Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 52

1.

Organ-on-a-chip technology: turning its potential for clinical benefit into reality.

Haddrick M, Simpson PB.

Drug Discov Today. 2019 May;24(5):1217-1223. doi: 10.1016/j.drudis.2019.03.011. Epub 2019 Mar 14. Review.

PMID:
30880172
2.

Open innovation in early drug discovery: roadmaps and roadblocks.

Reichman M, Simpson PB.

Drug Discov Today. 2016 May;21(5):779-88. doi: 10.1016/j.drudis.2015.12.008. Epub 2015 Dec 29. Review.

PMID:
26743597
3.

Opening the lead generation toolbox.

Simpson PB, Reichman M.

Nat Rev Drug Discov. 2014 Jan;13(1):3-4. doi: 10.1038/nrd4202. No abstract available.

PMID:
24378783
4.

Enzymatic characterisation of USP7 deubiquitinating activity and inhibition.

Wrigley JD, Eckersley K, Hardern IM, Millard L, Walters M, Peters SW, Mott R, Nowak T, Ward RA, Simpson PB, Hudson K.

Cell Biochem Biophys. 2011 Jun;60(1-2):99-111. doi: 10.1007/s12013-011-9186-4.

PMID:
21468692
5.

The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing.

Jones CD, Andrews DM, Barker AJ, Blades K, Daunt P, East S, Geh C, Graham MA, Johnson KM, Loddick SA, McFarland HM, McGregor A, Moss L, Rudge DA, Simpson PB, Swain ML, Tam KY, Tucker JA, Walker M.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73. doi: 10.1016/j.bmcl.2008.10.102. Epub 2008 Oct 25.

PMID:
18996007
6.

Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels.

Cuddon P, Bootman MD, Richards GR, Smith AJ, Simpson PB, Roderick HL.

Biol Res. 2008;41(2):183-95. doi: 10.4067/S0716-97602008000200008. Epub 2008 Oct 8.

7.

High-content assays in oncology drug discovery: opportunities and challenges.

Mouchet EH, Simpson PB.

IDrugs. 2008 Jun;11(6):422-7. Review.

PMID:
18509783
8.

Measurement and analysis of calcium signaling in heterogeneous cell cultures.

Richards GR, Jack AD, Platts A, Simpson PB.

Methods Enzymol. 2006;414:335-47.

PMID:
17110201
9.

Automated cell plating and sample treatments for fixed cells in high content assays.

Richards GR, Kerby JE, Chan GK, Simpson PB.

Methods Mol Biol. 2007;356:109-19.

PMID:
16988398
10.

A morphology- and kinetics-based cascade for human neural cell high content screening.

Richards GR, Smith AJ, Parry F, Platts A, Chan GK, Leveridge M, Kerby JE, Simpson PB.

Assay Drug Dev Technol. 2006 Apr;4(2):143-52.

PMID:
16712418
11.

New directions in kinetic high information content assays.

Simpson PB, Wafford KA.

Drug Discov Today. 2006 Mar;11(5-6):237-44. Review. No abstract available.

PMID:
16639807
12.

The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells.

Richards GR, Smith AJ, Cuddon P, Ma QP, Leveridge M, Kerby J, Roderick HL, Bootman MD, Simpson PB.

J Neurochem. 2006 Apr;97(1):201-10. Epub 2006 Mar 3.

13.

High content kinetic assays of neuronal signaling implemented on BD pathway HT.

Chan GK, Richards GR, Peters M, Simpson PB.

Assay Drug Dev Technol. 2005 Dec;3(6):623-36.

PMID:
16438658
14.

A new pyridazine series of GABAA alpha5 ligands.

van Niel MB, Wilson K, Adkins CH, Atack JR, Castro JL, Clarke DE, Fletcher S, Gerhard U, Mackey MM, Malpas S, Maubach K, Newman R, O'Connor D, Pillai GV, Simpson PB, Thomas SR, MacLeod AM.

J Med Chem. 2005 Sep 22;48(19):6004-11.

PMID:
16162003
15.

A high-throughput assay for modulators of ligand-gated chloride channels.

Hamelin M, Meng X, Cuddy M, Korsun K, Ondeyka J, Simpson PB, Cully DF, Priest BT.

Assay Drug Dev Technol. 2005 Feb;3(1):59-64.

PMID:
15798396
16.

A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells.

Ott TR, Pahuja A, Lio FM, Mistry MS, Gross M, Hudson SC, Wade WS, Simpson PB, Struthers RS, Alleva DG.

J Pharmacol Toxicol Methods. 2005 Mar-Apr;51(2):105-14. Epub 2004 Nov 5.

PMID:
15767203
17.

Quantitative assays of chemotaxis and chemokinesis for human neural cells.

Richards GR, Millard RM, Leveridge M, Kerby J, Simpson PB.

Assay Drug Dev Technol. 2004 Oct;2(5):465-72.

PMID:
15671644
18.

Multiple structural features of steroids mediate subtype-selective effects on human alpha4beta3delta GABAA receptors.

Pillai GV, Smith AJ, Hunt PA, Simpson PB.

