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Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials.

Hickmott JW, Gunawardane U, Jensen K, Korecki AJ, Simpson EM.

Gene Ther. 2018 Sep 26. doi: 10.1038/s41434-018-0043-6. [Epub ahead of print]


Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice.

Labouesse MA, Sartori AM, Weinmann O, Simpson EH, Kellendonk C, Weber-Stadlbauer U.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10493-10498. doi: 10.1073/pnas.1800171115. Epub 2018 Sep 25.


Ibrutinib for Treating Relapsed or Refractory Mantle Cell Lymphoma: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Tappenden P, Simpson E, Hamilton J, Pollard D, Clowes M, Kaltenthaler E, Meiklejohn D, Morley N.

Pharmacoeconomics. 2018 Sep 24. doi: 10.1007/s40273-018-0713-7. [Epub ahead of print] Review.


Efficacy and safety of dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults: A pooled analysis of two phase 2 clinical trials.

Tofte SJ, Papp K, Sadick N, Bohnert K, Simpson E, Thaçi D, Bieber T, Blauvelt A, Sofen H, Gooderham M, Chen Z, Gadkari A, Eckert L, Graham NMH, Pirozzi G, Ardeleanu M.

J Am Assoc Nurse Pract. 2018 Sep;30(9):529-541. doi: 10.1097/JXX.0000000000000088.


Partnering with African American Churches to Create a Community Coalition for Mental Health.

Hankerson SH, Wells K, Sullivan MA, Johnson J, Smith L, Crayton L, Miller-Sethi F, Brooks C, Rule A, Ahmad-Llewellyn J, Rhem D, Porter X, Croskey R, Simpson E, Butler C, Roberts S, James A, Jones L.

Ethn Dis. 2018 Sep 6;28(Suppl 2):467-474. doi: 10.18865/ed.28.S2.467. eCollection 2018.


Eliciting imitation in early infancy.

Meltzoff AN, Murray L, Simpson E, Heimann M, Nagy E, Nadel J, Pedersen EJ, Brooks R, Messinger DS, De Pascalis L, Subiaul F, Paukner A, Ferrari PF.

Dev Sci. 2018 Sep 6:e12738. doi: 10.1111/desc.12738. [Epub ahead of print] No abstract available.


Interindividual differences in neonatal sociality and emotionality predict juvenile social status in rhesus monkeys.

Wooddell LJ, Simpson EA, Murphy AM, Dettmer AM, Paukner A.

Dev Sci. 2018 Sep 1:e12749. doi: 10.1111/desc.12749. [Epub ahead of print]


Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders.

Paller A, Jaworski JC, Simpson EL, Boguniewicz M, Russell JJ, Block JK, Tofte S, Dunn JD, Feldman SR, Clark AR, Schwartz G, Eichenfield LF.

Am J Clin Dermatol. 2018 Aug 30. doi: 10.1007/s40257-018-0383-4. [Epub ahead of print] Review.


Dupilumab does not affect correlates of vaccine-induced immunity: a randomized, placebo-controlled trial in adults with moderate-to-severe atopic dermatitis.

Blauvelt A, Simpson EL, Tyring SK, Purcell LA, Shumel B, Petro CD, Akinlade B, Gadkari A, Eckert L, Graham NMH, Pirozzi G, Evans R.

J Am Acad Dermatol. 2018 Aug 6. pii: S0190-9622(18)32351-X. doi: 10.1016/j.jaad.2018.07.048. [Epub ahead of print]


Content and construct validity, predictors and distribution of self-reported atopic dermatitis severity in US adults.

Silverberg JI, Chiesa Fuxench ZC, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Simpson EL, Ong PY.

Ann Allergy Asthma Immunol. 2018 Aug 6. pii: S1081-1206(18)30626-4. doi: 10.1016/j.anai.2018.07.040. [Epub ahead of print] No abstract available.


