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The Cells of Bone and Their Interactions.

Ansari N, Sims NA.

Handb Exp Pharmacol. 2020 Feb 1. doi: 10.1007/164_2019_343. [Epub ahead of print]


Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.

Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA.

Nat Commun. 2019 Nov 4;10(1):5073. doi: 10.1038/s41467-019-13040-5.


Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms.

Sims NA, Martin TJ.

Annu Rev Physiol. 2020 Feb 10;82:507-529. doi: 10.1146/annurev-physiol-021119-034425. Epub 2019 Sep 25.


Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism.

Ho PWM, Chan AS, Pavlos NJ, Sims NA, Martin TJ.

Biochem Pharmacol. 2019 Nov;169:113627. doi: 10.1016/j.bcp.2019.113627. Epub 2019 Aug 30.


Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche.

Cao H, Cao B, Heazlewood CK, Domingues M, Sun X, Debele E, McGregor NE, Sims NA, Heazlewood SY, Nilsson SK.

Cells. 2019 Aug 27;8(9). pii: E985. doi: 10.3390/cells8090985.


Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown.

Blank M, Sims NA.

Curr Osteoporos Rep. 2019 Oct;17(5):270-280. doi: 10.1007/s11914-019-00524-y. Review.


Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs.

Gauci SJ, Golub SB, Tatarczuch L, Lee E, Chan D, Walsh NC, Little CB, Stanton H, Lokmic Z, Sims NA, Mackie EJ, Fosang AJ.

Matrix Biol. 2019 Oct;83:77-96. doi: 10.1016/j.matbio.2019.08.001. Epub 2019 Aug 2.


Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.

Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA.

Nat Commun. 2019 Jul 31;10(1):3436. doi: 10.1038/s41467-019-11373-9. Erratum in: Nat Commun. 2019 Nov 4;10(1):5073.


Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.

Liu X, D'Cruz AA, Hansen J, Croker BA, Lawlor KE, Sims NA, Wicks IP.

Osteoarthritis Cartilage. 2019 Oct;27(10):1557-1563. doi: 10.1016/j.joca.2019.05.018. Epub 2019 Jun 5.


Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

King A, Hoch NC, McGregor NE, Sims NA, Smyth IM, Heierhorst J.

Hum Mol Genet. 2019 Apr 22. pii: ddz083. doi: 10.1093/hmg/ddz083. [Epub ahead of print]


IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis.

McGregor NE, Murat M, Elango J, Poulton IJ, Walker EC, Crimeen-Irwin B, Ho PWM, Gooi JH, Martin TJ, Sims NA.

J Biol Chem. 2019 May 10;294(19):7850-7863. doi: 10.1074/jbc.RA119.008074. Epub 2019 Mar 28.


Isolation, Purification, Generation, and Culture of Osteocytes.

Gooi JH, Chia LY, Vrahnas C, Sims NA.

Methods Mol Biol. 2019;1914:39-51. doi: 10.1007/978-1-4939-8997-3_3.


Overcoming natural Wnt inhibition to optimize therapy.

Sims NA.

Nat Rev Rheumatol. 2019 Feb;15(2):67-68. doi: 10.1038/s41584-018-0153-y. Review. No abstract available.


Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta.

Bateman JF, Sampurno L, Maurizi A, Lamandé SR, Sims NA, Cheng TL, Schindeler A, Little DG.

J Cell Mol Med. 2019 Mar;23(3):1735-1745. doi: 10.1111/jcmm.14072. Epub 2018 Dec 30.


Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments.

Crossin R, Andrews ZB, Sims NA, Pang T, Mathai M, Gooi JH, Stefanidis A, Oldfield BJ, Lawrence AJ, Duncan JR.

Neuroendocrinology. 2018;107(4):340-354. doi: 10.1159/000493686. Epub 2018 Sep 12.


Retinoic Acid Receptor γ Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis.

Green AC, Rudolph-Stringer V, Straszkowski L, Tjin G, Crimeen-Irwin B, Walia M, Martin TJ, Sims NA, Purton LE.

J Bone Miner Res. 2018 Dec;33(12):2202-2213. doi: 10.1002/jbmr.3558. Epub 2018 Aug 8.


Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits.

Vrahnas C, Buenzli PR, Pearson TA, Pennypacker BL, Tobin MJ, Bambery KR, Duong LT, Sims NA.

Calcif Tissue Int. 2018 Dec;103(6):625-637. doi: 10.1007/s00223-018-0455-8. Epub 2018 Jul 17.


Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner.

Johnson RW, Sun Y, Ho PWM, Chan ASM, Johnson JA, Pavlos NJ, Sims NA, Martin TJ.

