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Items: 1 to 50 of 130

1.

In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals.

Rachid O, Simons KJ, Rawas-Qalaji M.

AAPS PharmSciTech. 2018 Nov;19(8):3886-3894. doi: 10.1208/s12249-018-1171-4. Epub 2018 Oct 15.

PMID:
30324360
2.

Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use.

Rachid O, Rawas-Qalaji M, Simons KJ.

Pharmaceutics. 2018 Feb 11;10(1). pii: E24. doi: 10.3390/pharmaceutics10010024.

3.

Epinephrine doses delivered from auto-injectors stored at excessively high temperatures.

Rachid O, Simons FE, Rawas-Qalaji M, Lewis S, Simons KJ.

Drug Dev Ind Pharm. 2016 Jan;42(1):131-135. Epub 2015 May 22.

PMID:
25997362
4.

Sublingual Diffusion of Epinephrine Microcrystals from Rapidly Disintegrating Tablets for the Potential First-Aid Treatment of Anaphylaxis: In Vitro and Ex Vivo Study.

Rawas-Qalaji MM, Werdy S, Rachid O, Simons FE, Simons KJ.

AAPS PharmSciTech. 2015 Oct;16(5):1203-12. doi: 10.1208/s12249-015-0306-0. Epub 2015 Mar 4.

5.

Epinephrine doses contained in outdated epinephrine auto-injectors collected in a Florida allergy practice.

Rachid O, Simons FE, Wein MB, Rawas-Qalaji M, Simons KJ.

Ann Allergy Asthma Immunol. 2015 Apr;114(4):354-356.e1. doi: 10.1016/j.anai.2015.01.015. Epub 2015 Feb 21. No abstract available.

PMID:
25707326
6.

Epinephrine autoinjectors: does freezing or refrigeration affect epinephrine dose delivery and enantiomeric purity?

Rachid O, Simons FE, Rawas-Qalaji M, Lewis S, Simons KJ.

J Allergy Clin Immunol Pract. 2015 Mar-Apr;3(2):294-6. doi: 10.1016/j.jaip.2014.11.015. Epub 2015 Jan 14. No abstract available.

PMID:
25609348
7.

Adrenaline (epinephrine) microcrystal sublingual tablet formulation: enhanced absorption in a preclinical model.

Rawas-Qalaji M, Rachid O, Mendez BA, Losada A, Simons FE, Simons KJ.

J Pharm Pharmacol. 2015 Jan;67(1):20-5. doi: 10.1111/jphp.12312. Epub 2014 Sep 26.

PMID:
25256073
8.

Long-term stability of epinephrine sublingual tablets for the potential first-aid treatment of anaphylaxis.

Rawas-Qalaji MM, Rachid O, Simons FE, Simons KJ.

Ann Allergy Asthma Immunol. 2013 Dec;111(6):568-70. doi: 10.1016/j.anai.2013.09.005. Epub 2013 Sep 29. No abstract available.

PMID:
24267371
9.

Epinephrine (adrenaline) absorption from new-generation, taste-masked sublingual tablets: a preclinical study.

Rachid O, Rawas-Qalaji MM, Simons FE, Simons KJ.

J Allergy Clin Immunol. 2013 Jan;131(1):236-8. doi: 10.1016/j.jaci.2012.10.016. Epub 2012 Nov 22. No abstract available.

PMID:
23177259
10.

Metabolic disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and skin administration in rats.

Fediuk DJ, Wang T, Chen Y, Parkinson FE, Namaka MP, Simons KJ, Burczynski FJ, Gu X.

Int J Toxicol. 2012 Sep-Oct;31(5):467-76. doi: 10.1177/1091581812459893.

PMID:
23064701
11.

Rapidly-disintegrating sublingual tablets of epinephrine: role of non-medicinal ingredients in formulation development.

Rachid O, Rawas-Qalaji M, Simons FE, Simons KJ.

Eur J Pharm Biopharm. 2012 Nov;82(3):598-604. doi: 10.1016/j.ejpb.2012.05.020. Epub 2012 Jun 7.

PMID:
22683694
12.

Histamine and H1-antihistamines: celebrating a century of progress.

Simons FE, Simons KJ.

