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Items: 1 to 50 of 131

1.

Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.

Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom SC, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC.

Int Immunopharmacol. 2012 Apr;12(4):651-6. doi: 10.1016/j.intimp.2012.01.008. Epub 2012 Feb 4.

2.

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.

Correia MA, Sinclair PR, De Matteis F.

Drug Metab Rev. 2011 Feb;43(1):1-26. doi: 10.3109/03602532.2010.515222. Epub 2010 Sep 23. Review.

3.

Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.

Dwyer BE, Stone ML, Gorman N, Sinclair PR, Perry G, Smith MA, Zhu X.

Neurosci Lett. 2009 Sep 25;461(3):302-5. doi: 10.1016/j.neulet.2009.06.007. Epub 2009 Jun 17.

4.

Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda.

Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM, Balestra D, Sinclair JF, Sinclair PR.

Hepatology. 2007 Dec;46(6):1927-834.

PMID:
17854053
5.

Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.

Gorman N, Trask HS, Robinson SW, Sinclair JF, Gerhard GS, Smith AG, Sinclair PR.

Toxicol Appl Pharmacol. 2007 Jun 1;221(2):235-42. Epub 2007 Mar 23.

PMID:
17466352
6.

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2007 Jul;35(7):1223-31. Epub 2007 Mar 28.

PMID:
17392391
7.

Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda.

Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM, Balestra D, Sinclair JF, Sinclair PR.

Hepatology. 2007 Jan;45(1):187-94.

PMID:
17187429
8.

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.

Yohe HC, O'Hara KA, Hunt JA, Kitzmiller TJ, Wood SG, Bement JL, Bement WJ, Szakacs JG, Wrighton SA, Jacobs JM, Kostrubsky V, Sinclair PR, Sinclair JF.

Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1269-79. Epub 2006 Jan 26.

9.

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.

Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2005 Dec;33(12):1827-36. Epub 2005 Sep 1.

PMID:
16141365
10.

Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.

Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Sinclair JF.

Biochem Biophys Res Commun. 2005 Aug 12;333(4):1211-7.

PMID:
15979568
11.

Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures.

Trask HW, Gorman N, Dwyer BE, Jacobs NJ, Jacobs JM, Sinclair JF, Balestra D, Sinclair PR.

Arch Biochem Biophys. 2005 Jul 1;439(1):1-11.

PMID:
15946643
12.

Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms.

Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Evans RM, Sinclair JF.

Toxicol Appl Pharmacol. 2005 Dec 1;209(2):174-82.

PMID:
15907335
13.

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.

Noreault TL, Kostrubsky VE, Wood SG, Nichols RC, Strom SC, Trask HW, Wrighton SA, Evans RM, Jacobs JM, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2005 Jul;33(7):993-1003. Epub 2005 Apr 15.

PMID:
15833926
14.

Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice.

Gorman N, Trask HW, Bement WJ, Szakacs JG, Elder GH, Balestra D, Jacobs NJ, Jacobs JM, Sinclair JF, Gerhard GS, Sinclair PR.

Hepatology. 2004 Oct;40(4):942-50.

PMID:
15382179
15.

Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.

Wolf KK, Wood SG, Bement JL, Sinclair PR, Wrighton SA, Jeffery E, Gonzalez FJ, Sinclair JF.

Drug Metab Dispos. 2004 Jul;32(7):681-4.

PMID:
15205381
16.

High-throughput non-heme iron assay for animal tissues.

Grundy MA, Gorman N, Sinclair PR, Chorney MJ, Gerhard GS.

J Biochem Biophys Methods. 2004 May 31;59(2):195-200.

PMID:
15163531
17.

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW.

Toxicol Appl Pharmacol. 2004 May 1;196(3):410-21.

PMID:
15094312
18.

A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity.

Hon T, Dodd A, Dirmeier R, Gorman N, Sinclair PR, Zhang L, Poyton RO.

