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Items: 1 to 50 of 145

1.

Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys.

Flora AD, Teel LD, Smith MA, Sinclair JF, Melton-Celsa AR, O'Brien AD.

PLoS One. 2013 Jul 17;8(7):e69706. doi: 10.1371/journal.pone.0069706. Print 2013.

2.

Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.

Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom SC, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC.

Int Immunopharmacol. 2012 Apr;12(4):651-6. doi: 10.1016/j.intimp.2012.01.008. Epub 2012 Feb 4.

3.

Human intestinal tissue and cultured colonic cells contain globotriaosylceramide synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide.

Zumbrun SD, Hanson L, Sinclair JF, Freedy J, Melton-Celsa AR, Rodriguez-Canales J, Hanson JC, O'Brien AD.

Infect Immun. 2010 Nov;78(11):4488-99. doi: 10.1128/IAI.00620-10. Epub 2010 Aug 23.

4.

Monoclonal antibody 11E10, which neutralizes shiga toxin type 2 (Stx2), recognizes three regions on the Stx2 A subunit, blocks the enzymatic action of the toxin in vitro, and alters the overall cellular distribution of the toxin.

Smith MJ, Melton-Celsa AR, Sinclair JF, Carvalho HM, Robinson CM, O'Brien AD.

Infect Immun. 2009 Jul;77(7):2730-40. doi: 10.1128/IAI.00005-09. Epub 2009 May 11.

5.

Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda.

Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM, Balestra D, Sinclair JF, Sinclair PR.

Hepatology. 2007 Dec;46(6):1927-834.

PMID:
17854053
6.

Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.

Gorman N, Trask HS, Robinson SW, Sinclair JF, Gerhard GS, Smith AG, Sinclair PR.

Toxicol Appl Pharmacol. 2007 Jun 1;221(2):235-42. Epub 2007 Mar 23.

PMID:
17466352
7.

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2007 Jul;35(7):1223-31. Epub 2007 Mar 28.

PMID:
17392391
8.

Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda.

Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM, Balestra D, Sinclair JF, Sinclair PR.

Hepatology. 2007 Jan;45(1):187-94.

PMID:
17187429
9.

Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.

Noreault-Conti TL, Jacobs JM, Trask HW, Wrighton SA, Sinclair JF, Nichols RC.

Toxicol Appl Pharmacol. 2006 Dec 15;217(3):245-51. Epub 2006 Sep 22.

PMID:
17083955
10.

Reduced inflammatory potential of peritoneal macrophages recruited in mice pretreated with a glycolipid synthesis inhibitor.

Yohe HC, Kitzmiller TJ, Bement WJ, Dwyer BE, Sinclair JF.

Inflammopharmacology. 2006 Aug;14(3-4):170-5.

PMID:
16983496
11.

Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization.

Robinson CM, Sinclair JF, Smith MJ, O'Brien AD.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9667-72. Epub 2006 Jun 9.

12.

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.

Yohe HC, O'Hara KA, Hunt JA, Kitzmiller TJ, Wood SG, Bement JL, Bement WJ, Szakacs JG, Wrighton SA, Jacobs JM, Kostrubsky V, Sinclair PR, Sinclair JF.

Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1269-79. Epub 2006 Jan 26.

14.

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.

Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2005 Dec;33(12):1827-36. Epub 2005 Sep 1.

PMID:
16141365
15.

Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.

Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Sinclair JF.

Biochem Biophys Res Commun. 2005 Aug 12;333(4):1211-7.

PMID:
15979568
16.

Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures.

Trask HW, Gorman N, Dwyer BE, Jacobs NJ, Jacobs JM, Sinclair JF, Balestra D, Sinclair PR.

Arch Biochem Biophys. 2005 Jul 1;439(1):1-11.

PMID:
15946643
17.

Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.

Kostrubsky SE, Sinclair JF, Strom SC, Wood S, Urda E, Stolz DB, Wen YH, Kulkarni S, Mutlib A.

Toxicol Sci. 2005 Sep;87(1):146-55. Epub 2005 Jun 2.

PMID:
15933229
18.

Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms.

Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Evans RM, Sinclair JF.

Toxicol Appl Pharmacol. 2005 Dec 1;209(2):174-82.

PMID:
15907335
19.

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.

Noreault TL, Kostrubsky VE, Wood SG, Nichols RC, Strom SC, Trask HW, Wrighton SA, Evans RM, Jacobs JM, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2005 Jul;33(7):993-1003. Epub 2005 Apr 15.

PMID:
15833926
20.

Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice.

Gorman N, Trask HW, Bement WJ, Szakacs JG, Elder GH, Balestra D, Jacobs NJ, Jacobs JM, Sinclair JF, Gerhard GS, Sinclair PR.

Hepatology. 2004 Oct;40(4):942-50.

PMID:
15382179
21.

Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.

Wolf KK, Wood SG, Bement JL, Sinclair PR, Wrighton SA, Jeffery E, Gonzalez FJ, Sinclair JF.

Drug Metab Dispos. 2004 Jul;32(7):681-4.

PMID:
15205381
22.
23.

To fill or not to fill.

Sinclair JF.

J Am Dent Assoc. 2003 Aug;134(8):1044-5; author reply 1045-6. No abstract available.

PMID:
12956342
24.

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.

Kostrubsky VE, Strom SC, Hanson J, Urda E, Rose K, Burliegh J, Zocharski P, Cai H, Sinclair JF, Sahi J.

Toxicol Sci. 2003 Nov;76(1):220-8. Epub 2003 Aug 27.

PMID:
12944587
25.

