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Items: 1 to 50 of 93

1.

Effect of IAPP on the proteome of cultured Rin-5F cells.

Miraee-Nedjad S, Sims PFG, Schwartz JM, Doig AJ.

BMC Biochem. 2018 Nov 12;19(1):9. doi: 10.1186/s12858-018-0099-3.

2.

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.

Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ.

Sci Rep. 2018 May 21;8(1):7949. doi: 10.1038/s41598-018-26170-5.

3.

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses.

Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD.

Genome Biol. 2017 Oct 27;18(1):201. doi: 10.1186/s13059-017-1338-4.

4.

Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring.

Lawless C, Holman SW, Brownridge P, Lanthaler K, Harman VM, Watkins R, Hammond DE, Miller RL, Sims PF, Grant CM, Eyers CE, Beynon RJ, Hubbard SJ.

Mol Cell Proteomics. 2016 Apr;15(4):1309-22. doi: 10.1074/mcp.M115.054288. Epub 2016 Jan 10.

5.

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p.

Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PF, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD.

Sci Rep. 2015 Oct 23;5:15518. doi: 10.1038/srep15518.

6.

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation.

Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PF, Grant CM, Hubbard SJ, Ashe MP, Pavitt GD.

PLoS Genet. 2015 May 14;11(5):e1005233. doi: 10.1371/journal.pgen.1005233. eCollection 2015 May.

7.

Global mRNA selection mechanisms for translation initiation.

Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PF, Grant CM, Pavitt GD, Hubbard SJ, Ashe MP.

Genome Biol. 2015 Jan 5;16:10. doi: 10.1186/s13059-014-0559-z.

8.

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.

Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PF, Ashe MP, Hubbard SJ, Pavitt GD, Grant CM.

PLoS Genet. 2015 Jan 8;11(1):e1004903. doi: 10.1371/journal.pgen.1004903. eCollection 2015 Jan.

9.

mRNA localization to P-bodies in yeast is bi-phasic with many mRNAs captured in a late Bfr1p-dependent wave.

Simpson CE, Lui J, Kershaw CJ, Sims PF, Ashe MP.

J Cell Sci. 2014 Mar 15;127(Pt 6):1254-62. doi: 10.1242/jcs.139055. Epub 2014 Jan 14.

10.

Puf3p induces translational repression of genes linked to oxidative stress.

Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PF, Pavitt GD, Hubbard SJ.

Nucleic Acids Res. 2014 Jan;42(2):1026-41. doi: 10.1093/nar/gkt948. Epub 2013 Oct 25.

11.

The use of selected reaction monitoring in quantitative proteomics.

Holman SW, Sims PF, Eyers CE.

Bioanalysis. 2012 Jul;4(14):1763-86. doi: 10.4155/BIO.12.126. Review.

12.

Software for analysing ion mobility mass spectrometry data to improve peptide identification.

Xia D, Ghali F, Gaskell SJ, O'Cualain R, Sims PF, Jones AR.

Proteomics. 2012 Jun;12(12):1912-6. doi: 10.1002/pmic.201200029.

PMID:
22623287
13.

A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance.

Southworth PM, Hyde JE, Sims PF.

Malar J. 2011 Oct 25;10:315. doi: 10.1186/1475-2875-10-315.

14.

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated.

Castelli LM, Lui J, Campbell SG, Rowe W, Zeef LA, Holmes LE, Hoyle NP, Bone J, Selley JN, Sims PF, Ashe MP.

Mol Biol Cell. 2011 Sep;22(18):3379-93. doi: 10.1091/mbc.E11-02-0153. Epub 2011 Jul 27.

15.

Structural analysis of alpha-helical proteins from wool using cysteine labelling and mass spectrometry.

O'Cualain RD, Sims PF, Carr CM.

Int J Biol Macromol. 2011 Oct 1;49(3):323-30. doi: 10.1016/j.ijbiomac.2011.05.007. Epub 2011 May 20.

PMID:
21624395
16.
17.

Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway.

Martin C, Chen S, Heilos D, Sauer G, Hunt J, Shaw AG, Sims PF, Jackson DA, Lovrić J.

PLoS One. 2010 Oct 12;5(10):e13322. doi: 10.1371/journal.pone.0013322.

19.

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.

Taylor EJ, Campbell SG, Griffiths CD, Reid PJ, Slaven JW, Harrison RJ, Sims PF, Pavitt GD, Delneri D, Ashe MP.

Mol Biol Cell. 2010 Jul 1;21(13):2202-16. doi: 10.1091/mbc.E09-11-0962. Epub 2010 May 5.

20.

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.

Wang P, Wang Q, Yang Y, Coward JK, Nzila A, Sims PF, Hyde JE.

Mol Biochem Parasitol. 2010 Jul;172(1):41-51. doi: 10.1016/j.molbiopara.2010.03.012. Epub 2010 Mar 27.

21.

Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins.

Chen S, Martin C, Maya-Mendoza A, Tang CW, Lovrić J, Sims PF, Jackson DA.

J Proteome Res. 2009 Nov;8(11):5196-211. doi: 10.1021/pr900549a.

PMID:
19775189
22.

