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Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial.

Simpson EL, Paller AS, Siegfried EC, Boguniewicz M, Sher L, Gooderham MJ, Beck LA, Guttman-Yassky E, Pariser D, Blauvelt A, Weisman J, Lockshin B, Hultsch T, Zhang Q, Kamal MA, Davis JD, Akinlade B, Staudinger H, Hamilton JD, Graham NMH, Pirozzi G, Gadkari A, Eckert L, Stahl N, Yancopoulos GD, Ruddy M, Bansal A.

JAMA Dermatol. 2019 Nov 6. doi: 10.1001/jamadermatol.2019.3336. [Epub ahead of print]


Reporting of Patient Global Assessments in Atopic Dermatitis Randomized Controlled Trials.

Grinich EE, Pawlitschek T, Simpson EL.

Dermatitis. 2019 Oct 28. doi: 10.1097/DER.0000000000000534. [Epub ahead of print] No abstract available.


Responder Threshold for Patient-Oriented Eczema Measure (POEM) and Children's Dermatology Life Quality Index (CDLQI) in Adolescents with Atopic Dermatitis.

Simpson EL, de Bruin-Weller M, Eckert L, Whalley D, Guillemin I, Reaney M, Chen Z, Nelson L, Qin S, Bansal A, Gadkari A.

Dermatol Ther (Heidelb). 2019 Oct 22. doi: 10.1007/s13555-019-00333-2. [Epub ahead of print]


Clinical effectiveness of denosumab, raloxifene, romosozumab, and teriparatide for the prevention of osteoporotic fragility fractures: A systematic review and network meta-analysis.

Simpson EL, Martyn-St James M, Hamilton J, Wong R, Gittoes N, Selby P, Davis S.

Bone. 2019 Oct 15;130:115081. doi: 10.1016/j.bone.2019.115081. [Epub ahead of print]


The Patient-reported Disease Burden in Adults with Atopic Dermatitis: A Cross-sectional Study in Europe and Canada.

de Bruin-Weller M, Gadkari A, Auziere S, Simpson EL, Puig L, Barbarot S, Girolomoni G, Papp K, Pink AE, Saba G, Werfel T, Eckert L.

J Eur Acad Dermatol Venereol. 2019 Oct 6. doi: 10.1111/jdv.16003. [Epub ahead of print]


Validity and reliability of an online self-report 24-h dietary recall method (Intake24): a doubly labelled water study and repeated-measures analysis.

Foster E, Lee C, Imamura F, Hollidge SE, Westgate KL, Venables MC, Poliakov I, Rowland MK, Osadchiy T, Bradley JC, Simpson EL, Adamson AJ, Olivier P, Wareham N, Forouhi NG, Brage S.

J Nutr Sci. 2019 Aug 30;8:e29. doi: 10.1017/jns.2019.20. eCollection 2019.


Laboratory safety of dupilumab in moderate-to-severe atopic dermatitis: results from three phase III trials (LIBERTY AD SOLO 1, LIBERTY AD SOLO 2, LIBERTY AD CHRONOS).

Wollenberg A, Beck LA, Blauvelt A, Simpson EL, Chen Z, Chen Q, Shumel B, Khokhar FA, Hultsch T, Rizova E, Rossi AB, Graham NMH, Pirozzi G, Lu Y, Ardeleanu M.

Br J Dermatol. 2019 Aug 13. doi: 10.1111/bjd.18434. [Epub ahead of print]


Alopecia areata in 2 patients treated with dupilumab: New onset and worsening.

Chung J, Slaught CL, Simpson EL.

JAAD Case Rep. 2019 Jul 30;5(8):643-645. doi: 10.1016/j.jdcr.2019.03.019. eCollection 2019 Aug. No abstract available.


A randomized controlled trial of an emollient with ceramide and filaggrin-associated amino acids for the primary prevention of atopic dermatitis in high-risk infants.

McClanahan D, Wong A, Kezic S, Samrao A, Hajar T, Hill E, Simpson EL.

J Eur Acad Dermatol Venereol. 2019 Jul 9. doi: 10.1111/jdv.15786. [Epub ahead of print]


Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated With Atopic Dermatitis in Adults and Adolescents.

