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Effect of ischemic preconditioning and a Kv7 channel blocker on cardiac ischemia-reperfusion injury in rats.

Corydon KK, Matchkov V, Fais R, Abramochkin D, Hedegaard ER, Comerma-Steffensen S, Simonsen U.

Eur J Pharmacol. 2019 Nov 21:172820. doi: 10.1016/j.ejphar.2019.172820. [Epub ahead of print]


Ultrasensitive Photonic Microsystem Enabling Sub-micrometric Monitoring of Arterial Oscillations for Advanced Cardiovascular Studies.

Rodríguez-Rodríguez R, Ackermann TN, Plaza JA, Simonsen U, Matchkov V, Llobera A, Munoz-Berbel X.

Front Physiol. 2019 Jul 23;10:940. doi: 10.3389/fphys.2019.00940. eCollection 2019.


Impact of pulmonary endarterectomy on pulmonary arterial wave propagation and reservoir function.

Su J, Hughes AD, Simonsen U, Nielsen-Kudsk JE, Parker KH, Howard LS, Mellemkjaer S.

Am J Physiol Heart Circ Physiol. 2019 Sep 1;317(3):H505-H516. doi: 10.1152/ajpheart.00181.2019. Epub 2019 Jun 21.


Simultaneous Measurements of Tension and Free H2S in Mesenteric Arteries.

Nielsen ER, Winther AK, Simonsen U.

Methods Mol Biol. 2019;2007:125-136. doi: 10.1007/978-1-4939-9528-8_9.


Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.

Simonsen U, Winther AK, Oliván-Viguera A, Comerma-Steffensen S, Köhler R, Bek T.

Int J Mol Sci. 2019 Apr 25;20(8). pii: E2032. doi: 10.3390/ijms20082032.


The role of SOX family members in solid tumours and metastasis.

Grimm D, Bauer J, Wise P, Krüger M, Simonsen U, Wehland M, Infanger M, Corydon TJ.

Semin Cancer Biol. 2019 Mar 23. pii: S1044-579X(18)30141-X. doi: 10.1016/j.semcancer.2019.03.004. [Epub ahead of print] Review.


Label-Free Multi Parameter Optical Interrogation of Endothelial Activation in Single Cells using a Lab on a Disc Platform.

King D, Glynn M, Cindric S, Kernan D, O'Connell T, Hakimjavadi R, Kearney S, Ackermann T, Berbel XM, Llobera A, Simonsen U, Laursen BE, Redmond EM, Cahill PA, Ducrée J.

Sci Rep. 2019 Mar 11;9(1):4157. doi: 10.1038/s41598-019-40612-8.


Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monotherapy Fails.

Munk NE, Knudsen JS, Comerma-Steffensen S, Simonsen U.

Sex Med Rev. 2019 Jul;7(3):430-441. doi: 10.1016/j.sxmr.2018.11.007. Epub 2019 Jan 30. Review.


The role of aliskiren in the management of hypertension and major cardiovascular outcomes: a systematic review and meta-analysis.

Bjerre HL, Christensen JB, Buus NH, Simonsen U, Su J.

J Hum Hypertens. 2019 Nov;33(11):795-806. doi: 10.1038/s41371-018-0149-8. Epub 2019 Jan 10.


Different mechanisms involved in liraglutide and glucagon-like peptide-1 vasodilatation in rat mesenteric small arteries.

Bangshaab M, Gutierrez A, Huynh KD, Knudsen JS, Arcanjo DDR, Petersen AG, Rungby J, Gejl M, Simonsen U.

Br J Pharmacol. 2019 Feb;176(3):386-399. doi: 10.1111/bph.14534. Epub 2018 Dec 9.


Perivascular adipose tissue: A new possible tissue augmenting coronary vasodilatation in response to acute hypoxia.

Simonsen U, Petersen AG.

Acta Physiol (Oxf). 2018 Dec;224(4):e13171. doi: 10.1111/apha.13171. Epub 2018 Aug 25. No abstract available.


Nitric Oxide Attenuates Arterial Pulse Wave Reflection in a Vasodilator Responding Pulmonary Arterial Hypertension Patient.

Su J, Hughes AD, Simonsen U, Howard LS.

