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Na/H exchanger NHE1 acts upstream of rho GTPases to promote neurite outgrowth.

Sin WC, Tam N, Moniz D, Lee C, Church J.

J Cell Commun Signal. 2020 Mar 6. doi: 10.1007/s12079-020-00556-5. [Epub ahead of print]


Connexin43 peptide, TAT-Cx43266-283, selectively targets glioma cells, impairs malignant growth and enhances survival in mouse models in vivo.

Jaraíz-Rodríguez M, Talaverón R, García-Vicente L, Pelaz SG, Domínguez-Prieto M, Álvarez-Vázquez A, Flores-Hernández R, Sin WC, Bechberger J, Medina JM, Naus CC, Tabernero A.

Neuro Oncol. 2019 Dec 28. pii: noz243. doi: 10.1093/neuonc/noz243. [Epub ahead of print]


Linking stemness with colorectal cancer initiation, progression, and therapy.

Iyer DN, Sin WY, Ng L.

World J Stem Cells. 2019 Aug 26;11(8):519-534. doi: 10.4252/wjsc.v11.i8.519. Review.


Frequency and Severity of Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with a Sulfonylurea-Based Regimen at University-Affiliated Hospitals in Korea: The Naturalistic Evaluation of Hypoglycemic Events in Diabetic Subjects Study.

Kim YS, Cho BL, Kim WS, Kim SH, Jung IH, Sin WY, Choi DH, Lee SJ, Lim CS, Kang KP, Yu BY, Jeung W, Park CG.

Korean J Fam Med. 2019 Jul;40(4):212-219. doi: 10.4082/kjfm.18.0051. Epub 2019 Jul 20.


Cx43-Associated Secretome and Interactome Reveal Synergistic Mechanisms for Glioma Migration and MMP3 Activation.

Aftab Q, Mesnil M, Ojefua E, Poole A, Noordenbos J, Strale PO, Sitko C, Le C, Stoynov N, Foster LJ, Sin WC, Naus CC, Chen VC.

Front Neurosci. 2019 Mar 19;13:143. doi: 10.3389/fnins.2019.00143. eCollection 2019.


Attitudes of visitors at adult intensive care unit toward organ donation and organ support.

Tsai NW, Leung YM, Ng PY, Liong T, Lee SF, Ngai CW, Sin WC, Koo J, Chan WM.

Chin Med J (Engl). 2019 Feb 5;132(3):373-376. doi: 10.1097/CM9.0000000000000059. No abstract available.


GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.

Kajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, Naus CC, Buxbaum J, Zhang B.

Acta Neuropathol Commun. 2018 Dec 21;6(1):144. doi: 10.1186/s40478-018-0642-x.


Design and synthesis of oligo-lipidated arginyl peptide (OLAP) dimers with enhanced physicochemical activity, peptide stability and their antimicrobial actions against MRSA infections.

Koh JJ, Lin S, Sin WWL, Ng ZH, Jung DY, Beuerman RW, Liu S.

Amino Acids. 2018 Oct;50(10):1329-1345. doi: 10.1007/s00726-018-2607-6. Epub 2018 Jul 31.


A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation.

Mok SWF, Zeng W, Niu Y, Coghi P, Wu Y, Sin WM, Ng SI, Gordillo-Martínez F, Gao JY, Law BYK, Liu L, Yao X, Wong VKW.

Front Pharmacol. 2018 Jul 3;9:710. doi: 10.3389/fphar.2018.00710. eCollection 2018.


Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture.

van Pel DM, Harada K, Song D, Naus CC, Sin WC.

J Cell Commun Signal. 2018 Dec;12(4):723-730. doi: 10.1007/s12079-018-0469-z. Epub 2018 Jun 16.


Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics.

Grek CL, Sheng Z, Naus CC, Sin WC, Gourdie RG, Ghatnekar GG.

Curr Opin Pharmacol. 2018 Aug;41:79-88. doi: 10.1016/j.coph.2018.05.002. Epub 2018 May 24. Review.


Antimicrobial activity profiles of Amphiphilic Xanthone derivatives are a function of their molecular Oligomerization.

Koh JJ, Lin S, Bai Y, Sin WWL, Aung TT, Li J, Chandra V, Pervushin K, Beuerman RW, Liu S.

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2281-2298. doi: 10.1016/j.bbamem.2018.05.006. Epub 2018 May 18.


Bicaval dual lumen cannula in adult veno-venous extracorporeal membrane oxygenation-clinical pearls for safe cannulation.

Ngai CW, Ng PY, Sin WC.

J Thorac Dis. 2018 Mar;10(Suppl 5):S624-S628. doi: 10.21037/jtd.2018.02.70. Review.


Conflicting Roles of Connexin43 in Tumor Invasion and Growth in the Central Nervous System.

Uzu M, Sin WC, Shimizu A, Sato H.

Int J Mol Sci. 2018 Apr 11;19(4). pii: E1159. doi: 10.3390/ijms19041159. Review.