Association of atopic dermatitis with allergic, autoimmune and cardiovascular comorbidities in US adults.

Silverberg JI, Gelfand JM, Margolis D, Boguniewicz M, Fonacier L, Grayson MH, Simpson EL, Ong P, Chiesa Fuxench ZC.

Ann Allergy Asthma Immunol. 2018 Aug 6. pii: S1081-1206(18)30628-8. doi: 10.1016/j.anai.2018.07.042. [Epub ahead of print] No abstract available.


Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost.

Filla I, Bailey MR, Schipani E, Winiger V, Mezias C, Balsam PD, Simpson EH.

Neuropsychopharmacology. 2018 Oct;43(11):2180-2189. doi: 10.1038/s41386-018-0159-9. Epub 2018 Jul 20.


New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina.

Simpson EM, Korecki AJ, Fornes O, McGill TJ, Cueva-Vargas JL, Agostinone J, Farkas RA, Hickmott JW, Lam SL, Mathelier A, Renner LM, Stoddard J, Zhou M, Di Polo A, Neuringer M, Wasserman WW.

Hum Gene Ther. 2018 Oct 2. doi: 10.1089/hum.2018.118. [Epub ahead of print]


Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis.

Thonhoff JR, Simpson EP, Appel SH.

Curr Opin Neurol. 2018 Oct;31(5):635-639. doi: 10.1097/WCO.0000000000000599.


Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression.

Duvarci S, Simpson EH, Schneider G, Kandel ER, Roeper J, Sigurdsson T.

Nat Commun. 2018 Jul 19;9(1):2822. doi: 10.1038/s41467-018-05214-4.


Patient burden and quality of life in atopic dermatitis in US adults: A population-based cross-sectional study.

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, Simpson EL, Ong PY, Chiesa Fuxench ZC.

Ann Allergy Asthma Immunol. 2018 Sep;121(3):340-347. doi: 10.1016/j.anai.2018.07.006. Epub 2018 Jul 16.


Risk of anesthesia-related complications in brachycephalic dogs.

Gruenheid M, Aarnes TK, McLoughlin MA, Simpson EM, Mathys DA, Mollenkopf DF, Wittum TE.

J Am Vet Med Assoc. 2018 Aug 1;253(3):301-306. doi: 10.2460/javma.253.3.301.


Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'".

Simpson EL, Reynolds NJ, Flohr C, Paller AS, Silverberg JI, Cork MJ, Guttman-Yassky E, Irvine AD.

J Am Acad Dermatol. 2018 Aug;79(2):e25-e26. doi: 10.1016/j.jaad.2018.03.048. No abstract available.


Severity strata for POEM, PO-SCORAD, and DLQI in US adults with atopic dermatitis.

Silverberg JI, Gelfand JM, Margolis DJ, Fonacier L, Boguniewicz M, Schwartz LB, Simpson E, Grayson MH, Ong PY, Fuxench ZCC.

Ann Allergy Asthma Immunol. 2018 Oct;121(4):464-471. doi: 10.1016/j.anai.2018.07.004. Epub 2018 Jul 9.


Understanding osteosarcomas.

Simpson E, Brown HL.

JAAPA. 2018 Aug;31(8):15-19. doi: 10.1097/01.JAA.0000541477.24116.8d.


Walk with Me: a protocol for a pilot RCT of a peer-led walking programme to increase physical activity in inactive older adults.

Tully MA, Cunningham C, Cupples ME, Farrell D, Hardeman W, Hunter RF, Laventure B, McDonough SM, Morgan J, Murphy MH, Simpson EEA, Tudor-Locke C, Wright A, Kee F.

Pilot Feasibility Stud. 2018 Jun 21;4:117. doi: 10.1186/s40814-018-0308-2. eCollection 2018.


Association of Inadequately Controlled Disease and Disease Severity With Patient-Reported Disease Burden in Adults With Atopic Dermatitis.