Circ Cardiovasc Interv. 2018 Mar;11(3):e006242. doi: 10.1161/CIRCINTERVENTIONS.117.006242. No abstract available.


Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn.

Pedersen J, Hedegaard ER, Simonsen U, Krüger M, Infanger M, Grimm D.

Basic Clin Pharmacol Toxicol. 2018 Oct;123(4):392-406. doi: 10.1111/bcpt.13051. Epub 2018 Jul 19. Review.


A Focus on Macitentan in the Treatment of Pulmonary Arterial Hypertension.

Bedan M, Grimm D, Wehland M, Simonsen U, Infanger M, Krüger M.

Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):103-113. doi: 10.1111/bcpt.13033. Epub 2018 Jun 5. Review.


Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide.

Winther AK, Fejerskov B, Ter Meer M, Jensen NBS, Dillion R, Schaffer JE, Chandrawati R, Stevens MM, Schultze Kool LJ, Simonsen U, Zelikin AN.

ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10741-10751. doi: 10.1021/acsami.8b01658. Epub 2018 Mar 23.


Impact of chronic hypoxia on proximal pulmonary artery wave propagation and mechanical properties in rats.

Su J, Logan CC, Hughes AD, Parker KH, Dhutia NM, Danielsen CC, Simonsen U.

Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1264-H1278. doi: 10.1152/ajpheart.00695.2017. Epub 2018 Mar 16.


Treatment with 24 h-delayed normo- and hyperbaric oxygenation in severe sepsis induced by cecal ligation and puncture in rats.

Bærnthsen NF, Hansen MB, Wahl AM, Simonsen U, Hyldegaard O.

J Inflamm (Lond). 2017 Nov 25;14:27. doi: 10.1186/s12950-017-0173-4. eCollection 2017.


Wave Intensity Analysis Provides Novel Insights Into Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.

Su J, Manisty C, Parker KH, Simonsen U, Nielsen-Kudsk JE, Mellemkjaer S, Connolly S, Lim PB, Whinnett ZI, Malik IS, Watson G, Davies JE, Gibbs S, Hughes AD, Howard L.

J Am Heart Assoc. 2017 Oct 31;6(11). pii: e006679. doi: 10.1161/JAHA.117.006679.


Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function.

Comerma-Steffensen SG, Carvacho I, Hedegaard ER, Simonsen U.

Front Pharmacol. 2017 Sep 20;8:660. doi: 10.3389/fphar.2017.00660. eCollection 2017.


Development of contractile properties in the fetal porcine urinary bladder.

Jakobsen LK, Trelborg KF, Simonsen U, Andersson KE, Olsen LH.

Pediatr Res. 2018 Jan;83(1-1):148-155. doi: 10.1038/pr.2017.181. Epub 2017 Oct 4.


The Combination of Valsartan and Sacubitril in the Treatment of Hypertension and Heart Failure - an Update.

Nielsen PM, Grimm D, Wehland M, Simonsen U, Krüger M.

Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):9-18. doi: 10.1111/bcpt.12912. Epub 2017 Oct 11. Review.


Activation of Veratridine Sensitive Sodium Channels, But not Electrical Field Stimulation, Dilates Porcine Retinal Arterioles with Preserved Perivascular Tissue.

Kratholm NM, Jensen PS, Kringelholt S, Simonsen U, Bek T.

Curr Eye Res. 2017 Nov;42(11):1497-1502. doi: 10.1080/02713683.2017.1337156. Epub 2017 Sep 14.


A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension.

Sorensen LM, Wehland M, Kruger M, Simonsen U, Nassef MZ, Infanger M, Grimm D.

Curr Pharm Des. 2017;23(34):5191-5199. doi: 10.2174/1381612823666170908114227. Review.


Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections.

Hansen MB, Rasmussen LS, Garred P, Pilely K, Wahl AM, Perner A, Madsen MB, Hedegaard ER, Simonsen U, Hyldegaard O.

Shock. 2018 Jun;49(6):667-674. doi: 10.1097/SHK.0000000000000975.


Pulmonary artery wave propagation and reservoir function in conscious man: impact of pulmonary vascular disease, respiration and dynamic stress tests.

Su J, Manisty C, Simonsen U, Howard LS, Parker KH, Hughes AD.

