Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 341


The cerebral angiome: High resolution MicroCT imaging of the whole brain cerebrovasculature in female and male mice.

Quintana DD, Lewis SE, Anantula Y, Garcia JA, Sarkar SN, Cavendish JZ, Brown CM, Simpkins JW.

Neuroimage. 2019 Nov 15;202:116109. doi: 10.1016/j.neuroimage.2019.116109. Epub 2019 Aug 22.


Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer's disease-like pathology.

Sarkar S, Engler-Chiurazzi EB, Cavendish JZ, Povroznik JM, Russell AE, Quintana DD, Mathers PH, Simpkins JW.

Brain Res. 2019 Oct 15;1721:146327. doi: 10.1016/j.brainres.2019.146327. Epub 2019 Jul 8.


Mitochondrial Movement and Number Deficits in Embryonic Cortical Neurons from 3xTg-AD Mice.

Cavendish JZ, Sarkar SN, Colantonio MA, Quintana DD, Ahmed N, White BA, Engler-Chiurazzi EB, Simpkins JW.

J Alzheimers Dis. 2019;70(1):139-151. doi: 10.3233/JAD-190143.


MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma.

Sarkar SN, Russell AE, Engler-Chiurazzi EB, Porter KN, Simpkins JW.

Aging Dis. 2019 Apr 1;10(2):329-352. doi: 10.14336/AD.2018.0409. eCollection 2019 Apr. Review.


Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells.

Russell AE, Jun S, Sarkar S, Geldenhuys WJ, Lewis SE, Rellick SL, Simpkins JW.

Front Cell Neurosci. 2019 Feb 14;13:51. doi: 10.3389/fncel.2019.00051. eCollection 2019.


Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy.

Quintana DD, Garcia JA, Sarkar SN, Jun S, Engler-Chiurazzi EB, Russell AE, Cavendish JZ, Simpkins JW.

Mitochondrion. 2019 Jul;47:244-255. doi: 10.1016/j.mito.2018.12.004. Epub 2018 Dec 27.


Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system.

Sprenkle NT, Lahiri A, Simpkins JW, Meares GP.

J Neurochem. 2019 Feb;148(4):516-530. doi: 10.1111/jnc.14642. Epub 2019 Jan 18.


Not all clots are created equal: a review of deficient thrombolysis with tissue plasminogen activator (tPA) in patients with metabolic syndrome.

Mosimah CI, Murray PJ, Simpkins JW.

Int J Neurosci. 2019 Jun;129(6):612-618. doi: 10.1080/00207454.2018.1550400. Epub 2018 Dec 27. Review.


MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia.

Ren X, Engler-Chiurazzi EB, Russell AE, Sarkar SN, Rellick SL, Lewis S, Corbin D, Clapper J, Simpkins JW.

Neurochem Int. 2019 Jul;127:73-79. doi: 10.1016/j.neuint.2018.10.019. Epub 2018 Oct 23.


Gradual common carotid artery occlusion as a novel model for cerebrovascular Hypoperfusion.

Quintana DD, Ren X, Hu H, Engler-Chiurazzi EB, Rellick SL, Lewis SE, Povroznik JM, Simpkins JW, Alvi M.

Metab Brain Dis. 2018 Dec;33(6):2039-2044. doi: 10.1007/s11011-018-0312-5. Epub 2018 Sep 28.


Correction: Reversing the Warburg effect as a treatment for glioblastoma.

Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir ST, Yan H, Bigner DD, Simpkins JW, Yang SH.

J Biol Chem. 2018 Sep 28;293(39):14973. doi: 10.1074/jbc.AAC118.005625. No abstract available.


Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction.

Sizemore G, Lucke-Wold B, Rosen C, Simpkins JW, Bhatia S, Sun D.

OBM Neurobiol. 2018;2(2). pii: 009. doi: 10.21926/obm.neurobiol.1802009. Epub 2018 Jun 4.


Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague-Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression.

Breckenridge CB, Foradori CD, Sawhney Coder P, Simpkins JW, Sielken RL Jr, Handa RJ.

Birth Defects Res. 2018 Feb 15;110(3):246-258. doi: 10.1002/bdr2.1130. Epub 2017 Nov 14.


Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury.

Wu J, Li R, Li W, Ren M, Thangthaeng N, Sumien N, Liu R, Yang S, Simpkins JW, Forster MJ, Yan LJ.

Free Radic Biol Med. 2017 Dec;113:244-254. doi: 10.1016/j.freeradbiomed.2017.10.008. Epub 2017 Oct 7.


Paper-Based Surface-Enhanced Raman Scattering Lateral Flow Strip for Detection of Neuron-Specific Enolase in Blood Plasma.

Gao X, Zheng P, Kasani S, Wu S, Yang F, Lewis S, Nayeem S, Engler-Chiurazzi EB, Wigginton JG, Simpkins JW, Wu N.

