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Items: 1 to 50 of 93

1.

How do genes that escape from X-chromosome inactivation contribute to Turner syndrome?

Peeters SB, Korecki AJ, Baldry SEL, Yang C, Tosefsky K, Balaton BP, Simpson EM, Brown CJ.

Am J Med Genet C Semin Med Genet. 2019 Mar;181(1):28-35. doi: 10.1002/ajmg.c.31672. Epub 2019 Feb 19.

PMID:
30779428
2.

Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.

Korecki AJ, Hickmott JW, Lam SL, Dreolini L, Mathelier A, Baker O, Kuehne C, Bonaguro RJ, Smith J, Tan CV, Zhou M, Goldowitz D, Deussing JM, Stewart AF, Wasserman WW, Holt RA, Simpson EM.

Genetics. 2019 Apr;211(4):1155-1177. doi: 10.1534/genetics.119.301984. Epub 2019 Feb 14.

3.

Correction: Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials.

Hickmott JW, Gunawardane U, Jensen K, Korecki AJ, Simpson EM.

Gene Ther. 2019 Apr;26(3-4):133. doi: 10.1038/s41434-018-0054-3.

PMID:
30602728
4.

Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials.

Hickmott JW, Gunawardane U, Jensen K, Korecki AJ, Simpson EM.

Gene Ther. 2018 Dec;25(8):524-537. doi: 10.1038/s41434-018-0043-6. Epub 2018 Sep 26. Erratum in: Gene Ther. 2019 Jan 2;:.

5.

New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina.

Simpson EM, Korecki AJ, Fornes O, McGill TJ, Cueva-Vargas JL, Agostinone J, Farkas RA, Hickmott JW, Lam SL, Mathelier A, Renner LM, Stoddard J, Zhou M, Di Polo A, Neuringer M, Wasserman WW.

Hum Gene Ther. 2019 Mar;30(3):257-272. doi: 10.1089/hum.2018.118. Epub 2018 Oct 2.

6.

Risk of anesthesia-related complications in brachycephalic dogs.

Gruenheid M, Aarnes TK, McLoughlin MA, Simpson EM, Mathys DA, Mollenkopf DF, Wittum TE.

J Am Vet Med Assoc. 2018 Aug 1;253(3):301-306. doi: 10.2460/javma.253.3.301.

PMID:
30020004
7.

Human cis-acting elements regulating escape from X-chromosome inactivation function in mouse.

Peeters SB, Korecki AJ, Simpson EM, Brown CJ.

Hum Mol Genet. 2018 Apr 1;27(7):1252-1262. doi: 10.1093/hmg/ddy039.

8.

HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.

Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA.

Elife. 2017 Oct 10;6. pii: e28672. doi: 10.7554/eLife.28672.

9.

Co-activator candidate interactions for orphan nuclear receptor NR2E1.

Corso-Díaz X, de Leeuw CN, Alonso V, Melchers D, Wong BK, Houtman R, Simpson EM.

BMC Genomics. 2016 Oct 26;17(1):832.

10.

PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.

Hickmott JW, Chen CY, Arenillas DJ, Korecki AJ, Lam SL, Molday LL, Bonaguro RJ, Zhou M, Chou AY, Mathelier A, Boye SL, Hauswirth WW, Molday RS, Wasserman WW, Simpson EM.

Mol Ther Methods Clin Dev. 2016 Aug 10;3:16051. doi: 10.1038/mtm.2016.51. eCollection 2016.

11.

rAAV-compatible MiniPromoters for restricted expression in the brain and eye.

de Leeuw CN, Korecki AJ, Berry GE, Hickmott JW, Lam SL, Lengyell TC, Bonaguro RJ, Borretta LJ, Chopra V, Chou AY, D'Souza CA, Kaspieva O, Laprise S, McInerny SC, Portales-Casamar E, Swanson-Newman MI, Wong K, Yang GS, Zhou M, Jones SJ, Holt RA, Asokan A, Goldowitz D, Wasserman WW, Simpson EM.

Mol Brain. 2016 May 10;9(1):52. doi: 10.1186/s13041-016-0232-4.

12.

Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness.