Grant L, Seiding Larsen L, Trennery C, Silverberg JI, Abramovits W, Simpson EL, Stalder JF, Paty J, Hahn-Pedersen J, Kragh N, Bang B, Arbuckle R.

Dermatitis. 2019 Jul/Aug;30(4):247-254. doi: 10.1097/DER.0000000000000486.


Pain Is a Common and Burdensome Symptom of Atopic Dermatitis in United States Adults.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Chiesa Fuxench ZC, Simpson EL, Ong PY.

J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2699-2706.e7. doi: 10.1016/j.jaip.2019.05.055. Epub 2019 Jun 20.


Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2.

Cork MJ, Eckert L, Simpson EL, Armstrong A, Barbarot S, Puig L, Girolomoni G, de Bruin-Weller M, Wollenberg A, Kataoka Y, Remitz A, Beissert S, Mastey V, Ardeleanu M, Chen Z, Gadkari A, Chao J.

J Dermatolog Treat. 2019 Jun 9:1-9. doi: 10.1080/09546634.2019.1612836. [Epub ahead of print]


Patient-reported outcomes of adalimumab, phototherapy, and placebo in the Vascular Inflammation in Psoriasis Trial: A randomized controlled study.

Noe MH, Wan MT, Shin DB, Armstrong AW, Duffin KC, Chiesa Fuxench ZC, Kalb RE, Menter A, Simpson EL, Takeshita J, Tyring SK, Van Voorhees AS, Mehta NN, Gelfand JM.

J Am Acad Dermatol. 2019 Oct;81(4):923-930. doi: 10.1016/j.jaad.2019.05.080. Epub 2019 Jun 1.


Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis.

Eichenfield LF, Bieber T, Beck LA, Simpson EL, Thaçi D, de Bruin-Weller M, Deleuran M, Silverberg JI, Ferrandiz C, Fölster-Holst R, Chen Z, Graham NMH, Pirozzi G, Akinlade B, Yancopoulos GD, Ardeleanu M.

Am J Clin Dermatol. 2019 Jun;20(3):443-456. doi: 10.1007/s40257-019-00445-7.


Validation and Interpretation of Short Form 12 and Comparison with Dermatology Life Quality Index in Atopic Dermatitis in Adults.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Chiesa Fuxench ZC, Simpson EL.

J Invest Dermatol. 2019 Oct;139(10):2090-2097.e3. doi: 10.1016/j.jid.2019.03.1152. Epub 2019 Apr 19.


Validation of five patient-reported outcomes for atopic dermatitis severity in adults.

Silverberg JI, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Fuxench ZC, Simpson EL.

Br J Dermatol. 2019 Apr 10. doi: 10.1111/bjd.18002. [Epub ahead of print]


Validation of a novel smartphone application-enabled, patient-operated skin barrier device.

Grinich EE, Shah AV, Simpson EL.

Skin Res Technol. 2019 Sep;25(5):612-617. doi: 10.1111/srt.12692. Epub 2019 Apr 3.


Direct and Indirect Effects of Crisaborole Ointment on Quality of Life in Patients with Atopic Dermatitis: A Mediation Analysis.

Simpson EL, Yosipovitch G, Bushmakin AG, Cappelleri JC, Luger T, Ständer S, Tom WL, Ports WC, Zielinski MA, Tallman AM, Tan H, Gerber RA.

Acta Derm Venereol. 2019 Jul 1;99(9):756-761. doi: 10.2340/00015555-3181.


Distribution of atopic dermatitis lesions in United States adults.

Silverberg JI, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Chiesa Fuxench ZC, Simpson EL, Gelfand JM.

J Eur Acad Dermatol Venereol. 2019 Jul;33(7):1341-1348. doi: 10.1111/jdv.15574. Epub 2019 Apr 15.


Navigating the landscape of core outcome set development in dermatology.

Prinsen CAC, Spuls PI, Kottner J, Thomas KS, Apfelbacher C, Chalmers JR, Deckert S, Furue M, Gerbens L, Kirkham J, Simpson EL, Alam M, Balzer K, Beeckman D, Eleftheriadou V, Ezzedine K, Horbach SER, Ingram JR, Layton AM, Weller K, Wild T, Wolkerstorfer A, Williams HC, Schmitt J.

