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Items: 32


Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments.

Heinrich EC, Djokic MA, Gilbertson D, DeYoung PN, Bosompra NO, Wu L, Anza-Ramirez C, Orr JE, Powell FL, Malhotra A, Simonson TS.

PLoS One. 2019 Jun 12;14(6):e0217089. doi: 10.1371/journal.pone.0217089. eCollection 2019.


Genetic variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans.

Heinrich EC, Wu L, Lawrence ES, Cole AM, Anza-Ramirez C, Villafuerte FC, Simonson TS.

Ann Hum Genet. 2019 May;83(3):171-176. doi: 10.1111/ahg.12299. Epub 2019 Feb 4.


Giants in Chest Medicine: Emeritus Professor Peter D. Wagner, MD.

Simonson TS.

Chest. 2019 Jan;155(1):9-11. doi: 10.1016/j.chest.2018.09.029. No abstract available.


Evolutionary history of Tibetans inferred from whole-genome sequencing.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD.

PLoS Genet. 2017 Apr 27;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr.


Oxygen transport adaptations to exercise in native highland populations.

Simonson TS, Wagner PD.

Exp Physiol. 2015 Nov;100(11):1231-2. doi: 10.1113/EP085073. No abstract available.


Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.

Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde LB.

Exp Physiol. 2015 Nov;100(11):1263-8. doi: 10.1113/EP085035. Review.


Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m.

Wagner PD, Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Ge RL.

Exp Physiol. 2015 Nov;100(11):1256-62. doi: 10.1113/EP085036. Review.


Altitude Adaptation: A Glimpse Through Various Lenses.

Simonson TS.

High Alt Med Biol. 2015 Jun;16(2):125-37. doi: 10.1089/ham.2015.0033. Review.


Metabolic aspects of high-altitude adaptation in Tibetans.

Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA.

Exp Physiol. 2015 Nov;100(11):1247-55. doi: 10.1113/EP085292. Epub 2015 Jul 14. Review.


Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity.

Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Wagner PD, Ge RL.

J Physiol. 2015 Jul 15;593(14):3207-18. doi: 10.1113/JP270518. Epub 2015 Jun 25. Erratum in: J Physiol. 2016 Feb 1;594(3):797.


Reply: To PMID 25172885.

Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL.

Exp Physiol. 2015 Mar;100(3):342. doi: 10.1113/EP085032. No abstract available.


Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m.

Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL.

Exp Physiol. 2014 Dec 1;99(12):1624-35. doi: 10.1113/expphysiol.2014.080820. Epub 2014 Aug 28.


A genetic mechanism for Tibetan high-altitude adaptation.

Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT.

Nat Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067. Epub 2014 Aug 17.


Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations.

Wuren T, Simonson TS, Qin G, Xing J, Huff CD, Witherspoon DJ, Jorde LB, Ge RL.

PLoS One. 2014 Mar 18;9(3):e88252. doi: 10.1371/journal.pone.0088252. eCollection 2014.


Less is more: blunted responses to hypoxia revealed in sea-level Tibetans.

Simonson TS, Powell FL.

J Appl Physiol (1985). 2014 Apr 1;116(7):711-2. doi: 10.1152/japplphysiol.01110.2013. Epub 2013 Oct 10. No abstract available.


Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians.

Xing J, Wuren T, Simonson TS, Watkins WS, Witherspoon DJ, Wu W, Qin G, Huff CD, Jorde LB, Ge RL.

PLoS Genet. 2013;9(7):e1003634. doi: 10.1371/journal.pgen.1003634. Epub 2013 Jul 18.


Metabolic insight into mechanisms of high-altitude adaptation in Tibetans.

Ge RL, Simonson TS, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA.

Mol Genet Metab. 2012 Jun;106(2):244-7. doi: 10.1016/j.ymgme.2012.03.003. Epub 2012 Mar 17.


Genetic determinants of Tibetan high-altitude adaptation.

Simonson TS, McClain DA, Jorde LB, Prchal JT.

Hum Genet. 2012 Apr;131(4):527-33. doi: 10.1007/s00439-011-1109-3. Epub 2011 Nov 9. Review.


Crohn's disease and genetic hitchhiking at IBD5.

Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL.

Mol Biol Evol. 2012 Jan;29(1):101-11. doi: 10.1093/molbev/msr151. Epub 2011 Aug 4.


Maximum-likelihood estimation of recent shared ancestry (ERSA).

Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB.

Genome Res. 2011 May;21(5):768-74. doi: 10.1101/gr.115972.110. Epub 2011 Feb 8.


Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes.

Simonson TS, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB.

PLoS One. 2011 Jan 31;6(1):e16338. doi: 10.1371/journal.pone.0016338.


Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping.

Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB.

Genomics. 2010 Oct;96(4):199-210. doi: 10.1016/j.ygeno.2010.07.004. Epub 2010 Jul 16.


Genetic evidence for high-altitude adaptation in Tibet.

Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R.

Science. 2010 Jul 2;329(5987):72-5. doi: 10.1126/science.1189406. Epub 2010 May 13.


Limited distribution of a cardiomyopathy-associated variant in India.

Simonson TS, Zhang Y, Huff CD, Xing J, Watkins WS, Witherspoon DJ, Woodward SR, Jorde LB.

Ann Hum Genet. 2010 Mar;74(2):184-8. doi: 10.1111/j.1469-1809.2010.00561.x. Epub 2010 Feb 18.


Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family.

Lorenzo VF, Yang Y, Simonson TS, Nussenzveig R, Jorde LB, Prchal JT, Ge RL.

Blood Cells Mol Dis. 2009 Nov-Dec;43(3):221-5. doi: 10.1016/j.bcmd.2009.04.006. Epub 2009 May 29. Erratum in: Blood Cells Mol Dis. 2010 Mar 15;44(3):198.


Bacillus anthracis in China and its relationship to worldwide lineages.

Simonson TS, Okinaka RT, Wang B, Easterday WR, Huynh L, U'Ren JM, Dukerich M, Zanecki SR, Kenefic LJ, Beaudry J, Schupp JM, Pearson T, Wagner DM, Hoffmaster A, Ravel J, Keim P.

BMC Microbiol. 2009 Apr 15;9:71. doi: 10.1186/1471-2180-9-71.


Global genetic population structure of Bacillus anthracis.

Van Ert MN, Easterday WR, Huynh LY, Okinaka RT, Hugh-Jones ME, Ravel J, Zanecki SR, Pearson T, Simonson TS, U'Ren JM, Kachur SM, Leadem-Dougherty RR, Rhoton SD, Zinser G, Farlow J, Coker PR, Smith KL, Wang B, Kenefic LJ, Fraser-Liggett CM, Wagner DM, Keim P.

PLoS One. 2007 May 23;2(5):e461.


Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain.

Van Ert MN, Easterday WR, Simonson TS, U'Ren JM, Pearson T, Kenefic LJ, Busch JD, Huynh LY, Dukerich M, Trim CB, Beaudry J, Welty-Bernard A, Read T, Fraser CM, Ravel J, Keim P.

J Clin Microbiol. 2007 Jan;45(1):47-53. Epub 2006 Nov 8.


Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei.

U'Ren JM, Van Ert MN, Schupp JM, Easterday WR, Simonson TS, Okinaka RT, Pearson T, Keim P.

J Clin Microbiol. 2005 Nov;43(11):5771-4.


Use of single nucleotide polymorphisms in the plcR gene for specific identification of Bacillus anthracis.

Easterday WR, Van Ert MN, Simonson TS, Wagner DM, Kenefic LJ, Allender CJ, Keim P.

J Clin Microbiol. 2005 Apr;43(4):1995-7.


Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis.

Van Ert MN, Hofstadler SA, Jiang Y, Busch JD, Wagner DM, Drader JJ, Ecker DJ, Hannis JC, Huynh LY, Schupp JM, Simonson TS, Keim P.

Biotechniques. 2004 Oct;37(4):642-4, 646, 648 passim.


Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing.

Pearson T, Busch JD, Ravel J, Read TD, Rhoton SD, U'Ren JM, Simonson TS, Kachur SM, Leadem RR, Cardon ML, Van Ert MN, Huynh LY, Fraser CM, Keim P.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13536-41. Epub 2004 Sep 3.

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