Front Endocrinol (Lausanne). 2018 May 16;9:241. doi: 10.3389/fendo.2018.00241. eCollection 2018.


Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

Tsantikos E, Lau M, Castelino CM, Maxwell MJ, Passey SL, Hansen MJ, McGregor NE, Sims NA, Steinfort DP, Irving LB, Anderson GP, Hibbs ML.

J Clin Invest. 2018 Jun 1;128(6):2406-2418. doi: 10.1172/JCI98224. Epub 2018 Apr 30.


IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy.

Lazzaro L, Tonkin BA, Poulton IJ, McGregor NE, Ferlin W, Sims NA.

Bone. 2018 Jul;112:120-127. doi: 10.1016/j.bone.2018.04.015. Epub 2018 Apr 19.


Nutritional Attributes, Substitutability, Scalability, and Environmental Intensity of an Illustrative Subset of Current and Future Protein Sources for Aquaculture Feeds: Joint Consideration of Potential Synergies and Trade-offs.

Pelletier N, Klinger DH, Sims NA, Yoshioka JR, Kittinger JN.

Environ Sci Technol. 2018 May 15;52(10):5532-5544. doi: 10.1021/acs.est.7b05468. Epub 2018 Apr 24. Review.


Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice.

Maltby S, Lochrin AJ, Bartlett B, Tay HL, Weaver J, Poulton IJ, Plank MW, Rosenberg HF, Sims NA, Foster PS.

J Immunol. 2018 Jan 15;200(2):632-642. doi: 10.4049/jimmunol.1700927. Epub 2017 Dec 6.


Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms.

Levesque JP, Sims NA, Pettit AR, Alexander KA, Tseng HW, Torossian F, Genêt F, Lataillade JJ, Le Bousse-Kerdilès MC.

J Bone Miner Res. 2018 Feb;33(2):365-366. doi: 10.1002/jbmr.3346. Epub 2017 Dec 27. No abstract available.


Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications.

Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdilès MC.

JCI Insight. 2017 Nov 2;2(21). pii: 96034. doi: 10.1172/jci.insight.96034.


Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6.

Cho DC, Brennan HJ, Johnson RW, Poulton IJ, Gooi JH, Tonkin BA, McGregor NE, Walker EC, Handelsman DJ, Martin TJ, Sims NA.

Nat Commun. 2017 Oct 9;8(1):806. doi: 10.1038/s41467-017-00920-x.


Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.

Ansari N, Ho PW, Crimeen-Irwin B, Poulton IJ, Brunt AR, Forwood MR, Divieti Pajevic P, Gooi JH, Martin TJ, Sims NA.

J Bone Miner Res. 2018 Jan;33(1):137-153. doi: 10.1002/jbmr.3291. Epub 2017 Oct 3.


Biomechanical testing of the calcified metacarpal articular surface and its association with subchondral bone microstructure in Thoroughbred racehorses.

Williamson AJ, Sims NA, Thomas CDL, Lee PVS, Stevenson MA, Whitton RC.

Equine Vet J. 2018 Mar;50(2):255-260. doi: 10.1111/evj.12748. Epub 2017 Sep 27.


Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice.

Gillies BR, Ryan BA, Tonkin BA, Poulton IJ, Ma Y, Kirby BJ, St-Arnaud R, Sims NA, Kovacs CS.

J Bone Miner Res. 2018 Jan;33(1):16-26. doi: 10.1002/jbmr.3217. Epub 2017 Aug 2.


High dose dietary vitamin D3 increases bone mass and strength in mice.

Williamson L, Hayes A, Hanson ED, Pivonka P, Sims NA, Gooi JH.

Bone Rep. 2017 Feb 10;6:44-50. doi: 10.1016/j.bonr.2017.02.001. eCollection 2017 Jun.


Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2017 Feb 1;144(3):530. doi: 10.1242/dev.148460. No abstract available.


Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation.

Vrahnas C, Pearson TA, Brunt AR, Forwood MR, Bambery KR, Tobin MJ, Martin TJ, Sims NA.

Bone. 2016 Dec;93:146-154. doi: 10.1016/j.bone.2016.09.022. Epub 2016 Sep 28.


Senescent Osteocytes: Do They Cause Damage and Can They Be Targeted to Preserve the Skeleton?

Sims NA.

J Bone Miner Res. 2016 Nov;31(11):1917-1919. doi: 10.1002/jbmr.2994. Epub 2016 Oct 6. No abstract available.


Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass.

Walker EC, Johnson RW, Hu Y, Brennan HJ, Poulton IJ, Zhang JG, Jenkins BJ, Smyth GK, Nicola NA, Sims NA.

J Biol Chem. 2016 Oct 7;291(41):21703-21716. Epub 2016 Aug 18.


Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption.

Sims NA.

Int J Biochem Cell Biol. 2016 Oct;79:14-23. doi: 10.1016/j.biocel.2016.08.003. Epub 2016 Aug 3. Review.


Towards the development of a sustainable soya bean-based feedstock for aquaculture.

Park H, Weier S, Razvi F, Peña PA, Sims NA, Lowell J, Hungate C, Kissinger K, Key G, Fraser P, Napier JA, Cahoon EB, Clemente TE.

Plant Biotechnol J. 2017 Feb;15(2):227-236. doi: 10.1111/pbi.12608. Epub 2016 Sep 13.


VPS35: Two Ways to Recycle the Parathyroid Hormone Receptor (PTH1R) in Osteoblasts.

Sims NA.

EBioMedicine. 2016 Jul;9:3-4. doi: 10.1016/j.ebiom.2016.06.029. Epub 2016 Jun 23. No abstract available.


Response to "Letter to the Editor: On osteocyte density in the human body".

Buenzli PR, Sims NA.

Bone. 2016 Jul;88:73. doi: 10.1016/j.bone.2016.04.015. Epub 2016 Apr 22. No abstract available.


Bone: Does anti-sclerostin therapy promote inflammation in rheumatoid arthritis?

Sims NA.

Nat Rev Endocrinol. 2016 Jun;12(6):314-6. doi: 10.1038/nrendo.2016.59. Epub 2016 Apr 22. No abstract available.


Prepubertal Di-n-Butyl Phthalate Exposure Alters Sertoli and Leydig Cell Function and Lowers Bone Density in Adult Male Mice.

Bielanowicz A, Johnson RW, Goh H, Moody SC, Poulton IJ, Croce N, Loveland KL, Hedger MP, Sims NA, Itman C.

Endocrinology. 2016 Jul;157(7):2595-603. doi: 10.1210/en.2015-1936. Epub 2016 Apr 8.


Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2016 Feb 15;143(4):648-57. doi: 10.1242/dev.125625. Epub 2016 Jan 11. Erratum in: Development. 2017 Feb 1;144(3):530.


Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy.

Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY.

J Biol Chem. 2016 Jan 22;291(4):1631-42. doi: 10.1074/jbc.M115.679753. Epub 2015 Nov 23.


Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

Sims NA, Romas E.

Arthritis Res Ther. 2015 Nov 17;17:328. doi: 10.1186/s13075-015-0861-5.


Correction for Chen et al., Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection.

Chen W, Foo SS, Taylor A, Lulla A, Merits A, Hueston L, Forwood MR, Walsh NC, Sims NA, Herrero LJ, Mahalingam S.

J Virol. 2015 Dec;89(23):12232. doi: 10.1128/JVI.02114-15. No abstract available.


Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone.

Johnson RW, McGregor NE, Brennan HJ, Crimeen-Irwin B, Poulton IJ, Martin TJ, Sims NA.

Bone. 2015 Dec;81:343-351. doi: 10.1016/j.bone.2015.08.005. Epub 2015 Aug 7.


Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.

Sims NA.

Cytokine Growth Factor Rev. 2015 Oct;26(5):517-22. doi: 10.1016/j.cytogfr.2015.07.014. Epub 2015 Jul 14. Review.


The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.

Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ, Walkley CR.

PLoS Genet. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160. eCollection 2015 Apr.


Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

Sims NA, Martin TJ.

Front Endocrinol (Lausanne). 2015 Mar 24;6:41. doi: 10.3389/fendo.2015.00041. eCollection 2015. Review. No abstract available.


RARγ is a negative regulator of osteoclastogenesis.

Green AC, Poulton IJ, Vrahnas C, Häusler KD, Walkley CR, Wu JY, Martin TJ, Gillespie MT, Chandraratna RA, Quinn JM, Sims NA, Purton LE.

J Steroid Biochem Mol Biol. 2015 Jun;150:46-53. doi: 10.1016/j.jsbmb.2015.03.005. Epub 2015 Mar 20.


Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle.

Genêt F, Kulina I, Vaquette C, Torossian F, Millard S, Pettit AR, Sims NA, Anginot A, Guerton B, Winkler IG, Barbier V, Lataillade JJ, Le Bousse-Kerdilès MC, Hutmacher DW, Levesque JP.

J Pathol. 2015 Jun;236(2):229-40. doi: 10.1002/path.4519. Epub 2015 Mar 26.


Quantifying the osteocyte network in the human skeleton.

Buenzli PR, Sims NA.

Bone. 2015 Jun;75:144-50. doi: 10.1016/j.bone.2015.02.016. Epub 2015 Feb 20.


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