PostOperative ST-segment elevation: not a blocked coronary artery, then what?

Sin WC, Kwong JM, Wong TC, Kwong C, Chan C, Siu CW.

Clin Case Rep. 2018 Feb 16;6(4):631-633. doi: 10.1002/ccr3.1116. eCollection 2018 Apr.


Breast cancer stem cells-from origins to targeted therapy.

Sin WC, Lim CL.

Stem Cell Investig. 2017 Nov 29;4:96. doi: 10.21037/sci.2017.11.03. eCollection 2017. Review.


Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance.

Lin S, Sin WLW, Koh JJ, Lim F, Wang L, Cao D, Beuerman RW, Ren L, Liu S.

J Med Chem. 2017 Dec 28;60(24):10135-10150. doi: 10.1021/acs.jmedchem.7b01348. Epub 2017 Dec 8.


Acute connexin43 temporal and spatial expression in response to ischemic stroke.

Freitas-Andrade M, She J, Bechberger J, Naus CC, Sin WC.

J Cell Commun Signal. 2018 Mar;12(1):193-204. doi: 10.1007/s12079-017-0430-6. Epub 2017 Nov 13.


Effects of Processing Parameters on Surface Roughness of Additive Manufactured Ti-6Al-4V via Electron Beam Melting.

Wang P, Sin WJ, Nai MLS, Wei J.

Materials (Basel). 2017 Sep 22;10(10). pii: E1121. doi: 10.3390/ma10101121.


An update on minding the gap in cancer.

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):237-243. doi: 10.1016/j.bbamem.2017.06.015. Epub 2017 Jun 24. Review.


Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA).

Lin S, Koh JJ, Aung TT, Sin WLW, Lim F, Wang L, Lakshminarayanan R, Zhou L, Tan DTH, Cao D, Beuerman RW, Ren L, Liu S.

J Med Chem. 2017 Jul 27;60(14):6152-6165. doi: 10.1021/acs.jmedchem.7b00380. Epub 2017 Jul 7.


Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice.

Kuah LF, Tang LH, Sutton T, Lim JH, Sin WL, Lamirande E, Subbarao K, Lau YF.

J Gen Virol. 2017 Feb;98(2):155-165. doi: 10.1099/jgv.0.000683. Epub 2017 Mar 13.


Complication of venovenous extracorporeal membrane oxygenation cannulation - the significance of an inferior vena cava anomaly.

Yeung Ng P, Wong CC, Young K, Kwong YY, Sin WC.

Clin Case Rep. 2016 Oct 24;4(12):1132-1134. eCollection 2016 Dec.


Management of health care workers following occupational exposure to hepatitis B, hepatitis C, and human immunodeficiency virus.

Sin WW, Lin AW, Chan KC, Wong KH.

Hong Kong Med J. 2016 Oct;22(5):472-7. Epub 2016 Aug 26.


HMGB1/RAGE Signaling and Pro-Inflammatory Cytokine Responses in Non-HIV Adults with Active Pulmonary Tuberculosis.

Lui G, Wong CK, Ip M, Chu YJ, Yung IM, Cheung CS, Zheng L, Lam JS, Wong KT, Sin WW, Choi KW, Lee N.

PLoS One. 2016 Jul 19;11(7):e0159132. doi: 10.1371/journal.pone.0159132. eCollection 2016.


Speckle tracking echocardiography in patients with septic shock: a case control study (SPECKSS).

Ng PY, Sin WC, Ng AK, Chan WM.

Crit Care. 2016 May 14;20(1):145. doi: 10.1186/s13054-016-1327-0.


Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion.

Naus CC, Aftab Q, Sin WC.

Semin Cell Dev Biol. 2016 Feb;50:59-66. doi: 10.1016/j.semcdb.2015.12.008. Epub 2015 Dec 17. Review.


Effect of Music Therapy on Postoperative Pain Management in Gynecological Patients: A Literature Review.

Sin WM, Chow KM.

Pain Manag Nurs. 2015 Dec;16(6):978-87. doi: 10.1016/j.pmn.2015.06.008. Review.


Caring for parents: a consequentialist approach.

Sin W.

Med Health Care Philos. 2016 Mar;19(1):3-10. doi: 10.1007/s11019-015-9668-z.


A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation.

Chen Y, Chan AC, Chan SC, Chok SH, Sharr W, Fung J, Liu JH, Zhen Z, Sin WC, Lo CM, Tse HF, Yiu KH.

J Cardiol. 2016 Feb;67(2):140-6. doi: 10.1016/j.jjcc.2015.08.001. Epub 2015 Aug 21.


Astrocytes promote glioma invasion via the gap junction protein connexin43.

Sin WC, Aftab Q, Bechberger JF, Leung JH, Chen H, Naus CC.

Oncogene. 2016 Mar 24;35(12):1504-16. doi: 10.1038/onc.2015.210. Epub 2015 Jul 13.


Gap junctions modulate glioma invasion by direct transfer of microRNA.