J Allergy Clin Immunol. 2011 Dec;128(6):1139-1150.e4. doi: 10.1016/j.jaci.2011.09.005. Epub 2011 Oct 27. Review.

PMID:
22035879
13.

Tissue disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and topical administration in rats.

Fediuk DJ, Wang T, Chen Y, Parkinson FE, Namaka MP, Simons KJ, Burczynski FJ, Gu X.

Biopharm Drug Dispos. 2011 Oct;32(7):369-79. doi: 10.1002/bdd.765. Epub 2011 Aug 2.

PMID:
21812003
14.

Dissolution testing of sublingual tablets: a novel in vitro method.

Rachid O, Rawas-Qalaji M, Simons FE, Simons KJ.

AAPS PharmSciTech. 2011 Jun;12(2):544-52. doi: 10.1208/s12249-011-9615-0. Epub 2011 Apr 27.

15.

A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens.

Faris JD, Zhang Z, Lu H, Lu S, Reddy L, Cloutier S, Fellers JP, Meinhardt SW, Rasmussen JB, Xu SS, Oliver RP, Simons KJ, Friesen TL.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13544-9. doi: 10.1073/pnas.1004090107. Epub 2010 Jul 12.

16.

Epinephrine and its use in anaphylaxis: current issues.

Simons KJ, Simons FE.

Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):354-61. doi: 10.1097/ACI.0b013e32833bc670. Review.

PMID:
20543673
17.

Epinephrine (adrenaline) in anaphylaxis.

Simons FER, Simons KJ.

Chem Immunol Allergy. 2010;95:211-222. doi: 10.1159/000315954. Epub 2010 Jun 1. Review.

PMID:
20519893
18.

An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.

Rachid O, Simons FE, Rawas-Qalaji M, Simons KJ.

AAPS PharmSciTech. 2010 Jun;11(2):550-7. doi: 10.1208/s12249-010-9402-3. Epub 2010 Mar 30.

19.

Long-term stability of epinephrine dispensed in unsealed syringes for the first-aid treatment of anaphylaxis.

Rawas-Qalaji M, Simons FE, Collins D, Simons KJ.

Ann Allergy Asthma Immunol. 2009 Jun;102(6):500-3. doi: 10.1016/S1081-1206(10)60124-X.

PMID:
19558009
20.

H1 antihistamines: current status and future directions.

Simons FE, Simons KJ.

World Allergy Organ J. 2008 Sep;1(9):145-55. doi: 10.1097/WOX.0b013e318186fb3a.

21.

Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis.

Vadas P, Gold M, Perelman B, Liss GM, Lack G, Blyth T, Simons FE, Simons KJ, Cass D, Yeung J.

N Engl J Med. 2008 Jan 3;358(1):28-35. doi: 10.1056/NEJMoa070030.

22.

Relevance of H1-receptor occupancy to H1-antihistamine dosing in children.

Simons KJ, Benedetti MS, Simons FE, Gillard M, Baltes E.

J Allergy Clin Immunol. 2007 Jun;119(6):1551-4. No abstract available.

PMID:
17556060
23.

Fast-disintegrating sublingual epinephrine tablets: effect of tablet dimensions on tablet characteristics.

Rawas-Qalaji MM, Simons FE, Simons KJ.

Drug Dev Ind Pharm. 2007 May;33(5):523-30.

PMID:
17520443
25.

Fast-disintegrating sublingual tablets: effect of epinephrine load on tablet characteristics.

Rawas-Qalaji MM, Simons FE, Simons KJ.

AAPS PharmSciTech. 2006 Apr 28;7(2):E41.

26.

Sublingual epinephrine tablets versus intramuscular injection of epinephrine: dose equivalence for potential treatment of anaphylaxis.

Rawas-Qalaji MM, Simons FE, Simons KJ.

J Allergy Clin Immunol. 2006 Feb;117(2):398-403.

PMID:
16461140
27.

Molecular characterization of the major wheat domestication gene Q.

Simons KJ, Fellers JP, Trick HN, Zhang Z, Tai YS, Gill BS, Faris JD.

Genetics. 2006 Jan;172(1):547-55. Epub 2005 Sep 19.

28.

Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years.

Simons FE, Simons KJ.

