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A functional genetic screen defines the AKT-induced senescence signaling network.

Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB.

Cell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0384-8. [Epub ahead of print]


Macrophage markers soluble CD163 and soluble mannose receptor are associated with liver injury in patients with paracetamol overdose.

Siggaard CB, Kazankov K, Rødgaard-Hansen S, Møller HJ, Donnelly MC, Simpson KJ, Grønbaek H.

Scand J Gastroenterol. 2019 May;54(5):623-632. doi: 10.1080/00365521.2019.1608292. Epub 2019 May 8.


Descriptive, observational study of pharmaceutical and non-pharmaceutical arrests, use, and overdoses in Maine.

Simpson KJ, Moran MT, Foster ML, Shah DT, Chung DY, Nichols SD, McCall KL, Piper BJ.

BMJ Open. 2019 Apr 29;9(4):e027117. doi: 10.1136/bmjopen-2018-027117.


Spine and Lower Extremity Kinematics Exhibited During Running by Adolescent Idiopathic Scoliosis Patients With Spinal Fusion.

Kakar RS, Li Y, Brown CN, Oswald TS, Simpson KJ.

Spine Deform. 2019 Mar;7(2):254-261. doi: 10.1016/j.jspd.2018.08.015.


Society of Biomolecular Imaging and Informatics Special Issue.

Fennell M, Simpson KJ.

Assay Drug Dev Technol. 2019 Jan;17(1):1-2. doi: 10.1089/adt.2018.29086.sbi2. No abstract available.


Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.

Ma X, Zhang L, Song J, Nguyen E, Lee RS, Rodgers SJ, Li F, Huang C, Schittenhelm RB, Chan H, Chheang C, Wu J, Brown KK, Mitchell CA, Simpson KJ, Daly RJ.

Nat Commun. 2019 Jan 17;10(1):296. doi: 10.1038/s41467-018-08154-1.


Postural control of individuals with spinal fusion for adolescent idiopathic scoliosis.

Li Y, Kakar RS, Fu YC, Walker M, Brown CN, Oswald TS, Simpson KJ.

Clin Biomech (Bristol, Avon). 2019 Jan;61:46-51. doi: 10.1016/j.clinbiomech.2018.11.001. Epub 2018 Nov 7.


Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC.

Am J Pathol. 2019 Feb;189(2):258-271. doi: 10.1016/j.ajpath.2018.10.007. Epub 2018 Nov 16.


A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.

Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca JE, Golenkina S, Cuiping X, Gruber S, Angjeli B, Kanitz EE, Cronin SJF, Neely GG, Wernitznig A, Humbert PO, Simpson KJ, Mitsiades CS, Richardson HE, Penninger JM.

PLoS Genet. 2018 Oct 16;14(10):e1007688. doi: 10.1371/journal.pgen.1007688. eCollection 2018 Oct.


Letter: acute liver failure of indeterminate aetiology-Authors' reply.

Brennan PN, Donnelly MC, Simpson KJ.

Aliment Pharmacol Ther. 2018 Nov;48(9):1025-1026. doi: 10.1111/apt.14975. No abstract available.


Society of Biomolecular Imaging and Informatics Special Issue.

Fennell M, Simpson KJ.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):289-290. doi: 10.1089/adt.2018.29080.edi. No abstract available.


TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.


MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer.

Lin HM, Nikolic I, Yang J, Castillo L, Deng N, Chan CL, Yeung NK, Dodson E, Elsworth B, Spielman C, Lee BY, Boyer Z, Simpson KJ, Daly RJ, Horvath LG, Swarbrick A.

Sci Rep. 2018 May 18;8(1):7820. doi: 10.1038/s41598-018-26050-y.


Challenges in the diagnosis of leptospirosis outwith endemic settings: a Scottish single centre experience.

Russell CD, Jones ME, O'Shea DT, Simpson KJ, Mitchell A, Laurenson IF.

J R Coll Physicians Edinb. 2018 Mar;48(1):9-15. doi: 10.4997/JRCPE.2018.102.


Knee strength, power and stair performance of the elderly 5 years after unicompartmental knee arthroplasty.

Li Y, Kakar RS, Fu YC, Mahoney OM, Kinsey TL, Simpson KJ.

Eur J Orthop Surg Traumatol. 2018 Oct;28(7):1411-1416. doi: 10.1007/s00590-018-2198-7. Epub 2018 Apr 13.


Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans.

Thom K, Gilhooly P, McGowan K, Malloy K, Jarvis LM, Crossan C, Scobie L, Blatchford O, Smith-Palmer A, Donnelly MC, Davidson JS, Johannessen I, Simpson KJ, Dalton HR, Petrik J.

Euro Surveill. 2018 Mar;23(12). doi: 10.2807/1560-7917.ES.2018.23.12.17-00174.


Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.


Upper Trunk-Pelvis Coordination During Running Using the Continuous Relative Fourier Phase Method.

Li Y, Kakar RS, Walker MA, Guan L, Simpson KJ.

