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Genetic architecture of human plasma lipidome and its link to cardiovascular disease.

Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M; FinnGen Project, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S.

Nat Commun. 2019 Sep 24;10(1):4329. doi: 10.1038/s41467-019-11954-8.


Daily Walking among Commuters: A Cross-Sectional Study of Associations with Residential, Work, and Regional Accessibility in Melbourne, Australia (2012-2014).

Barr A, Simons K, Mavoa S, Badland H, Giles-Corti B, Scheurer J, Korevaar E, Stewart J, Bentley R.

Environ Health Perspect. 2019 Sep;127(9):97004. doi: 10.1289/EHP3395. Epub 2019 Sep 18.


SAVE-CLC: An Intervention to Reduce Suicide Risk in Older Veterans following Discharge from VA Nursing Facilities.

Luci K, Simons K, Hagemann L, Jacobs ML, Bower ES, Eichorst MK, Hilgeman MM.

Clin Gerontol. 2019 Sep 16:1-8. doi: 10.1080/07317115.2019.1666444. [Epub ahead of print]


miRMap: Profiling 14q32 microRNA Expression and DNA Methylation Throughout the Human Vasculature.

Goossens EAC, de Vries MR, Simons KH, Putter H, Quax PHA, Nossent AY.

Front Cardiovasc Med. 2019 Aug 8;6:113. doi: 10.3389/fcvm.2019.00113. eCollection 2019.


Suzanne Eaton (1959-2019): A pioneer in quantitative tissue morphogenesis.

Knust E, Simons K.

J Cell Biol. 2019 Sep 2;218(9):2819-2821. doi: 10.1083/jcb.201907088. Epub 2019 Aug 22. No abstract available.


Genotypes and Genomic Regions Associated With Rhizoctonia solani Resistance in Common Bean.

Oladzad A, Zitnick-Anderson K, Jain S, Simons K, Osorno JM, McClean PE, Pasche JS.

Front Plant Sci. 2019 Jul 24;10:956. doi: 10.3389/fpls.2019.00956. eCollection 2019.


A feasibility study to investigate post-operative oxygen consumption (POpOC) after colorectal surgery requiring bowel resection.

Taylor HE, Simons K, Willmott C, Smith RER, Bramley DEP.

Pilot Feasibility Stud. 2019 Jul 22;5:94. doi: 10.1186/s40814-019-0477-7. eCollection 2019.


The impact of cultural and linguistic diversity on hospital readmission in patients hospitalised with acute heart failure.

Seman M, Karanatsios B, Simons K, Falls R, Tan N, Wong C, Barrington-Brown C, Cox N, Neil CJ.

Eur Heart J Qual Care Clin Outcomes. 2019 Jul 23. pii: qcz034. doi: 10.1093/ehjqcco/qcz034. [Epub ahead of print]


Choroidal melanoma diagnosed by aspiration cytology: A case report with cyto-histologic correlation and review of the literature.

Abbott DW, Simons K, Giorgadze T.

Ann Diagn Pathol. 2019 Jun 22;42:39-41. doi: 10.1016/j.anndiagpath.2019.06.010. [Epub ahead of print]


External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment.

Wassenaar A, Schoonhoven L, Devlin JW, van Haren FMP, Slooter AJC, Jorens PG, van der Jagt M, Simons KS, Egerod I, Burry LD, Beishuizen A, Matos J, Donders ART, Pickkers P, van den Boogaard M.

Crit Care Med. 2019 Oct;47(10):e827-e835. doi: 10.1097/CCM.0000000000003911.


Reflection on modern methods: when worlds collide-prediction, machine learning and causal inference.

Blakely T, Lynch J, Simons K, Bentley R, Rose S.

Int J Epidemiol. 2019 Jul 11. pii: dyz132. doi: 10.1093/ije/dyz132. [Epub ahead of print]


CD8+ T Cells Protect During Vein Graft Disease Development.

Simons KH, de Vries MR, Peters HAB, Jukema JW, Quax PHA, Arens R.

Front Cardiovasc Med. 2019 Jun 13;6:77. doi: 10.3389/fcvm.2019.00077. eCollection 2019.


Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias.