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

Nichols RC, Cooper S, Trask HW, Gorman N, Dalton TP, Nebert DW, Sinclair JF, Sinclair PR.

Biochem Pharmacol. 2003 Feb 15;65(4):545-50.

PMID:
12566081
26.

Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda.

Sinclair PR, Gorman N, Trask HW, Bement WJ, Szakacs JG, Elder GH, Balestra D, Sinclair JF, Gerhard GS.

Hepatology. 2003 Feb;37(2):351-8.

PMID:
12540785
27.

Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes.

Wen YH, Sahi J, Urda E, Kulkarni S, Rose K, Zheng X, Sinclair JF, Cai H, Strom SC, Kostrubsky VE.

Drug Metab Dispos. 2002 Sep;30(9):977-84.

PMID:
12167562
28.

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.

Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR.

Hepatology. 2002 Apr;35(4):912-21.

PMID:
11915039
29.
30.

Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Szakacs J, Gonzalez FJ, Dalton TP, Nebert DW, Sinclair JF.

Arch Biochem Biophys. 2000 Dec 15;384(2):383-90.

PMID:
11368328
31.

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair PR, Sinclair JF, Nebert DW, De Matteis F.

Biochem Pharmacol. 2001 Apr 1;61(7):843-9.

PMID:
11274970
32.

Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Sinclair JF, Gerhard GS, Szakacs JG, Andrews NC, Levy JE.

Hepatology. 2001 Feb;33(2):406-12.

PMID:
11172342
33.

Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.

Jacobs JM, Nichols C, Marek D, Gorman N, Walton HS, Sinclair PR, Sinclair JF.

Toxicol Appl Pharmacol. 2000 Nov 1;168(3):177-82.

PMID:
11042089
34.

Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.

Sinclair JF, Szakacs JG, Wood SG, Walton HS, Bement JL, Gonzalez FJ, Jeffery EH, Wrighton SA, Bement WJ, Sinclair PR.

Toxicol Appl Pharmacol. 2000 Oct 15;168(2):114-22.

PMID:
11032766
35.

The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.

Kostrubsky VE, Sinclair JF, Ramachandran V, Venkataramanan R, Wen YH, Kindt E, Galchev V, Rose K, Sinz M, Strom SC.

Drug Metab Dispos. 2000 Oct;28(10):1192-7.

PMID:
10997939
36.

Purification of luciferase subunits from recombinant sources.

Sinclair JF.

Methods Enzymol. 2000;305:152-7. No abstract available.

PMID:
10812597
37.

Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.

Sinclair JF, Szakacs JG, Wood SG, Kostrubsky VE, Jeffery EH, Wrighton SA, Bement WJ, Wright D, Sinclair PR.

Biochem Pharmacol. 2000 Feb 15;59(4):445-54.

PMID:
10644054
38.

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Dalton TP, Sinclair JF, Smith AG, Nebert DW.

Toxicol Appl Pharmacol. 2000 Jan 1;162(1):60-7.

PMID:
10631128
39.

Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes.

Jacobs JM, Marek D, Walton HS, Sinclair PR, Sinclair JF.

Arch Biochem Biophys. 1999 Nov 1;371(1):8-14.

PMID:
10525283
40.

Preventive dentistry hailed.

Sinclair JF.

J Am Dent Assoc. 1999 Aug;130(8):1160. No abstract available.

PMID:
10491922
41.

Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.

Gorman N, Walton HS, Bement WJ, Honsinger CP, Szakacs JG, Sinclair JF, Sinclair PR.

Biochem Pharmacol. 1999 Jul 15;58(2):375-82.

PMID:
10423181
42.

The use of human hepatocyte cultures to study the induction of cytochrome P-450.

Kostrubsky VE, Ramachandran V, Venkataramanan R, Dorko K, Esplen JE, Zhang S, Sinclair JF, Wrighton SA, Strom SC.

Drug Metab Dispos. 1999 Aug;27(8):887-94.

PMID:
10421615
44.

Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes.

Jacobs JM, Nichols CE, Andrew AS, Marek DE, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF.

Toxicol Appl Pharmacol. 1999 May 15;157(1):51-9.

PMID:
10329507
45.

Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures.

Waldren CA, Ueno AM, Schaeffer BK, Wood SG, Sinclair PR, Doolittle DJ, Smith CJ, Harvey WF, Shibuya ML, Gustafson DL, Vannais DB, Puck TT, Sinclair JF.

Mutat Res. 1999 Mar 10;425(1):29-46.

PMID:
10082914
46.

CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator).

Gorman N, Walton HS, Sinclair JF, Sinclair PR.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):405-12.

PMID:
9972481
47.

Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase.

Louis CA, Wood SG, Walton HS, Sinclair PR, Sinclair JF.

Arch Biochem Biophys. 1998 Dec 15;360(2):239-47.

PMID:
9851836
48.

Uroporphyrinogen oxidation catalyzed by human cytochromes P450.

Sinclair PR, Gorman N, Tsyrlov IB, Fuhr U, Walton HS, Sinclair JF.

Drug Metab Dispos. 1998 Oct;26(10):1019-25.

PMID:
9763408
49.

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.

Kostrubsky VE, Lewis LD, Strom SC, Wood SG, Schuetz EG, Schuetz JD, Sinclair PR, Wrighton SA, Sinclair JF.

Arch Biochem Biophys. 1998 Jul 15;355(2):131-6.

PMID:
9675018
50.

Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.

Jacobs JM, Sinclair PR, Sinclair JF, Gorman N, Walton HS, Wood SG, Nichols C.

Toxicology. 1998 Feb 6;125(2-3):95-105.

PMID:
9570325

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