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NAD+ in Brain Aging and Neurodegenerative Disorders.

Lautrup S, Sinclair DA, Mattson MP, Fang EF.

Cell Metab. 2019 Oct 1;30(4):630-655. doi: 10.1016/j.cmet.2019.09.001. Review.


Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice.

Ross JM, Coppotelli G, Branca RM, Kim KM, Lehtiö J, Sinclair DA, Olson L.

Aging Cell. 2019 Sep 6:e13029. doi: 10.1111/acel.13029. [Epub ahead of print]


Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research.

Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK.

AIDS Res Hum Retroviruses. 2019 Sep 23. doi: 10.1089/AID.2019.0130. [Epub ahead of print]


Forecasted Size of Measles Outbreaks Associated With Vaccination Exemptions for Schoolchildren.

Sinclair DR, Grefenstette JJ, Krauland MG, Galloway DD, Frankeny RJ, Travis C, Burke DS, Roberts MS.

JAMA Netw Open. 2019 Aug 2;2(8):e199768. doi: 10.1001/jamanetworkopen.2019.9768.


Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.

Palmeira CM, Teodoro JS, Amorim JA, Steegborn C, Sinclair DA, Rolo AP.

Free Radic Biol Med. 2019 Sep;141:483-491. doi: 10.1016/j.freeradbiomed.2019.07.017. Epub 2019 Jul 24. Review.


A novel topical therapy for resistant and early peristomal pyoderma gangrenosum.

Pearson WA, Prentice DA, Sinclair DL, Lim LY, Carville KJ.

Int Wound J. 2019 Oct;16(5):1136-1143. doi: 10.1111/iwj.13164. Epub 2019 Jul 12.


Transcriptional changes in the stress pathway are related to symptoms in schizophrenia and to mood in schizoaffective disorder.

Lee CH, Sinclair D, O'Donnell M, Galletly C, Liu D, Weickert CS, Weickert TW.

Schizophr Res. 2019 Jul 8. pii: S0920-9964(19)30247-6. doi: 10.1016/j.schres.2019.06.026. [Epub ahead of print]


Sex differences in the response to dietary restriction in rodents.

Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ.

Curr Opin Physiol. 2018 Dec;6:28-34. doi: 10.1016/j.cophys.2018.03.008. Epub 2018 Mar 27.


Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice.

Youngson NA, Uddin GM, Das A, Martinez C, Connaughton HS, Whiting S, Yu J, Sinclair DA, Aitken RJ, Morris MJ.

Reproduction. 2019 Aug 1;158(2):171-181. doi: 10.1530/REP-18-0574.


Electroconvulsive Therapy for Treatment-Resistant Schizophrenia.

Sinclair DJM, Zhao S, Qi F, Nyakyoma K, Kwong JSW, Adams CE.

Schizophr Bull. 2019 Jun 18;45(4):730-732. doi: 10.1093/schbul/sbz037. No abstract available.


Lazarus Effect of High Dose Corticosteroids in a Patient With West Nile Virus Encephalitis: A Coincidence or a Clue?

Leis AA, Sinclair DJ.

Front Med (Lausanne). 2019 Apr 25;6:81. doi: 10.3389/fmed.2019.00081. eCollection 2019.


Molecular and Cellular Characterization of SIRT1 Allosteric Activators.

Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA.

Methods Mol Biol. 2019;1983:133-149. doi: 10.1007/978-1-4939-9434-2_8.


Neurovascular Lesions in Pediatric Epilepsy.

Kassiri J, Rajapakse T, Wheatley M, Sinclair DB.

J Child Neurol. 2019 Sep;34(10):549-555. doi: 10.1177/0883073819838445. Epub 2019 May 8.


Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism.

Zieba J, Sinclair D, Sebree T, Bonn-Miller M, Gutterman D, Siegel S, Karl T.

Pharmacol Biochem Behav. 2019 Jun;181:93-100. doi: 10.1016/j.pbb.2019.05.002. Epub 2019 May 4.


A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of O-GlcNAc Turnover on Chromatin-Associated Proteins.

Liu TW, Myschyshyn M, Sinclair DA, Vocadlo DJ.

