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Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.

Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S.

J Am Soc Nephrol. 2019 Oct 1. pii: ASN.2019020163. doi: 10.1681/ASN.2019020163. [Epub ahead of print]


In utero exposure to maternal diabetes impairs nephron progenitor differentiation.

Cerqueira DM, Hemker SL, Bodnar AJ, Ortiz DM, Oladipupo FO, Mukherjee E, Gong Z, Appolonia C, Muzumdar RH, Sims-Lucas S, Ho J.

Am J Physiol Renal Physiol. 2019 Sep 11. doi: 10.1152/ajprenal.00204.2019. [Epub ahead of print]


Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates.

Francipane MG, Han B, Oxburgh L, Sims-Lucas S, Li Z, Lagasse E.

J Tissue Eng Regen Med. 2019 Sep;13(9):1724-1731. doi: 10.1002/term.2924. Epub 2019 Jul 30.


Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.

Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S.

J Am Soc Nephrol. 2019 Jul;30(7):1192-1205. doi: 10.1681/ASN.2018111170. Epub 2019 May 29.


Metabolic requirements of the nephron.

Cargill K, Sims-Lucas S.

Pediatr Nephrol. 2018 Dec 15. doi: 10.1007/s00467-018-4157-2. [Epub ahead of print] Review.


A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome.

Su S, Guntur AR, Nguyen DC, Fakory SS, Doucette CC, Leech C, Lotana H, Kelley M, Kohli J, Martino J, Sims-Lucas S, Liaw L, Vary C, Rosen CJ, Brown AC.

Cell Rep. 2018 Dec 11;25(11):3215-3228.e9. doi: 10.1016/j.celrep.2018.11.037.


Editorial: Organogenesis: From Development to Disease.

Sims-Lucas S, Good M, Vainio SJ.

Front Cell Dev Biol. 2017 Sep 20;5:85. doi: 10.3389/fcell.2017.00085. eCollection 2017. No abstract available.


Endothelial marker-expressing stromal cells are critical for kidney formation.

Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, Ho J, Humphreys BD, Bates C, Sims-Lucas S.

Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F611-F620. doi: 10.1152/ajprenal.00136.2017. Epub 2017 May 24.


Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.

Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES.

J Biol Chem. 2017 Jun 16;292(24):10239-10249. doi: 10.1074/jbc.M117.785022. Epub 2017 Apr 30.


N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics.

Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, Edmunds L, Wang Y, Sims-Lucas S, Churley L, Kelly S, Sun M, Stolz D, Graves JA.

Cell Death Discov. 2016 Dec 12;2:16082. doi: 10.1038/cddiscovery.2016.82. eCollection 2016.


Correction: Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux.

Walker KA, Sims-Lucas S, Di Giovanni VE, Schaefer C, Sunseri WM, Novitskaya T, de Caestecker MP, Chen F, Bates CM.

PLoS One. 2016 Nov 18;11(11):e0167191. doi: 10.1371/journal.pone.0167191. eCollection 2016.


Testicular Hypoplasia Is Driven by Defective Vascular Formation.

Dangle P, Salgado C, Reyes-Mugica M, Schneck F, Ost M, Sims-Lucas S.

Urology. 2017 Mar;101:94-98. doi: 10.1016/j.urology.2016.10.010. Epub 2016 Oct 17.


Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number.

Bebee TW, Sims-Lucas S, Park JW, Bushnell D, Cieply B, Xing Y, Bates CM, Carstens RP.

Dev Dyn. 2016 Oct;245(10):991-1000. doi: 10.1002/dvdy.24431. Epub 2016 Jul 28.


Dictyostelium discoideum RabS and Rab2 colocalize with the Golgi and contractile vacuole system and regulate osmoregulation.

Maringer K, Yarbrough A, Sims-Lucas S, Saheb E, Jawed S, Bush J.

J Biosci. 2016 Jun;41(2):205-17.


CD146(+) cells are essential for kidney vasculature development.

Halt KJ, Pärssinen HE, Junttila SM, Saarela U, Sims-Lucas S, Koivunen P, Myllyharju J, Quaggin S, Skovorodkin IN, Vainio SJ.

Kidney Int. 2016 Aug;90(2):311-324. doi: 10.1016/j.kint.2016.02.021. Epub 2016 Apr 18.


A FANCD2/FANCI-Associated Nuclease 1-Knockout Model Develops Karyomegalic Interstitial Nephritis.

Airik R, Schueler M, Airik M, Cho J, Porath JD, Mukherjee E, Sims-Lucas S, Hildebrandt F.

J Am Soc Nephrol. 2016 Dec;27(12):3552-3559. Epub 2016 Mar 29.


Intrapulmonary Bronchopulmonary Anastomoses and Plexiform Lesions in Idiopathic Pulmonary Arterial Hypertension.

Galambos C, Sims-Lucas S, Abman SH, Cool CD.