J Appl Biomech. 2018 Aug 1;34(4):312-319. doi: 10.1123/jab.2017-0250. Epub 2018 Jul 10.


Systematic review: non A-E, seronegative or indeterminate hepatitis; what is this deadly disease?

Brennan PN, Donnelly MC, Simpson KJ.

Aliment Pharmacol Ther. 2018 Apr;47(8):1079-1091. doi: 10.1111/apt.14566. Epub 2018 Feb 21.


A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.

Cluse LA, Nikolic I, Knight D, Madhamshettiwar PB, Luu J, Cowley KJ, Semple T, Arnau GM, Shortt J, Johnstone RW, Simpson KJ.

Methods Mol Biol. 2018;1725:201-227. doi: 10.1007/978-1-4939-7568-6_17.


Does chronic ankle instability influence lower extremity muscle activation of females during landing?

Li Y, Ko J, Walker MA, Brown CN, Schmidt JD, Kim SH, Simpson KJ.

J Electromyogr Kinesiol. 2018 Feb;38:81-87. doi: 10.1016/j.jelekin.2017.11.009. Epub 2017 Nov 22.


Discovering cancer vulnerabilities using high-throughput micro-RNA screening.

Nikolic I, Elsworth B, Dodson E, Wu SZ, Gould CM, Mestdagh P, Marshall GM, Horvath LG, Simpson KJ, Swarbrick A.

Nucleic Acids Res. 2017 Dec 15;45(22):12657-12670. doi: 10.1093/nar/gkx1072.


A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

Darby WG, Grace MS, Simpson KJ, Woodman OL, McIntyre P.

Assay Drug Dev Technol. 2018 Jan;16(1):15-26. doi: 10.1089/adt.2017.799. Epub 2017 Nov 17.


SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.

Rada P, Pardo V, Mobasher MA, García-Martínez I, Ruiz L, González-Rodríguez Á, Sanchez-Ramos C, Muntané J, Alemany S, James LP, Simpson KJ, Monsalve M, Valdecantos MP, Valverde ÁM.

Antioxid Redox Signal. 2018 May 1;28(13):1187-1208. doi: 10.1089/ars.2017.7373. Epub 2017 Dec 11.


Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5658-5660. doi: 10.1038/onc.2017.239.


Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.

Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stacker SA.

Sci Signal. 2017 Oct 3;10(499). pii: eaal2987. doi: 10.1126/scisignal.aal2987.


Spine kinematics exhibited during the stop-jump by physically active individuals with adolescent idiopathic scoliosis and spinal fusion.

Kakar RS, Li Y, Brown CN, Kim SH, Oswald TS, Simpson KJ.

Spine J. 2018 Jan;18(1):155-163. doi: 10.1016/j.spinee.2017.08.221. Epub 2017 Sep 28.


Society of Biomolecular Imaging and Informatics Special Issue.

Fennell M, Simpson KJ.

Assay Drug Dev Technol. 2017 Aug/Sep;15(6):237-238. doi: 10.1089/adt.2017.29063.edi. No abstract available.


Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes.

Preston S, Jiao Y, Baell JB, Keiser J, Crawford S, Koehler AV, Wang T, Simpson MM, Kaplan RM, Cowley KJ, Simpson KJ, Hofmann A, Jabbar A, Gasser RB.

Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):286-294. doi: 10.1016/j.ijpddr.2017.05.004. Epub 2017 May 28.


What is the accuracy of an early third trimester sonogram for identifying LGA infants born to GDM patients diagnosed with the one-step approach?

Simpson KJ, Pavicic M, Lee GT.

J Matern Fetal Neonatal Med. 2018 Oct;31(19):2628-2633. doi: 10.1080/14767058.2017.1350643. Epub 2017 Jul 11.


Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.

Jiao Y, Preston S, Koehler AV, Stroehlein AJ, Chang BCH, Simpson KJ, Cowley KJ, Palmer MJ, Laleu B, Wells TNC, Jabbar A, Gasser RB.

Parasit Vectors. 2017 Jul 5;10(1):323. doi: 10.1186/s13071-017-2246-x.


Intratrunk Coordination During High-Effort Treadmill Running in Individuals With Spinal Fusion for Adolescent Idiopathic Scoliosis.

Li Y, Kakar RS, Walker MA, Fu YC, Oswald TS, Brown CN, Simpson KJ.

J Appl Biomech. 2017 Dec 1;33(6):437-445. doi: 10.1123/jab.2017-0085. Epub 2017 Oct 30.


Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5576-5592. doi: 10.1038/onc.2017.175. Epub 2017 Jun 5. Erratum in: Oncogene. 2017 Oct 5;36(40):5658-5660.


Signalome-wide assessment of host cell response to hepatitis C virus.

Haqshenas G, Wu J, Simpson KJ, Daly RJ, Netter HJ, Baumert TF, Doerig C.

Nat Commun. 2017 May 8;8:15158. doi: 10.1038/ncomms15158.


Review article: hepatitis E-a concise review of virology, epidemiology, clinical presentation and therapy.

Donnelly MC, Scobie L, Crossan CL, Dalton H, Hayes PC, Simpson KJ.