Scalabrino ML, Boye SL, Fransen KM, Noel JM, Dyka FM, Min SH, Ruan Q, De Leeuw CN, Simpson EM, Gregg RG, McCall MA, Peachey NS, Boye SE.

Hum Mol Genet. 2015 Nov 1;24(21):6229-39. doi: 10.1093/hmg/ddv341. Epub 2015 Aug 26.

13.

Combined serial analysis of gene expression and transcription factor binding site prediction identifies novel-candidate-target genes of Nr2e1 in neocortex development.

Schmouth JF, Arenillas D, Corso-Díaz X, Xie YY, Bohacec S, Banks KG, Bonaguro RJ, Wong SH, Jones SJ, Marra MA, Simpson EM, Wasserman WW.

BMC Genomics. 2015 Jul 24;16:545. doi: 10.1186/s12864-015-1770-3.

14.
15.

Pulmonary artery dissection in eight dogs with patent ductus arteriosus.

Scansen BA, Simpson EM, López-Alvarez J, Thomas WP, Bright JM, Eason BD, Rush JE, Dukes-McEwan J, Green HW 3rd, Cunningham SM, Visser LC, Kent AM, Schober KE.

J Vet Cardiol. 2015 Jun;17(2):107-19. doi: 10.1016/j.jvc.2014.12.001. Epub 2015 Jan 14.

PMID:
25596918
16.

Dual MMP7-proximity-activated and folate receptor-targeted nanoparticles for siRNA delivery.

Li H, Miteva M, Kirkbride KC, Cheng MJ, Nelson CE, Simpson EM, Gupta MK, Duvall CL, Giorgio TD.

Biomacromolecules. 2015 Jan 12;16(1):192-201. doi: 10.1021/bm501394m. Epub 2014 Dec 19.

17.

Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors.

de Leeuw CN, Dyka FM, Boye SL, Laprise S, Zhou M, Chou AY, Borretta L, McInerny SC, Banks KG, Portales-Casamar E, Swanson MI, D'Souza CA, Boye SE, Jones SJ, Holt RA, Goldowitz D, Hauswirth WW, Wasserman WW, Simpson EM.

Mol Ther Methods Clin Dev. 2014 Jan 8;1:5.

18.

Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice.

Schmouth JF, Castellarin M, Laprise S, Banks KG, Bonaguro RJ, McInerny SC, Borretta L, Amirabbasi M, Korecki AJ, Portales-Casamar E, Wilson G, Dreolini L, Jones SJ, Wasserman WW, Goldowitz D, Holt RA, Simpson EM.

BMC Biol. 2013 Oct 14;11:106. doi: 10.1186/1741-7007-11-106.

19.

Absence of NR2E1 mutations in patients with aniridia.

Corso-Díaz X, Borrie AE, Bonaguro R, Schuetz JM, Rosenberg T, Jensen H, Brooks BP, Macdonald IM, Pasutto F, Walter MA, Grønskov K, Brooks-Wilson A, Simpson EM.

Mol Vis. 2012;18:2770-82. Epub 2012 Nov 22.

20.

Targeting of >1.5 Mb of human DNA into the mouse X chromosome reveals presence of cis-acting regulators of epigenetic silencing.

Yang C, McLeod AJ, Cotton AM, de Leeuw CN, Laprise S, Banks KG, Simpson EM, Brown CJ.

Genetics. 2012 Dec;192(4):1281-93. doi: 10.1534/genetics.112.143743. Epub 2012 Sep 28.

21.

The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.

Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.

22.

Control of terrestrial animal rabies in Anne Arundel County, Maryland, after oral vaccination of raccoons (1998-2007).

Horman JT, Shannon KV, Simpson EM, Burja TM, Fey RH, Smith JJ, Phillips FB.

J Am Vet Med Assoc. 2012 Sep 15;241(6):725-34. doi: 10.2460/javma.241.6.725.

PMID:
22947155
23.

Beyond knockouts: cre resources for conditional mutagenesis.

Murray SA, Eppig JT, Smedley D, Simpson EM, Rosenthal N.

Mamm Genome. 2012 Oct;23(9-10):587-99. doi: 10.1007/s00335-012-9430-2. Epub 2012 Aug 29. Erratum in: Mamm Genome. 2012 Dec;23(11-12):791.

24.

The transcription factor encyclopedia.