Simpson EL, Guttman-Yassky E, Margolis DJ, Feldman SR, Qureshi A, Hata T, Mastey V, Wei W, Eckert L, Chao J, Arnold RJG, Yu T, Vekeman F, Suárez-Fariñas M, Gadkari A.

JAMA Dermatol. 2018 Aug 1;154(8):903-912. doi: 10.1001/jamadermatol.2018.1572.


Ibrutinib for Treating Waldenström's Macroglobulinaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Tappenden P, Carroll C, Stevens J, Simpson E, Thokala P, Wong R, Wright J, Auer R.

Pharmacoeconomics. 2018 Jun 27. doi: 10.1007/s40273-018-0680-z. [Epub ahead of print] Review.


Sarilumab for Previously-Treated Moderate or Severe Rheumatoid Arthritis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Bermejo I, Ren S, Simpson E, Clowes M, Scott DL, Young A, Stevenson M.

Pharmacoeconomics. 2018 Jun 8. doi: 10.1007/s40273-018-0677-7. [Epub ahead of print] Review.


Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

Thonhoff JR, Beers DR, Zhao W, Pleitez M, Simpson EP, Berry JD, Cudkowicz ME, Appel SH.

Neurol Neuroimmunol Neuroinflamm. 2018 May 18;5(4):e465. doi: 10.1212/NXI.0000000000000465. eCollection 2018 Jul.


Technical report: 3D printing of the brain for use as a visual-aid tool to communicate MR imaging features of hypoxic ischaemic injury at term with non-physicians.

Andronikou S, Simpson E, Klemm M, Vedajallam S, Chacko A, Thai NJ.

Childs Nerv Syst. 2018 Aug;34(8):1573-1577. doi: 10.1007/s00381-018-3838-2. Epub 2018 May 26.


The state of aging policy and politics in the Trump era.

Miller EA, Nadash P, Gusmano MK, Simpson E, Ronneberg CR.

J Aging Soc Policy. 2018 May-Jun;30(3-4):193-208. doi: 10.1080/08959420.2018.1481314.


Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial.

Mehta NN, Shin DB, Joshi AA, Dey AK, Armstrong AW, Duffin KC, Fuxench ZC, Harrington CL, Hubbard RA, Kalb RE, Menter A, Rader DJ, Reilly MP, Simpson EL, Takeshita J, Torigian DA, Werner TJ, Troxel AB, Tyring SK, Vanderbeek SB, Van Voorhees AS, Playford MP, Ahlman MA, Alavi A, Gelfand JM.

Circ Cardiovasc Imaging. 2018 Jun;11(6):e007394. doi: 10.1161/CIRCIMAGING.117.007394.


Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative.

Grinich EE, Schmitt J, Küster D, Spuls PI, Williams HC, Chalmers JR, Thomas KS, Apfelbacher C, Prinsen CAC, Furue M, Stuart B, Carter B, Simpson EL.

Br J Dermatol. 2018 Aug;179(2):540-541. doi: 10.1111/bjd.16732. Epub 2018 Jun 25. No abstract available.


Parental Problem Drinking and Emerging Adult Problem Behavior: The Moderating Role of Parental Support.

Finan LJ, Simpson E, Schulz J, Ohannessian CM.

J Child Fam Stud. 2018 Apr;27(4):1175-1185. Epub 2017 Nov 17.


What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis.

Simpson E, Hock E, Stevenson M, Wong R, Dracup N, Wailoo A, Conaghan P, Estrach C, Edwards C, Wakefield R.

Health Technol Assess. 2018 Apr;22(20):1-258. doi: 10.3310/hta22200.


Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Chalmers JR, Thomas KS, Apfelbacher C, Williams HC, Prinsen CA, Spuls PI, Simpson E, Gerbens LAA, Boers M, Barbarot S, Stalder JF, Abuabara K, Aoki V, Ardeleanu M, Armstrong J, Bang B, Berents TL, Burton T, Butler L, Chubachi T, Cresswell-Melville A, DeLozier A, Eckert L, Eichenfield L, Flohr C, Futamura M, Gadkari A, Gjerde ES, van Halewijn KF, Hawkes C, Howells L, Howie L, Humphreys R, Ishii HA, Kataoka Y, Katayama I, Kouwenhoven W, Langan SM, Leshem YA, Merhand S, Mina-Osorio P, Murota H, Nakahara T, Nunes FP, Nygaard U, Nygårdas M, Ohya Y, Ono E, Rehbinder E, Rogers NK, Romeijn GLE, Schuttelaar MLA, Sears AV, Simpson MA, Singh JA, Srour J, Stuart B, Svensson Å, Talmo G, Talmo H, Teixeira HD, Thyssen JP, Todd G, Torchet F, Volke A, von Kobyletzki L, Weisshaar E, Wollenberg A, Zaniboni M.

Br J Dermatol. 2018 May;178(5):e332-e341. doi: 10.1111/bjd.16543. Epub 2018 Apr 19.


Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype.

Simpson EL, Villarreal M, Jepson B, Rafaels N, David G, Hanifin J, Taylor P, Boguniewicz M, Yoshida T, De Benedetto A, Barnes KC, Leung DYM, Beck LA.

J Invest Dermatol. 2018 Oct;138(10):2224-2233. doi: 10.1016/j.jid.2018.03.1517. Epub 2018 Mar 28.


Developing drugs for treatment of atopic dermatitis in children (≥3 months to <18 years of age): Draft guidance for industry.

Siegfried EC, Jaworski JC, Eichenfield LF, Paller A, Hebert AA, Simpson EL, Altman E, Arena C, Blauvelt A, Block J, Boguniewicz M, Chen S, Cordoro K, Hanna D, Horii K, Hultsch T, Lee J, Leung DY, Lio P, Milner J, Omachi T, Schneider C, Schneider L, Sidbury R, Smith T, Sugarman J, Taha S, Tofte S, Tollefson M, Tom WL, West DP, Whitney L, Zane L.

Pediatr Dermatol. 2018 May;35(3):303-322. doi: 10.1111/pde.13452. Epub 2018 Mar 30.


Neuregulin1 modulation of experimental autoimmune encephalomyelitis (EAE).

Allender E, Deol H, Schram S, Maheras KJ, Gow A, Simpson EH, Song F.

J Neuroimmunol. 2018 May 15;318:56-64. doi: 10.1016/j.jneuroim.2018.02.008. Epub 2018 Mar 11.


Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity.

Marshall SA, McGuane JT, Soh YM, Gehring HM, Simpson E, Parry LJ.

Reprod Fertil Dev. 2018 Mar 14. doi: 10.1071/RD17544. [Epub ahead of print]


EEG beta desynchronization during hand goal-directed action observation in newborn monkeys and its relation to the emergence of hand motor skills.

Festante F, Vanderwert RE, Sclafani V, Paukner A, Simpson EA, Suomi SJ, Fox NA, Ferrari PF.

Dev Cogn Neurosci. 2018 Apr;30:142-149. doi: 10.1016/j.dcn.2018.02.010. Epub 2018 Mar 1.


Baricitinib for Previously Treated Moderate or Severe Rheumatoid Arthritis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Ren S, Bermejo I, Simpson E, Wong R, Scott DL, Young A, Stevenson M.

Pharmacoeconomics. 2018 Jul;36(7):769-778. doi: 10.1007/s40273-018-0616-7. Review.


Occupational Therapy Practitioners' Perspectives of Mental Health Practices With Clients in Stroke Rehabilitation.

Simpson EK, Ramirez NM, Branstetter B, Reed A, Lines E.

OTJR (Thorofare N J). 2018 Jul;38(3):181-189. doi: 10.1177/1539449218759627. Epub 2018 Mar 1.