Aliment Pharmacol Ther. 2017 Jul;46(2):126-141. doi: 10.1111/apt.14109. Epub 2017 Apr 27. Review.


EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.

European Association for the Study of the Liver. Electronic address:; Clinical practice guidelines panel, Wendon, J; Panel members, Cordoba J, Dhawan A, Larsen FS, Manns M, Samuel D, Simpson KJ, Yaron I; EASL Governing Board representative, Bernardi M.

J Hepatol. 2017 May;66(5):1047-1081. doi: 10.1016/j.jhep.2016.12.003.


Editorial: are earlier referrals to transplant centres responsible for improved outcomes in patients with acute liver failure? Authors' reply.

Donnelly MC, Davidson JS, Martin K, Baird A, Hayes PC, Simpson KJ.

Aliment Pharmacol Ther. 2017 May;45(9):1273. doi: 10.1111/apt.14009. No abstract available.


Review of Physical Activity Benefits and Potential Considerations for Individuals with Surgical Fusion of Spine for Scoliosis.

Kakar RS, Simpson KJ, DAS BM, Brown CN.

Int J Exerc Sci. 2017 Mar 1;10(2):166-177. eCollection 2017.


Lower extremity kinematics of curve sprinting displayed by runners using a transtibial prosthesis.

Li Y, Simpson KJ, Nolan L, Miller M, Johnson B.

J Sports Sci. 2018 Feb;36(3):293-302. doi: 10.1080/02640414.2017.1303186. Epub 2017 Mar 21.


Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology.

Williams SP, Gould CM, Nowell CJ, Karnezis T, Achen MG, Simpson KJ, Stacker SA.

Sci Data. 2017 Mar 1;4:170009. doi: 10.1038/sdata.2017.9.


Knocking down the obstacles to functional genomics data sharing.

Simpson KJ, Smith JA.

Sci Data. 2017 Mar 1;4:170019. doi: 10.1038/sdata.2017.19.


Patellar tendon straps decrease pre-landing quadriceps activation in males with patellar tendinopathy.

Rosen AB, Ko J, Simpson KJ, Brown CN.

Phys Ther Sport. 2017 Mar;24:13-19. doi: 10.1016/j.ptsp.2016.09.007. Epub 2016 Sep 13.


Acute liver failure in Scotland: changes in aetiology and outcomes over time (the Scottish Look-Back Study).

Donnelly MC, Davidson JS, Martin K, Baird A, Hayes PC, Simpson KJ.

Aliment Pharmacol Ther. 2017 Mar;45(6):833-843. doi: 10.1111/apt.13943. Epub 2017 Jan 18.


SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

Hoffman AF, Simpson KJ, Horvath P, Lovitt C, Silver S, Easton E, LaBarbera DV, Mendez M, Rothenberg ME, Seldin J, Wardwell-Swanson J, Fennell M.

Assay Drug Dev Technol. 2017 Jan;15(1):1-7. doi: 10.1089/adt.2016.29054.afh. No abstract available.


Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Lufti M, Iyer S, Simpson KJ, Bird PI, Kluck RM, Johnstone RW, Trapani JA.

Cell Death Differ. 2017 Jun;24(6):961-970. doi: 10.1038/cdd.2016.119. Epub 2017 Jan 6.


Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.

Moore JK, MacKinnon AC, Man TY, Manning JR, Forbes SJ, Simpson KJ.

Aliment Pharmacol Ther. 2017 Feb;45(3):443-454. doi: 10.1111/apt.13878. Epub 2016 Nov 28.


Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient.

Donnelly MC, Imlach SN, Abravanel F, Ramalingam S, Johannessen I, Petrik J, Fraser AR, Campbell JD, Bramley P, Dalton HR, Hayes PC, Kamar N, Simpson KJ.

Gastroenterology. 2017 Jan;152(1):300-301. doi: 10.1053/j.gastro.2016.05.060. Epub 2016 Nov 21. No abstract available.


Concussion History and Time Since Concussion Do not Influence Static and Dynamic Balance in Collegiate Athletes.

Merritt ED, Brown CN, Queen RM, Simpson KJ, Schmidt JD.

J Sport Rehabil. 2017 Nov;26(6):518-523. doi: 10.1123/jsr.2016-0119. Epub 2016 Nov 11.


Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion.

Foo CH, Rootes CL, Cowley K, Marsh GA, Gould CM, Deffrasnes C, Cowled CJ, Klein R, Riddell SJ, Middleton D, Simpson KJ, Wang LF, Bean AG, Stewart CR.

PLoS Pathog. 2016 Oct 26;12(10):e1005974. doi: 10.1371/journal.ppat.1005974. eCollection 2016 Oct.


Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour.

Kumarasingha R, Karpe AV, Preston S, Yeo TC, Lim DSL, Tu CL, Luu J, Simpson KJ, Shaw JM, Gasser RB, Beale DJ, Morrison PD, Palombo EA, Boag PR.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):171-178. doi: 10.1016/j.ijpddr.2016.08.002. Epub 2016 Aug 26.

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