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Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.

Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL.

ERJ Open Res. 2018 Nov 5;4(4). pii: 00031-2018. doi: 10.1183/23120541.00031-2018. eCollection 2018 Oct.


Enabling precision medicine in neonatology, an integrated repository for preterm birth research.

Sirota M, Thomas CG, Liu R, Zuhl M, Banerjee P, Wong RJ, Quaintance CC, Leite R, Chubiz J, Anderson R, Chappell J, Kim M, Grobman W, Zhang G, Rokas A, England SK, Parry S, Shaw GM, Simpson JL, Thomson E, Butte AJ; March of Dimes Prematurity Research Centers.

Sci Data. 2018 Nov 6;5:180219. doi: 10.1038/sdata.2018.219.


The contribution of respiratory microbiome analysis to a treatable traits model of care.

Taylor SL, O'Farrell HE, Simpson JL, Yang IA, Rogers GB.

Respirology. 2018 Oct 3. doi: 10.1111/resp.13411. [Epub ahead of print] Review.


Transitioning Tube Feeding Formula to Real Food Ingredients in a Patient Less than the Age of One.

Simpson JL, Almond MA, Ayers K, Zeller KA, Sieren LM.

Am Surg. 2018 Sep 1;84(9):e385-e387. No abstract available.


Transitioning Tube Feeding Formula to Real Food Ingredients in a Patient Less than the Age of One.

Simpson JL, Almond MA, Ayers K, Zeller KA, Sieren LM.

Am Surg. 2018 Sep 1;84(9):e385-e387. No abstract available.


Forty years of IVF.

Niederberger C, Pellicer A, Cohen J, Gardner DK, Palermo GD, O'Neill CL, Chow S, Rosenwaks Z, Cobo A, Swain JE, Schoolcraft WB, Frydman R, Bishop LA, Aharon D, Gordon C, New E, Decherney A, Tan SL, Paulson RJ, Goldfarb JM, Brännström M, Donnez J, Silber S, Dolmans MM, Simpson JL, Handyside AH, Munné S, Eguizabal C, Montserrat N, Izpisua Belmonte JC, Trounson A, Simon C, Tulandi T, Giudice LC, Norman RJ, Hsueh AJ, Sun Y, Laufer N, Kochman R, Eldar-Geva T, Lunenfeld B, Ezcurra D, D'Hooghe T, Fauser BCJM, Tarlatzis BC, Meldrum DR, Casper RF, Fatemi HM, Devroey P, Galliano D, Wikland M, Sigman M, Schoor RA, Goldstein M, Lipshultz LI, Schlegel PN, Hussein A, Oates RD, Brannigan RE, Ross HE, Pennings G, Klock SC, Brown S, Van Steirteghem A, Rebar RW, LaBarbera AR.

Fertil Steril. 2018 Jul 15;110(2):185-324.e5. doi: 10.1016/j.fertnstert.2018.06.005. Review.


Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients.

Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, Hansbro PM, Williams E, Horvat J, Simpson JL, Young P, Oliver BG, Baines KJ.

J Allergy Clin Immunol. 2018 May 30. pii: S0091-6749(18)30773-5. doi: 10.1016/j.jaci.2018.04.037. [Epub ahead of print]


Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.

Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW.

ERJ Open Res. 2018 Mar 23;4(1). pii: 00130-2017. doi: 10.1183/23120541.00130-2017. eCollection 2018 Jan.


The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma.

Lu J, Xiong L, Zhang X, Liu Z, Wang S, Zhang C, Zheng J, Wang G, Zheng R, Simpson JL, Wang F.

Mediators Inflamm. 2017;2017:3890601. doi: 10.1155/2017/3890601. Epub 2017 Dec 13. Review.


Risky Business: Meeting the Structural Needs of Transdisciplinary Science.

Wise PH, Shaw GM, Druzin ML, Darmstadt GL, Quaintance C, Mäkinen E, Relman DA, Quake SR, Butte AJ, Angst MS, Muglia LJ, Macones G, Driscoll D, Ober C, Simpson JL, Katz M, Howse J, Stevenson DK.