Growth Patterns and Individual Variation in Mid-sagittal Facial Soft Tissue Depth from Childhood to Adulthood.

McKinnon MR, Simpson EK, Henneberg M.

J Forensic Sci. 2018 Mar 1. doi: 10.1111/1556-4029.13768. [Epub ahead of print]


Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis.

Glatz M, Jo JH, Kennedy EA, Polley EC, Segre JA, Simpson EL, Kong HH.

PLoS One. 2018 Feb 28;13(2):e0192443. doi: 10.1371/journal.pone.0192443. eCollection 2018.


Family functioning and adolescent internalizing symptoms: A latent profile analysis.

Simpson EG, Vannucci A, Ohannessian CM.

J Adolesc. 2018 Apr;64:136-145. doi: 10.1016/j.adolescence.2018.02.004. Epub 2018 Mar 2.


Understanding pre-, peri- and post-menopausal women's intentions to perform muscle-strengthening activities using the Theory of Planned Behaviour.

Doherty J, Giles M, Gallagher AM, Simpson EEA.

Maturitas. 2018 Mar;109:89-96. doi: 10.1016/j.maturitas.2017.12.014. Epub 2017 Dec 23.


Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease.

Sargeant JA, Bawden S, Aithal GP, Simpson EJ, Macdonald IA, Turner MC, Cegielski J, Smith K, Dorling JL, Gowland PA, Nimmo MA, King JA.

Eur J Appl Physiol. 2018 Apr;118(4):817-828. doi: 10.1007/s00421-018-3818-y. Epub 2018 Feb 6.


Baricitinib in adult patients with moderate-to-severe atopic dermatitis: a phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study.

Guttman-Yassky E, Silverberg JI, Nemoto O, Forman SB, Wilke A, Prescilla R, de la Peña A, Nunes FP, Janes J, Gamalo M, Donley D, Paik J, DeLozier AM, Nickoloff BJ, Simpson EL.

J Am Acad Dermatol. 2018 Feb 1. pii: S0190-9622(18)30129-4. doi: 10.1016/j.jaad.2018.01.018. [Epub ahead of print]


Human cis-acting elements regulating escape from X-chromosome inactivation function in mouse.

Peeters SB, Korecki AJ, Simpson EM, Brown CJ.

Hum Mol Genet. 2018 Apr 1;27(7):1252-1262. doi: 10.1093/hmg/ddy039.


Selective duodenography for controlled first-pass bolus distention of the duodenum in neonates and young children with bile-stained vomiting.

Andronikou S, Arthur S, Simpson E, Chopra M.

Clin Radiol. 2018 May;73(5):506.e1-506.e8. doi: 10.1016/j.crad.2017.12.020. Epub 2018 Feb 21.


Initial validation of the Burden of Disease in Atopic Eczema instrument, a quality-of-life measure for adult atopic dermatitis.

Wang AR, Dunlap RR, Darwish MA, Simpson EL, Hanifin JM, Qureshi AA, Du L, Drucker AM.

Br J Dermatol. 2018 May;178(5):1211-1212. doi: 10.1111/bjd.16398. Epub 2018 Mar 30. No abstract available.


An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice.

Bailey MR, Goldman O, Bello EP, Chohan MO, Jeong N, Winiger V, Chun E, Schipani E, Kalmbach A, Cheer JF, Balsam PD, Simpson EH.

J Neurosci. 2018 Feb 28;38(9):2149-2162. doi: 10.1523/JNEUROSCI.2088-17.2018. Epub 2018 Jan 24.


Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE).

Simpson EL, Flohr C, Eichenfield LF, Bieber T, Sofen H, Taïeb A, Owen R, Putnam W, Castro M, DeBusk K, Lin CY, Voulgari A, Yen K, Omachi TA.

J Am Acad Dermatol. 2018 May;78(5):863-871.e11. doi: 10.1016/j.jaad.2018.01.017. Epub 2018 Jan 17.

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