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Items: 1 to 50 of 69

1.

Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model.

Laprairie RB, Bagher AM, Rourke JL, Zrein A, Cairns EA, Kelly MEM, Sinal CJ, Kulkarni PM, Thakur GA, Denovan-Wright EM.

Neuropharmacology. 2019 Jun;151:1-12. doi: 10.1016/j.neuropharm.2019.03.033. Epub 2019 Mar 30.

PMID:
30940536
2.

The impact of chemerin or chemokine-like receptor 1 loss on the mouse gut microbiome.

Dranse HJ, Zheng A, Comeau AM, Langille MGI, Zabel BA, Sinal CJ.

PeerJ. 2018 Sep 12;6:e5494. doi: 10.7717/peerj.5494. eCollection 2018.

3.

The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension.

Watts SW, Darios ES, Mullick AE, Garver H, Saunders TL, Hughes ED, Filipiak WE, Zeidler MG, McMullen N, Sinal CJ, Kumar RK, Ferland DJ, Fink GD.

FASEB J. 2018 Jun 15:fj201800479. doi: 10.1096/fj.201800479. [Epub ahead of print]

PMID:
29906243
4.

Bone Marrow Adipose Tissue and Skeletal Health.

Muruganandan S, Govindarajan R, Sinal CJ.

Curr Osteoporos Rep. 2018 Aug;16(4):434-442. doi: 10.1007/s11914-018-0451-y. Review.

5.

Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis.

Haberl EM, Pohl R, Rein-Fischboeck L, Feder S, Sinal CJ, Buechler C.

Anticancer Res. 2018 May;38(5):2649-2657.

PMID:
29715085
6.

Ex vivo analysis of serum chemerin activity in murine models of obesity.

Haberl EM, Pohl R, Rein-Fischboeck L, Feder S, Eisinger K, Krautbauer S, Sinal CJ, Buechler C.

Cytokine. 2018 Apr;104:42-45. doi: 10.1016/j.cyto.2018.02.004. Epub 2018 Feb 6.

PMID:
29414326
7.

The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma.

Alzahrani F, Clattenburg L, Muruganandan S, Bullock M, MacIsaac K, Wigerius M, Williams BA, Graham ME, Rigby MH, Trites JR, Taylor SM, Sinal CJ, Fawcett JP, Hart RD.

J Otolaryngol Head Neck Surg. 2017 Feb 22;46(1):15. doi: 10.1186/s40463-017-0187-1.

8.

CMKLR1 activation ex vivo does not increase proportionally to serum total chemerin in obese humans.

Toulany J, Parlee SD, Sinal CJ, Slayter K, McNeil S, Goralski KB.

Endocr Connect. 2016 Nov;5(6):70-81. Epub 2016 Nov 8.

9.

Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation.

Muruganandan S, Govindarajan R, McMullen NM, Sinal CJ.

Stem Cells. 2017 Mar;35(3):711-724. doi: 10.1002/stem.2520. Epub 2016 Nov 11.

10.

Adipocyte-secreted chemerin is processed to a variety of isoforms and influences MMP3 and chemokine secretion through an NFkB-dependent mechanism.

Dranse HJ, Muruganandan S, Fawcett JP, Sinal CJ.

Mol Cell Endocrinol. 2016 Nov 15;436:114-29. doi: 10.1016/j.mce.2016.07.017. Epub 2016 Jul 25.

PMID:
27461525
11.

Effects of alpha-lipoic acid on chemerin secretion in 3T3-L1 and human adipocytes.

Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, López-Yoldi M, Sinal CJ, Martínez JA, Moreno-Aliaga MJ.

Biochim Biophys Acta. 2016 Mar;1861(3):260-8. doi: 10.1016/j.bbalip.2015.12.011. Epub 2015 Dec 22.

PMID:
26721419
12.

CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway.

Rourke JL, Dranse HJ, Sinal CJ.

Mol Cell Endocrinol. 2015 Dec 5;417:36-51. doi: 10.1016/j.mce.2015.09.002. Epub 2015 Sep 9.

PMID:
26363224
13.

Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis.

Dranse HJ, Rourke JL, Stadnyk AW, Sinal CJ.

Physiol Rep. 2015 Aug;3(8). pii: e12497. doi: 10.14814/phy2.12497.

14.

Effect of N-Acetylcysteine on Adipose-Derived Stem Cell and Autologous Fat Graft Survival in a Mouse Model.

Gillis J, Gebremeskel S, Phipps KD, MacNeil LA, Sinal CJ, Johnston B, Hong P, Bezuhly M.