Am J Respir Crit Care Med. 2016 Mar 1;193(5):574-6. doi: 10.1164/rccm.201507-1508LE. No abstract available.


Role of hypoxia during nephrogenesis.

Hemker SL, Sims-Lucas S, Ho J.

Pediatr Nephrol. 2016 Oct;31(10):1571-7. doi: 10.1007/s00467-016-3333-5. Epub 2016 Feb 12. Review.


Prorenin receptor is critical for nephron progenitors.

Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM, Yosypiv IV.

Dev Biol. 2016 Jan 15;409(2):382-91. doi: 10.1016/j.ydbio.2015.11.024. Epub 2015 Dec 3.


The multifaceted role of the renal microvasculature during acute kidney injury.

Maringer K, Sims-Lucas S.

Pediatr Nephrol. 2016 Aug;31(8):1231-40. doi: 10.1007/s00467-015-3231-2. Epub 2015 Oct 22. Review.


Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.

Phua YL, Chu JY, Marrone AK, Bodnar AJ, Sims-Lucas S, Ho J.

Physiol Rep. 2015 Oct;3(10). pii: e12537. doi: 10.14814/phy2.12537.


Fibroblast growth factor receptor signaling in kidney and lower urinary tract development.

Walker KA, Sims-Lucas S, Bates CM.

Pediatr Nephrol. 2016 Jun;31(6):885-95. doi: 10.1007/s00467-015-3151-1. Epub 2015 Aug 21. Review.


In utero intra-cardiac tomato-lectin injections on mouse embryos to gauge renal blood flow.

Rymer CC, Sims-Lucas S.

J Vis Exp. 2015 Feb 4;(96). doi: 10.3791/52398.


Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.

Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM.

Dev Biol. 2015 Apr 1;400(1):82-93. doi: 10.1016/j.ydbio.2015.01.018. Epub 2015 Jan 30.


Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia.

Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C.

J Pediatr. 2015 Jan;166(1):178-83. doi: 10.1016/j.jpeds.2014.09.010. Epub 2014 Oct 11.


Functional genetic targeting of embryonic kidney progenitor cells ex vivo.

Junttila S, Saarela U, Halt K, Manninen A, Pärssinen H, Lecca MR, Brändli AW, Sims-Lucas S, Skovorodkin I, Vainio SJ.

J Am Soc Nephrol. 2015 May;26(5):1126-37. doi: 10.1681/ASN.2013060584. Epub 2014 Sep 8.


Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins.

Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH.

Thorax. 2015 Jan;70(1):84-5. doi: 10.1136/thoraxjnl-2014-205851. Epub 2014 Jul 21.


Renal blood flow and oxygenation drive nephron progenitor differentiation.

Rymer C, Paredes J, Halt K, Schaefer C, Wiersch J, Zhang G, Potoka D, Vainio S, Gittes GK, Bates CM, Sims-Lucas S.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F337-45. doi: 10.1152/ajprenal.00208.2014. Epub 2014 Jun 11.


Unwrapping the origins and roles of the renal endothelium.

Stolz DB, Sims-Lucas S.

Pediatr Nephrol. 2015 Jun;30(6):865-72. doi: 10.1007/s00467-014-2798-3. Epub 2014 Mar 15. Review.


Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning.

Hum S, Rymer C, Schaefer C, Bushnell D, Sims-Lucas S.

PLoS One. 2014 Feb 5;9(2):e88400. doi: 10.1371/journal.pone.0088400. eCollection 2014.


Dicer function is required in the metanephric mesenchyme for early kidney development.

Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J.

Am J Physiol Renal Physiol. 2014 Apr 1;306(7):F764-72. doi: 10.1152/ajprenal.00426.2013. Epub 2014 Feb 5.


Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia.

Galambos C, Sims-Lucas S, Abman SH.

J Pediatr. 2014 Jan;164(1):192-5. doi: 10.1016/j.jpeds.2013.08.035. Epub 2013 Sep 27.


Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia.

Galambos C, Sims-Lucas S, Abman SH.

Ann Am Thorac Soc. 2013 Oct;10(5):474-81. doi: 10.1513/AnnalsATS.201305-124OC.


Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme.

Sims-Lucas S, Schaefer C, Bushnell D, Ho J, Logar A, Prochownik E, Gittes G, Bates CM.

PLoS One. 2013 Jun 18;8(6):e65993. doi: 10.1371/journal.pone.0065993. Print 2013.


Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.

Sarin M, Wang Y, Zhang F, Rothermund K, Zhang Y, Lu J, Sims-Lucas S, Beer-Stolz D, Van Houten BE, Vockley J, Goetzman ES, Graves JA, Prochownik EV.

Cell Death Dis. 2013 Jun 13;4:e670. doi: 10.1038/cddis.2013.201.


Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux.