Rämö JT, Ripatti P, Tabassum R, Söderlund S, Matikainen N, Gerl MJ, Klose C, Surma MA, Stitziel NO, Havulinna AS, Pirinen M, Salomaa V, Freimer NB, Jauhiainen M, Palotie A, Taskinen MR, Simons K, Ripatti S.

J Am Heart Assoc. 2019 Jul 2;8(13):e012415. doi: 10.1161/JAHA.119.012415. Epub 2019 Jun 29.


Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer.

Lee B, Lipton L, Cohen J, Tie J, Javed AA, Li L, Goldstein D, Burge M, Cooray P, Nagrial A, Tebbutt NC, Thomson B, Nikfarjam M, Harris M, Haydon A, Lawrence B, Tai DWM, Simons K, Lennon AM, Wolfgang CL, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P.

Ann Oncol. 2019 Sep 1;30(9):1472-1478. doi: 10.1093/annonc/mdz200.


Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium: Results of the REDUCE Study.

Rood PJT, Zegers M, Slooter AJC, Beishuizen A, Simons KS, van der Voort PHJ, van der Woude MCE, Spronk PE, van der Hoeven JG, Pickkers P, van den Boogaard M.

Anesthesiology. 2019 Aug;131(2):328-335. doi: 10.1097/ALN.0000000000002812.


The Urban Liveability Index: developing a policy-relevant urban liveability composite measure and evaluating associations with transport mode choice.

Higgs C, Badland H, Simons K, Knibbs LD, Giles-Corti B.

Int J Health Geogr. 2019 Jun 11;18(1):14. doi: 10.1186/s12942-019-0178-8.


Safety Planning to Manage Suicide Risk with Older Adults: Case Examples and Recommendations.

Conti EC, Jahn DR, Simons KV, Edinboro LPC, Jacobs ML, Vinson L, Stahl ST, Van Orden KA.

Clin Gerontol. 2019 May 17:1-6. doi: 10.1080/07317115.2019.1611685. [Epub ahead of print]


IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.

Simons KH, de Vries MR, de Jong RCM, Peters HAB, Jukema JW, Quax PHA.

J Cell Mol Med. 2019 Jun;23(6):3888-3896. doi: 10.1111/jcmm.14247. Epub 2019 Apr 1.


The implementation of a multidisciplinary approach for potential organ donors in the emergency department.

Witjes M, Kotsopoulos AMM, Otterspoor L, Herold IHF, Simons KS, Woittiez K, Eijkenboom JJA, van der Hoeven JG, Jansen NE, Abdo WF.

Transplantation. 2019 Mar 12. doi: 10.1097/TP.0000000000002701. [Epub ahead of print]


Successful management of epithelial ingrowth after sequential intracameral 5-fluorouracil and Descemet-stripping automated endothelial keratoplasty.

Koenig SB, Koenig LR, Connor TB, Simons KB.

J Cataract Refract Surg. 2019 May;45(5):690-693. doi: 10.1016/j.jcrs.2018.12.030. Epub 2019 Mar 8.


The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study.

Westerdijk K, Simons KS, Zegers M, Wever PC, Pickkers P, de Jager CPC.

PLoS One. 2019 Feb 27;14(2):e0212861. doi: 10.1371/journal.pone.0212861. eCollection 2019.


Age Differences in Suicide Risk Screening and Management Prior to Suicide Attempts.

Simons K, Van Orden K, Conner KR, Bagge C.

Am J Geriatr Psychiatry. 2019 Jun;27(6):604-608. doi: 10.1016/j.jagp.2019.01.017. Epub 2019 Jan 22.


Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics.

Grzybek M, Palladini A, Alexaki VI, Surma MA, Simons K, Chavakis T, Klose C, Coskun Ü.

Mol Metab. 2019 Apr;22:12-20. doi: 10.1016/j.molmet.2019.01.009. Epub 2019 Jan 30.


T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.

Simons KH, de Jong A, Jukema JW, de Vries MR, Arens R, Quax PHA.

Nat Rev Cardiol. 2019 Jun;16(6):325-343. doi: 10.1038/s41569-019-0164-7. Review.


Registry-based randomized clinical trials as a method to improve cancer care in Australia.

Foroughi S, Wong HL, Gately L, Lee M, Simons K, Tie J, Burgess AW, Gibbs P.

