptors.

Rayes D, Spitzmaul G, Sine SM, Bouzat C.

Mol Pharmacol. 2005 Nov;68(5):1475-83. Epub 2005 Aug 23.

PMID:
16118362
50.

Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor.

Mukhtasimova N, Free C, Sine SM.

J Gen Physiol. 2005 Jul;126(1):23-39. Epub 2005 Jun 13.

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