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Items: 1 to 50 of 140

1.

Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support.

Puri M, Hoover SB, Hewitt SM, Wei BR, Adissu HA, Halsey CHC, Beck J, Bradley C, Cramer SD, Durham AC, Esplin DG, Frank C, Lyle LT, McGill LD, Sánchez MD, Schaffer PA, Traslavina RP, Buza E, Yang HH, Lee MP, Dwyer JE, Simpson RM.

J Pathol Inform. 2019 Feb 7;10:4. doi: 10.4103/jpi.jpi_59_18. eCollection 2019.

2.

Frailty: an in-depth qualitative study exploring the views of community care staff.

Coker JF, Martin ME, Simpson RM, Lafortune L.

BMC Geriatr. 2019 Feb 19;19(1):47. doi: 10.1186/s12877-019-1069-3.

3.

Intrinsic and regulated properties of minimally edited trypanosome mRNAs.

Tylec BL, Simpson RM, Kirby LE, Chen R, Sun Y, Koslowsky DJ, Read LK.

Nucleic Acids Res. 2019 Apr 23;47(7):3640-3657. doi: 10.1093/nar/gkz012.

4.

High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.

Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey YC, Cawley J, Tice CM, Yin J, McKnight C, Klummp-Thomas C, Zhang X, Guha R, Hoover S, Simpson RM, Nguyen HM, Corey E, Thomas CJ, Proia DA, Kelly K.

Sci Rep. 2018 Nov 22;8(1):17239. doi: 10.1038/s41598-018-35417-0.

5.

Urgent care axis for the older adult: where is best to target interventions?

Bunn JG, Croft SJ, O'Keeffe C, Jacques RM, Simpson RM, Stone T, Conroy SP, Mason SM.

Emerg Med J. 2019 Jan;36(1):22-26. doi: 10.1136/emermed-2018-207505. Epub 2018 Sep 3.

6.

Accuracy of pre-hospital trauma notification calls.

James MK, Clarke LA, Simpson RM, Noto AJ, Sclair JR, Doughlin GK, Lee SW.

Am J Emerg Med. 2019 Apr;37(4):620-626. doi: 10.1016/j.ajem.2018.06.058. Epub 2018 Jun 27.

PMID:
30041910
7.

High throughput sequencing revolution reveals conserved fundamentals of U-indel editing.

Zimmer SL, Simpson RM, Read LK.

Wiley Interdiscip Rev RNA. 2018 Jun 11:e1487. doi: 10.1002/wrna.1487. [Epub ahead of print] Review.

PMID:
29888550
8.

Open-label, cluster randomised controlled trial and economic evaluation of a brief letter from a GP on unscheduled medical contacts associated with the start of the school year: the PLEASANT trial.

Julious SA, Horspool MJ, Davis S, Franklin M, Smithson WH, Norman P, Simpson RM, Elphick H, Bortolami O, Cooper C.

BMJ Open. 2018 Apr 20;8(4):e017367. doi: 10.1136/bmjopen-2017-017367.

9.

Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas.

Hernandez B, Adissu HA, Wei BR, Michael HT, Merlino G, Simpson RM.

Int J Mol Sci. 2018 Jan 30;19(2). pii: E394. doi: 10.3390/ijms19020394. Review.

10.

MRB7260 is essential for productive protein-RNA interactions within the RNA editing substrate binding complex during trypanosome RNA editing.

McAdams NM, Simpson RM, Chen R, Sun Y, Read LK.

RNA. 2018 Apr;24(4):540-556. doi: 10.1261/rna.065169.117. Epub 2018 Jan 12.

11.

DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.

Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML, Zhang Z, Wang X, Del Barco Barrantes I, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C, Xu Q.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):425-437. doi: 10.1161/ATVBAHA.117.310079. Epub 2017 Dec 28.

PMID:
29284609
12.

cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma.

He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, Huang J.

Stem Cell Reports. 2017 Jun 6;8(6):1630-1644. doi: 10.1016/j.stemcr.2017.04.029. Epub 2017 May 25.

13.

Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization.

Simpson RM, Bruno AE, Chen R, Lott K, Tylec BL, Bard JE, Sun Y, Buck MJ, Read LK.

Nucleic Acids Res. 2017 Jul 27;45(13):7965-7983. doi: 10.1093/nar/gkx458.

14.

Dehumanization: its operations and its origins.

Simpson RM.

J Law Biosci. 2015 Oct 16;3(1):178-184. eCollection 2016 Apr.

15.

Climate change, cooperation and moral bioenhancement.

Handfield T, Huang PH, Simpson RM.

J Med Ethics. 2016 Nov;42(11):742-747. doi: 10.1136/medethics-2016-103593. Epub 2016 Aug 24.

PMID:
27558776
16.

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models.

Venugopalan A, Lee MJ, Niu G, Medina-Echeverz J, Tomita Y, Lizak MJ, Cultraro CM, Simpson RM, Chen X, Trepel JB, Guha U.

