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Items: 1 to 50 of 200

1.

Assays for NAD+-Dependent Reactions and NAD+ Metabolites.

Schultz MB, Lu Y, Braidy N, Sinclair DA.

Methods Mol Biol. 2018;1813:77-90. doi: 10.1007/978-1-4939-8588-3_6.

PMID:
30097862
2.

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Dai H, Sinclair DA, Ellis JL, Steegborn C.

Pharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22. Review.

PMID:
29577959
3.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008.

PMID:
29570999
4.

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR.

Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001.

PMID:
29570992
5.

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.

PMID:
29514072
6.

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Rajman L, Chwalek K, Sinclair DA.

Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Review.

PMID:
29514064
7.

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR.

Mol Metab. 2018 Jan;7:1-11. doi: 10.1016/j.molmet.2017.10.012. Epub 2017 Nov 6.

8.

Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

Sci Rep. 2017 Nov 8;7(1):15063. doi: 10.1038/s41598-017-14866-z.

9.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA.

Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242.

10.

Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP.

J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1703-1709. doi: 10.1093/gerona/glx041.

PMID:
28329397
11.

Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3).

Cronise RJ, Sinclair DA, Bremer AA.

Metab Syndr Relat Disord. 2017 Feb;15(1):4-5. doi: 10.1089/met.2017.0004. Epub 2017 Feb 6. No abstract available.

12.

Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster.

Liu TW, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ.

Nat Chem Biol. 2017 Feb;13(2):161-167. doi: 10.1038/nchembio.2247. Epub 2016 Dec 5.

PMID:
27918560
13.

SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation.

Prola A, Pires Da Silva J, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, Eid P, Ventura-Clapier R, Garnier A, Lemaire C.

Cell Death Differ. 2017 Feb;24(2):343-356. doi: 10.1038/cdd.2016.138. Epub 2016 Dec 2.

14.

Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.

Cronise RJ, Sinclair DA, Bremer AA.

Metab Syndr Relat Disord. 2017 Feb;15(1):6-17. doi: 10.1089/met.2016.0108. Epub 2016 Nov 21. Review.

15.

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

Bonkowski MS, Sinclair DA.

Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93. Epub 2016 Aug 24. Review.

16.

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.

17.

Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice.

Uddin GM, Youngson NA, Sinclair DA, Morris MJ.

Front Pharmacol. 2016 Aug 19;7:258. doi: 10.3389/fphar.2016.00258. eCollection 2016.

18.

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.

Cell Rep. 2016 Sep 6;16(10):2641-2650. doi: 10.1016/j.celrep.2016.08.006. Epub 2016 Aug 25.

19.

Synthesis and Assay of SIRT1-Activating Compounds.

Dai H, Ellis JL, Sinclair DA, Hubbard BP.

Methods Enzymol. 2016;574:213-244. doi: 10.1016/bs.mie.2016.01.012. Epub 2016 Feb 9.

20.

O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.

Ferrer CM, Lu TY, Bacigalupa ZA, Katsetos CD, Sinclair DA, Reginato MJ.

Oncogene. 2017 Jan 26;36(4):559-569. doi: 10.1038/onc.2016.228. Epub 2016 Jun 27.

21.

Restoring stem cells - all you need is NAD(.).

Wu LE, Sinclair DA.

Cell Res. 2016 Sep;26(9):971-2. doi: 10.1038/cr.2016.80. Epub 2016 Jun 24.

22.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.

23.

Why NAD(+) Declines during Aging: It's Destroyed.

Schultz MB, Sinclair DA.

Cell Metab. 2016 Jun 14;23(6):965-966. doi: 10.1016/j.cmet.2016.05.022.

24.

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.

Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC.

Aging Cell. 2016 Aug;15(4):706-15. doi: 10.1111/acel.12481. Epub 2016 Apr 20.

25.

Meiotic recombination is suppressed near the histone-defined border of euchromatin and heterochromatin on chromosome 2L of Drosophila melanogaster.

Coulthard AB, Taylor-Kamall RW, Hallson G, Axentiev A, Sinclair DA, Honda BM, Hilliker AJ.

Genome. 2016 Apr;59(4):289-94. doi: 10.1139/gen-2015-0171.

26.

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.

Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC.

Sci Rep. 2016 Mar 18;6:23229. doi: 10.1038/srep23229.

27.

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC.

Mech Ageing Dev. 2016 Mar;154:30-42. doi: 10.1016/j.mad.2016.01.004. Epub 2016 Feb 22.

28.

PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study.

Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H, Brun E, Hjorthaug K, Viney ZN, Pike LC, Federico M, Luminari S, Radford J, Trotman J, Fosså A, Berkahn L, Molin D, D'Amore F, Sinclair DA, Smith P, O'Doherty MJ, Stevens L, Johnson PW.

Blood. 2016 Mar 24;127(12):1531-8. doi: 10.1182/blood-2015-11-679407. Epub 2016 Jan 8.

29.

When stem cells grow old: phenotypes and mechanisms of stem cell aging.

Schultz MB, Sinclair DA.

Development. 2016 Jan 1;143(1):3-14. doi: 10.1242/dev.130633. Review.

30.

Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability.

Kim J, Sturgill D, Tran AD, Sinclair DA, Oberdoerffer P.

Nucleic Acids Res. 2016 Apr 20;44(7):e64. doi: 10.1093/nar/gkv1482. Epub 2015 Dec 19.

31.

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.

Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, Graumann J, Mazloum NA.

J Biol Chem. 2016 Jan 29;291(5):2119-35. doi: 10.1074/jbc.M115.675645. Epub 2015 Dec 11.

32.

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.

Winnik S, Auwerx J, Sinclair DA, Matter CM.

Eur Heart J. 2015 Dec 21;36(48):3404-12. doi: 10.1093/eurheartj/ehv290. Epub 2015 Jun 25. Review.

33.

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M.

Stem Cell Res. 2015 Jul;15(1):130-40. doi: 10.1016/j.scr.2015.05.007. Epub 2015 May 22.

34.

Correction: nicotinamide impairs entry into and exit from meiosis I in mouse oocytes.

Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair DA, Homer H.

PLoS One. 2015 Jun 3;10(6):e0130058. doi: 10.1371/journal.pone.0130058. eCollection 2015. No abstract available.

35.

Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

36.

Oogonial stem cells as a model to study age-associated infertility in women.

Garg N, Sinclair DA.

Reprod Fertil Dev. 2015 Jul;27(6):969-74. doi: 10.1071/RD14461. Review.

37.

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.

Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263.

38.

Randomized clinical trial to evaluate mental practice in enhancing advanced laparoscopic surgical performance.

Louridas M, Bonrath EM, Sinclair DA, Dedy NJ, Grantcharov TP.

Br J Surg. 2015 Jan;102(1):37-44. doi: 10.1002/bjs.9657. Epub 2014 Oct 21.

PMID:
25332065
39.

Measuring PGC-1α and its acetylation status in mouse primary myotubes.

Gomes AP, Sinclair DA.

Methods Mol Biol. 2015;1241:49-57. doi: 10.1007/978-1-4939-1875-1_5.

PMID:
25308487
40.

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK.

Aging Cell. 2014 Dec;13(6):1075-85. doi: 10.1111/acel.12273. Epub 2014 Sep 25.

41.

Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.

Rimmelé P, Bigarella CL, Liang R, Izac B, Dieguez-Gonzalez R, Barbet G, Donovan M, Brugnara C, Blander JM, Sinclair DA, Ghaffari S.

Stem Cell Reports. 2014 Jun 6;3(1):44-59. doi: 10.1016/j.stemcr.2014.04.015. eCollection 2014 Jul 8.

42.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.

Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.

Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16.

43.

The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease.

Cronise RJ, Sinclair DA, Bremer AA.

Metab Syndr Relat Disord. 2014 Sep;12(7):355-61. doi: 10.1089/met.2014.0027. Epub 2014 Jun 11.

44.

SIRT2 controls the pentose phosphate switch.

Wu LE, Sinclair DA.

EMBO J. 2014 Jun 17;33(12):1287-8. doi: 10.15252/embj.201488713. Epub 2014 May 13. No abstract available.

45.

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA.

EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12.

46.

The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.

Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ.

Cell Metab. 2014 Mar 4;19(3):418-30. doi: 10.1016/j.cmet.2014.02.009.

47.

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.

Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM.

Eur Heart J. 2015 Jan 1;36(1):51-9. doi: 10.1093/eurheartj/ehu095. Epub 2014 Mar 6.

48.

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.

Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R.

Cell Rep. 2014 Mar 13;6(5):836-43. doi: 10.1016/j.celrep.2014.01.031. Epub 2014 Feb 27.

49.

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6. doi: 10.1073/pnas.1400705111. Epub 2014 Feb 20.

50.

Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

Hubbard BP, Sinclair DA.

Trends Pharmacol Sci. 2014 Mar;35(3):146-54. doi: 10.1016/j.tips.2013.12.004. Epub 2014 Jan 16. Review.

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