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Items: 1 to 50 of 83

1.

Advances in the treatment of cytomegalovirus.

Krishna BA, Wills MR, Sinclair JH.

Br Med Bull. 2019 Sep 19;131(1):5-17. doi: 10.1093/bmb/ldz031.

2.

A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.

Poole EL, Kew VG, Lau JCH, Murray MJ, Stamminger T, Sinclair JH, Reeves MB.

Cell Rep. 2018 Jul 17;24(3):594-606. doi: 10.1016/j.celrep.2018.06.048.

3.

Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection.

Krishna BA, Poole EL, Jackson SE, Smit MJ, Wills MR, Sinclair JH.

mBio. 2017 Dec 5;8(6). pii: e01754-17. doi: 10.1128/mBio.01754-17.

4.

Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells.

Jackson SE, Sedikides GX, Okecha G, Poole EL, Sinclair JH, Wills MR.

Front Immunol. 2017 Jun 26;8:733. doi: 10.3389/fimmu.2017.00733. eCollection 2017.

5.

Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.

Krishna BA, Spiess K, Poole EL, Lau B, Voigt S, Kledal TN, Rosenkilde MM, Sinclair JH.

Nat Commun. 2017 Feb 2;8:14321. doi: 10.1038/ncomms14321.

6.

Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells.

Krishna BA, Lau B, Jackson SE, Wills MR, Sinclair JH, Poole E.

Sci Rep. 2016 Apr 19;6:24674. doi: 10.1038/srep24674.

7.

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries.

Karniely S, Weekes MP, Antrobus R, Rorbach J, van Haute L, Umrania Y, Smith DL, Stanton RJ, Minczuk M, Lehner PJ, Sinclair JH.

mBio. 2016 Mar 29;7(2):e00029. doi: 10.1128/mBio.00029-16.

8.

The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?

Wills MR, Poole E, Lau B, Krishna B, Sinclair JH.

Cell Mol Immunol. 2015 Mar;12(2):128-38. doi: 10.1038/cmi.2014.75. Epub 2014 Aug 18. Review.

9.

The use of primary human cells (fibroblasts, monocytes, and others) to assess human cytomegalovirus function.

Poole E, Reeves M, Sinclair JH.

Methods Mol Biol. 2014;1119:81-98. doi: 10.1007/978-1-62703-788-4_6.

PMID:
24639219
10.

Human cytomegalovirus manipulation of latently infected cells.

Sinclair JH, Reeves MB.

Viruses. 2013 Nov 21;5(11):2803-24. doi: 10.3390/v5112803. Review.

11.

Circulating dendritic cells isolated from healthy seropositive donors are sites of human cytomegalovirus reactivation in vivo.

Reeves MB, Sinclair JH.

J Virol. 2013 Oct;87(19):10660-7. doi: 10.1128/JVI.01539-13. Epub 2013 Jul 24.

12.

Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection.

Weekes MP, Tan SY, Poole E, Talbot S, Antrobus R, Smith DL, Montag C, Gygi SP, Sinclair JH, Lehner PJ.

Science. 2013 Apr 12;340(6129):199-202. doi: 10.1126/science.1235047.

13.

Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function.

Mason GM, Poole E, Sissons JG, Wills MR, Sinclair JH.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14538-43. doi: 10.1073/pnas.1204836109. Epub 2012 Jul 23.

14.

A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity.

Kuan WL, Poole E, Fletcher M, Karniely S, Tyers P, Wills M, Barker RA, Sinclair JH.

J Exp Med. 2012 Jan 16;209(1):1-10. doi: 10.1084/jem.20111126. Epub 2011 Dec 19.

15.
16.
17.

Inhibition of epidermal growth factor receptor (EGFR) expression by human cytomegalovirus correlates with an increase in the expression and binding of Wilms' Tumour 1 protein to the EGFR promoter.

Jafferji I, Bain M, King C, Sinclair JH.

J Gen Virol. 2009 Jul;90(Pt 7):1569-74. doi: 10.1099/vir.0.009670-0. Epub 2009 Mar 25.

PMID:
19321755
19.

Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death.

Reeves MB, Davies AA, McSharry BP, Wilkinson GW, Sinclair JH.