Oncotarget. 2016 Aug 23;7(34):54137-54156. doi: 10.18632/oncotarget.11021.

17.

Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.

Wei BR, Michael HT, Halsey CH, Peer CJ, Adhikari A, Dwyer JE, Hoover SB, El Meskini R, Kozlov S, Weaver Ohler Z, Figg WD, Merlino G, Simpson RM.

Pigment Cell Melanoma Res. 2016 Nov;29(6):643-655. doi: 10.1111/pcmr.12512. Epub 2016 Sep 22.

18.

In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood-Brain Barrier.

Bakhsheshian J, Wei BR, Hall MD, Simpson RM, Gottesman MM.

Methods Mol Biol. 2016;1461:227-39. doi: 10.1007/978-1-4939-3813-1_19.

PMID:
27424909
19.

Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.

Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K.

Oncogene. 2017 Jan 26;36(4):525-533. doi: 10.1038/onc.2016.223. Epub 2016 Jul 4.

PMID:
27375016
20.

Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation.

Yu B, Wong MM, Potter CM, Simpson RM, Karamariti E, Zhang Z, Zeng L, Warren D, Hu Y, Wang W, Xu Q.

Stem Cells. 2016 Sep;34(9):2368-80. doi: 10.1002/stem.2410. Epub 2016 Jun 28.

21.

Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.

LeBlanc AK, Mazcko C, Brown DE, Koehler JW, Miller AD, Miller CR, Bentley RT, Packer RA, Breen M, Boudreau CE, Levine JM, Simpson RM, Halsey C, Kisseberth W, Rossmeisl JH Jr, Dickinson PJ, Fan TM, Corps K, Aldape K, Puduvalli V, Pluhar GE, Gilbert MR.

Neuro Oncol. 2016 Sep;18(9):1209-18. doi: 10.1093/neuonc/now051. Epub 2016 May 14. Review.

22.

High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editing.

Simpson RM, Bruno AE, Bard JE, Buck MJ, Read LK.

RNA. 2016 May;22(5):677-95. doi: 10.1261/rna.055160.115. Epub 2016 Feb 23.

23.

Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage.

Simpson RM, Hong X, Wong MM, Karamariti E, Bhaloo SI, Warren D, Kong W, Hu Y, Xu Q.

Stem Cells. 2016 May;34(5):1225-38. doi: 10.1002/stem.2328. Epub 2016 Mar 4.

24.

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier.

Kumar JS, Wei BR, Madigan JP, Simpson RM, Hall MD, Gottesman MM.

Sci Rep. 2016 Feb 8;6:20418. doi: 10.1038/srep20418.

25.

Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire.

Keegan J, Raphael CE, Parker K, Simpson RM, Strain S, de Silva R, Di Mario C, Collinson J, Stables RH, Wage R, Drivas P, Sugathapala M, Prasad SK, Firmin DN.

J Cardiovasc Magn Reson. 2015 Oct 2;17:85. doi: 10.1186/s12968-015-0189-y.

26.

Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.

Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee CS, Hsu D, Smith JL, Yuen G, Yue J, Ann DK, Simpson RM, Creighton CJ, Figg WD, Gucek M, Luo J.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1724-33. doi: 10.1073/pnas.1415569112. Epub 2015 Mar 24.

27.

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.

Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, Varmus HE, Guha U.

Cancer Discov. 2015 May;5(5):534-49. doi: 10.1158/2159-8290.CD-14-0750. Epub 2015 Mar 3.

28.

Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics.

Keegan J, Patel HC, Simpson RM, Mohiaddin RH, Firmin DN.

J Cardiovasc Magn Reson. 2015 Feb 4;17(1):8. doi: 10.1186/s12968-014-0105-x.

29.

Integrative genomic and transcriptomic characterization of matched primary and metastatic liver and colorectal carcinoma.

Roessler S, Lin G, Forgues M, Budhu A, Hoover S, Simpson RM, Wu X, He P, Qin LX, Tang ZY, Ye QH, Wang XW.

Int J Biol Sci. 2015 Jan 1;11(1):88-98. doi: 10.7150/ijbs.10583. eCollection 2015.

30.

The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity.

Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM.

Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5.

31.

Functional analysis of prognostic gene expression network genes in metastatic breast cancer models.

Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW.

PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014.

32.

Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

Padmakumar V, Masiuk KE, Luger D, Lee C, Coppola V, Tessarollo L, Hoover SB, Karavanova I, Buonanno A, Simpson RM, Yuspa SH.

BMC Dev Biol. 2014 May 28;14:24. doi: 10.1186/1471-213X-14-24.

33.

Mass spectrometry in cancer biomarker research: a case for immunodepletion of abundant blood-derived proteins from clinical tissue specimens.