Hong X, Sin WC, Harris AL, Naus CC.

Oncotarget. 2015 Jun 20;6(17):15566-77.


Reduction in gap junction intercellular communication promotes glioma migration.

Aftab Q, Sin WC, Naus CC.

Oncotarget. 2015 May 10;6(13):11447-64.


Intracranial plasmacytoma with hypoglossal nerve palsy in multiple myeloma.

Sin WY, Grant I.

Postgrad Med J. 2015 Mar;91(1073):174-5. doi: 10.1136/postgradmedj-2014-133051. No abstract available.


Pannexin 2 protein expression is not restricted to the CNS.

Le Vasseur M, Lelowski J, Bechberger JF, Sin WC, Naus CC.

Front Cell Neurosci. 2014 Nov 25;8:392. doi: 10.3389/fncel.2014.00392. eCollection 2014.


Podoplanin: a marker for reactive gliosis in gliomas and brain injury.

Kolar K, Freitas-Andrade M, Bechberger JF, Krishnan H, Goldberg GS, Naus CC, Sin WC.

J Neuropathol Exp Neurol. 2015 Jan;74(1):64-74. doi: 10.1097/NEN.0000000000000150.


Severe influenza A H7N9 pneumonia with rapid virological response to intravenous zanamivir.

Ho PL, Sin WC, Chan JF, Cheng VC, Chan KH.

Eur Respir J. 2014 Aug;44(2):535-7. doi: 10.1183/09031936.00006414. Epub 2014 Apr 2. No abstract available.


Systemic lupus erythematosus mimicking lymphoma: the relevance of the clinical background in interpreting imaging studies.

Gillmore R, Sin WY.

BMJ Case Rep. 2014 Feb 27;2014. pii: bcr2013201802. doi: 10.1136/bcr-2013-201802.


A prenatal case of split-hand malformation associated with 17p13.3 triplication - a dilemma in genetic counseling.

Luk HM, Wong VC, Lo IF, Chan KY, Lau ET, Kan AS, Tang MH, Tang WF, She WM, Chu YW, Sin WK, Chung BH.

Eur J Med Genet. 2014 Feb;57(2-3):81-4. doi: 10.1016/j.ejmg.2013.12.005. Epub 2013 Dec 28.


Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress.

Le HT, Sin WC, Lozinsky S, Bechberger J, Vega JL, Guo XQ, Sáez JC, Naus CC.

J Biol Chem. 2014 Jan 17;289(3):1345-54. doi: 10.1074/jbc.M113.508390. Epub 2013 Dec 3.


A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections.

Lee N, Hui DS, Zuo Z, Ngai KL, Lui GC, Wo SK, Tam WW, Chan MC, Wong BC, Wong RY, Choi KW, Sin WW, Lee EL, Tomlinson B, Hayden FG, Chan PK.

Clin Infect Dis. 2013 Dec;57(11):1511-9. doi: 10.1093/cid/cit597. Epub 2013 Sep 17.


Takotsubo cardiomyopathy associated with severe hypocalcemia secondary to idiopathic hypoparathyroidism.

Rhee HS, Lee SW, Jung YK, Jeon U, Park SH, Lee SJ, Sin WY, Jin DK.

Korean Circ J. 2013 Aug;43(8):573-7. doi: 10.4070/kcj.2013.43.8.573. Epub 2013 Aug 31.


Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.

Kozoriz MG, Lai S, Vega JL, Sáez JC, Sin WC, Bechberger JF, Naus CC.

Neuropharmacology. 2013 Dec;75:549-56. doi: 10.1016/j.neuropharm.2013.05.003. Epub 2013 May 31.


Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.

Gielen PR, Aftab Q, Ma N, Chen VC, Hong X, Lozinsky S, Naus CC, Sin WC.

Neuropharmacology. 2013 Dec;75:539-48. doi: 10.1016/j.neuropharm.2013.05.002. Epub 2013 May 18.


Scrambler therapy for patients with cancer pain - case series -.

Park HS, Sin WK, Kim HY, Moon JY, Park SY, Kim YC, Lee SC.

Korean J Pain. 2013 Jan;26(1):65-71. doi: 10.3344/kjp.2013.26.1.65. Epub 2013 Jan 4.


Role of gap junction protein connexin43 in astrogliosis induced by brain injury.

Theodoric N, Bechberger JF, Naus CC, Sin WC.

PLoS One. 2012;7(10):e47311. doi: 10.1371/journal.pone.0047311. Epub 2012 Oct 23.


Activation and regulation of interferon-β in immune responses.

Sin WX, Li P, Yeong JP, Chin KC.

Immunol Res. 2012 Sep;53(1-3):25-40. doi: 10.1007/s12026-012-8293-7. Review.


Opposing roles of connexin43 in glioma progression.

Sin WC, Crespin S, Mesnil M.

Biochim Biophys Acta. 2012 Aug;1818(8):2058-67. doi: 10.1016/j.bbamem.2011.10.022. Epub 2011 Oct 29. Review.

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