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The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts.

Garner KEL, Hull NJ, Sims AH, Lamb R, Clarke RB.

J Mammary Gland Biol Neoplasia. 2019 Sep 12. doi: 10.1007/s10911-019-09435-1. [Epub ahead of print]


Factors That Influence the Choice of Academic Pediatrics by Underrepresented Minorities.

Dixon G, Kind T, Wright J, Stewart N, Sims A, Barber A.

Pediatrics. 2019 Aug;144(2). pii: e20182759. doi: 10.1542/peds.2018-2759. Epub 2019 Jul 23.


Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.


Efficacy and safety of bronchial thermoplasty in clinical practice: a prospective, longitudinal, cohort study using evidence from the UK Severe Asthma Registry.

Burn J, Sims AJ, Patrick H, Heaney LG, Niven RM.

BMJ Open. 2019 Jun 19;9(6):e026742. doi: 10.1136/bmjopen-2018-026742.


Development of mouse models of angiosarcoma driven by p53.

Salter DM, Griffin M, Muir M, Teo K, Culley J, Smith JR, Gomez-Cuadrado L, Matchett K, Sims AH, Hayward L, Henderson NC, Brunton VG.

Dis Model Mech. 2019 Jul 9;12(7). pii: dmm038612. doi: 10.1242/dmm.038612.


On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer.

Bownes RJ, Turnbull AK, Martinez-Perez C, Cameron DA, Sims AH, Oikonomidou O.

Breast Cancer Res. 2019 Jun 14;21(1):73. doi: 10.1186/s13058-019-1159-3.


Intergenerational fitness effects of the early life environment in a wild rodent.

Van Cann J, Koskela E, Mappes T, Sims A, Watts PC.

J Anim Ecol. 2019 Sep;88(9):1355-1365. doi: 10.1111/1365-2656.13039. Epub 2019 Jun 20.


PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.

Santiago-Gómez A, Kedward T, Simões BM, Dragoni I, NicAmhlaoibh R, Trivier E, Sabin V, Gee JM, Sims AH, Howell SJ, Clarke RB.

Cancer Lett. 2019 Aug 28;458:66-75. doi: 10.1016/j.canlet.2019.05.014. Epub 2019 May 20.


Correction: PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer.

Loi S, Michiels S, Baselga J, Bartlett JMS, Singhal SK, Sabine VS, Sims AH, Sahmoud T, Michael Dixon J, Piccart MJ, Sotiriou C.

PLoS One. 2019 Apr 23;14(4):e0216175. doi: 10.1371/journal.pone.0216175. eCollection 2019.


Perspectives on gender parity in bioanalysis: an interview with Atreyee Sims.

Sims A.

Bioanalysis. 2019 Apr;11(7):671-672. doi: 10.4155/bio-2019-0054. Epub 2019 Apr 18.


Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.

Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC.

Antiviral Res. 2019 Jul;167:45-67. doi: 10.1016/j.antiviral.2019.04.006. Epub 2019 Apr 8. Review.


Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.

Cassetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, Soong DYH, Cotechini T, Anur P, Lin EY, Fidanza A, Lopez-Yrigoyen M, Millar MR, Urman A, Ai Z, Spellman PT, Hwang ES, Dixon JM, Wiechmann L, Coussens LM, Smith HO, Pollard JW.

Cancer Cell. 2019 Apr 15;35(4):588-602.e10. doi: 10.1016/j.ccell.2019.02.009. Epub 2019 Mar 28.


123I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults.

Roberts G, Lloyd JJ, Petrides GS, Donaghy PC, Kane JPM, Durcan R, Lawley S, Howe K, Sims AJ, Taylor JP, O'Brien JT, Thomas AJ.

Ann Nucl Med. 2019 Jun;33(6):434-443. doi: 10.1007/s12149-019-01352-x. Epub 2019 Mar 21.


Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research.

Selli C, Sims AH.

Breast Cancer (Auckl). 2019 Feb 19;13:1178223419829072. doi: 10.1177/1178223419829072. eCollection 2019. Review.


Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer.

Bishop RT, Marino S, de Ridder D, Allen RJ, Lefley DV, Sims AH, Wang N, Ottewell PD, Idris AI.

Cancer Lett. 2019 May 28;450:76-87. doi: 10.1016/j.canlet.2019.02.032. Epub 2019 Feb 18.


Understanding the Changing Health Care Needs of Individuals Aging With Spinal Cord Injury.

Kern SB, Hunter LN, Sims AC, Berzins D, Riekena H, Andrews ML, Alderfer JK, Nelson K, Kushner R.

Top Spinal Cord Inj Rehabil. 2019 Winter;25(1):62-73. doi: 10.1310/sci2501-62.


Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer.

Bonello M, Sims AH, Langdon SP.

Cancer Biol Med. 2018 Nov;15(4):375-388. doi: 10.20892/j.issn.2095-3941.2018.0062.


Correction to: Use of Expert Judgement Across NICE Guidance‑Making Programmes: A Review of Current Processes and Suitability of Existing Tools to Support the Use of Expert Elicitation.

Peel A, Jenks M, Choudhury M, Lovett R, Rejon-Parrilla JC, Sims A, Craig J.

Appl Health Econ Health Policy. 2019 Apr;17(2):263-264. doi: 10.1007/s40258-019-00463-w.


To what extent is the low anterior resection syndrome (LARS) associated with quality of life as measured using the EORTC C30 and CR38 quality of life questionnaires?

Kupsch J, Kuhn M, Matzel KE, Zimmer J, Radulova-Mauersberger O, Sims A, Witzigmann H, Stelzner S.

Int J Colorectal Dis. 2019 Apr;34(4):747-762. doi: 10.1007/s00384-019-03249-7. Epub 2019 Feb 5.


Specialist mental health care for older adults in New Zealand-an exploration of service models and routine data.

Cunningham R, Peterson D, Sims A.

N Z Med J. 2019 Feb 1;132(1489):30-38.


HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer.

Jarman EJ, Ward C, Turnbull AK, Martinez-Perez C, Meehan J, Xintaropoulou C, Sims AH, Langdon SP.

Breast Cancer Res. 2019 Jan 22;21(1):10. doi: 10.1186/s13058-019-1097-0.


Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours.

Selli C, Turnbull AK, Pearce DA, Li A, Fernando A, Wills J, Renshaw L, Thomas JS, Dixon JM, Sims AH.

Breast Cancer Res. 2019 Jan 7;21(1):2. doi: 10.1186/s13058-018-1089-5.


Impact of post-fire management on soil respiration, carbon and nitrogen content in a managed hemiboreal forest.

Parro K, Köster K, Jõgiste K, Seglinš K, Sims A, Stanturf JA, Metslaid M.

J Environ Manage. 2019 Mar 1;233:371-377. doi: 10.1016/j.jenvman.2018.12.050. Epub 2018 Dec 24.


The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis.

Chefer S, Seidel J, Cockrell AS, Yount B, Solomon J, Hagen KR, Liu DX, Huzella LM, Kumar MR, Postnikova E, Bohannon JK, Lackemeyer MG, Cooper K, Endlich-Frazier A, Sharma H, Thomasson D, Bartos C, Sayre PJ, Sims A, Dyall J, Holbrook MR, Jahrling PB, Baric RS, Johnson RF.

mSphere. 2018 Dec 12;3(6). pii: e00540-18. doi: 10.1128/mSphere.00540-18.


Factors Associated with Human Papillomavirus Vaccination among Women in the United States.

Sims A, Archie-Booker E, Waldrop RT, Claridy M, Gerbi G.

ARC J Public Health Community Med. 2018;3(1):6-12. doi: 10.20431/2456-0596.0301002.


Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors.

Nirmal AJ, Regan T, Shih BB, Hume DA, Sims AH, Freeman TC.

Cancer Immunol Res. 2018 Nov;6(11):1388-1400. doi: 10.1158/2326-6066.CIR-18-0342. Epub 2018 Sep 28.