J Pediatr. 2017 Dec;191:255-258. doi: 10.1016/j.jpeds.2017.08.072. No abstract available.


The International Glossary on Infertility and Fertility Care, 2017.

Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, Rienzi L, Sunde A, Schmidt L, Cooke ID, Simpson JL, van der Poel S.

Hum Reprod. 2017 Sep 1;32(9):1786-1801. doi: 10.1093/humrep/dex234.


Sputum colour can identify patients with neutrophilic inflammation in asthma.

Pabreja K, Gibson P, Lochrin AJ, Wood L, Baines KJ, Simpson JL.

BMJ Open Respir Res. 2017 Oct 9;4(1):e000236. doi: 10.1136/bmjresp-2017-000236. eCollection 2017.


Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD.

Negewo NA, Gibson PG, Wark PA, Simpson JL, McDonald VM.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 6;12:2929-2942. doi: 10.2147/COPD.S136256. eCollection 2017.


Response from the Editors: First birth following spindle transfer.

Alikani M, Fauser BCJ, García-Velasco JA, Simpson JL, Johnson MH.

Reprod Biomed Online. 2017 Nov;35(5):548. doi: 10.1016/j.rbmo.2017.07.002. Epub 2017 Jul 20. No abstract available.


The International Glossary on Infertility and Fertility Care, 2017.

Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, Rienzi L, Sunde A, Schmidt L, Cooke ID, Simpson JL, van der Poel S.

Fertil Steril. 2017 Sep;108(3):393-406. doi: 10.1016/j.fertnstert.2017.06.005. Epub 2017 Jul 29.


Intensive referral to mutual-help groups: A field trial of adaptations for rural veterans.

Grant KM, Young LB, Tyler KA, Simpson JL, Pulido RD, Timko C.

Patient Educ Couns. 2018 Jan;101(1):79-84. doi: 10.1016/j.pec.2017.07.012. Epub 2017 Jul 14.


Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial.

Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Powell H, Taylor SL, Leong LEX, Rogers GB, Simpson JL.

Lancet. 2017 Aug 12;390(10095):659-668. doi: 10.1016/S0140-6736(17)31281-3. Epub 2017 Jul 4.


Why are we still talking about chromosomal heteromorphisms?

Tempest HG, Simpson JL.

Reprod Biomed Online. 2017 Jul;35(1):1-2. doi: 10.1016/j.rbmo.2017.05.006. No abstract available.


Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma.

Hansbro PM, Kim RY, Starkey MR, Donovan C, Dua K, Mayall JR, Liu G, Hansbro NG, Simpson JL, Wood LG, Hirota JA, Knight DA, Foster PS, Horvat JC.

Immunol Rev. 2017 Jul;278(1):41-62. doi: 10.1111/imr.12543. Review.


Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology.

Taylor SL, Leong LEX, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Baraket M, Marks GB, Gibson PG, Simpson JL, Rogers GB.

J Allergy Clin Immunol. 2018 Jan;141(1):94-103.e15. doi: 10.1016/j.jaci.2017.03.044. Epub 2017 May 4.


Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes.

Brooks CR, van Dalen CJ, Hermans IF, Gibson PG, Simpson JL, Douwes J.

Allergy. 2017 Oct;72(10):1583-1586. doi: 10.1111/all.13185. Epub 2017 Jun 1.


First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation.

Alikani M, Fauser BCJ, García-Valesco JA, Simpson JL, Johnson MH.

Reprod Biomed Online. 2017 Apr;34(4):333-336. doi: 10.1016/j.rbmo.2017.02.004. No abstract available.


Alternatives to induced sputum for identifying inflammatory subtypes of asthma.

Simpson JL, Bafadhel M.

Respirology. 2017 May;22(4):624-625. doi: 10.1111/resp.13036. Epub 2017 Mar 29. No abstract available.