ACS Cent Sci. 2019 Apr 24;5(4):663-670. doi: 10.1021/acscentsci.9b00044. Epub 2019 Mar 1.


Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z.

Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10.


Frailty biomarkers in humans and rodents: Current approaches and future advances.

Kane AE, Sinclair DA.

Mech Ageing Dev. 2019 Jun;180:117-128. doi: 10.1016/j.mad.2019.03.007. Epub 2019 Apr 17. Review.


Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster.

Syrzycka M, Hallson G, Fitzpatrick KA, Kim I, Cotsworth S, Hollebakken RE, Simonetto K, Yang L, Luongo S, Beja K, Coulthard AB, Hilliker AJ, Sinclair DA, Honda BM.

G3 (Bethesda). 2019 May 7;9(5):1581-1595. doi: 10.1534/g3.119.0003.


Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E.

Cell Metab. 2019 Jun 4;29(6):1274-1290.e9. doi: 10.1016/j.cmet.2019.03.001. Epub 2019 Mar 28.


Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.

Bertoldo MJ, Uddin GM, Youngson NA, Agapiou D, Walters KA, Sinclair DA, Morris MJ, Gilchrist RB.

Hum Reprod Open. 2018 May 29;2018(3):hoy010. doi: 10.1093/hropen/hoy010. eCollection 2018.


Electroconvulsive therapy for treatment-resistant schizophrenia.

Sinclair DJ, Zhao S, Qi F, Nyakyoma K, Kwong JS, Adams CE.

Cochrane Database Syst Rev. 2019 Mar 19;3:CD011847. doi: 10.1002/14651858.CD011847.pub2.


Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

Feng J, LaChance A, Sinclair DA, Asgari MM.

BMJ Case Rep. 2019 Mar 8;12(3). pii: e227233. doi: 10.1136/bcr-2018-227233.


Epigenetic changes during aging and their reprogramming potential.

Kane AE, Sinclair DA.

Crit Rev Biochem Mol Biol. 2019 Feb;54(1):61-83. doi: 10.1080/10409238.2019.1570075. Epub 2019 Mar 1.


Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2019 Feb 7;176(4):944-945. doi: 10.1016/j.cell.2019.01.026. No abstract available.



Greaves WW, Das R, McKenzie JG, Sinclair DC 2nd, Hegmann KT.

J Occup Environ Med. 2018 Dec;60(12):e640-e646. doi: 10.1097/JOM.0000000000001492. No abstract available.


Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.


Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects.

Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G.

Sci Rep. 2018 Nov 8;8(1):16778. doi: 10.1038/s41598-018-35249-y.


Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.

Kane AE, Sinclair DA.

Circ Res. 2018 Sep 14;123(7):868-885. doi: 10.1161/CIRCRESAHA.118.312498. Review.


Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects.

Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G.

Sci Rep. 2018 Oct 2;8(1):14685. doi: 10.1038/s41598-018-33008-7. Erratum in: Sci Rep. 2018 Nov 8;8(1):16778.


Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.

Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM.

Mol Cell. 2018 Sep 6;71(5):718-732.e9. doi: 10.1016/j.molcel.2018.07.031.


Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.

Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L.

Nat Rev Cardiol. 2019 Jan;16(1):33-55. doi: 10.1038/s41569-018-0074-0. Review.


Tackling overutilization of hospital tests and treatments: Lessons learned from a grassroots approach.

Hicks LK, O'Brien P, Sholzberg M, Veloce N, Trafford A, Sinclair D.

Healthc Manage Forum. 2018 Sep;31(5):186-190. doi: 10.1177/0840470418781172. Epub 2018 Aug 22.


Assays for NAD+-Dependent Reactions and NAD+ Metabolites.

Schultz MB, Lu Y, Braidy N, Sinclair DA.

Methods Mol Biol. 2018;1813:77-90. doi: 10.1007/978-1-4939-8588-3_6.


Emergency medicine definitions, CAEP, and the journey to excellence.

Sinclair D.

CJEM. 2018 Jul;20(4):487-488. doi: 10.1017/cem.2018.419. No abstract available.


Compressed Animated Light Fields with Real-Time View-Dependent Reconstruction.