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW.

Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24.

25.

Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing.

Schmouth JF, Bonaguro RJ, Corso-Diaz X, Simpson EM.

PLoS Genet. 2012;8(3):e1002544. doi: 10.1371/journal.pgen.1002544. Epub 2012 Mar 1. Review.

26.

Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.

Schmouth JF, Banks KG, Mathelier A, Gregory-Evans CY, Castellarin M, Holt RA, Gregory-Evans K, Wasserman WW, Simpson EM.

Mol Cell Biol. 2012 Apr;32(7):1296-311. doi: 10.1128/MCB.06016-11. Epub 2012 Jan 30.

27.

A rare cause of ear pain in a young boy.

Oliver AM, Simpson EM, Jerath RS.

J Pediatr. 2012 Feb;160(2):350. doi: 10.1016/j.jpeds.2011.08.030. Epub 2011 Oct 13. No abstract available.

PMID:
22000301
28.

A high G418-resistant neo(R) transgenic mouse and mouse embryonic fibroblast (MEF) feeder layers for cytotoxicity and gene targeting in vivo and in vitro.

Aubrecht J, Goad ME, Czopik AK, Lerner CP, Johnson KA, Simpson EM, Schiestl RH.

Drug Chem Toxicol. 2011 Oct;34(4):433-9. doi: 10.3109/01480545.2010.544316. Epub 2011 Jul 11.

PMID:
21740348
29.

Kinematic and behavioral evidence for a distinction between trotting and ambling gaits in the cockroach Blaberus discoidalis.

Bender JA, Simpson EM, Tietz BR, Daltorio KA, Quinn RD, Ritzmann RE.

J Exp Biol. 2011 Jun 15;214(Pt 12):2057-64. doi: 10.1242/jeb.056481.

30.

Computer-assisted 3D kinematic analysis of all leg joints in walking insects.

Bender JA, Simpson EM, Ritzmann RE.

PLoS One. 2010 Oct 26;5(10):e13617. doi: 10.1371/journal.pone.0013617.

31.

A regulatory toolbox of MiniPromoters to drive selective expression in the brain.

Portales-Casamar E, Swanson DJ, Liu L, de Leeuw CN, Banks KG, Ho Sui SJ, Fulton DL, Ali J, Amirabbasi M, Arenillas DJ, Babyak N, Black SF, Bonaguro RJ, Brauer E, Candido TR, Castellarin M, Chen J, Chen Y, Cheng JC, Chopra V, Docking TR, Dreolini L, D'Souza CA, Flynn EK, Glenn R, Hatakka K, Hearty TG, Imanian B, Jiang S, Khorasan-zadeh S, Komljenovic I, Laprise S, Liao NY, Lim JS, Lithwick S, Liu F, Liu J, Lu M, McConechy M, McLeod AJ, Milisavljevic M, Mis J, O'Connor K, Palma B, Palmquist DL, Schmouth JF, Swanson MI, Tam B, Ticoll A, Turner JL, Varhol R, Vermeulen J, Watkins RF, Wilson G, Wong BK, Wong SH, Wong TY, Yang GS, Ypsilanti AR, Jones SJ, Holt RA, Goldowitz D, Wasserman WW, Simpson EM.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16589-94. doi: 10.1073/pnas.1009158107. Epub 2010 Aug 31.

32.

Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.

Wong BK, Hossain SM, Trinh E, Ottmann GA, Budaghzadeh S, Zheng QY, Simpson EM.

Genes Brain Behav. 2010 Oct;9(7):681-94. doi: 10.1111/j.1601-183X.2010.00602.x. Epub 2010 Jun 21.

33.

Laboratory Animal Management Assistant (LAMA): a LIMS for active research colonies.

Milisavljevic M, Hearty T, Wong TY, Portales-Casamar E, Simpson EM, Wasserman WW.

Mamm Genome. 2010 Jun;21(5-6):224-30. doi: 10.1007/s00335-010-9258-6. Epub 2010 Apr 22.

34.

Expression analysis of novel striatal-enriched genes in Huntington disease.

Mazarei G, Neal SJ, Becanovic K, Luthi-Carter R, Simpson EM, Leavitt BR.