Asia Pac J Clin Oncol. 2019 Jun;15(3):188-189. doi: 10.1111/ajco.13122. Epub 2019 Feb 12. No abstract available.


Lipidomics in Major Depressive Disorder.

Walther A, Cannistraci CV, Simons K, Durán C, Gerl MJ, Wehrli S, Kirschbaum C.

Front Psychiatry. 2018 Oct 15;9:459. doi: 10.3389/fpsyt.2018.00459. eCollection 2018.


In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals.

Rachid O, Simons KJ, Rawas-Qalaji M.

AAPS PharmSciTech. 2018 Nov;19(8):3886-3894. doi: 10.1208/s12249-018-1171-4. Epub 2018 Oct 15.


Noise in the intensive care unit and its influence on sleep quality: a multicenter observational study in Dutch intensive care units.

Simons KS, Verweij E, Lemmens PMC, Jelfs S, Park M, Spronk PE, Sonneveld JPC, Feijen HM, van der Steen MS, Kohlrausch AG, van den Boogaard M, de Jager CPC.

Crit Care. 2018 Oct 5;22(1):250. doi: 10.1186/s13054-018-2182-y.


Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients.

Gerl MJ, Vaz WLC, Domingues N, Klose C, Surma MA, Sampaio JL, Almeida MS, Rodrigues G, Araújo-Gonçalves P, Ferreira J, Borbinha C, Marto JP, Viana-Baptista M, Simons K, Vieira OV.

Sci Rep. 2018 Oct 3;8(1):14764. doi: 10.1038/s41598-018-33116-4.


Circulating Small Non-coding RNAs as Biomarkers for Recovery After Exhaustive or Repetitive Exercise.

Håkansson KEJ, Sollie O, Simons KH, Quax PHA, Jensen J, Nossent AY.

Front Physiol. 2018 Aug 22;9:1136. doi: 10.3389/fphys.2018.01136. eCollection 2018.


Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure.

Nieto-Garai JA, Glass B, Bunn C, Giese M, Jennings G, Brankatschk B, Agarwal S, Börner K, Contreras FX, Knölker HJ, Zankl C, Simons K, Schroeder C, Lorizate M, Kräusslich HG.

Front Immunol. 2018 Sep 4;9:1983. doi: 10.3389/fimmu.2018.01983. eCollection 2018.


The impact of social housing on mental health: longitudinal analyses using marginal structural models and machine learning-generated weights.

Bentley R, Baker E, Simons K, Simpson JA, Blakely T.

Int J Epidemiol. 2018 Oct 1;47(5):1414-1422. doi: 10.1093/ije/dyy116.


Re-inventing the randomized controlled trial in medical oncology: The registry-based trial.

Foroughi S, Wong HL, Gately L, Lee M, Simons K, Tie J, Burgess AW, Gibbs P.

Asia Pac J Clin Oncol. 2018 Dec;14(6):365-373. doi: 10.1111/ajco.12992. Epub 2018 Jun 26. Review.


High-resolution crossover mapping reveals similarities and differences of male and female recombination in maize.

Kianian PMA, Wang M, Simons K, Ghavami F, He Y, Dukowic-Schulze S, Sundararajan A, Sun Q, Pillardy J, Mudge J, Chen C, Kianian SF, Pawlowski WP.

Nat Commun. 2018 Jun 18;9(1):2370. doi: 10.1038/s41467-018-04562-5.


The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.

Simons KH, de Vries MR, Peters HAB, Hamming JF, Jukema JW, Quax PHA.

J Mol Cell Cardiol. 2018 Aug;121:16-24. doi: 10.1016/j.yjmcc.2018.06.001. Epub 2018 Jun 4.


Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study.

Simons KS, van den Boogaard M, Hendriksen E, Gerretsen J, van der Hoeven JG, Pickkers P, de Jager CPC.

Crit Care. 2018 May 25;22(1):137. doi: 10.1186/s13054-018-2054-5.


Delirium prediction in the intensive care unit: comparison of two delirium prediction models.

Wassenaar A, Schoonhoven L, Devlin JW, van Haren FMP, Slooter AJC, Jorens PG, van der Jagt M, Simons KS, Egerod I, Burry LD, Beishuizen A, Matos J, Donders ART, Pickkers P, van den Boogaard M.