Interaction with checkpoint kinase 1 modulates the recruitment of nucleophosmin to chromatin.

Chen S, Maya-Mendoza A, Zeng K, Tang CW, Sims PF, Loric J, Jackson DA.

J Proteome Res. 2009 Oct;8(10):4693-704. doi: 10.1021/pr900396d.

PMID:
19694479
23.

Lamin B1 maintains the functional plasticity of nucleoli.

Martin C, Chen S, Maya-Mendoza A, Lovric J, Sims PF, Jackson DA.

J Cell Sci. 2009 May 15;122(Pt 10):1551-62. doi: 10.1242/jcs.046284. Epub 2009 Apr 21.

24.

Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

Hyde JE, Dittrich S, Wang P, Sims PF, de Crécy-Lagard V, Hanson AD.

Trends Parasitol. 2008 Nov;24(11):502-8. doi: 10.1016/j.pt.2008.08.004. Epub 2008 Sep 19.

25.

An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.

Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE.

Mol Microbiol. 2008 Feb;67(3):609-18. Epub 2007 Dec 18.

27.

Characterisation of exogenous folate transport in Plasmodium falciparum.

Wang P, Wang Q, Sims PF, Hyde JE.

Mol Biochem Parasitol. 2007 Jul;154(1):40-51. Epub 2007 Apr 8.

28.

Proteomics of the human malaria parasite Plasmodium falciparum.

Sims PF, Hyde JE.

Expert Rev Proteomics. 2006 Feb;3(1):87-95. Review.

29.

Functional identification of orthologous genes encoding pterin recycling activity in Plasmodium falciparum and Toxoplasma gondii.

Wang Q, Hauser V, Read M, Wang P, Hanson AD, Sims PF, Hyde JE.

Mol Biochem Parasitol. 2006 Mar;146(1):109-12. Epub 2005 Nov 28. No abstract available.

30.

A glycine-cleavage complex as part of the folate one-carbon metabolism of Plasmodium falciparum.

Salcedo E, Sims PF, Hyde JE.

Trends Parasitol. 2005 Sep;21(9):406-11. Review.

31.

Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.

Nzila A, Ward SA, Marsh K, Sims PF, Hyde JE.

Trends Parasitol. 2005 Jul;21(7):334-9. Review.

32.

Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

Nzila A, Ward SA, Marsh K, Sims PF, Hyde JE.

Trends Parasitol. 2005 Jun;21(6):292-8. Review.

33.

Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum.

Wang P, Nirmalan N, Wang Q, Sims PF, Hyde JE.

Mol Biochem Parasitol. 2004 May;135(1):77-87.

PMID:
15287589
34.
36.
37.

Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites.

Sardarian A, Douglas KT, Read M, Sims PF, Hyde JE, Chitnumsub P, Sirawaraporn R, Sirawaraporn W.

Org Biomol Chem. 2003 Mar 21;1(6):960-4.

PMID:
12929634
38.

Molecular evidence for multiple Toxoplasma gondii infections in individual patients in England and Wales: public health implications.

Aspinall TV, Guy EC, Roberts KE, Joynson DH, Hyde JE, Sims PF.

Int J Parasitol. 2003 Jan;33(1):97-103.

PMID:
12547351
39.
40.

Rapid positive selection of stable integrants following transfection of Plasmodium falciparum.

Wang P, Wang Q, Sims PF, Hyde JE.

Mol Biochem Parasitol. 2002 Aug 7;123(1):1-10.

PMID:
12165384
41.

Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction--food for thought?

Aspinall TV, Marlee D, Hyde JE, Sims PF.

Int J Parasitol. 2002 Aug;32(9):1193-9.

PMID:
12117502
42.

The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis.

Aspinall TV, Joynson DH, Guy E, Hyde JE, Sims PF.

J Infect Dis. 2002 Jun 1;185(11):1637-43. Epub 2002 May 17.

PMID:
12023770
43.

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

Sibley CH, Hyde JE, Sims PF, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM, Nzila AM.

Trends Parasitol. 2001 Dec;17(12):582-8. Review.

PMID:
11756042
44.

Sulfa-drug resistance in Plasmodium falciparum.

Hyde JE, Sims PF.

Trends Parasitol. 2001 Jun;17(6):265-6. No abstract available.

PMID:
11426433
45.

Functional Analysis of six novel ORFs on the left arm of Chromosome XII of Saccharomyces cerevisiae reveals three of them responding to S-starvation.

Zhang N, Merlotti C, Wu J, Ismail T, El-Moghazy AN, Khan SA, Butt A, Gardner DC, Sims PF, Oliver SG.

Yeast. 2001 Mar 15;18(4):325-34.

46.
47.

Characterization of three genes encoding enzymes of the folate biosynthetic pathway in Plasmodium falciparum.

Lee CS, Salcedo E, Wang Q, Wang P, Sims PF, Hyde JE.

Parasitology. 2001 Jan;122 Pt 1:1-13.

PMID:
11197757
48.

Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolase.

Hart DO, He S, Chany CJ 2nd, Withers SG, Sims PF, Sinnott ML, Brumer H 3rd.

Biochemistry. 2000 Aug 15;39(32):9826-36.

PMID:
10933800
49.
50.

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