The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Zheng J, Shi Y, Xiong L, Zhang W, Li Y, Gibson PG, Simpson JL, Zhang C, Lu J, Sai J, Wang G, Wang F.

J Immunol Res. 2017;2017:8539294. doi: 10.1155/2017/8539294. Epub 2017 Mar 2.


Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.


Commentary re: Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.

Simpson JL, Kuliev A.

Reprod Biomed Online. 2016 Nov;33(5):585-586. doi: 10.1016/j.rbmo.2016.08.018. Epub 2016 Aug 31. No abstract available.


Cross-Country Individual Participant Analysis of 4.1 Million Singleton Births in 5 Countries with Very High Human Development Index Confirms Known Associations but Provides No Biologic Explanation for 2/3 of All Preterm Births.

Ferrero DM, Larson J, Jacobsson B, Di Renzo GC, Norman JE, Martin JN Jr, D'Alton M, Castelazo E, Howson CP, Sengpiel V, Bottai M, Mayo JA, Shaw GM, Verdenik I, Tul N, Velebil P, Cairns-Smith S, Rushwan H, Arulkumaran S, Howse JL, Simpson JL.

PLoS One. 2016 Sep 13;11(9):e0162506. doi: 10.1371/journal.pone.0162506. eCollection 2016. Review.


Psychological Burden and Gender Differences in Methamphetamine-Dependent Individuals in Treatment.

Simpson JL, Grant KM, Daly PM, Kelley SG, Carlo G, Bevins RA.

J Psychoactive Drugs. 2016 Sep-Oct;48(4):261-9. doi: 10.1080/02791072.2016.1213470.


The Olympic Games and Athletic Sex Assignment.

Genel M, Simpson JL, de la Chapelle A.

JAMA. 2016 Oct 4;316(13):1359-1360. doi: 10.1001/jama.2016.11850. No abstract available.


Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD.

Negewo NA, McDonald VM, Baines KJ, Wark PA, Simpson JL, Jones PW, Gibson PG.

Int J Chron Obstruct Pulmon Dis. 2016 Jul 1;11:1495-504. doi: 10.2147/COPD.S100338. eCollection 2016.


Associations Between Family History of Substance Use, Childhood Trauma, and Age of First Drug Use in Persons With Methamphetamine Dependence.

Svingen L, Dykstra RE, Simpson JL, Jaffe AE, Bevins RA, Carlo G, DiLillo D, Grant KM.

J Addict Med. 2016 Jul-Aug;10(4):269-73. doi: 10.1097/ADM.0000000000000233.


Periostin levels and eosinophilic inflammation in poorly-controlled asthma.

Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Jia G, Holweg CT, Gibson PG.

BMC Pulm Med. 2016 Apr 30;16(1):67. doi: 10.1186/s12890-016-0230-4.


Preimplantation diagnosis and other modern methods for prenatal diagnosis.

Simpson JL, Rechitsky S.

J Steroid Biochem Mol Biol. 2017 Jan;165(Pt A):124-130. doi: 10.1016/j.jsbmb.2016.03.022. Epub 2016 Apr 21. Review.


TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus-Induced Exacerbations in a Mouse Model of Allergic Airways Disease.

Nguyen TH, Maltby S, Simpson JL, Eyers F, Baines KJ, Gibson PG, Foster PS, Yang M.

J Immunol. 2016 May 1;196(9):3547-58. doi: 10.4049/jimmunol.1502339. Epub 2016 Apr 1.


Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?

Hodge S, Upham JW, Pizzutto S, Petsky HL, Yerkovich S, Baines KJ, Gibson P, Simpson JL, Buntain H, Chen ACH, Hodge G, Chang AB.

Chest. 2016 Feb;149(2):508-515. doi: 10.1016/j.chest.2015.10.066.


Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids.

Simpson JL, Carroll M, Yang IA, Reynolds PN, Hodge S, James AL, Gibson PG, Upham JW.