Anal Chem. 2017 Sep 19;89(18):10104-10110. doi: 10.1021/acs.analchem.7b03015. Epub 2017 Sep 1.


Circulating leucocytes perpetuate stroke-induced aortic dysfunction.

Asano S, O'Connell GC, Lemaster KC, DeVallance ER, Branyan KW, Simpkins JW, Frisbee JC, Barr TL, Chantler PD.

Exp Physiol. 2017 Oct 1;102(10):1321-1331. doi: 10.1113/EP086510. Epub 2017 Sep 2.


TNF-α and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-α-Induced Neurotoxicity.

Russell AE, Doll DN, Sarkar SN, Simpkins JW.

J Clin Cell Immunol. 2016 Dec;7(6). pii: 467. doi: 10.4172/2155-9899.1000467. Epub 2016 Nov 14.


Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells.

Rellick SL, Hu H, Simpkins JW, Ren X.

J Vis Exp. 2016 Nov 19;(117). doi: 10.3791/54847.


A novel mechanism of non-feminizing estrogens in neuroprotection.

Engler-Chiurazzi EB, Covey DF, Simpkins JW.

Exp Gerontol. 2017 Aug;94:99-102. doi: 10.1016/j.exger.2016.10.013. Epub 2016 Nov 3. Review.


Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens.

Qian M, Engler-Chiurazzi EB, Lewis SE, Rath NP, Simpkins JW, Covey DF.

Org Biomol Chem. 2016 Oct 18;14(41):9790-9805.


Reprint of: From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.

Engler-Chiurazzi EB, Singh M, Simpkins JW.

Brain Res. 2016 Aug 15;1645:79-82. doi: 10.1016/j.brainres.2016.06.016. Epub 2016 Jun 16. Review.


Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16.


Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity.

Sarkar S, Jun S, Rellick S, Quintana DD, Cavendish JZ, Simpkins JW.

Brain Res. 2016 Sep 1;1646:139-151. doi: 10.1016/j.brainres.2016.05.026. Epub 2016 May 25.


Deciphering the Blood-Brain Barrier Damage in Stroke: Mitochondrial Mechanism.

Ren X, Simpkins JW.

J Neuroinfect Dis. 2015 Oct;6(Suppl 2). pii: e002. Epub 2015 Aug 22. No abstract available.


Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the 'Neuronal Warburg Effect'.

Sun J, Ren X, Qi W, Yuan D, Simpkins JW.

J Ethnopharmacol. 2016 Jul 1;187:249-58. doi: 10.1016/j.jep.2016.04.034. Epub 2016 Apr 22.


Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition.

Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz TR, McBride CR, Yi J, Engels K, Simpkins JW.

J Toxicol Environ Health A. 2016;79(11):447-52. doi: 10.1080/15287394.2016.1164101. Epub 2016 Apr 19.


Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury.

Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW.

Prog Neurobiol. 2017 Oct;157:188-211. doi: 10.1016/j.pneurobio.2015.12.008. Epub 2016 Feb 15. Review.


Tert-butylhydroquinone compromises survival in murine experimental stroke.

Sun J, Hu H, Ren X, Simpkins JW.

Neurotoxicol Teratol. 2016 Mar-Apr;54:15-21. doi: 10.1016/ Epub 2016 Jan 28.


Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity.

Hu H, Doll DN, Sun J, Lewis SE, Wimsatt JH, Kessler MJ, Simpkins JW, Ren X.

Aging Dis. 2016 Jan 2;7(1):14-27. doi: 10.14336/AD.2015.0906. eCollection 2016 Jan.


From the 90's to now: A brief historical perspective on more than two decades of estrogen neuroprotection.

Engler-Chiurazzi EB, Singh M, Simpkins JW.

Brain Res. 2016 Feb 15;1633:96-100. doi: 10.1016/j.brainres.2015.12.044. Epub 2015 Dec 29.


MiR-34a regulates blood-brain barrier permeability and mitochondrial function by targeting cytochrome c.

Bukeirat M, Sarkar SN, Hu H, Quintana DD, Simpkins JW, Ren X.

J Cereb Blood Flow Metab. 2016 Feb;36(2):387-92. doi: 10.1177/0271678X15606147. Epub 2015 Sep 30.


Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots.

Yang SH, Li W, Sumien N, Forster M, Simpkins JW, Liu R.

Prog Neurobiol. 2017 Oct;157:273-291. doi: 10.1016/j.pneurobio.2015.10.005. Epub 2015 Nov 18. Review.


The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity.

Petrone AB, O'Connell GC, Regier MD, Chantler PD, Simpkins JW, Barr TL.

Transl Stroke Res. 2016 Apr;7(2):103-10. doi: 10.1007/s12975-015-0431-9. Epub 2015 Oct 30.


Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke behavioral outcomes.

