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Maternal Risk Modeling in Critical Care-Development of a Multivariable Risk Prediction Model for Death and Prolonged Intensive Care.

Simpson NB, Shankar-Hari M, Rowan KM, Cecconi M, von Dadelszen P, Huning EY, Magee LA, Payne BA, Quinn AC, Harrison DA.

Crit Care Med. 2020 Jan 9. doi: 10.1097/CCM.0000000000004223. [Epub ahead of print]


Mothers' postpartum sleep disturbance is associated with the ability to sustain sensitivity toward infants.

King LS, Rangel E, Simpson N, Tikotzky L, Manber R.

Sleep Med. 2019 Jul 27;65:74-83. doi: 10.1016/j.sleep.2019.07.017. [Epub ahead of print]


MAVRIC: A Multicentre Randomised Controlled Trial of Transabdominal Versus Transvaginal Cervical Cerclage.

Shennan A, Chandiramani M, Bennett P, David AL, Girling J, Ridout A, Seed PT, Simpson N, Thornton S, Tydeman G, Quenby S, Carter J.

Am J Obstet Gynecol. 2019 Oct 1. pii: S0002-9378(19)31206-2. doi: 10.1016/j.ajog.2019.09.040. [Epub ahead of print]


FDA Approval Summary: Tagraxofusp-erzs For Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm.

Jen EY, Gao X, Li L, Zhuang L, Simpson NE, Aryal B, Wang R, Przepiorka D, Shen YL, Leong R, Liu C, Sheth CM, Bowen S, Goldberg KB, Farrell AT, Blumenthal GM, Pazdur R.

Clin Cancer Res. 2019 Sep 23. doi: 10.1158/1078-0432.CCR-19-2329. [Epub ahead of print]


Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.

Shao Y, Forster SC, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD.

Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.


Reducing the impact of preterm birth: Preterm birth commissioning in the United Kingdom.

Story L, Simpson NAB, David AL, Alfirevic Z Z, Bennett PR, Jolly M, Shennan AH; UK Preterm Clinical Network.

Eur J Obstet Gynecol Reprod Biol X. 2019 Apr 21;3:100018. doi: 10.1016/j.eurox.2019.100018. eCollection 2019 Jul. Review.


An FDA oncology analysis of toxicities associated with PBD-containing antibody-drug conjugates.

Saber H, Simpson N, Ricks TK, Leighton JK.

Regul Toxicol Pharmacol. 2019 Oct;107:104429. doi: 10.1016/j.yrtph.2019.104429. Epub 2019 Jul 17.


Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications.

Haack M, Simpson N, Sethna N, Kaur S, Mullington J.

Neuropsychopharmacology. 2020 Jan;45(1):205-216. doi: 10.1038/s41386-019-0439-z. Epub 2019 Jun 17. Review.


Angioembolization significantly improves vascular injuries in blunt splenic trauma.

Lauerman MH, Brenner M, Simpson N, Shanmuganathan K, Stein DM, Scalea T.

Eur J Trauma Emerg Surg. 2019 Jun 6. doi: 10.1007/s00068-019-01151-z. [Epub ahead of print]


The Hennepin Ketamine Study Investigators' Reply.

Ho JD, Cole JB, Klein LR, Olives TD, Driver BE, Moore JC, Nystrom PC, Arens AM, Simpson NS, Hick JL, Chavez RA, Lynch WL, Miner JR.

Prehosp Disaster Med. 2019 Apr;34(2):111-113. doi: 10.1017/S1049023X19000219.


iValidate: a communication-based clinical intervention in life-limiting illness.

Simpson N, Milnes S, Martin P, Phillips A, Silverman J, Keely G, Forrester M, Dunning T, Corke C, Orford N.

BMJ Support Palliat Care. 2019 Apr 11. pii: bmjspcare-2018-001669. doi: 10.1136/bmjspcare-2018-001669. [Epub ahead of print]


Cognitive Behavioral Therapy for Prenatal Insomnia: A Randomized Controlled Trial.

Manber R, Bei B, Simpson N, Asarnow L, Rangel E, Sit A, Lyell D.

Obstet Gynecol. 2019 May;133(5):911-919. doi: 10.1097/AOG.0000000000003216.


Emerging concepts of shear stress in placental development and function.

Morley LC, Beech DJ, Walker JJ, Simpson NAB.

Mol Hum Reprod. 2019 Jun 6;25(6):329-339. doi: 10.1093/molehr/gaz018.


Maternal Fatty Fish Intake Prior to and during Pregnancy and Risks of Adverse Birth Outcomes: Findings from a British Cohort.