Biochem Pharmacol. 2004 Sep 1;68(5):819-31.

PMID:
15294445
19.

Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors.

Smith AJ, Oxley B, Malpas S, Pillai GV, Simpson PB.

J Pharmacol Exp Ther. 2004 Nov;311(2):601-9. Epub 2004 Jun 21.

PMID:
15210837
20.

Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.

Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA.

Br J Pharmacol. 2004 May;142(1):97-106. Epub 2004 Apr 20.

21.

Native and recombinant human Edg4 receptor-mediated Ca(2+) signalling.

Simpson PB, Villullas IR, Schurov I, Kerby J, Millard R, Haldon C, Beer MS, McAllister G.

Assay Drug Dev Technol. 2002 Nov;1(1 Pt 1):31-40.

PMID:
15090154
22.

Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice.

Simpson PB, Mistry MS, Maki RA, Yang W, Schwarz DA, Johnson EB, Lio FM, Alleva DG.

J Immunol. 2003 Oct 1;171(7):3333-7.

23.
24.

Methodological approaches for the study of GABA(A) receptor pharmacology and functional responses.

Smith AJ, Simpson PB.

Anal Bioanal Chem. 2003 Nov;377(5):843-51. Epub 2003 Aug 23. Review.

PMID:
12937886
25.

Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells.

Villullas IR, Smith AJ, Heavens RP, Simpson PB.

J Neurosci Res. 2003 Jul 15;73(2):215-26.

PMID:
12836164
26.

Estrogen receptor ligands affect mitochondrial activity in SH-SY5Y human neuroblastoma cells.

Simpson PB, Woollacott AJ, Moneer Z, Rand V, Seabrook GR.

Neuroreport. 2002 May 24;13(7):957-60.

PMID:
12004198
27.
29.

Retinoic acid evoked-differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis.

Simpson PB, Bacha JI, Palfreyman EL, Woollacott AJ, McKernan RM, Kerby J.

Anal Biochem. 2001 Nov 15;298(2):163-9.

PMID:
11757502
30.

alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.

Adkins CE, Pillai GV, Kerby J, Bonnert TP, Haldon C, McKernan RM, Gonzalez JE, Oades K, Whiting PJ, Simpson PB.

J Biol Chem. 2001 Oct 19;276(42):38934-9. Epub 2001 Aug 8.

31.

Pharmacology of recombinant human GABA(A) receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay.

Simpson PB, Woollacott AJ, Pillai GV, Maubach KA, Hadingham KL, Martin K, Choudhury HI, Seabrook GR.

J Neurosci Methods. 2000 Jun 30;99(1-2):91-100.

PMID:
10936648
32.

Functional characterization of bradykinin analogues on recombinant human bradykinin B(1) and B(2) receptors.

Simpson PB, Woollacott AJ, Hill RG, Seabrook GR.

Eur J Pharmacol. 2000 Mar 24;392(1-2):1-9.

PMID:
10748265
33.
34.

Images of Ca2+ flux in astrocytes: evidence for spatially distinct sites of Ca2+ release and uptake.

Laskey AD, Roth BJ, Simpson PB, Russell JT.

Cell Calcium. 1998 Jun;23(6):423-32.

PMID:
9924634
35.

Specialized distributions of mitochondria and endoplasmic reticulum proteins define Ca2+ wave amplification sites in cultured astrocytes.

Simpson PB, Mehotra S, Langley D, Sheppard CA, Russell JT.

J Neurosci Res. 1998 Jun 15;52(6):672-83.

PMID:
9669316
36.

Role of mitochondrial Ca2+ regulation in neuronal and glial cell signalling.

Simpson PB, Russell JT.

Brain Res Brain Res Rev. 1998 Mar;26(1):72-81. Review.

PMID:
9600625
38.

Characterization of ryanodine receptors in oligodendrocytes, type 2 astrocytes, and O-2A progenitors.

Simpson PB, Holtzclaw LA, Langley DB, Russell JT.

J Neurosci Res. 1998 May 15;52(4):468-82.

PMID:
9589392
39.
41.

Comparison of type 2 inositol 1,4,5-trisphosphate receptor distribution and subcellular Ca2+ release sites that support Ca2+ waves in cultured astrocytes.

Sheppard CA, Simpson PB, Sharp AH, Nucifora FC, Ross CA, Lange GD, Russell JT.

J Neurochem. 1997 Jun;68(6):2317-27.

43.
45.

Neuronal Ca2+ stores: activation and function.

Simpson PB, Challiss RA, Nahorski SR.

Trends Neurosci. 1995 Jul;18(7):299-306. Review.

PMID:
7571010
46.

Divalent cation entry in cultured rat cerebellar granule cells measured using Mn2+ quench of fura 2 fluorescence.

Simpson PB, Challiss RA, Nahorski SR.

Eur J Neurosci. 1995 May 1;7(5):831-40.

PMID:
7613620
48.
49.
50.

Phospholipid monolayers and systemic lupus erythematosus.

Simpson PB, Oppenheim RC.

N Z Med J. 1977 Jul 13;86(591):19-20.

PMID:
271858

Supplemental Content

Loading ...
Support Center