Crit Care. 2018 May 5;22(1):114. doi: 10.1186/s13054-018-2037-6.


Effect of Dynamic Light Application on Cognitive Performance and Well-being of Intensive Care Nurses.

Simons KS, Boeijen ERK, Mertens MC, Rood P, de Jager CPC, van den Boogaard M.

Am J Crit Care. 2018 May;27(3):245-248. doi: 10.4037/ajcc2018908.


The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis.

Simons KH, Aref Z, Peters HAB, Welten SP, Nossent AY, Jukema JW, Hamming JF, Arens R, de Vries MR, Quax PHA.

Int J Cardiol. 2018 Jun 1;260:184-190. doi: 10.1016/j.ijcard.2018.02.015.


Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial.

van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators, van der Woude MCE, Besselink A, Hofstra LS, Spronk PE, van den Bergh W, Donker DW, Fuchs M, Karakus A, Koeman M, van Duijnhoven M, Hannink G.

JAMA. 2018 Feb 20;319(7):680-690. doi: 10.1001/jama.2018.0160. Erratum in: JAMA. 2018 Apr 10;319(14):1510.


Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use.

Rachid O, Rawas-Qalaji M, Simons KJ.

Pharmaceutics. 2018 Feb 11;10(1). pii: E24. doi: 10.3390/pharmaceutics10010024.


Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study.

Tie J, Cohen JD, Wang Y, Li L, Christie M, Simons K, Elsaleh H, Kosmider S, Wong R, Yip D, Lee M, Tran B, Rangiah D, Burge M, Goldstein D, Singh M, Skinner I, Faragher I, Croxford M, Bampton C, Haydon A, Jones IT, S Karapetis C, Price T, Schaefer MJ, Ptak J, Dobbyn L, Silliman N, Kinde I, Tomasetti C, Papadopoulos N, Kinzler K, Volgestein B, Gibbs P.

Gut. 2019 Apr;68(4):663-671. doi: 10.1136/gutjnl-2017-315852. Epub 2018 Feb 2.


How Can Omic Science be Improved?

Simons K.

Proteomics. 2018 Mar;18(5-6):e1800039. doi: 10.1002/pmic.201800039. Epub 2018 Mar 2.


Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T.

Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.


Comparative long-term trend analysis of daily weather conditions with daily pollen concentrations in Brussels, Belgium.

Bruffaerts N, De Smedt T, Delcloo A, Simons K, Hoebeke L, Verstraeten C, Van Nieuwenhuyse A, Packeu A, Hendrickx M.

Int J Biometeorol. 2018 Mar;62(3):483-491. doi: 10.1007/s00484-017-1457-3. Epub 2017 Oct 24.


A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons.

Simons KH, Peters HAB, Jukema JW, de Vries MR, Quax PHA.

J Intern Med. 2017 Dec;282(6):522-536. doi: 10.1111/joim.12679. Epub 2017 Sep 27.


Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments.

Sezgin E, Azbazdar Y, Ng XW, Teh C, Simons K, Weidinger G, Wohland T, Eggeling C, Ozhan G.

FEBS J. 2017 Aug;284(15):2513-2526. doi: 10.1111/febs.14139. Epub 2017 Jul 6.


Heritability and responses to high fat diet of plasma lipidomics in a twin study.

Frahnow T, Osterhoff MA, Hornemann S, Kruse M, Surma MA, Klose C, Simons K, Pfeiffer AFH.

Sci Rep. 2017 Jun 16;7(1):3750. doi: 10.1038/s41598-017-03965-6.


A PC-based shutter glasses controller for visual stimulation using multithreading in LabWindows/CVI.

Gramatikov I, Simons K, Guyton D, Gramatikov B.

Comput Methods Programs Biomed. 2017 May;143:151-158. doi: 10.1016/j.cmpb.2017.03.008. Epub 2017 Mar 10.


The Influence of End-of-Life Care on Organ Donor Potential.

Witjes M, Kotsopoulos A, Herold IHF, Otterspoor L, Simons KS, van Vliet J, de Blauw M, Festen B, Eijkenboom JJA, Jansen NE, van der Hoeven JG, Abdo WF.

Am J Transplant. 2017 Jul;17(7):1922-1927. doi: 10.1111/ajt.14286. Epub 2017 May 2.

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