Nykjaer C, Higgs C, Greenwood DC, Simpson NAB, Cade JE, Alwan NA.

Nutrients. 2019 Mar 16;11(3). pii: E643. doi: 10.3390/nu11030643.


The rsmS (ybaM) mutation causes bypass suppression of the RsmAB post-transcriptional virulence regulation system in enterobacterial phytopathogens.

Monson RE, Apagyi K, Bowden SD, Simpson N, Williamson NR, Cubitt MF, Harris S, Toth IK, Salmond GPC.

Sci Rep. 2019 Mar 14;9(1):4525. doi: 10.1038/s41598-019-40970-3.


Emergency Department Management of Out-of-Hospital Laryngeal Tubes.

Driver BE, Scharber SK, Horton GB, Braude DA, Simpson NS, Reardon RF.

Ann Emerg Med. 2019 Sep;74(3):403-409. doi: 10.1016/j.annemergmed.2019.01.025. Epub 2019 Feb 27.


Paternal contributions to large-for-gestational-age term babies: findings from a multicenter prospective cohort study.

Derraik JGB, Pasupathy D, McCowan LME, Poston L, Taylor RS, Simpson NAB, Dekker GA, Myers J, Vieira MC, Cutfield WS, Ahlsson F; SCOPE consortium.

J Dev Orig Health Dis. 2019 Oct;10(5):529-535. doi: 10.1017/S2040174419000035. Epub 2019 Feb 28.


Maternal Iodine Status and Associations with Birth Outcomes in Three Major Cities in the United Kingdom.

Snart CJP, Keeble C, Taylor E, Cade JE, Stewart PM, Zimmermann M, Reid S, Threapleton DE, Poston L, Myers JE, Simpson NAB, Greenwood DC, Hardie LJ.

Nutrients. 2019 Feb 20;11(2). pii: E441. doi: 10.3390/nu11020441.


Extra-parenchymal splenic abnormalities not vascular injury predict need for primary splenectomy.

Lauerman M, Brenner M, Simpson N, Shanmuganathan K, Stein D, Scalea T.

Eur J Trauma Emerg Surg. 2019 Feb 5. doi: 10.1007/s00068-019-01085-6. [Epub ahead of print]


Heart rate variability rebound following exposure to persistent and repetitive sleep restriction.

Yang H, Haack M, Dang R, Gautam S, Simpson NS, Mullington JM.

Sleep. 2019 Feb 1;42(2). doi: 10.1093/sleep/zsy226.


An outbreak of synthetic cannabinoid exposures reported to a regional poison center: "K2" identified as 5F-ADB.

Arens AM, Olives TD, Simpson NS, Laes JR, Anderson DL, Bangh SA, Lee SC, Martin S, Banister SD, Gerona RR, Cole JB.

Clin Toxicol (Phila). 2019 Jan;57(1):69-71. doi: 10.1080/15563650.2018.1497170. Epub 2018 Nov 15. No abstract available.


Stage 2 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis.

Newbury DF, Simpson NH, Thompson PA, Bishop DVM.

Version 2. Wellcome Open Res. 2018 Oct 10 [revised 2018 Jan 1];3:85. doi: 10.12688/wellcomeopenres.14677.2. eCollection 2018.


Piezo1 channels are mechanosensors in human fetoplacental endothelial cells.

Morley LC, Shi J, Gaunt HJ, Hyman AJ, Webster PJ, Williams C, Forbes K, Walker JJ, Simpson NAB, Beech DJ.

Mol Hum Reprod. 2018 Oct 1;24(10):510-520. doi: 10.1093/molehr/gay033.


Is infant arterial stiffness associated with maternal blood pressure in pregnancy? Findings from a UK birth cohort (Baby VIP study).

Ng KYB, Simpson NAB, Cade JE, Greenwood DC, Mcardle HJ, Ciantar E, Alwan NA.

PLoS One. 2018 Jul 12;13(7):e0200159. doi: 10.1371/journal.pone.0200159. eCollection 2018.


Radiosynthesis and in vivo evaluation of [11C]MOV as a PET imaging agent for COX-2.

Prabhakaran J, Underwood M, Zanderigo F, Simpson NR, Cooper AR, Matthew J, Rubin-Falcone H, Parsey RV, Mann JJ, Dileep Kumar JS.

Bioorg Med Chem Lett. 2018 Aug 1;28(14):2432-2435. doi: 10.1016/j.bmcl.2018.06.015. Epub 2018 Jun 12.


Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007-2012.

Khan SU, Gurley ES, Gerloff N, Rahman MZ, Simpson N, Rahman M, Haider N, Chowdhury S, Balish A, Zaman RU, Nasreen S, Chandra Das B, Azziz-Baumgartner E, Sturm-Ramirez K, Davis CT, Donis RO, Luby SP.