Doll DN, Engler-Chiurazzi EB, Lewis SE, Hu H, Kerr AE, Ren X, Simpkins JW.

Behav Brain Funct. 2015 Oct 13;11(1):32. doi: 10.1186/s12993-015-0077-5.


Effect of Age, Duration of Exposure, and Dose of Atrazine on Sexual Maturation and the Luteinizing Hormone Surge in the Female Sprague-Dawley Rat.

Breckenridge CB, Sawhney Coder P, Tisdel MO, Simpkins JW, Yi KD, Foradori CD, Handa RJ.

Birth Defects Res B Dev Reprod Toxicol. 2015 Oct;104(5):204-17. doi: 10.1002/bdrb.21154. Epub 2015 Oct 6.


Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype.

Moses BS, Slone WL, Thomas P, Evans R, Piktel D, Angel PM, Walsh CM, Cantrell PS, Rellick SL, Martin KH, Simpkins JW, Gibson LF.

Exp Hematol. 2016 Jan;44(1):50-9.e1-2. doi: 10.1016/j.exphem.2015.09.003. Epub 2015 Sep 25.


Bryostatin extends tPA time window to 6 h following middle cerebral artery occlusion in aged female rats.

Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD.

Eur J Pharmacol. 2015 Oct 5;764:404-12. doi: 10.1016/j.ejphar.2015.07.035. Epub 2015 Jul 17.


Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.

Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW.

Compr Physiol. 2015 Jul 1;5(3):1147-60. doi: 10.1002/cphy.c140057. Review.


Sequential Upregulation of Superoxide Dismutase 2 and Heme Oxygenase 1 by tert-Butylhydroquinone Protects Mitochondria during Oxidative Stress.

Sun J, Ren X, Simpkins JW.

Mol Pharmacol. 2015 Sep;88(3):437-49. doi: 10.1124/mol.115.098269. Epub 2015 Jun 16.


Estrogen amelioration of Aβ-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ, AKAP and Drp1.

Sarkar S, Jun S, Simpkins JW.

Brain Res. 2015 Aug 7;1616:101-11. doi: 10.1016/j.brainres.2015.04.059. Epub 2015 May 8.


Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier.

Doll DN, Hu H, Sun J, Lewis SE, Simpkins JW, Ren X.

Stroke. 2015 Jun;46(6):1681-9. doi: 10.1161/STROKEAHA.115.009099. Epub 2015 Apr 28.


The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population.

Jin K, Simpkins JW, Ji X, Leis M, Stambler I.

Aging Dis. 2014 Dec 15;6(1):1-5. doi: 10.14336/AD.2014.1210. eCollection 2015 Feb.


High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept.

Gatson JW, Simpkins JW, Uteshev VV.

Brain Res Bull. 2015 Mar;112:35-41. doi: 10.1016/j.brainresbull.2015.01.008. Epub 2015 Jan 31.


Isolation and identification of twelve metabolites of isocorynoxeine in rat urine and their neuroprotective activities in HT22 cell assay.

Qi W, Chen F, Sun J, Simpkins JW, Yuan D.

Planta Med. 2015 Jan;81(1):46-55. doi: 10.1055/s-0034-1383357. Epub 2014 Dec 17.


Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity.

Doll DN, Rellick SL, Barr TL, Ren X, Simpkins JW.

J Neurochem. 2015 Feb;132(4):443-51. doi: 10.1111/jnc.13008. Epub 2015 Jan 29.


Validation of a self-administered computerized system to detect cognitive impairment in older adults.

Brinkman SD, Reese RJ, Norsworthy LA, Dellaria DK, Kinkade JW, Benge J, Brown K, Ratka A, Simpkins JW.

J Appl Gerontol. 2014 Dec;33(8):942-62. doi: 10.1177/0733464812455099. Epub 2012 Sep 18.


17β-estradiol and inflammation: implications for ischemic stroke.

Petrone AB, Simpkins JW, Barr TL.

Aging Dis. 2014 Oct 1;5(5):340-5. doi: 10.14336/AD.2014.0500340. eCollection 2014 Oct. Review.


Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets.

Doll DN, Barr TL, Simpkins JW.

Aging Dis. 2014 Oct 1;5(5):294-306. doi: 10.14336/AD.2014.0500294. eCollection 2014 Oct. Review.


Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration.

Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE, Chen YW, Tan Z, Huber JD, Rosen CL.

J Alzheimers Dis. 2015;43(3):711-24. doi: 10.3233/JAD-141422. Review.


Urinary metabolites of isorhynchophylline in rats and their neuroprotective activities in the HT22 cell assay.

Chen F, Qi W, Sun J, Simpkins JW, Yuan D.

Fitoterapia. 2014 Sep;97:156-63. doi: 10.1016/j.fitote.2014.05.022. Epub 2014 Jun 6.

Supplemental Content

Loading ...
Support Center