Prieto DA, Johann DJ Jr, Wei BR, Ye X, Chan KC, Nissley DV, Simpson RM, Citrin DE, Mackall CL, Linehan WM, Blonder J.

Biomark Med. 2014;8(2):269-86. doi: 10.2217/bmm.13.101.

34.

TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms.

Simmons JK, Patel J, Michalowski A, Zhang S, Wei BR, Sullivan P, Gamache B, Felsenstein K, Kuehl WM, Simpson RM, Zingone A, Landgren O, Mock BA.

Mol Oncol. 2014 Mar;8(2):261-72. doi: 10.1016/j.molonc.2013.11.007. Epub 2013 Dec 3.

35.

Digital pathology and image analysis augment biospecimen annotation and biobank quality assurance harmonization.

Wei BR, Simpson RM.

Clin Biochem. 2014 Mar;47(4-5):274-9. doi: 10.1016/j.clinbiochem.2013.12.008. Epub 2013 Dec 18.

36.

Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2.

Bakhsheshian J, Wei BR, Chang KE, Shukla S, Ambudkar SV, Simpson RM, Gottesman MM, Hall MD.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20801-6. doi: 10.1073/pnas.1312159110. Epub 2013 Dec 2.

37.

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.

Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM.

Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21.

38.

B cell-specific deficiencies in mTOR limit humoral immune responses.

Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA.

J Immunol. 2013 Aug 15;191(4):1692-703. doi: 10.4049/jimmunol.1201767. Epub 2013 Jul 15.

39.

Normal viability of Kai1/Cd82 deficient mice.

Risinger JI, Custer M, Feigenbaum L, Simpson RM, Hoover SB, Webster JD, Chandramouli GV, Tessarollo L, Barrett JC.

Mol Carcinog. 2014 Aug;53(8):610-24. doi: 10.1002/mc.22009. Epub 2013 Feb 8.

PMID:
23401136
40.

MR assessment of regional myocardial mechanics.

Simpson RM, Keegan J, Firmin DN.

J Magn Reson Imaging. 2013 Mar;37(3):576-99. doi: 10.1002/jmri.23756. Epub 2012 Jul 23. Review.

PMID:
22826177
41.

Investigation into diagnostic agreement using automated computer-assisted histopathology pattern recognition image analysis.

Webster JD, Michalowski AM, Dwyer JE, Corps KN, Wei BR, Juopperi T, Hoover SB, Simpson RM.

J Pathol Inform. 2012;3:18. doi: 10.4103/2153-3539.95130. Epub 2012 Apr 18.

42.

Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.

Zhang M, Ju W, Yao Z, Yu P, Wei BR, Simpson RM, Waitz R, Fassò M, Allison JP, Waldmann TA.

J Immunol. 2012 Jun 15;188(12):6156-64. doi: 10.4049/jimmunol.1102604. Epub 2012 May 16.

43.

CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.

Suh KS, Malik M, Shukla A, Ryscavage A, Wright L, Jividen K, Crutchley JM, Dumont RA, Fernandez-Salas E, Webster JD, Simpson RM, Yuspa SH.

Carcinogenesis. 2012 May;33(5):986-95. doi: 10.1093/carcin/bgs115. Epub 2012 Mar 1.

44.

Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.

Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J.

J Proteome Res. 2012 Mar 2;11(3):1561-70. doi: 10.1021/pr200612y. Epub 2012 Feb 6.

PMID:
22214408
45.

3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity.

Landsberg MJ, Jones SA, Rothnagel R, Busby JN, Marshall SD, Simpson RM, Lott JS, Hankamer B, Hurst MR.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20544-9. doi: 10.1073/pnas.1111155108. Epub 2011 Dec 7.

46.

Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga.

Busby JN, Landsberg MJ, Simpson RM, Jones SA, Hankamer B, Hurst MR, Lott JS.

J Mol Biol. 2012 Jan 13;415(2):359-71. doi: 10.1016/j.jmb.2011.11.018. Epub 2011 Nov 15.

PMID:
22108167
47.

Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity.

Paek SY, Miyagawa F, Zhang H, Linton JT, Hoover SB, Simpson RM, Katz SI.

J Invest Dermatol. 2012 Mar;132(3 Pt 1):677-86. doi: 10.1038/jid.2011.347. Epub 2011 Nov 17.

48.

The value of biomedical research training for veterinary anatomic and clinical pathologists.

Sharkey LC, Simpson RM, Wellman ML, Craig LE, Birkebak TA, Kock ND, Miller MA, Harris RK, Munson L; ACVP Training Program Development Task Force.

Vet Pathol. 2012 Jul;49(4):581-5. doi: 10.1177/0300985811420583. Epub 2011 Oct 4.

PMID:
21971986
49.
50.

Dental hyponatraemia.

Simpson RM.

Scott Med J. 2011 Aug;56(3):181. doi: 10.1258/smj.2011.011129.

PMID:
21873727

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