J Biol Chem. 2003 Dec 12;278(50):50771-80. Epub 2003 Sep 25.

19.

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

Nichols RC, Cooper S, Trask HW, Gorman N, Dalton TP, Nebert DW, Sinclair JF, Sinclair PR.

Biochem Pharmacol. 2003 Feb 15;65(4):545-50.

PMID:
12566081
20.

Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda.

Sinclair PR, Gorman N, Trask HW, Bement WJ, Szakacs JG, Elder GH, Balestra D, Sinclair JF, Gerhard GS.

Hepatology. 2003 Feb;37(2):351-8.

PMID:
12540785
21.

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.

Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR.

Hepatology. 2002 Apr;35(4):912-21.

PMID:
11915039
22.

Release of Cr(III) from Cr(III) picolinate upon metabolic activation.

Kareus SA, Kelley C, Walton HS, Sinclair PR.

J Hazard Mater. 2001 Jun 29;84(2-3):163-74.

PMID:
11406304
23.

Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Smith AG, Clothier B, Carthew P, Childs NL, Sinclair PR, Nebert DW, Dalton TP.

Toxicol Appl Pharmacol. 2001 Jun 1;173(2):89-98.

PMID:
11384210
24.

Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Szakacs J, Gonzalez FJ, Dalton TP, Nebert DW, Sinclair JF.

Arch Biochem Biophys. 2000 Dec 15;384(2):383-90.

PMID:
11368328
25.

Measurement of heme concentration.

Sinclair PR, Gorman N, Jacobs JM.

Curr Protoc Toxicol. 2001 May;Chapter 8:Unit 8.3. doi: 10.1002/0471140856.tx0803s00.

PMID:
20954156
26.

Measurement of ALA synthase activity.

Sinclair PR, Gorman N, Cornell NW.

Curr Protoc Toxicol. 2001 May;Chapter 8:Unit 8.2. doi: 10.1002/0471140856.tx0802s00.

PMID:
20954155
27.

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair PR, Sinclair JF, Nebert DW, De Matteis F.

Biochem Pharmacol. 2001 Apr 1;61(7):843-9.

PMID:
11274970
28.

Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Sinclair JF, Gerhard GS, Szakacs JG, Andrews NC, Levy JE.

Hepatology. 2001 Feb;33(2):406-12.

PMID:
11172342
29.

Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.

Jacobs JM, Nichols C, Marek D, Gorman N, Walton HS, Sinclair PR, Sinclair JF.

Toxicol Appl Pharmacol. 2000 Nov 1;168(3):177-82.

PMID:
11042089
30.

Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.

Sinclair JF, Szakacs JG, Wood SG, Walton HS, Bement JL, Gonzalez FJ, Jeffery EH, Wrighton SA, Bement WJ, Sinclair PR.

Toxicol Appl Pharmacol. 2000 Oct 15;168(2):114-22.

PMID:
11032766
31.

Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.

Sinclair JF, Szakacs JG, Wood SG, Kostrubsky VE, Jeffery EH, Wrighton SA, Bement WJ, Wright D, Sinclair PR.

Biochem Pharmacol. 2000 Feb 15;59(4):445-54.

PMID:
10644054
32.

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Dalton TP, Sinclair JF, Smith AG, Nebert DW.

Toxicol Appl Pharmacol. 2000 Jan 1;162(1):60-7.

PMID:
10631128
33.

Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes.

Jacobs JM, Marek D, Walton HS, Sinclair PR, Sinclair JF.

Arch Biochem Biophys. 1999 Nov 1;371(1):8-14.

PMID:
10525283
34.

Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.

Gorman N, Walton HS, Bement WJ, Honsinger CP, Szakacs JG, Sinclair JF, Sinclair PR.

Biochem Pharmacol. 1999 Jul 15;58(2):375-82.

PMID:
10423181
35.

Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes.

Jacobs JM, Nichols CE, Andrew AS, Marek DE, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF.