Sci Rep. 2018 Jun 20;8(1):9396. doi: 10.1038/s41598-018-27515-w.


Ventilation management in Victorian intensive care unit patients without acute respiratory distress syndrome.

Eyeington CT, Glassford NJ, Darvall J, Casamento A, Haydon T, Taori G, Knott C, McGain F, Vetro J, Simpson N, Sarode V, Richardson A, Dunnachie C, Crisman M, Musci J, Woinarski N, Lynham R, Eastwood GM, Bellomo R, Karalapillai D.

Crit Care Resusc. 2018 Jun;20(2):101-108.


Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis.

Newbury DF, Simpson NH, Thompson PA, Bishop DVM.

Wellcome Open Res. 2018 Feb 12;3:10. doi: 10.12688/wellcomeopenres.13828.2. eCollection 2018.


Tumor necrosis factor-α potentiates the effects of angiotensin II on subfornical organ neurons.

Simpson NJ, Ferguson AV.

Am J Physiol Regul Integr Comp Physiol. 2018 Sep 1;315(3):R425-R433. doi: 10.1152/ajpregu.00044.2018. Epub 2018 Apr 18.


Getting the balance right-tackling the obesogenic environment by reducing unhealthy options in a hospital shop without affecting profit.

Simpson N, Bartley A, Davies A, Perman S, Rodger AJ.

J Public Health (Oxf). 2018 Dec 1;40(4):e545-e551. doi: 10.1093/pubmed/fdy053.


Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis.

Shaw DJ, Hill RE, Simpson N, Husseini FS, Robb K, Greetham GM, Towrie M, Parker AW, Robinson D, Hirst JD, Hoskisson PA, Hunt NT.

Chem Sci. 2017 Dec 1;8(12):8384-8399. doi: 10.1039/c7sc03336b. Epub 2017 Oct 16.


Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.

Youssef MM, Underwood MD, Huang YY, Hsiung SC, Liu Y, Simpson NR, Bakalian MJ, Rosoklija GB, Dwork AJ, Arango V, Mann JJ.

Int J Neuropsychopharmacol. 2018 Jun 1;21(6):528-538. doi: 10.1093/ijnp/pyy008.


Is dietary macronutrient composition during pregnancy associated with offspring birth weight? An observational study.

Sharma SS, Greenwood DC, Simpson NAB, Cade JE.

Br J Nutr. 2018 Feb;119(3):330-339. doi: 10.1017/S0007114517003609. Epub 2018 Jan 10.


Diffusion tensor imaging determines three-dimensional architecture of human cervix: a cross-sectional study.

Nott JP, Pervolaraki E, Benson AP, Bonney EA, Pickering JD, Wilkinson N, Simpson N.

BJOG. 2018 Jun;125(7):812-818. doi: 10.1111/1471-0528.15002. Epub 2017 Dec 11.


Septic shock resuscitation in the first hour.

Simpson N, Lamontagne F, Shankar-Hari M.

Curr Opin Crit Care. 2017 Dec;23(6):561-566. doi: 10.1097/MCC.0000000000000460. Review.


Comparison of pulmonary artery catheter, echocardiography, and arterial waveform analysis monitoring in predicting the hemodynamic state during and after cardiac surgery.

Power P, Bone A, Simpson N, Yap CH, Gower S, Bailey M.

Int J Crit Illn Inj Sci. 2017 Jul-Sep;7(3):156-162. doi: 10.4103/2229-5151.214411.


Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011.

Chakraborty A, Rahman M, Hossain MJ, Khan SU, Haider MS, Sultana R, Ali Rimi N, Islam MS, Haider N, Islam A, Sultana Shanta I, Sultana T, Al Mamun A, Homaira N, Goswami D, Nahar K, Alamgir ASM, Rahman M, Mahbuba Jamil K, Azziz-Baumgartner E, Simpson N, Shu B, Lindstrom S, Gerloff N, Davis CT, Katz JM, Mikolon A, Uyeki TM, Luby SP, Sturm-Ramirez K.

J Infect Dis. 2017 Sep 15;216(suppl_4):S520-S528. doi: 10.1093/infdis/jix019.


Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States.

Pulit-Penaloza JA, Simpson N, Yang H, Creager HM, Jones J, Carney P, Belser JA, Yang G, Chang J, Zeng H, Thor S, Jang Y, Killian ML, Jenkins-Moore M, Janas-Martindale A, Dubovi E, Wentworth DE, Stevens J, Tumpey TM, Davis CT, Maines TR.