J Physiol. 2017 Oct 15;595(20):6463-6476. doi: 10.1113/JP274385. Epub 2017 Sep 11.


Structure-function studies of BPP-BrachyNH2 and synthetic analogues thereof with Angiotensin I-Converting Enzyme.

Arcanjo DDR, Vasconcelos AG, Nascimento LA, Mafud AC, Plácido A, Alves MMM, Delerue-Matos C, Bemquerer MP, Vale N, Gomes P, Oliveira EB, Lima FCA, Mascarenhas YP, Carvalho FAA, Simonsen U, Ramos RM, Leite JRSA.

Eur J Med Chem. 2017 Oct 20;139:401-411. doi: 10.1016/j.ejmech.2017.08.019. Epub 2017 Aug 7.


Pulmonary Artery Occlusion and Mediastinal Fibrosis in a Patient on Dopamine Agonist Treatment for Hyperprolactinemia.

Su J, Simonsen U, Carlsen J, Mellemkjaer S.

Front Pharmacol. 2017 Jul 20;8:492. doi: 10.3389/fphar.2017.00492. eCollection 2017.


Levosimendan Prevents and Reverts Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension.

Hansen MS, Andersen A, Holmboe S, Schultz JG, Ringgaard S, Simonsen U, Happé C, Bogaard HJ, Nielsen-Kudsk JE.

J Cardiovasc Pharmacol. 2017 Oct;70(4):232-238. doi: 10.1097/FJC.0000000000000508.


Down-regulation of KCa2.3 channels causes erectile dysfunction in mice.

Comerma-Steffensen S, Kun A, Hedegaard ER, Mogensen S, Aalkjaer C, Köhler R, Mønster Christensen B, Simonsen U.

Sci Rep. 2017 Jun 19;7(1):3839. doi: 10.1038/s41598-017-04188-5.


Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.

Laursen M, Beck L, Kehler J, Christoffersen CT, Bundgaard C, Mogensen S, Mow TJ, Pinilla E, Knudsen JS, Hedegaard ER, Grunnet M, Simonsen U.

Br J Pharmacol. 2017 Aug;174(15):2563-2575. doi: 10.1111/bph.13868. Epub 2017 Jul 5.


Azilsartan Medoxomil, an Angiotensin II Receptor Antagonist for the Treatment of Hypertension.

Hjermitslev M, Grimm DG, Wehland M, Simonsen U, Krüger M.

Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):225-233. doi: 10.1111/bcpt.12800. Epub 2017 Jun 19. Review.


Ivabradine: Current and Future Treatment of Heart Failure.

Thorup L, Simonsen U, Grimm D, Hedegaard ER.

Basic Clin Pharmacol Toxicol. 2017 Aug;121(2):89-97. doi: 10.1111/bcpt.12784. Epub 2017 May 10. Review.


Novel Aspects of Physiology and Pharmacology Related to the Urogenital Tract.

Simonsen U.

Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:3-4. doi: 10.1111/bcpt.12673. No abstract available.


Modulation of Dopaminergic Pathways to Treat Erectile Dysfunction.

Simonsen U, Comerma-Steffensen S, Andersson KE.

Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:63-74. doi: 10.1111/bcpt.12653. Review.


Mechanisms Involved in Thromboxane A2 -induced Vasoconstriction of Rat Intracavernous Small Penile Arteries.

Grann M, Comerma-Steffensen S, Arcanjo DD, Simonsen U.

Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:86-95. doi: 10.1111/bcpt.12544. Epub 2016 Jan 25.


A review of wave mechanics in the pulmonary artery with an emphasis on wave intensity analysis.

Su J, Hilberg O, Howard L, Simonsen U, Hughes AD.

Acta Physiol (Oxf). 2016 Dec;218(4):239-249. doi: 10.1111/apha.12803. Epub 2016 Sep 29. Review.


Emerging roles of calcium-activated K channels and TRPV4 channels in lung oedema and pulmonary circulatory collapse.

Simonsen U, Wandall-Frostholm C, Oliván-Viguera A, Köhler R.

Acta Physiol (Oxf). 2017 Jan;219(1):176-187. doi: 10.1111/apha.12768. Epub 2016 Sep 16. Review.


