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Maternal prenatal and early postnatal distress and child stress responses at age 6.

Simons SSH, Zijlmans MAC, Cillessen AHN, de Weerth C.

Stress. 2019 Nov;22(6):654-663. doi: 10.1080/10253890.2019.1608945. Epub 2019 May 16.


An Approach to Greater Specificity for Glucocorticoids.

Chow CC, Simons SS Jr.

Front Endocrinol (Lausanne). 2018 Mar 13;9:76. doi: 10.3389/fendo.2018.00076. eCollection 2018. Review.


Associations between circadian and stress response cortisol in children.

Simons SS, Cillessen AH, de Weerth C.

Stress. 2017 Jan;20(1):52-58. doi: 10.1080/10253890.2016.1276165. Epub 2017 Jan 23.


Cortisol stress responses and children's behavioral functioning at school.

Simons SS, Cillessen AH, de Weerth C.

Dev Psychobiol. 2017 Mar;59(2):217-224. doi: 10.1002/dev.21484. Epub 2016 Oct 24.


Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.

Pradhan MA, Blackford JA Jr, Devaiah BN, Thompson PS, Chow CC, Singer DS, Simons SS Jr.

J Biol Chem. 2016 Jan 1;291(1):342-54. doi: 10.1074/jbc.M115.683722. Epub 2015 Oct 26.


Development of the cortisol circadian rhythm in the light of stress early in life.

Simons SS, Beijers R, Cillessen AH, de Weerth C.

Psychoneuroendocrinology. 2015 Dec;62:292-300. doi: 10.1016/j.psyneuen.2015.08.024. Epub 2015 Sep 5.


Theory of partial agonist activity of steroid hormones.

Chow CC, Ong KM, Kagan B, Simons SS Jr.

AIMS Mol Sci. 2015;2(2):101-123.


Kinetically-defined component actions in gene repression.

Chow CC, Finn KK, Storchan GB, Lu X, Sheng X, Simons SS Jr.

PLoS Comput Biol. 2015 Mar 27;11(3):e1004122. doi: 10.1371/journal.pcbi.1004122. eCollection 2015 Mar.


The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events.

Simon TW, Simons SS Jr, Preston RJ, Boobis AR, Cohen SM, Doerrer NG, Fenner-Crisp PA, McMullin TS, McQueen CA, Rowlands JC; RISK21 Dose-Response Subteam.

Crit Rev Toxicol. 2014 Aug;44 Suppl 3:17-43. doi: 10.3109/10408444.2014.931925. Review.


Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.

Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr.

Mol Endocrinol. 2014 Jul;28(7):1194-206. doi: 10.1210/me.2014-1069. Epub 2014 May 21.


A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.

Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr.

Biochemistry. 2014 Mar 25;53(11):1753-67. doi: 10.1021/bi5000178. Epub 2014 Mar 11.


Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges.

Simons SS Jr, Edwards DP, Kumar R.

Mol Endocrinol. 2014 Feb;28(2):173-82. doi: 10.1210/me.2013-1334. Epub 2013 Nov 27. Review.


A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.

Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons SS Jr.

J Biol Chem. 2013 Nov 22;288(47):34055-72. doi: 10.1074/jbc.M113.512426. Epub 2013 Oct 6.


Variable steroid receptor responses: Intrinsically disordered AF1 is the key.

Simons SS Jr, Kumar R.

Mol Cell Endocrinol. 2013 Aug 25;376(1-2):81-4. doi: 10.1016/j.mce.2013.06.007. Epub 2013 Jun 17. Review.


Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.

Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA Jr, Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr.

J Biol Chem. 2013 May 24;288(21):15167-80. doi: 10.1074/jbc.M113.453936. Epub 2013 Apr 4.


PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.

Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr.

J Biol Chem. 2013 Jan 4;288(1):42-58. doi: 10.1074/jbc.M112.427740. Epub 2012 Nov 17.


Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations.

Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R.

J Biol Chem. 2012 Dec 28;287(53):44546-60. doi: 10.1074/jbc.M112.411330. Epub 2012 Nov 6.


Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.

Blackford JA Jr, Guo C, Zhu R, Dougherty EJ, Chow CC, Simons SS Jr.

J Biol Chem. 2012 Nov 30;287(49):40982-95. doi: 10.1074/jbc.M112.414805. Epub 2012 Oct 10.


Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction.

Awasthi S, Simons SS Jr.

Mol Cell Endocrinol. 2012 May 15;355(1):121-34. doi: 10.1016/j.mce.2012.02.001. Epub 2012 Feb 11.


Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification.

Dougherty EJ, Guo C, Simons SS Jr, Chow CC.