J Am Acad Dermatol. 2019 Jul;81(1):297-305. doi: 10.1016/j.jaad.2019.03.009. Epub 2019 Mar 13.


Conjunctivitis in dupilumab clinical trials.

Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, Prens E, Asbell P, Akpek E, Corren J, Bachert C, Hirano I, Weyne J, Korotzer A, Chen Z, Hultsch T, Zhu X, Davis JD, Mannent L, Hamilton JD, Teper A, Staudinger H, Rizova E, Pirozzi G, Graham NMH, Shumel B, Ardeleanu M, Wollenberg A.

Br J Dermatol. 2019 Sep;181(3):459-473. doi: 10.1111/bjd.17869. Epub 2019 May 7.


The Burden of Childhood Atopic Dermatitis in the Primary Care Setting: A Report from the Meta-LARC Consortium.

Al-Naqeeb J, Danner S, Fagnan LJ, Ramsey K, Michaels L, Mitchell J, Branca K, Morris C, Nease DE Jr, Zittleman L, Levy B, Daly J, Hahn D, Dolor RJ, Williams HC, Chalmers JR, Hanifin J, Tofte S, Zuckerman KE, Hansis K, Gundersen M, Block J, Karr F, Dunbrasky S, Siebe K, Dillon K, Cibotti R, Lapidus J, Simpson EL.

J Am Board Fam Med. 2019 Mar-Apr;32(2):191-200. doi: 10.3122/jabfm.2019.02.180225.


The prevalence of elevated gamma-glutamyltransferase and sorbitol dehydrogenase activity in racing Thoroughbreds and their associations with viral infection.

Ramsay JD, Evanoff R, Mealey RH, Simpson EL.

Equine Vet J. 2019 Nov;51(6):738-742. doi: 10.1111/evj.13092. Epub 2019 Apr 10.


Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Chiesa Fuxench ZC, Simpson EL.

Br J Dermatol. 2019 Sep;181(3):554-565. doi: 10.1111/bjd.17683. Epub 2019 Mar 5.


Dupilumab provides important clinical benefits to patients with atopic dermatitis who do not achieve clear or almost clear skin according to the Investigator's Global Assessment: a pooled analysis of data from two phase III trials.

Silverberg JI, Simpson EL, Ardeleanu M, Thaçi D, Barbarot S, Bagel J, Chen Z, Eckert L, Chao J, Korotzer A, Rizova E, Rossi AB, Lu Y, Graham NMH, Hultsch T, Pirozzi G, Akinlade B.

Br J Dermatol. 2019 Jul;181(1):80-87. doi: 10.1111/bjd.17791. Epub 2019 Apr 11.


Rheumatoid arthritis treated with 6-months of first-line biologic or biosimilar therapy: an updated systematic review and network meta-analysis.

Simpson EL, Ren S, Hock ES, Stevens JW, Binard A, Pers YM, Archer R, Paisley S, Stevenson MD, Herpin C, Ghabri S.

Int J Technol Assess Health Care. 2019 Jan;35(1):36-44. doi: 10.1017/S0266462318003628. Epub 2019 Feb 6.


Improvement of atopic dermatitis with dupilumab occurs equally well across different anatomical regions: data from phase III clinical trials.

Blauvelt A, Rosmarin D, Bieber T, Simpson EL, Bagel J, Worm M, Deleuran M, Katoh N, Kawashima M, Shumel B, Chen Z, Rossi AB, Hultsch T, Ardeleanu M.

Br J Dermatol. 2019 Jul;181(1):196-197. doi: 10.1111/bjd.17703. Epub 2019 Mar 22. No abstract available.


Atopic Dermatitis in US Adults: From Population to Health Care Utilization.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Chiesa Fuxench Z, Simpson EL.

J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1524-1532.e2. doi: 10.1016/j.jaip.2019.01.005. Epub 2019 Jan 14.


The Rise in Atopic Dermatitis in Young Children: What Is the Explanation?

Hajar T, Simpson EL.

