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The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila.

Wong KKL, Liu TW, Parker JM, Sinclair DAR, Chen YY, Khoo KH, Vocadlo DJ, Verheyen EM.

Proc Natl Acad Sci U S A. 2020 Jan 13. pii: 201912894. doi: 10.1073/pnas.1912894117. [Epub ahead of print]


Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.

Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, Naqi A, Zhang SD, Sinclair DA, O'Byrne KJ, Richard DJ.

Nat Commun. 2019 Dec 3;10(1):5501. doi: 10.1038/s41467-019-13167-5.


NAD+ in Brain Aging and Neurodegenerative Disorders.

Lautrup S, Sinclair DA, Mattson MP, Fang EF.

Cell Metab. 2019 Oct 1;30(4):630-655. doi: 10.1016/j.cmet.2019.09.001. Review.


Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice.

Ross JM, Coppotelli G, Branca RM, Kim KM, Lehtiö J, Sinclair DA, Olson L.

Aging Cell. 2019 Dec;18(6):e13029. doi: 10.1111/acel.13029. Epub 2019 Sep 6.


Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research.

Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK.

AIDS Res Hum Retroviruses. 2019 Nov/Dec;35(11-12):999-1012. doi: 10.1089/AID.2019.0130. Epub 2019 Sep 23.


Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.

Palmeira CM, Teodoro JS, Amorim JA, Steegborn C, Sinclair DA, Rolo AP.

Free Radic Biol Med. 2019 Sep;141:483-491. doi: 10.1016/j.freeradbiomed.2019.07.017. Epub 2019 Jul 24. Review.


Sex differences in the response to dietary restriction in rodents.

Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ.

Curr Opin Physiol. 2018 Dec;6:28-34. doi: 10.1016/j.cophys.2018.03.008. Epub 2018 Mar 27.


Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice.

Youngson NA, Uddin GM, Das A, Martinez C, Connaughton HS, Whiting S, Yu J, Sinclair DA, Aitken RJ, Morris MJ.

Reproduction. 2019 Aug 1;158(2):171-181. doi: 10.1530/REP-18-0574.


Molecular and Cellular Characterization of SIRT1 Allosteric Activators.

Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA.

Methods Mol Biol. 2019;1983:133-149. doi: 10.1007/978-1-4939-9434-2_8.


A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of O-GlcNAc Turnover on Chromatin-Associated Proteins.

Liu TW, Myschyshyn M, Sinclair DA, Vocadlo DJ.

ACS Cent Sci. 2019 Apr 24;5(4):663-670. doi: 10.1021/acscentsci.9b00044. Epub 2019 Mar 1.


Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z.

Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10.


Frailty biomarkers in humans and rodents: Current approaches and future advances.

Kane AE, Sinclair DA.

Mech Ageing Dev. 2019 Jun;180:117-128. doi: 10.1016/j.mad.2019.03.007. Epub 2019 Apr 17. Review.


Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster.

Syrzycka M, Hallson G, Fitzpatrick KA, Kim I, Cotsworth S, Hollebakken RE, Simonetto K, Yang L, Luongo S, Beja K, Coulthard AB, Hilliker AJ, Sinclair DA, Honda BM.

G3 (Bethesda). 2019 May 7;9(5):1581-1595. doi: 10.1534/g3.119.0003.


Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E.

Cell Metab. 2019 Jun 4;29(6):1274-1290.e9. doi: 10.1016/j.cmet.2019.03.001. Epub 2019 Mar 28.


Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.

Bertoldo MJ, Uddin GM, Youngson NA, Agapiou D, Walters KA, Sinclair DA, Morris MJ, Gilchrist RB.

Hum Reprod Open. 2018 May 29;2018(3):hoy010. doi: 10.1093/hropen/hoy010. eCollection 2018.


Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

Feng J, LaChance A, Sinclair DA, Asgari MM.

BMJ Case Rep. 2019 Mar 8;12(3). pii: e227233. doi: 10.1136/bcr-2018-227233.


Epigenetic changes during aging and their reprogramming potential.

Kane AE, Sinclair DA.

Crit Rev Biochem Mol Biol. 2019 Feb;54(1):61-83. doi: 10.1080/10409238.2019.1570075. Epub 2019 Mar 1. Review.


Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2019 Feb 7;176(4):944-945. doi: 10.1016/j.cell.2019.01.026. No abstract available.


Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.


Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects.

Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G.

Sci Rep. 2018 Nov 8;8(1):16778. doi: 10.1038/s41598-018-35249-y.


Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.

Kane AE, Sinclair DA.

Circ Res. 2018 Sep 14;123(7):868-885. doi: 10.1161/CIRCRESAHA.118.312498. Review.


Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects.

Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G.

Sci Rep. 2018 Oct 2;8(1):14685. doi: 10.1038/s41598-018-33008-7. Erratum in: Sci Rep. 2018 Nov 8;8(1):16778.


Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.

Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM.

Mol Cell. 2018 Sep 6;71(5):718-732.e9. doi: 10.1016/j.molcel.2018.07.031.


Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.

Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L.

Nat Rev Cardiol. 2019 Jan;16(1):33-55. doi: 10.1038/s41569-018-0074-0. Review.


Assays for NAD+-Dependent Reactions and NAD+ Metabolites.

Schultz MB, Lu Y, Braidy N, Sinclair DA.

Methods Mol Biol. 2018;1813:77-90. doi: 10.1007/978-1-4939-8588-3_6.


Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Dai H, Sinclair DA, Ellis JL, Steegborn C.

Pharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22. Review.


Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945.


Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR.

Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Rajman L, Chwalek K, Sinclair DA.

Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Review.


Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.

Bustamante S, Jayasena T, Richani D, Gilchrist RB, Wu LE, Sinclair DA, Sachdev PS, Braidy N.

Metabolomics. 2017 Dec 23;14(1):15. doi: 10.1007/s11306-017-1310-z.


Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR.

Mol Metab. 2018 Jan;7:1-11. doi: 10.1016/j.molmet.2017.10.012. Epub 2017 Nov 6.


Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

Sci Rep. 2017 Nov 8;7(1):15063. doi: 10.1038/s41598-017-14866-z.


A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA.

Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242.


Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP.

J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1703-1709. doi: 10.1093/gerona/glx041.


Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3).

Cronise RJ, Sinclair DA, Bremer AA.

Metab Syndr Relat Disord. 2017 Feb;15(1):4-5. doi: 10.1089/met.2017.0004. Epub 2017 Feb 6. No abstract available.


Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster.

Liu TW, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ.

Nat Chem Biol. 2017 Feb;13(2):161-167. doi: 10.1038/nchembio.2247. Epub 2016 Dec 5.


SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation.

Prola A, Pires Da Silva J, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, Eid P, Ventura-Clapier R, Garnier A, Lemaire C.

Cell Death Differ. 2017 Feb;24(2):343-356. doi: 10.1038/cdd.2016.138. Epub 2016 Dec 2.


Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.

Cronise RJ, Sinclair DA, Bremer AA.

Metab Syndr Relat Disord. 2017 Feb;15(1):6-17. doi: 10.1089/met.2016.0108. Epub 2016 Nov 21. Review.


Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

Bonkowski MS, Sinclair DA.

Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93. Epub 2016 Aug 24. Review.


NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.


Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice.

Uddin GM, Youngson NA, Sinclair DA, Morris MJ.

Front Pharmacol. 2016 Aug 19;7:258. doi: 10.3389/fphar.2016.00258. eCollection 2016.


JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.

Cell Rep. 2016 Sep 6;16(10):2641-2650. doi: 10.1016/j.celrep.2016.08.006. Epub 2016 Aug 25.


Synthesis and Assay of SIRT1-Activating Compounds.

Dai H, Ellis JL, Sinclair DA, Hubbard BP.

Methods Enzymol. 2016;574:213-244. doi: 10.1016/bs.mie.2016.01.012. Epub 2016 Feb 9.


O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.

Ferrer CM, Lu TY, Bacigalupa ZA, Katsetos CD, Sinclair DA, Reginato MJ.

Oncogene. 2017 Jan 26;36(4):559-569. doi: 10.1038/onc.2016.228. Epub 2016 Jun 27.


Restoring stem cells - all you need is NAD(.).

Wu LE, Sinclair DA.

Cell Res. 2016 Sep;26(9):971-2. doi: 10.1038/cr.2016.80. Epub 2016 Jun 24.


Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.


Why NAD(+) Declines during Aging: It's Destroyed.

Schultz MB, Sinclair DA.

Cell Metab. 2016 Jun 14;23(6):965-966. doi: 10.1016/j.cmet.2016.05.022.


Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.

Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC.

Aging Cell. 2016 Aug;15(4):706-15. doi: 10.1111/acel.12481. Epub 2016 Apr 20.


Meiotic recombination is suppressed near the histone-defined border of euchromatin and heterochromatin on chromosome 2L of Drosophila melanogaster.

Coulthard AB, Taylor-Kamall RW, Hallson G, Axentiev A, Sinclair DA, Honda BM, Hilliker AJ.

Genome. 2016 Apr;59(4):289-94. doi: 10.1139/gen-2015-0171.

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