Plast Reconstr Surg. 2015 Aug;136(2):179e-188e. doi: 10.1097/PRS.0000000000001443.

PMID:
26218392
15.

NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.

Clattenburg L, Wigerius M, Qi J, Rainey JK, Rourke JL, Muruganandan S, Sinal CJ, Fawcett JP.

Mol Cell Biol. 2015 Jul;35(13):2265-77. doi: 10.1128/MCB.00062-15. Epub 2015 Apr 27.

16.

Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice.

Rourke JL, Muruganandan S, Dranse HJ, McMullen NM, Sinal CJ.

J Endocrinol. 2014 Aug;222(2):201-15. doi: 10.1530/JOE-14-0069. Epub 2014 Jun 3.

PMID:
24895415
17.

The impact of bone marrow adipocytes on osteoblast and osteoclast differentiation.

Muruganandan S, Sinal CJ.

IUBMB Life. 2014 Mar;66(3):147-155. doi: 10.1002/iub.1254. Epub 2014 Mar 17. Review.

18.

Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis.

Muruganandan S, Dranse HJ, Rourke JL, McMullen NM, Sinal CJ.

Stem Cells. 2013 Oct;31(10):2172-82. doi: 10.1002/stem.1450.

19.

Chemerin connects fat to arterial contraction.

Watts SW, Dorrance AM, Penfold ME, Rourke JL, Sinal CJ, Seitz B, Sullivan TJ, Charvat TT, Thompson JM, Burnett R, Fink GD.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1320-8. doi: 10.1161/ATVBAHA.113.301476. Epub 2013 Apr 4.

20.

Elastase and tryptase govern TNFα-mediated production of active chemerin by adipocytes.

Parlee SD, McNeil JO, Muruganandan S, Sinal CJ, Goralski KB.

PLoS One. 2012;7(12):e51072. doi: 10.1371/journal.pone.0051072. Epub 2012 Dec 5.

21.

Towards an integrative approach to understanding the role of chemerin in human health and disease.

Rourke JL, Dranse HJ, Sinal CJ.

Obes Rev. 2013 Mar;14(3):245-62. doi: 10.1111/obr.12009. Epub 2012 Dec 6. Review.

PMID:
23216632
22.

Chemerin: a potential endocrine link between obesity and type 2 diabetes.

Roman AA, Parlee SD, Sinal CJ.

Endocrine. 2012 Oct;42(2):243-51. Epub 2012 May 19. Review.

PMID:
22610747
23.

Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis.

Issa ME, Muruganandan S, Ernst MC, Parlee SD, Zabel BA, Butcher EC, Sinal CJ, Goralski KB.

Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1621-31. doi: 10.1152/ajpcell.00187.2011. Epub 2012 Mar 28.

24.

Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.

Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ.

Endocrinology. 2012 Feb;153(2):672-82. doi: 10.1210/en.2011-1490. Epub 2011 Dec 20.

25.

A procedure for creating a frailty index based on deficit accumulation in aging mice.

Parks RJ, Fares E, Macdonald JK, Ernst MC, Sinal CJ, Rockwood K, Howlett SE.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):217-27. doi: 10.1093/gerona/glr193. Epub 2011 Oct 21.

PMID:
22021390
26.

Chemerin, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) target gene that promotes mesenchymal stem cell adipogenesis.

Muruganandan S, Parlee SD, Rourke JL, Ernst MC, Goralski KB, Sinal CJ.

J Biol Chem. 2011 Jul 8;286(27):23982-95. doi: 10.1074/jbc.M111.220491. Epub 2011 May 14.

27.

Chemerin: at the crossroads of inflammation and obesity.

Ernst MC, Sinal CJ.

Trends Endocrinol Metab. 2010 Nov;21(11):660-7. doi: 10.1016/j.tem.2010.08.001. Review.

PMID:
20817486
28.

Influence of peroxisome proliferator-activated receptor-alpha (PPARα) activity on adverse effects associated with amiodarone exposure in mice.

Ernst MC, Sinal CJ, Pollak PT.

Pharmacol Res. 2010 Nov;62(5):408-15. doi: 10.1016/j.phrs.2010.07.004. Epub 2010 Jul 21.

PMID:
20654716
29.

Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-{alpha}.

Parlee SD, Ernst MC, Muruganandan S, Sinal CJ, Goralski KB.

Endocrinology. 2010 Jun;151(6):2590-602. doi: 10.1210/en.2009-0794. Epub 2010 Apr 2.

PMID:
20363880
30.

Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes.

Ernst MC, Issa M, Goralski KB, Sinal CJ.

Endocrinology. 2010 May;151(5):1998-2007. doi: 10.1210/en.2009-1098. Epub 2010 Mar 12.