J Infect Dis. 2017 Sep 15;216(suppl_4):S499-S507. doi: 10.1093/infdis/jiw620.


Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization.

Simpson NS, Scott-Sutherland J, Gautam S, Sethna N, Haack M.

Pain. 2018 Jan;159(1):33-40. doi: 10.1097/j.pain.0000000000001053.


Effect of communication skills training on outcomes in critically ill patients with life-limiting illness referred for intensive care management: a before-and-after study.

Orford NR, Milnes S, Simpson N, Keely G, Elderkin T, Bone A, Martin P, Bellomo R, Bailey M, Corke C.

BMJ Support Palliat Care. 2019 Mar;9(1):e21. doi: 10.1136/bmjspcare-2016-001231. Epub 2017 Jun 28.


The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.

Simpson NJ, Ferguson AV.

J Neurophysiol. 2017 Sep 1;118(3):1532-1541. doi: 10.1152/jn.00238.2017. Epub 2017 Jun 21.


Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

McGinnis R, Steinthorsdottir V, Williams NO, Thorleifsson G, Shooter S, Hjartardottir S, Bumpstead S, Stefansdottir L, Hildyard L, Sigurdsson JK, Kemp JP, Silva GB, Thomsen LCV, Jääskeläinen T, Kajantie E, Chappell S, Kalsheker N, Moffett A, Hiby S, Lee WK, Padmanabhan S, Simpson NAB, Dolby VA, Staines-Urias E, Engel SM, Haugan A, Trogstad L, Svyatova G, Zakhidova N, Najmutdinova D; FINNPEC Consortium; GOPEC Consortium, Dominiczak AF, Gjessing HK, Casas JP, Dudbridge F, Walker JJ, Pipkin FB, Thorsteinsdottir U, Geirsson RT, Lawlor DA, Iversen AC, Magnus P, Laivuori H, Stefansson K, Morgan L.

Nat Genet. 2017 Aug;49(8):1255-1260. doi: 10.1038/ng.3895. Epub 2017 Jun 19.


Radiation-related toxicities and outcomes in endometrial cancer: are obese women at a disadvantage?

Smits A, McGrane J, Lopes A, Kent E, Bekkers R, Massuger L, Simpson N, Galaal K.

Int J Clin Oncol. 2017 Oct;22(5):945-953. doi: 10.1007/s10147-017-1147-5. Epub 2017 Jun 15.


Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4.

Maïssa N, Covarelli V, Janel S, Durel B, Simpson N, Bernard SC, Pardo-Lopez L, Bouzinba-Ségard H, Faure C, Scott MGH, Coureuil M, Morand PC, Lafont F, Nassif X, Marullo S, Bourdoulous S.

Nat Commun. 2017 Jun 1;8:15764. doi: 10.1038/ncomms15764.


Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment.

Chen XS, Reader RH, Hoischen A, Veltman JA, Simpson NH, Francks C, Newbury DF, Fisher SE.

Sci Rep. 2017 Apr 25;7:46105. doi: 10.1038/srep46105.


Regulatory Forum Review*: Utility of in Vitro Secondary Pharmacology Data to Assess Risk of Drug-induced Valvular Heart Disease in Humans: Regulatory Considerations.

Papoian T, Jagadeesh G, Saulnier M, Simpson N, Ravindran A, Yang B, Laniyonu AA, Khan I, Szarfman A.

Toxicol Pathol. 2017 Apr;45(3):381-388. doi: 10.1177/0192623317690609. Epub 2017 Jan 1. Review.


Predicting delivery of a small-for-gestational-age infant and adverse perinatal outcome in women with suspected pre-eclampsia.

Griffin M, Seed PT, Duckworth S, North R, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D, Kenny LC, Redman CWG, Shennan AH, Chappell LC.

Ultrasound Obstet Gynecol. 2018 Mar;51(3):387-395. doi: 10.1002/uog.17490. Epub 2018 Feb 7.


Stress and burnout in intensive care medicine: an Australian perspective.

Simpson N, Knott CI.

Med J Aust. 2017 Feb 20;206(3):107-108. No abstract available.


Innate Immunity in Systemic Sclerosis.

Dowson C, Simpson N, Duffy L, O'Reilly S.

Curr Rheumatol Rep. 2017 Jan;19(1):2. doi: 10.1007/s11926-017-0630-3. Review.


In vivo evaluation of IGF1R/IR PET ligand [18F]BMS-754807 in rodents.

Prabhakaran J, Dewey SL, McClure R, Simpson NR, Tantawy MN, Mann JJ, Pham W, Kumar JSD.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):941-943. doi: 10.1016/j.bmcl.2016.12.086. Epub 2017 Jan 7.

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