JAMA Netw Open. 2018 Nov 2;1(7):e184205. doi: 10.1001/jamanetworkopen.2018.4205. No abstract available.


Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".

Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M.

J Allergy Clin Immunol. 2019 Mar;143(3):894-913. doi: 10.1016/j.jaci.2019.01.003. Epub 2019 Jan 9.


The socioeconomics of atopic dermatitis.

Chung J, Simpson EL.

Ann Allergy Asthma Immunol. 2019 Apr;122(4):360-366. doi: 10.1016/j.anai.2018.12.017. Epub 2018 Dec 28. Review.


Measurement Properties of the Hospital Anxiety and Depression Scale Used in Atopic Dermatitis in Adults.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Chiesa Fuxench ZC, Simpson EL.

J Invest Dermatol. 2019 Jun;139(6):1388-1391. doi: 10.1016/j.jid.2018.11.029. Epub 2018 Dec 17. No abstract available.


Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial.

Simpson EL, Parnes JR, She D, Crouch S, Rees W, Mo M, van der Merwe R.

J Am Acad Dermatol. 2019 Apr;80(4):1013-1021. doi: 10.1016/j.jaad.2018.11.059. Epub 2018 Dec 12.


Health Utility Scores of Atopic Dermatitis in US Adults.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Ong PY, Fuxench ZC, Simpson EL.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1246-1252.e1. doi: 10.1016/j.jaip.2018.11.043. Epub 2018 Dec 8.


A Phase 2 Randomized Trial of Apremilast in Patients with Atopic Dermatitis.

Simpson EL, Imafuku S, Poulin Y, Ungar B, Zhou L, Malik K, Wen HC, Xu H, Estrada YD, Peng X, Chen M, Shah N, Suarez-Farinas M, Pavel AB, Nograles K, Guttman-Yassky E.

J Invest Dermatol. 2019 May;139(5):1063-1072. doi: 10.1016/j.jid.2018.10.043. Epub 2018 Dec 5.


Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population.

Chiesa Fuxench ZC, Block JK, Boguniewicz M, Boyle J, Fonacier L, Gelfand JM, Grayson MH, Margolis DJ, Mitchell L, Silverberg JI, Schwartz L, Simpson EL, Ong PY.

J Invest Dermatol. 2019 Mar;139(3):583-590. doi: 10.1016/j.jid.2018.08.028. Epub 2018 Oct 30.


Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families.

Simpson EL, Paller AS, Boguniewicz M, Eichenfield LF, Feldman SR, Silverberg JI, Chamlin SL, Zane LT.

Dermatol Ther (Heidelb). 2018 Dec;8(4):605-619. doi: 10.1007/s13555-018-0263-0. Epub 2018 Oct 22.


Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders.

Paller A, Jaworski JC, Simpson EL, Boguniewicz M, Russell JJ, Block JK, Tofte S, Dunn JD, Feldman SR, Clark AR, Schwartz G, Eichenfield LF.

Am J Clin Dermatol. 2018 Dec;19(6):821-838. doi: 10.1007/s40257-018-0383-4. Review.


Dupilumab does not affect correlates of vaccine-induced immunity: A randomized, placebo-controlled trial in adults with moderate-to-severe atopic dermatitis.

Blauvelt A, Simpson EL, Tyring SK, Purcell LA, Shumel B, Petro CD, Akinlade B, Gadkari A, Eckert L, Graham NMH, Pirozzi G, Evans R.

J Am Acad Dermatol. 2019 Jan;80(1):158-167.e1. doi: 10.1016/j.jaad.2018.07.048. Epub 2018 Aug 6.


Content and construct validity, predictors, and distribution of self-reported atopic dermatitis severity in US adults.

Silverberg JI, Chiesa Fuxench ZC, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Simpson EL, Ong PY.

Ann Allergy Asthma Immunol. 2018 Dec;121(6):729-734.e4. doi: 10.1016/j.anai.2018.07.040. Epub 2018 Aug 6.


Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Simpson EL, Ong PY, Chiesa Fuxench ZC.

Ann Allergy Asthma Immunol. 2018 Nov;121(5):604-612.e3. doi: 10.1016/j.anai.2018.07.042. Epub 2018 Aug 6.