PLoS One. 2012;7(1):e30225. doi: 10.1371/journal.pone.0030225. Epub 2012 Jan 17.


The road less traveled: new views of steroid receptor action from the path of dose-response curves.

Simons SS Jr, Chow CC.

Mol Cell Endocrinol. 2012 Jan 30;348(2):373-82. doi: 10.1016/j.mce.2011.05.030. Epub 2011 Jun 1. Review.


Inferring mechanisms from dose-response curves.

Chow CC, Ong KM, Dougherty EJ, Simons SS Jr.

Methods Enzymol. 2011;487:465-83. doi: 10.1016/B978-0-12-381270-4.00016-0.


Glucocorticoid receptor cofactors as therapeutic targets.

Simons SS Jr.

Curr Opin Pharmacol. 2010 Dec;10(6):613-9. doi: 10.1016/j.coph.2010.08.001. Epub 2010 Aug 26. Review.


STAMP alters the growth of transformed and ovarian cancer cells.

He Y, Blackford JA Jr, Kohn EC, Simons SS Jr.

BMC Cancer. 2010 Apr 7;10:128. doi: 10.1186/1471-2407-10-128.


A theoretical framework for gene induction and experimental comparisons.

Ong KM, Blackford JA Jr, Kagan BL, Simons SS Jr, Chow CC.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7107-12. doi: 10.1073/pnas.0911095107. Epub 2010 Mar 29.


Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells.

Luo M, Simons SS Jr.

Hum Immunol. 2009 Oct;70(10):785-9. doi: 10.1016/j.humimm.2009.07.029. Epub 2009 Aug 6.


Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction.

Ronacher K, Hadley K, Avenant C, Stubsrud E, Simons SS Jr, Louw A, Hapgood JP.

Mol Cell Endocrinol. 2009 Feb 27;299(2):219-31. doi: 10.1016/j.mce.2008.10.008. Epub 2008 Oct 19.


What goes on behind closed doors: physiological versus pharmacological steroid hormone actions.

Simons SS Jr.

Bioessays. 2008 Aug;30(8):744-56. doi: 10.1002/bies.20792. Review.


Modulation of transcription parameters in glucocorticoid receptor-mediated repression.

Sun Y, Tao YG, Kagan BL, He Y, Simons SS Jr.

Mol Cell Endocrinol. 2008 Nov 25;295(1-2):59-69. doi: 10.1016/j.mce.2008.05.008. Epub 2008 May 21.


Differential modulation of glucocorticoid and progesterone receptor transactivation.

Szapary D, Song LN, He Y, Simons SS Jr.

Mol Cell Endocrinol. 2008 Feb 13;283(1-2):114-26. doi: 10.1016/j.mce.2007.11.031. Epub 2007 Dec 8.


Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.

Suino-Powell K, Xu Y, Zhang C, Tao YG, Tolbert WD, Simons SS Jr, Xu HE.

Mol Cell Biol. 2008 Mar;28(6):1915-23. Epub 2007 Dec 26.


Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors.

Wang D, Wang Q, Awasthi S, Simons SS Jr.

Biochemistry. 2007 Jul 10;46(27):8036-49. Epub 2007 Jun 16.


Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.

Kim Y, Sun Y, Chow C, Pommier YG, Simons SS Jr.

J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):3-17. Epub 2006 May 24.


PCR expression mutagenesis: a high-throughput mutation assay applied to the glucocorticoid receptor ligand-binding domain.

Chen J, Blackford JA Jr, Simons SS Jr.

Biochem Biophys Res Commun. 2004 Sep 3;321(4):893-9.


Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors.

Wang Q, Anzick S, Richter WF, Meltzer P, Simons SS Jr.

J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):197-210.


Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.

Wang Q, Blackford JA Jr, Song LN, Huang Y, Cho S, Simons SS Jr.

Mol Endocrinol. 2004 Jun;18(6):1376-95. Epub 2004 Mar 11.


Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1.

Anzick SL, Azorsa DO, Simons SS Jr, Meltzer PS.

BMC Cancer. 2003 Sep 10;3:22.


Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft.

Murphy PJ, Morishima Y, Chen H, Galigniana MD, Mansfield JF, Simons SS Jr, Pratt WB.

J Biol Chem. 2003 Sep 12;278(37):34764-73. Epub 2003 Jun 13.


Anthrax lethal factor represses glucocorticoid and progesterone receptor activity.

Webster JI, Tonelli LH, Moayeri M, Simons SS Jr, Leppla SH, Sternberg EM.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5706-11. Epub 2003 Apr 30.


A second pathway for modulating glucocorticoid receptor transactivation properties.

Chen S, Simons SS Jr.

Mol Cell Endocrinol. 2003 Jan 31;199(1-2):129-42.


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