Legionnaire's Disease in an Immunocompetent Host: An Unlikely Diagnosis.

Sims AN, Lewis BS, Prabhakaran P.

Clin Pediatr (Phila). 2018 Dec;57(14):1696-1698. doi: 10.1177/0009922818803402. Epub 2018 Sep 27. No abstract available.


Infant Walker-Related Injuries in the United States.

Sims A, Chounthirath T, Yang J, Hodges NL, Smith GA.

Pediatrics. 2018 Oct;142(4). pii: e20174332. doi: 10.1542/peds.2017-4332. Epub 2018 Sep 17.


Predictive markers of endocrine response in breast cancer.

Mosly D, Turnbull A, Sims A, Ward C, Langdon S.

World J Exp Med. 2018 Aug 30;8(1):1-7. doi: 10.5493/wjem.v8.i1.1. eCollection 2018 Aug 30.


Use of Expert Judgement Across NICE Guidance-Making Programmes: A Review of Current Processes and Suitability of Existing Tools to Support the Use of Expert Elicitation.

Peel A, Jenks M, Choudhury M, Lovett R, Rejon-Parrilla JC, Sims A, Craig J.

Appl Health Econ Health Policy. 2018 Dec;16(6):819-836. doi: 10.1007/s40258-018-0415-5. Erratum in: Appl Health Econ Health Policy. 2019 Apr;17(2):263-264.


Neoadjuvant Endocrine Therapy in Breast Cancer Upregulates the Cytotoxic Drug Pump ABCG2/BCRP, and May Lead to Resistance to Subsequent Chemotherapy.

Baxter DE, Kim B, Hanby AM, Verghese ET, Sims AH, Hughes TA.

Clin Breast Cancer. 2018 Dec;18(6):481-488. doi: 10.1016/j.clbc.2018.07.002. Epub 2018 Jul 6.


Clinically-relevant cardiopulmonary interactions for the pediatric intensivist.

Sasser WC, Sims AN, Loberger JM, Tofil NM, Prabhakaran P.

Minerva Pediatr. 2019 Feb;71(1):76-81. doi: 10.23736/S0026-4946.18.05338-0. Epub 2018 Jul 23. Review.


Systematic Review of Economic Models Used to Compare Techniques for Detecting Peripheral Arterial Disease.

Moloney E, O'Connor J, Craig D, Robalino S, Chrysos A, Javanbakht M, Sims A, Stansby G, Wilkes S, Allen J.

Pharmacoecon Open. 2019 Mar;3(1):21-30. doi: 10.1007/s41669-018-0076-1. Review.


Regulation of breast cancer induced bone disease by cancer-specific IKKβ.

Marino S, Bishop RT, Capulli M, Sophocleous A, Logan JG, Mollat P, Mognetti B, Ventura L, Sims AH, Rucci N, Ralston SH, Idris AI.

Oncotarget. 2018 Mar 23;9(22):16134-16148. doi: 10.18632/oncotarget.24743. eCollection 2018 Mar 23.


Novel Signal Noise Reduction Method through Cluster Analysis, Applied to Photoplethysmography.

Waugh W, Allen J, Wightman J, Sims AJ, Beale TAW.

Comput Math Methods Med. 2018 Jan 29;2018:6812404. doi: 10.1155/2018/6812404. eCollection 2018.


The third New Zealand Psychiatry of Old Age services and workforce survey.

Cheung G, Sims A, Copeland B, Collins C, Bharathan S.

Australas Psychiatry. 2018 Aug;26(4):405-409. doi: 10.1177/1039856218765891. Epub 2018 Apr 5.


The Memokath-051 Stent for the Treatment of Ureteric Obstruction: A NICE Medical Technology Guidance.

Eaton Turner E, Jenks M, McCool R, Marshall C, Millar L, Wood H, Peel A, Craig J, Sims AJ.

Appl Health Econ Health Policy. 2018 Aug;16(4):445-464. doi: 10.1007/s40258-018-0389-3. Review.