Patient burden and quality of life in atopic dermatitis in US adults: A population-based cross-sectional study.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Simpson EL, Ong PY, Chiesa Fuxench ZC.

Ann Allergy Asthma Immunol. 2018 Sep;121(3):340-347. doi: 10.1016/j.anai.2018.07.006. Epub 2018 Jul 16.


Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'".

Simpson EL, Reynolds NJ, Flohr C, Paller AS, Silverberg JI, Cork MJ, Guttman-Yassky E, Irvine AD.

J Am Acad Dermatol. 2018 Aug;79(2):e25-e26. doi: 10.1016/j.jaad.2018.03.048. No abstract available.


Association of Inadequately Controlled Disease and Disease Severity With Patient-Reported Disease Burden in Adults With Atopic Dermatitis.

Simpson EL, Guttman-Yassky E, Margolis DJ, Feldman SR, Qureshi A, Hata T, Mastey V, Wei W, Eckert L, Chao J, Arnold RJG, Yu T, Vekeman F, Suárez-Fariñas M, Gadkari A.

JAMA Dermatol. 2018 Aug 1;154(8):903-912. doi: 10.1001/jamadermatol.2018.1572.


Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial.

Mehta NN, Shin DB, Joshi AA, Dey AK, Armstrong AW, Duffin KC, Fuxench ZC, Harrington CL, Hubbard RA, Kalb RE, Menter A, Rader DJ, Reilly MP, Simpson EL, Takeshita J, Torigian DA, Werner TJ, Troxel AB, Tyring SK, Vanderbeek SB, Van Voorhees AS, Playford MP, Ahlman MA, Alavi A, Gelfand JM.

Circ Cardiovasc Imaging. 2018 Jun;11(6):e007394. doi: 10.1161/CIRCIMAGING.117.007394.


Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative.

Grinich EE, Schmitt J, Küster D, Spuls PI, Williams HC, Chalmers JR, Thomas KS, Apfelbacher C, Prinsen CAC, Furue M, Stuart B, Carter B, Simpson EL.

Br J Dermatol. 2018 Aug;179(2):540-541. doi: 10.1111/bjd.16732. Epub 2018 Jun 25. No abstract available.


Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype.

Simpson EL, Villarreal M, Jepson B, Rafaels N, David G, Hanifin J, Taylor P, Boguniewicz M, Yoshida T, De Benedetto A, Barnes KC, Leung DYM, Beck LA.

J Invest Dermatol. 2018 Oct;138(10):2224-2233. doi: 10.1016/j.jid.2018.03.1517. Epub 2018 Mar 28.


Developing drugs for treatment of atopic dermatitis in children (≥3 months to <18 years of age): Draft guidance for industry.

Siegfried EC, Jaworski JC, Eichenfield LF, Paller A, Hebert AA, Simpson EL, Altman E, Arena C, Blauvelt A, Block J, Boguniewicz M, Chen S, Cordoro K, Hanna D, Horii K, Hultsch T, Lee J, Leung DY, Lio P, Milner J, Omachi T, Schneider C, Schneider L, Sidbury R, Smith T, Sugarman J, Taha S, Tofte S, Tollefson M, Tom WL, West DP, Whitney L, Zane L.

Pediatr Dermatol. 2018 May;35(3):303-322. doi: 10.1111/pde.13452. Epub 2018 Mar 30.


Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis.

Glatz M, Jo JH, Kennedy EA, Polley EC, Segre JA, Simpson EL, Kong HH.

PLoS One. 2018 Feb 28;13(2):e0192443. doi: 10.1371/journal.pone.0192443. eCollection 2018.


Baricitinib in adult patients with moderate-to-severe atopic dermatitis: A phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study.

Guttman-Yassky E, Silverberg JI, Nemoto O, Forman SB, Wilke A, Prescilla R, de la Peña A, Nunes FP, Janes J, Gamalo M, Donley D, Paik J, DeLozier AM, Nickoloff BJ, Simpson EL.

J Am Acad Dermatol. 2019 Apr;80(4):913-921.e9. doi: 10.1016/j.jaad.2018.01.018. Epub 2018 Feb 2.


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