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Items: 1 to 50 of 90

1.

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.

PMID:
31233808
2.

Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.

Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC.

Antiviral Res. 2019 Jul;167:45-67. doi: 10.1016/j.antiviral.2019.04.006. Epub 2019 Apr 8. Review.

PMID:
30974127
3.

Understanding the Changing Health Care Needs of Individuals Aging With Spinal Cord Injury.

Kern SB, Hunter LN, Sims AC, Berzins D, Riekena H, Andrews ML, Alderfer JK, Nelson K, Kushner R.

Top Spinal Cord Inj Rehabil. 2019 Winter;25(1):62-73. doi: 10.1310/sci2501-62.

PMID:
30774290
4.

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.

5.

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1012-E1021. doi: 10.1073/pnas.1706928115. Epub 2018 Jan 16.

6.

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.

7.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.

8.

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling.

Burnum-Johnson KE, Kyle JE, Eisfeld AJ, Casey CP, Stratton KG, Gonzalez JF, Habyarimana F, Negretti NM, Sims AC, Chauhan S, Thackray LB, Halfmann PJ, Walters KB, Kim YM, Zink EM, Nicora CD, Weitz KK, Webb-Robertson BM, Nakayasu ES, Ahmer B, Konkel ME, Motin V, Baric RS, Diamond MS, Kawaoka Y, Waters KM, Smith RD, Metz TO.

Analyst. 2017 Jan 26;142(3):442-448. doi: 10.1039/c6an02486f.

9.

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses.

Nakayasu ES, Nicora CD, Sims AC, Burnum-Johnson KE, Kim YM, Kyle JE, Matzke MM, Shukla AK, Chu RK, Schepmoes AA, Jacobs JM, Baric RS, Webb-Robertson BJ, Smith RD, Metz TO.

mSystems. 2016 May 10;1(3). pii: e00043-16. eCollection 2016 May-Jun.

10.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.

11.

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.

Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, Weiss SR.

MBio. 2016 Mar 29;7(2):e00258. doi: 10.1128/mBio.00258-16.

12.

SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.

13.

Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme.

Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK, Marasco WA, Baric RS, Sims AC, Pyrc K, Li W, Sui J.

J Virol. 2015 Jul;89(14):7202-13. doi: 10.1128/JVI.00854-15. Epub 2015 Apr 29.

14.

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Menachery VD, Eisfeld AJ, Schäfer A, Josset L, Sims AC, Proll S, Fan S, Li C, Neumann G, Tilton SC, Chang J, Gralinski LE, Long C, Green R, Williams CM, Weiss J, Matzke MM, Webb-Robertson BJ, Schepmoes AA, Shukla AK, Metz TO, Smith RD, Waters KM, Katze MG, Kawaoka Y, Baric RS.

MBio. 2014 May 20;5(3):e01174-14. doi: 10.1128/mBio.01174-14.

15.

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.

Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62. doi: 10.1073/pnas.1311542110. Epub 2013 Sep 16.

16.

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.

Mitchell HD, Eisfeld AJ, Sims AC, McDermott JE, Matzke MM, Webb-Robertson BJ, Tilton SC, Tchitchek N, Josset L, Li C, Ellis AL, Chang JH, Heegel RA, Luna ML, Schepmoes AA, Shukla AK, Metz TO, Neumann G, Benecke AG, Smith RD, Baric RS, Kawaoka Y, Katze MG, Waters KM.

PLoS One. 2013 Jul 25;8(7):e69374. doi: 10.1371/journal.pone.0069374. Print 2013.

17.

A Simulation Framework to Investigate in vitro Viral Infection Dynamics.

Bankhead A 3rd, Mancini E, Sims AC, Baric RS, McWeeney S, Sloot PM.

J Comput Sci. 2013 May 1;4(3):127-134.

18.

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.

Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR 3rd, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS.

J Virol. 2013 Apr;87(7):3885-902. doi: 10.1128/JVI.02520-12. Epub 2013 Jan 30.

19.

Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production.

Plant EP, Sims AC, Baric RS, Dinman JD, Taylor DR.

Viruses. 2013 Jan 18;5(1):279-94. doi: 10.3390/v5010279.

20.

RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus.

Ishimaru D, Plant EP, Sims AC, Yount BL Jr, Roth BM, Eldho NV, Pérez-Alvarado GC, Armbruster DW, Baric RS, Dinman JD, Taylor DR, Hennig M.

Nucleic Acids Res. 2013 Feb 1;41(4):2594-608. doi: 10.1093/nar/gks1361. Epub 2012 Dec 28.

21.

Ocular zoonotic onchocerca infection in a resident of Oregon.

Eberhard ML, Sims AC, Bishop HS, Mathison BA, Hoffman RS.

Am J Trop Med Hyg. 2012 Dec;87(6):1073-5. doi: 10.4269/ajtmh.2012.12-0469. Epub 2012 Oct 29.

22.

Minimally invasive external mini-glaucoma shunt implantation without conjunctival dissection.

Hoffman RS, Crandall AS, Crandall DA, Fine IH, Packer M, Sims AC.