Walker KA, Sims-Lucas S, Di Giovanni VE, Schaefer C, Sunseri WM, Novitskaya T, de Caestecker MP, Chen F, Bates CM.

PLoS One. 2013;8(2):e56062. doi: 10.1371/journal.pone.0056062. Epub 2013 Feb 7. Erratum in: PLoS One. 2016 Nov 18;11(11):e0167191.


Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.

Spencer JD, Schwaderer AL, Wang H, Bartz J, Kline J, Eichler T, DeSouza KR, Sims-Lucas S, Baker P, Hains DS.

Kidney Int. 2013 Apr;83(4):615-25. doi: 10.1038/ki.2012.410. Epub 2013 Jan 9.


Three-dimensional analysis of the islet vasculature.

El-Gohary Y, Sims-Lucas S, Lath N, Tulachan S, Guo P, Xiao X, Welsh C, Paredes J, Wiersch J, Prasadan K, Shiota C, Gittes GK.

Anat Rec (Hoboken). 2012 Sep;295(9):1473-81. doi: 10.1002/ar.22530. Epub 2012 Jul 16.


Analysis of 3D branching pattern: hematoxylin and eosin method.

Sims-Lucas S.

Methods Mol Biol. 2012;886:73-86. doi: 10.1007/978-1-61779-851-1_7.


Mitochondrial structure, function and dynamics are temporally controlled by c-Myc.

Graves JA, Wang Y, Sims-Lucas S, Cherok E, Rothermund K, Branca MF, Elster J, Beer-Stolz D, Van Houten B, Vockley J, Prochownik EV.

PLoS One. 2012;7(5):e37699. doi: 10.1371/journal.pone.0037699. Epub 2012 May 21.


Ureteric morphogenesis requires Fgfr1 and Fgfr2/Frs2α signaling in the metanephric mesenchyme.

Sims-Lucas S, Di Giovanni V, Schaefer C, Cusack B, Eswarakumar VP, Bates CM.

J Am Soc Nephrol. 2012 Apr;23(4):607-17. doi: 10.1681/ASN.2011020165. Epub 2012 Jan 26.


Whole-mount imaging demonstrates hypervascularity of the pancreatic ducts and other pancreatic structures.

El-Gohary Y, Tulachan S, Branca M, Sims-Lucas S, Guo P, Prasadan K, Shiota C, Gittes GK.

Anat Rec (Hoboken). 2012 Mar;295(3):465-73. doi: 10.1002/ar.22420. Epub 2012 Jan 26.


The pro-apoptotic protein Bim is a microRNA target in kidney progenitors.

Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA.

J Am Soc Nephrol. 2011 Jun;22(6):1053-63. doi: 10.1681/ASN.2010080841. Epub 2011 May 5.


Betaglycan is required for the establishment of nephron endowment in the mouse.

Walker KA, Sims-Lucas S, Caruana G, Cullen-McEwen L, Li J, Sarraj MA, Bertram JF, Stenvers KL.

PLoS One. 2011 Apr 18;6(4):e18723. doi: 10.1371/journal.pone.0018723.


Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium.

Sims-Lucas S, Cusack B, Eswarakumar VP, Zhang J, Wang F, Bates CM.

Development. 2011 Apr;138(7):1275-80. doi: 10.1242/dev.062158. Epub 2011 Feb 24.


Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent.

Paredes J, Sims-Lucas S, Wang H, Lu W, Coley B, Gittes GK, Bates CM.

Am J Physiol Renal Physiol. 2011 May;300(5):F1262-5. doi: 10.1152/ajprenal.00720.2010. Epub 2011 Feb 16.


Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development.

Sims-Lucas S, Cusack B, Baust J, Eswarakumar VP, Masatoshi H, Takeuchi A, Bates CM.

Dev Dyn. 2011 Jan;240(1):240-9. doi: 10.1002/dvdy.22501.


High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.

Hains DS, Sims-Lucas S, Carpenter A, Saha M, Murawski I, Kish K, Gupta I, McHugh K, Bates CM.

J Urol. 2010 May;183(5):2077-84. doi: 10.1016/j.juro.2009.12.095. Epub 2010 Mar 19.


Redirection of renal mesenchyme to stromal and chondrocytic fates in the presence of TGF-beta2.

Sims-Lucas S, Young RJ, Martinez G, Taylor D, Grimmond SM, Teasdale R, Little MH, Bertram JF, Caruana G.

Differentiation. 2010 Apr-Jun;79(4-5):272-84. doi: 10.1016/j.diff.2010.01.004. Epub 2010 Feb 18.


Three-dimensional imaging reveals ureteric and mesenchymal defects in Fgfr2-mutant kidneys.

Sims-Lucas S, Argyropoulos C, Kish K, McHugh K, Bertram JF, Quigley R, Bates CM.

J Am Soc Nephrol. 2009 Dec;20(12):2525-33. doi: 10.1681/ASN.2009050532. Epub 2009 Oct 15.

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