J Allergy Clin Immunol. 2005 Aug;116(2):355-61.

PMID:
16083790
29.

Genetic analysis of the species cytoplasm specific gene (scs d) derived from durum wheat.

Gehlhar SB, Simons KJ, Maan SS, Kianian SF.

J Hered. 2005 Jul-Aug;96(4):404-9. Epub 2005 Apr 20.

PMID:
15843637
30.
31.

Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography.

Gu X, Li H, Macnair KR, Simons FE, Simons KJ.

J Pharm Biomed Anal. 2005 Apr 1;37(4):663-7. Epub 2004 Dec 25.

PMID:
15797786
33.

Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine.

Gu X, Fediuk DJ, Simons FE, Simons KJ.

Drug Dev Ind Pharm. 2004;30(10):1009-17.

PMID:
15595567
34.

Constant infusion of epinephrine, but not bolus treatment, improves haemodynamic recovery in anaphylactic shock in dogs.

Mink SN, Simons FE, Simons KJ, Becker AB, Duke K.

Clin Exp Allergy. 2004 Nov;34(11):1776-83.

PMID:
15544604
35.
37.

Detailed mapping of the species cytoplasm-specific (scs) gene in durum wheat.

Simons KJ, Gehlhar SB, Maan SS, Kianian SF.

Genetics. 2003 Dec;165(4):2129-36.

38.

H1-antihistaminic activity of cetirizine and fexofenadine in allergic children.

Simons FE, J Semus M, Goritz SS, Simons KJ.

Pediatr Allergy Immunol. 2003 Jun;14(3):207-11.

PMID:
12787300
39.

Clinical pharmacology of H1-antihistamines in the skin.

Simons FE, Silver NA, Gu X, Simons KJ.

J Allergy Clin Immunol. 2002 Nov;110(5):777-83.

PMID:
12417888
40.

Content analysis of social phobics' discourse in cognitive-behavioral therapy.

Biran MW, Simons KJ, Stiles WB.

Am J Psychother. 2002;56(2):233-43.

PMID:
12125300
41.
42.

Clinical pharmacology of H1-antihistamines.

Simons FE, Simons KJ.

Clin Allergy Immunol. 2002;17:141-78. Review. No abstract available.

PMID:
12113216
43.

Epinephrine fails to hasten hemodynamic recovery in fully developed canine anaphylactic shock.

Bautista E, Simons FE, Simons KJ, Becker AB, Duke K, Tillett M, Kepron W, Mink SN.

Int Arch Allergy Immunol. 2002 Jun;128(2):151-64.

PMID:
12065916
44.

EpiPen Jr versus EpiPen in young children weighing 15 to 30 kg at risk for anaphylaxis.

Simons FE, Gu X, Silver NA, Simons KJ.

J Allergy Clin Immunol. 2002 Jan;109(1):171-5.

PMID:
11799385
45.

Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: is the ampule/syringe/needle method practical?

Simons FE, Chan ES, Gu X, Simons KJ.

J Allergy Clin Immunol. 2001 Dec;108(6):1040-4.

PMID:
11742286
46.

Epinephrine absorption in adults: intramuscular versus subcutaneous injection.

Simons FE, Gu X, Simons KJ.

J Allergy Clin Immunol. 2001 Nov;108(5):871-3.

PMID:
11692118
47.

Skin concentrations of H1-receptor antagonists.

Simons FE, Silver NA, Gu X, Simons KJ.

J Allergy Clin Immunol. 2001 Mar;107(3):526-30.

PMID:
11240955
48.

Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast.

Simons FE, Johnston L, Gu X, Simons KJ.

Ann Allergy Asthma Immunol. 2001 Jan;86(1):44-50.

PMID:
11206237
49.

Can epinephrine inhalations be substituted for epinephrine injection in children at risk for systemic anaphylaxis?

Simons FE, Gu X, Johnston LM, Simons KJ.

Pediatrics. 2000 Nov;106(5):1040-4.

PMID:
11061773
50.

Clinical pharmacology of the H1-receptor antagonists cetirizine and loratadine in children.

Simons FE, Johnston L, Simons KJ.

Pediatr Allergy Immunol. 2000 May;11(2):116-9.

PMID:
10893015

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