J Glaucoma. 2014 Apr-May;23(4):254-7. doi: 10.1097/IJG.0b013e31826a7edf.

PMID:
22922664
23.

Improved quality control processing of peptide-centric LC-MS proteomics data.

Matzke MM, Waters KM, Metz TO, Jacobs JM, Sims AC, Baric RS, Pounds JG, Webb-Robertson BJ.

Bioinformatics. 2011 Oct 15;27(20):2866-72. doi: 10.1093/bioinformatics/btr479. Epub 2011 Aug 18.

24.

Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.

te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ.

PLoS Pathog. 2010 Nov 4;6(11):e1001176. doi: 10.1371/journal.ppat.1001176.

25.

Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures.

Pyrc K, Sims AC, Dijkman R, Jebbink M, Long C, Deming D, Donaldson E, Vabret A, Baric R, van der Hoek L, Pickles R.

J Virol. 2010 Nov;84(21):11255-63. doi: 10.1128/JVI.00947-10. Epub 2010 Aug 18.

26.

Systematic assembly and genetic manipulation of the mouse hepatitis virus A59 genome.

Donaldson EF, Sims AC, Baric RS.

Methods Mol Biol. 2008;454:293-315. doi: 10.1007/978-1-59745-181-9_21.

PMID:
19057869
27.

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9. doi: 10.1073/pnas.0808116105. Epub 2008 Nov 26.

28.

Systematic assembly of a full-length infectious clone of human coronavirus NL63.

Donaldson EF, Yount B, Sims AC, Burkett S, Pickles RJ, Baric RS.

J Virol. 2008 Dec;82(23):11948-57. doi: 10.1128/JVI.01804-08. Epub 2008 Sep 25.

29.

A Reverse genetics system for dsRNA viruses.

Baric RS, Sims AC.

Cell Host Microbe. 2007 Apr 19;1(2):90-1.

30.

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium.

Sims AC, Burkett SE, Yount B, Pickles RJ.

Virus Res. 2008 Apr;133(1):33-44. Epub 2007 Apr 23. Review.

31.

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing.

Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS.

J Virol. 2007 Jul;81(13):7086-98. Epub 2007 Apr 11.

32.

SARS coronavirus replicase proteins in pathogenesis.

Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR.

Virus Res. 2008 Apr;133(1):88-100. Epub 2007 Mar 29.

33.

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.

Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS.

J Virol. 2007 Jun;81(12):6356-68. Epub 2007 Mar 28.

34.

Renilla luciferase as a reporter to assess SARS-CoV mRNA transcription regulation and efficacy of anti-SARS-CoV agents.

Roberts RS, Yount BL, Sims AC, Baker S, Baric RS.

Adv Exp Med Biol. 2006;581:597-600. No abstract available.

PMID:
17037604
35.

SARS coronavirus vaccine development.

Baric RS, Sheahan T, Deming D, Donaldson E, Yount B, Sims AC, Roberts RS, Frieman M, Rockx B.

Adv Exp Med Biol. 2006;581:553-60. No abstract available.

PMID:
17037597
36.

SARS CoV replication and pathogenesis in human airway epithelial cultures.

Sims AC, Yount B, Burkett SE, Baric RS, Pickles RJ.

Adv Exp Med Biol. 2006;581:535-8. No abstract available.

PMID:
17037593
37.

SARS coronavirus accessory ORFs encode luxury functions.

Frieman MB, Yount B, Sims AC, Deming DJ, Morrison TE, Sparks J, Denison M, Heise M, Baric RS.

Adv Exp Med Biol. 2006;581:149-52. No abstract available.

PMID:
17037522
38.

Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b.

Pekosz A, Schaecher SR, Diamond MS, Fremont DH, Sims AC, Baric RS.

Adv Exp Med Biol. 2006;581:115-20. No abstract available.

PMID:
17037516
39.

The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication.

Graham RL, Sims AC, Baric RS, Denison MR.

Adv Exp Med Biol. 2006;581:67-72.

PMID:
17037506
40.

Mutational analysis of MHV-A59 replicase protein-nsp10.

Donaldson EF, Sims AC, Deming DJ, Baric RS.

Adv Exp Med Biol. 2006;581:61-6. No abstract available.

PMID:
17037505
41.
42.

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice.

Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS.

J Virol. 2005 Dec;79(23):14909-22.

43.
44.

Humanized mice develop coronavirus respiratory disease.

Baric RS, Sims AC.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8073-4. Epub 2005 May 31. No abstract available.

45.

Development of mouse hepatitis virus and SARS-CoV infectious cDNA constructs.

Baric RS, Sims AC.

Curr Top Microbiol Immunol. 2005;287:229-52. Review.

PMID:
15609514
46.
47.

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication.

Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS.

J Virol. 2004 Jun;78(11):5957-65.

48.

MHV-A59 gene 1 proteins are associated with two distinct membrane populations.

Denison MR, Sims AC.

Adv Exp Med Biol. 2001;494:655-61. No abstract available.

PMID:
11774541
49.

Mortality statistics in psychiatry.

Sims AC.

Br J Psychiatry. 2001 Dec;179:477-8. No abstract available.

PMID:
11731346
50.

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