PMID:
20228173
31.

Role of chemerin/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells.

Muruganandan S, Roman AA, Sinal CJ.

J Bone Miner Res. 2010 Feb;25(2):222-34. doi: 10.1359/jbmr.091106.

32.

Elucidation of chemerin and chemokine-like receptor-1 function in adipocytes by adenoviral-mediated shRNA knockdown of gene expression.

Goralski KB, Sinal CJ.

Methods Enzymol. 2009;460:289-312. doi: 10.1016/S0076-6879(09)05214-8.

PMID:
19446731
33.

Predation threat exerts specific effects on rat maternal behaviour and anxiety-related behaviour of male and female offspring.

Mashoodh R, Sinal CJ, Perrot-Sinal TS.

Physiol Behav. 2009 Mar 23;96(4-5):693-702. doi: 10.1016/j.physbeh.2009.01.001. Epub 2009 Jan 13.

PMID:
19171159
34.

Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program.

Muruganandan S, Roman AA, Sinal CJ.

Cell Mol Life Sci. 2009 Jan;66(2):236-53. doi: 10.1007/s00018-008-8429-z. Review.

PMID:
18854943
35.

Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism.

Muruganandan S, Sinal CJ.

Clin Pharmacol Ther. 2008 Jun;83(6):818-28. doi: 10.1038/clpt.2008.50. Epub 2008 Mar 19. Review.

PMID:
18388875
36.

Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer.

Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, Richardson TA, Sharma R, Sinal CJ.

Drug Metab Dispos. 2008 Feb;36(2):205-16. doi: 10.1124/dmd.107.018747.

PMID:
18218849
37.

The pesticide adjuvant, Toximul, alters hepatic metabolism through effects on downstream targets of PPARalpha.

Upham J, Acott PD, O'regan P, Sinal CJ, Crocker JF, Geldenhuys L, Murphy MG.

Biochim Biophys Acta. 2007 Sep;1772(9):1057-64. Epub 2007 Jun 16.

38.

Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism.

Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ.

J Biol Chem. 2007 Sep 21;282(38):28175-88. Epub 2007 Jul 16.

39.

Type 2 diabetes and cardiovascular disease: getting to the fat of the matter.

Goralski KB, Sinal CJ.

Can J Physiol Pharmacol. 2007 Jan;85(1):113-32. Review.

PMID:
17487251
40.

Sex differences in the chloride cotransporters, NKCC1 and KCC2, in the developing hypothalamus.

Perrot-Sinal TS, Sinal CJ, Reader JC, Speert DB, McCarthy MM.

J Neuroendocrinol. 2007 Apr;19(4):302-8.

PMID:
17355320
41.

Evidence for non-genomic transmission of ecological information via maternal behavior in female rats.

McLeod J, Sinal CJ, Perrot-Sinal TS.

Genes Brain Behav. 2007 Feb;6(1):19-29.

42.

Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha.

Hanniman EA, Lambert G, Inoue Y, Gonzalez FJ, Sinal CJ.

J Lipid Res. 2006 Nov;47(11):2503-14. Epub 2006 Aug 23.

43.

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC.

Circ Res. 2006 Aug 18;99(4):442-50. Epub 2006 Jul 20.

44.

Brain cyclosporin A levels are determined by ontogenic regulation of mdr1a expression.

Goralski KB, Acott PD, Fraser AD, Worth D, Sinal CJ.

Drug Metab Dispos. 2006 Feb;34(2):288-95. Epub 2005 Nov 22.

PMID:
16303871
45.

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice.

Hanniman EA, Lambert G, McCarthy TC, Sinal CJ.

J Lipid Res. 2005 Dec;46(12):2595-604. Epub 2005 Sep 26.

46.

Toll-like receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation.

Goralski KB, Abdulla D, Sinal CJ, Arsenault A, Renton KW.

Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G434-43. Epub 2005 May 5.

47.

Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids.

McCarthy TC, Li X, Sinal CJ.

J Biol Chem. 2005 Jun 17;280(24):23232-42. Epub 2005 Apr 11.

48.

Chipping away at gallstones.

Goralski KB, Sinal CJ.

Nat Med. 2004 Dec;10(12):1301-2. No abstract available.

PMID:
15580253
49.

Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation.

McCarthy TC, Pollak PT, Hanniman EA, Sinal CJ.

J Pharmacol Exp Ther. 2004 Dec;311(3):864-73. Epub 2004 Jul 20.

PMID:
15265979
50.

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.

Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA.

Genes Dev. 2004 Jan 15;18(2):157-69. Epub 2004 Jan 16.

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