Science. 2007 Jun 1;316(5829):1345-8.

20.

Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter.

Woodhall DL, Groves IJ, Reeves MB, Wilkinson G, Sinclair JH.

J Biol Chem. 2006 Dec 8;281(49):37652-60. Epub 2006 Oct 11.

21.

The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism.

Poole E, King CA, Sinclair JH, Alcami A.

EMBO J. 2006 Sep 20;25(18):4390-9. Epub 2006 Aug 24.

22.
23.

An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling.

Reeves MB, Lehner PJ, Sissons JG, Sinclair JH.

J Gen Virol. 2005 Nov;86(Pt 11):2949-54.

PMID:
16227215
24.

Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.

Reeves MB, MacAry PA, Lehner PJ, Sissons JG, Sinclair JH.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4140-5. Epub 2005 Feb 28.

25.

Vascular endothelial and smooth muscle cells are unlikely to be major sites of latency of human cytomegalovirus in vivo.

Reeves MB, Coleman H, Chadderton J, Goddard M, Sissons JG, Sinclair JH.

J Gen Virol. 2004 Nov;85(Pt 11):3337-41.

PMID:
15483249
27.

Human cytomegalovirus and immunopathology.

Sissons JG, Carmichael AJ, McKinney N, Sinclair JH, Wills MR.

Springer Semin Immunopathol. 2002;24(2):169-85. Review. No abstract available.

PMID:
12503063
28.

Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors.

Fairley JA, Baillie J, Bain M, Sinclair JH.

J Gen Virol. 2002 Nov;83(Pt 11):2803-10.

PMID:
12388817
29.

Control of cytomegalovirus lytic gene expression by histone acetylation.

Murphy JC, Fischle W, Verdin E, Sinclair JH.

EMBO J. 2002 Mar 1;21(5):1112-20.

30.

The human cytomegalovirus 86-kilodalton major immediate-early protein interacts physically and functionally with histone acetyltransferase P/CAF.

Bryant LA, Mixon P, Davidson M, Bannister AJ, Kouzarides T, Sinclair JH.

J Virol. 2000 Aug;74(16):7230-7.

31.

Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product.

Wilkinson GW, Kelly C, Sinclair JH, Rickards C.

J Gen Virol. 1998 May;79 ( Pt 5):1233-45.

PMID:
9603339
33.
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36.

Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow.

Minton EJ, Tysoe C, Sinclair JH, Sissons JG.

J Virol. 1994 Jun;68(6):4017-21.

37.
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39.

Polymorphonuclear cells are not sites of persistence of human cytomegalovirus in healthy individuals.

Taylor-Wiedeman J, Hayhurst GP, Sissons JG, Sinclair JH.

J Gen Virol. 1993 Feb;74 ( Pt 2):265-8.

PMID:
8381466
40.
42.

Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line.

Sinclair JH, Baillie J, Bryant LA, Taylor-Wiedeman JA, Sissons JG.

J Gen Virol. 1992 Feb;73 ( Pt 2):433-5.

PMID:
1311364
43.

Median dermoid cyst.

Worthington JP, Sinclair JH.

N Z Dent J. 1992 Jan;88(391):17-9.

PMID:
1570119
44.

Pathogenesis of human cytomegalovirus disease and the kidney.

Sissons JG, Sinclair JH, Borysiewicz LK.

Kidney Int Suppl. 1991 Dec;35:S8-12. Review.

PMID:
1663185
45.

The retrotransposon copia regulates Drosophila gene expression both positively and negatively.

Bryant LA, Brierley C, Flavell AJ, Sinclair JH.

Nucleic Acids Res. 1991 Oct 25;19(20):5533-6.

46.
47.

Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells.

Taylor-Wiedeman J, Sissons JG, Borysiewicz LK, Sinclair JH.

J Gen Virol. 1991 Sep;72 ( Pt 9):2059-64.

PMID:
1654370
48.
49.

Repression of human cytomegalovirus gene expression associated with a novel immediate early regulatory region binding factor.

Shelbourn SL, Kothari SK, Sissons JG, Sinclair JH.

Nucleic Acids Res. 1989 Nov 25;17(22):9165-71.

50.

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