Chest. 2016 Mar;149(3):704-13. doi: 10.1016/j.chest.2015.12.018. Epub 2015 Dec 24.


Neutrophil extracellular traps are associated with inflammation in chronic airway disease.

Wright TK, Gibson PG, Simpson JL, McDonald VM, Wood LG, Baines KJ.

Respirology. 2016 Apr;21(3):467-75. doi: 10.1111/resp.12730. Epub 2016 Jan 25.


COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species.

Simpson JL, Baines KJ, Horvat JC, Essilfie AT, Brown AC, Tooze M, McDonald VM, Gibson PG, Hansbro PM.

Respirology. 2016 May;21(4):697-704. doi: 10.1111/resp.12734. Epub 2016 Jan 18.


Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.

Hodge S, Hodge G, Simpson JL, Yang IA, Upham J, James A, Gibson PG, Reynolds PN; AMAZES Study Research Group.

Clin Exp Allergy. 2016 Jan;46(1):60-70. doi: 10.1111/cea.12634.


Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma.

Wang G, Baines KJ, Fu JJ, Wood LG, Simpson JL, McDonald VM, Cowan DC, Taylor DR, Cowan JO, Gibson PG.

Eur Respir J. 2016 Apr;47(4):1123-33. doi: 10.1183/13993003.01098-2015. Epub 2015 Dec 23.


Absence of airway inflammation in a large proportion of adolescents with asthma.

Brooks CR, van Dalen CJ, Zacharasiewicz A, Simpson JL, Harper JL, Le Gros G, Gibson PG, Pearce N, Douwes J.

Respirology. 2016 Apr;21(3):460-6. doi: 10.1111/resp.12701. Epub 2015 Dec 22.


Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.

Harper J, Wells D, Simpson JL.

Prenat Diagn. 2016 Jan;36(1):25-8. doi: 10.1002/pd.4757. Epub 2016 Jan 4. No abstract available.


Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

Simpson JL, Daly J, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Hugenholtz P, Willner D, Gibson PG.

Eur Respir J. 2016 Mar;47(3):792-800. doi: 10.1183/13993003.00405-2015. Epub 2015 Dec 2.


Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma.

Baines KJ, Wright TK, Simpson JL, McDonald VM, Wood LG, Parsons KS, Wark PA, Gibson PG.

Mediators Inflamm. 2015;2015:407271. doi: 10.1155/2015/407271. Epub 2015 Oct 19.


Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice.

BenMohamed L, Osorio N, Khan AA, Srivastava R, Huang L, Krochmal JJ, Garcia JM, Simpson JL, Wechsler SL.

Curr Eye Res. 2016 Jun;41(6):747-56. doi: 10.3109/02713683.2015.1061024. Epub 2015 Sep 23.


Genetics of primary ovarian insufficiency: new developments and opportunities.

Qin Y, Jiao X, Simpson JL, Chen ZJ.

Hum Reprod Update. 2015 Nov-Dec;21(6):787-808. doi: 10.1093/humupd/dmv036. Epub 2015 Aug 4. Review.


CSB-PGBD3 Mutations Cause Premature Ovarian Failure.

Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ.

PLoS Genet. 2015 Jul 28;11(7):e1005419. doi: 10.1371/journal.pgen.1005419. eCollection 2015 Jul.


Chromosome territory repositioning induced by PHA-activation of lymphocytes: A 2D and 3D appraisal.

Ioannou D, Kandukuri L, Simpson JL, Tempest HG.

Mol Cytogenet. 2015 Jul 3;8:47. doi: 10.1186/s13039-015-0146-3. eCollection 2015.


Improving assisted reproductive technology pregnancy rates: excluding aneuploid and interrogating euploid embryos.

Simpson JL, Kuliev A, Rechitsky S.

Fertil Steril. 2015 Sep;104(3):557-8. doi: 10.1016/j.fertnstert.2015.06.017. Epub 2015 Jun 29. No abstract available.


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