Koniaris C, Kosek M, Sinclair D, Mitchell K.

IEEE Trans Vis Comput Graph. 2019 Apr;25(4):1666-1680. doi: 10.1109/TVCG.2018.2818156. Epub 2018 Mar 22.


Seizure outcome in pediatric medically refractory temporal lobe epilepsy surgery: selective amygdalohippocampectomy versus anterior temporal lobectomy.

Elliott CA, Broad A, Narvacan K, Steve TA, Snyder T, Urlacher J, Wheatley BM, Sinclair DB.

J Neurosurg Pediatr. 2018 Sep;22(3):276-282. doi: 10.3171/2018.4.PEDS17607. Epub 2018 Jun 22.


Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF.

Aging Cell. 2018 Aug;17(4):e12751. doi: 10.1111/acel.12751. Epub 2018 Apr 14.


Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Dai H, Sinclair DA, Ellis JL, Steegborn C.

Pharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22. Review.


Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.

Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945.


Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR.

Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001.


Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector.

Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Cree W, Daniels T, Danilov M, Daugherty SJ, Daughhetee J, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Didberidze T, Dilling J, Dolgolenko A, Dolinski MJ, Fairbank W, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gornea R, Graham K, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Jamil A, Jewell MJ, Johnson A, Johnston S, Karelin A, Kaufman LJ, Koffas T, Kravitz S, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Leonard DS, Li GS, Li S, Licciardi C, Lin YH, MacLellan R, Michel T, Mong B, Moore D, Murray K, Nelson R, Njoya O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Rowson PC, Russell JJ, Schmidt S, Schubert A, Sinclair D, Stekhanov V, Tarka M, Tolba T, Tsang R, Vogel P, Vuilleumier JL, Wagenpfeil M, Waite A, Walton T, Weber M, Wen LJ, Wichoski U, Wrede G, Yang L, Yen YR, Zeldovich OY, Zettlemoyer J, Ziegler T; EXO-200 Collaboration.

Phys Rev Lett. 2018 Feb 16;120(7):072701. doi: 10.1103/PhysRevLett.120.072701.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Rajman L, Chwalek K, Sinclair DA.

Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Review.


Identifying Older Adults at Risk of Delirium Following Elective Surgery: A Systematic Review and Meta-Analysis.

Watt J, Tricco AC, Talbot-Hamon C, Pham B, Rios P, Grudniewicz A, Wong C, Sinclair D, Straus SE.

J Gen Intern Med. 2018 Apr;33(4):500-509. doi: 10.1007/s11606-017-4204-x. Epub 2018 Jan 26.


Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis.

Watt J, Tricco AC, Talbot-Hamon C, Pham B, Rios P, Grudniewicz A, Wong C, Sinclair D, Straus SE.

BMC Med. 2018 Jan 12;16(1):2. doi: 10.1186/s12916-017-0986-2. Review.


Intra-operative Video Characterization of Carotid Artery Pulsation Patterns in Case Series with Post-endarterectomy Hypertension and Hyperperfusion Syndrome.

Xiao Y, Rivaz H, Kasuya H, Yokosako S, Mindru C, Teitelbaum J, Sirhan D, Sinclair D, Angle M, Lo BWY.

Transl Stroke Res. 2018 Oct;9(5):452-458. doi: 10.1007/s12975-017-0605-8. Epub 2018 Jan 10.


Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.

Bustamante S, Jayasena T, Richani D, Gilchrist RB, Wu LE, Sinclair DA, Sachdev PS, Braidy N.

Metabolomics. 2017 Dec 23;14(1):15. doi: 10.1007/s11306-017-1310-z.


Interventions to increase tuberculosis case detection at primary healthcare or community-level services.

Mhimbira FA, Cuevas LE, Dacombe R, Mkopi A, Sinclair D.

Cochrane Database Syst Rev. 2017 Nov 28;11:CD011432. doi: 10.1002/14651858.CD011432.pub2. Review.


Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR.

Mol Metab. 2018 Jan;7:1-11. doi: 10.1016/j.molmet.2017.10.012. Epub 2017 Nov 6.


Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

Sci Rep. 2017 Nov 8;7(1):15063. doi: 10.1038/s41598-017-14866-z.

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