Inhibition of KV7 Channels Protects the Rat Heart against Myocardial Ischemia and Reperfusion Injury.

Hedegaard ER, Johnsen J, Povlsen JA, Jespersen NR, Shanmuganathan JA, Laursen MR, Kristiansen SB, Simonsen U, Bøtker HE.

J Pharmacol Exp Ther. 2016 Apr;357(1):94-102. doi: 10.1124/jpet.115.230409. Epub 2016 Feb 11.


Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed.

Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R.

Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. doi: 10.1111/bcpt.12560. Epub 2016 Feb 29.


Mechanisms involved in extracellular matrix remodeling and arterial stiffness induced by hyaluronan accumulation.

Lorentzen KA, Chai S, Chen H, Danielsen CC, Simonsen U, Wogensen L.

Atherosclerosis. 2016 Jan;244:195-203. doi: 10.1016/j.atherosclerosis.2015.11.016. Epub 2015 Dec 1.


A Novel Vasoactive Proline-Rich Oligopeptide from the Skin Secretion of the Frog Brachycephalus ephippium.

Arcanjo DD, Vasconcelos AG, Comerma-Steffensen SG, Jesus JR, Silva LP, Pires Júnior OR, Costa-Neto CM, Oliveira EB, Migliolo L, Franco OL, Restini CB, Paulo M, Bendhack LM, Bemquerer MP, Oliveira AP, Simonsen U, Leite JR.

PLoS One. 2015 Dec 14;10(12):e0145071. doi: 10.1371/journal.pone.0145071. eCollection 2015.


Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries.

Engholm M, Pinilla E, Mogensen S, Matchkov V, Hedegaard ER, Chen H, Mulvany MJ, Simonsen U.

Br J Pharmacol. 2016 Mar;173(5):839-55. doi: 10.1111/bph.13393. Epub 2016 Jan 27.


New roles of factors from perivascular tissue in regulation of vascular tone.

Simonsen U, Boedtkjer E.

Acta Physiol (Oxf). 2016 Feb;216(2):159-62. doi: 10.1111/apha.12620. Epub 2015 Nov 16. No abstract available.


Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide-Induced Relaxation of Rat Mesenteric Small Arteries.

Hedegaard ER, Gouliaev A, Winther AK, Arcanjo DD, Aalling M, Renaltan NS, Wood ME, Whiteman M, Skovgaard N, Simonsen U.

J Pharmacol Exp Ther. 2016 Jan;356(1):53-63. doi: 10.1124/jpet.115.227017. Epub 2015 Oct 22.


Pressure Myography to Study the Function and Structure of Isolated Small Arteries.

Schjørring OL, Carlsson R, Simonsen U.

Methods Mol Biol. 2015;1339:277-95. doi: 10.1007/978-1-4939-2929-0_19.


Impaired endothelial calcium signaling is responsible for the defective dilation of mesenteric resistance arteries from db/db mice to acetylcholine.

Chen H, Kold-Petersen H, Laher I, Simonsen U, Aalkjaer C.

Eur J Pharmacol. 2015 Nov 15;767:17-23. doi: 10.1016/j.ejphar.2015.09.043. Epub 2015 Sep 28.


LCZ696 (Valsartan/Sacubitril)--A Possible New Treatment for Hypertension and Heart Failure.

Andersen MB, Simonsen U, Wehland M, Pietsch J, Grimm D.

Basic Clin Pharmacol Toxicol. 2016 Jan;118(1):14-22. doi: 10.1111/bcpt.12453. Epub 2015 Sep 4. Review.


Involvement of hydrogen sulfide in perivascular and hypoxia-induced inhibition of endothelin contraction in porcine retinal arterioles.

Winther AK, Dalsgaard T, Hedegaard ER, Simonsen U.

Nitric Oxide. 2015 Nov 15;50:1-9. doi: 10.1016/j.niox.2015.07.002. Epub 2015 Jul 17.


Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation.

Wandall-Frostholm C, Dalsgaard T, Bajoriūnas V, Oliván-Viguera A, Sadda V, Beck L, Mogensen S, Stankevicius E, Simonsen U, Köhler R.

Br J Pharmacol. 2015 Sep;172(18):4493-4505. doi: 10.1111/bph.13234. Epub 2015 Jul 24.


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