Hum Mol Genet. 2010 Feb 15;19(4):609-22. doi: 10.1093/hmg/ddp527. Epub 2009 Nov 23.

35.

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC.

Nature. 2009 Jan 29;457(7229):599-602. doi: 10.1038/nature07586. Epub 2008 Dec 10.

36.

Multicentric reticulohistiocytosis: diagnosis at the nailbeds.

Simpson EM, Goeckeritz BE, Teague DJ, Oliver AM.

J Rheumatol. 2008 Nov;35(11):2272-3. doi: 10.3899/jrheum.080423. No abstract available.

PMID:
19004054
37.

Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus.

Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM.

Genomics. 2009 Mar;93(3):196-204. doi: 10.1016/j.ygeno.2008.09.014. Epub 2008 Dec 3.

38.

Identification of a set of genes showing regionally enriched expression in the mouse brain.

D'Souza CA, Chopra V, Varhol R, Xie YY, Bohacec S, Zhao Y, Lee LL, Bilenky M, Portales-Casamar E, He A, Wasserman WW, Goldowitz D, Marra MA, Holt RA, Simpson EM, Jones SJ.

BMC Neurosci. 2008 Jul 14;9:66. doi: 10.1186/1471-2202-9-66.

39.

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing.

Kumar RA, McGhee KA, Leach S, Bonaguro R, Maclean A, Aguirre-Hernandez R, Abrahams BS, Coccaro EF, Hodgins S, Turecki G, Condon A, Muir WJ, Brooks-Wilson AR, Blackwood DH, Simpson EM.

Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):880-9. doi: 10.1002/ajmg.b.30696.

PMID:
18205168
40.
41.

Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications.

Oberlander TF, Bonaguro RJ, Misri S, Papsdorf M, Ross CJ, Simpson EM.

Mol Psychiatry. 2008 Jan;13(1):65-73. Epub 2007 May 22.

PMID:
17519929
42.

Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations.

Kumar RA, Leach S, Bonaguro R, Chen J, Yokom DW, Abrahams BS, Seaver L, Schwartz CE, Dobyns W, Brooks-Wilson A, Simpson EM.

Genes Brain Behav. 2007 Aug;6(6):503-16. Epub 2006 Nov 29.

43.

Hippi is essential for node cilia assembly and Sonic hedgehog signaling.

Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW.

Dev Biol. 2006 Dec 15;300(2):523-33. Epub 2006 Sep 9.

44.

Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.

Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, McCaffery JM, El-Husseini AE, Leavitt BR, Hayden MR.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600. Epub 2006 Jun 12.

45.

SAGE2Splice: unmapped SAGE tags reveal novel splice junctions.

Kuo BY, Chen Y, Bohacec S, Johansson O, Wasserman WW, Simpson EM.

PLoS Comput Biol. 2006 Apr;2(4):e34. Epub 2006 Apr 28.

46.

A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells.

Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charest D, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman B, Holt RA, Hou J, Kuo BY, Lee LL, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu AL, Pandoh P, Riggins GJ, de Algara TR, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie YY, Yang G, Zhang I, Hirst M, Jones SJ, Helgason CD, Simpson EM, Hoodless PA, Marra MA.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18485-90. Epub 2005 Dec 13.

47.

Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus.

Christie BR, Li AM, Redila VA, Booth H, Wong BK, Eadie BD, Ernst C, Simpson EM.

Neuroscience. 2006 Feb;137(3):1031-7. Epub 2005 Nov 14.

PMID:
16289828
48.

Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.

Abrahams BS, Kwok MC, Trinh E, Budaghzadeh S, Hossain SM, Simpson EM.

J Neurosci. 2005 Jul 6;25(27):6263-70. Erratum in: J Neurosci. 2005 Aug 3;25(31):table of contents.

49.

Of mice and men: will the intersection of social science and genetics create new approaches for intimate partner violence?

Janssen PA, Nicholls TL, Kumar RA, Stefanakis H, Spidel AL, Simpson EM.

J Interpers Violence. 2005 Jan;20(1):61-71. Review.

PMID:
15618562
50.

Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.

Houde C, Banks KG, Coulombe N, Rasper D, Grimm E, Roy S, Simpson EM, Nicholson DW.

J Neurosci. 2004 Nov 3;24(44):9977-84.

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