A randomized controlled trial comparing the Thompson hemiarthroplasty with the Exeter polished tapered stem and Unitrax modular head in the treatment of displaced intracapsular fractures of the hip: the WHiTE 3: HEMI Trial.

Sims AL, Parsons N, Achten J, Griffin XL, Costa ML, Reed MR; CORNET trainee collaborative.

Bone Joint J. 2018 Mar 1;100-B(3):352-360. doi: 10.1302/0301-620X.100B3.BJJ-2017-0872.R2.


Epigenome-wide SRC-1-Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer.

Ward E, Varešlija D, Charmsaz S, Fagan A, Browne AL, Cosgrove N, Cocchiglia S, Purcell SP, Hudson L, Das S, O'Connor D, O'Halloran PJ, Sims AH, Hill AD, Young LS.

Clin Cancer Res. 2018 Aug 1;24(15):3692-3703. doi: 10.1158/1078-0432.CCR-17-2615. Epub 2018 Mar 22.


Outcome of bowel function following anterior resection for rectal cancer-an analysis using the low anterior resection syndrome (LARS) score.

Kupsch J, Jackisch T, Matzel KE, Zimmer J, Schreiber A, Sims A, Witzigmann H, Stelzner S.

Int J Colorectal Dis. 2018 Jun;33(6):787-798. doi: 10.1007/s00384-018-3006-x. Epub 2018 Mar 15.


Using a Community Bus Tour for Pediatric Residents to Increase Their Knowledge of Health Disparities.

Lichtenstein C, de la Torre D, Falusi O, Sims A, Smiley Y, Baiyewu M.

Acad Pediatr. 2018 Aug;18(6):717-719. doi: 10.1016/j.acap.2018.03.004. Epub 2018 Mar 9.


Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.


MCL-1 is a prognostic indicator and drug target in breast cancer.

Campbell KJ, Dhayade S, Ferrari N, Sims AH, Johnson E, Mason SM, Dickson A, Ryan KM, Kalna G, Edwards J, Tait SWG, Blyth K.

Cell Death Dis. 2018 Jan 16;9(2):19. doi: 10.1038/s41419-017-0035-2.


MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1012-E1021. doi: 10.1073/pnas.1706928115. Epub 2018 Jan 16.


Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis.

Sarvi S, Patel H, Li J, Dodd GL, Creedon H, Muir M, Ward J, Dawson JC, Lee M, Culley J, Salter DM, Sims AH, Byron A, Brunton VG.

Cancer Res. 2018 Mar 15;78(6):1484-1496. doi: 10.1158/0008-5472.CAN-17-1518. Epub 2018 Jan 12.


Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

Hollis RL, Meynert AM, Churchman M, Rye T, Mackean M, Nussey F, Arends MJ, Sims AH, Semple CA, Herrington CS, Gourley C.

BMC Cancer. 2018 Jan 3;18(1):16. doi: 10.1186/s12885-017-3981-2.


GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

De Francesco EM, Sims AH, Maggiolini M, Sotgia F, Lisanti MP, Clarke RB.

Breast Cancer Res. 2017 Dec 6;19(1):129. doi: 10.1186/s13058-017-0923-5.


Predicting the risk of cucurbit downy mildew in the eastern United States using an integrated aerobiological model.

Neufeld KN, Keinath AP, Gugino BK, McGrath MT, Sikora EJ, Miller SA, Ivey ML, Langston DB, Dutta B, Keever T, Sims A, Ojiambo PS.

Int J Biometeorol. 2018 Apr;62(4):655-668. doi: 10.1007/s00484-017-1474-2. Epub 2017 Nov 25.


Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.


Complications following vaginal mesh procedures for stress urinary incontinence: an 8 year study of 92,246 women.

Keltie K, Elneil S, Monga A, Patrick H, Powell J, Campbell B, Sims AJ.

Sci Rep. 2017 Sep 20;7(1):12015. doi: 10.1038/s41598-017-11821-w.

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