Toxicol Appl Pharmacol. 1999 May 15;157(1):51-9.

PMID:
10329507
36.

Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures.

Waldren CA, Ueno AM, Schaeffer BK, Wood SG, Sinclair PR, Doolittle DJ, Smith CJ, Harvey WF, Shibuya ML, Gustafson DL, Vannais DB, Puck TT, Sinclair JF.

Mutat Res. 1999 Mar 10;425(1):29-46.

PMID:
10082914
37.

CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator).

Gorman N, Walton HS, Sinclair JF, Sinclair PR.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):405-12.

PMID:
9972481
38.

Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase.

Louis CA, Wood SG, Walton HS, Sinclair PR, Sinclair JF.

Arch Biochem Biophys. 1998 Dec 15;360(2):239-47.

PMID:
9851836
39.

Uroporphyrinogen oxidation catalyzed by human cytochromes P450.

Sinclair PR, Gorman N, Tsyrlov IB, Fuhr U, Walton HS, Sinclair JF.

Drug Metab Dispos. 1998 Oct;26(10):1019-25.

PMID:
9763408
40.

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.

Kostrubsky VE, Lewis LD, Strom SC, Wood SG, Schuetz EG, Schuetz JD, Sinclair PR, Wrighton SA, Sinclair JF.

Arch Biochem Biophys. 1998 Jul 15;355(2):131-6.

PMID:
9675018
41.

Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.

Jacobs JM, Sinclair PR, Sinclair JF, Gorman N, Walton HS, Wood SG, Nichols C.

Toxicology. 1998 Feb 6;125(2-3):95-105.

PMID:
9570325
42.

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

Sinclair PR, Gorman N, Dalton T, Walton HS, Bement WJ, Sinclair JF, Smith AG, Nebert DW.

Biochem J. 1998 Feb 15;330 ( Pt 1):149-53.

43.

Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors.

Taketani S, Immenschuh S, Go S, Sinclair PR, Stockert RJ, Liem HH, Muller Eberhard U.

Hepatology. 1998 Mar;27(3):808-14.

PMID:
9500711
44.

Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes.

Sinclair PR, Walton HS, Gorman N, Jacobs JM, Sinclair JF.

Toxicol Appl Pharmacol. 1997 Dec;147(2):171-9.

PMID:
9439713
45.

Ascorbic acid deficiency in porphyria cutanea tarda.

Sinclair PR, Gorman N, Shedlofsky SI, Honsinger CP, Sinclair JF, Karagas MR, Anderson KE.

J Lab Clin Med. 1997 Aug;130(2):197-201.

PMID:
9280147
46.

Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney.

Sinclair PR, Gorman N, Walton HS, Sinclair JF, Lee CA, Rifkind AB.

Drug Metab Dispos. 1997 Jul;25(7):779-83.

PMID:
9224771
47.

Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity.

Kostrubsky VE, Szakacs JG, Jeffery EH, Wood SG, Bement WJ, Wrighton SA, Sinclair PR, Sinclair JF.

Toxicol Appl Pharmacol. 1997 Apr;143(2):315-23.

PMID:
9144448
48.

Effect of Taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes: comparison to dexamethasone.

Kostrubsky VE, Lewis LD, Wood SG, Sinclair PR, Wrighton SA, Sinclair JF.

Toxicol Appl Pharmacol. 1997 Jan;142(1):79-86.

PMID:
9007036
49.

Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A.

Kostrubsky VE, Szakacs JG, Jeffery EH, Woods SG, Bement WJ, Wrighton SA, Sinclair PR, Sinclair JF.

Ann Clin Lab Sci. 1997 Jan-Feb;27(1):57-62.

PMID:
8997458
50.

Cloning and identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen oxidase.

Glerum DM, Shtanko A, Tzagoloff A, Gorman N, Sinclair PR.

Yeast. 1996 Nov;12(14):1421-5.

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