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Intratumoral genetic and functional heterogeneity in pediatric glioblastoma.

Hoffman M, Gillmor A, Kunz DJ, Johnston MJ, Nikolic A, Narta K, Zarrei M, King JC, Ellestad K, Dang NH, Cavalli FMG, Kushida M, Coutinho FJ, Zhu Y, Luu B, Ma Y, Mungall AJ, Moore RA, Marra MA, Taylor MD, Pugh TJ, Dirks PB, Strother D, Lafay-Cousin L, Resnick AC, Scherer SW, Senger DL, Simons BD, Chan JA, Morrissy AS, Gallo M.

Cancer Res. 2019 Mar 15. pii: canres.3441.2018. doi: 10.1158/0008-5472.CAN-18-3441. [Epub ahead of print]


Crypt fusion as a homeostatic mechanism in the human colon.

Baker AM, Gabbutt C, Williams MJ, Cereser B, Jawad N, Rodriguez-Justo M, Jansen M, Barnes CP, Simons BD, McDonald SA, Graham TA, Wright NA.

Gut. 2019 Mar 14. pii: gutjnl-2018-317540. doi: 10.1136/gutjnl-2018-317540. [Epub ahead of print]


The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism.

Jörg DJ, Caygill EE, Hakes AE, Contreras EG, Brand AH, Simons BD.

Elife. 2019 Feb 22;8. pii: e40919. doi: 10.7554/eLife.40919.


A single-cell molecular map of mouse gastrulation and early organogenesis.

Pijuan-Sala B, Griffiths JA, Guibentif C, Hiscock TW, Jawaid W, Calero-Nieto FJ, Mulas C, Ibarra-Soria X, Tyser RCV, Ho DLL, Reik W, Srinivas S, Simons BD, Nichols J, Marioni JC, Göttgens B.

Nature. 2019 Feb;566(7745):490-495. doi: 10.1038/s41586-019-0933-9. Epub 2019 Feb 20.


Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.

Kitadate Y, Jörg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C, Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto Y, Takahashi S, Simons BD, Yoshida S.

Cell Stem Cell. 2019 Jan 3;24(1):79-92.e6. doi: 10.1016/j.stem.2018.11.013. Epub 2018 Dec 20.


Statistical theory of branching morphogenesis.

Hannezo E, Simons BD.

Dev Growth Differ. 2018 Dec;60(9):512-521. doi: 10.1111/dgd.12570. Epub 2018 Oct 24. Review.


Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate.

Tischler J, Gruhn WH, Reid J, Allgeyer E, Buettner F, Marr C, Theis F, Simons BD, Wernisch L, Surani MA.

EMBO J. 2019 Jan 3;38(1). pii: e99518. doi: 10.15252/embj.201899518. Epub 2018 Sep 26.


Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Sznurkowska MK, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley CJ, Nichols J, Göttgens B, Huch M, Philpott A, Simons BD.

Dev Cell. 2018 Aug 6;46(3):360-375.e5. doi: 10.1016/j.devcel.2018.06.028. Epub 2018 Jul 26.


Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Rulands S, Lee HJ, Clark SJ, Angermueller C, Smallwood SA, Krueger F, Mohammed H, Dean W, Nichols J, Rugg-Gunn P, Kelsey G, Stegle O, Simons BD, Reik W.

Cell Syst. 2018 Jul 25;7(1):63-76.e12. doi: 10.1016/j.cels.2018.06.012.


Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland.

Lilja AM, Rodilla V, Huyghe M, Hannezo E, Landragin C, Renaud O, Leroy O, Rulands S, Simons BD, Fre S.

Nat Cell Biol. 2018 Jun;20(6):677-687. doi: 10.1038/s41556-018-0108-1. Epub 2018 May 21.


The developmental origin of brain tumours: a cellular and molecular framework.

Azzarelli R, Simons BD, Philpott A.

Development. 2018 May 14;145(10). pii: dev162693. doi: 10.1242/dev.162693. Review.


Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

Stamp C, Zupanic A, Sachdeva A, Stoll EA, Shanley DP, Mathers JC, Kirkwood TBL, Heer R, Simons BD, Turnbull DM, Greaves LC.

EBioMedicine. 2018 May;31:166-173. doi: 10.1016/j.ebiom.2018.04.017. Epub 2018 Apr 25.


Universality of clone dynamics during tissue development.

Rulands S, Lescroart F, Chabab S, Hindley CJ, Prior N, Sznurkowska MK, Huch M, Philpott A, Blanpain C, Simons BD.

Nat Phys. 2018 May;14(5):469-474. doi: 10.1038/s41567-018-0055-6. Epub 2018 Feb 26.


Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta.

Lee CQE, Turco MY, Gardner L, Simons BD, Hemberger M, Moffett A.

Development. 2018 Apr 16;145(16). pii: dev162305. doi: 10.1242/dev.162305.


Live imaging of neurogenesis in the adult mouse hippocampus.

Pilz GA, Bottes S, Betizeau M, Jörg DJ, Carta S, Simons BD, Helmchen F, Jessberger S.

Science. 2018 Feb 9;359(6376):658-662. doi: 10.1126/science.aao5056.


Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.

Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, Jörg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, Göttgens B, Marioni JC.

Nat Cell Biol. 2018 Feb;20(2):127-134. doi: 10.1038/s41556-017-0013-z. Epub 2018 Jan 8.


Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.

Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E610-E619. doi: 10.1073/pnas.1715911114. Epub 2018 Jan 8.


Muscle Stem Cells Exhibit Distinct Clonal Dynamics in Response to Tissue Repair and Homeostatic Aging.

Tierney MT, Stec MJ, Rulands S, Simons BD, Sacco A.

Cell Stem Cell. 2018 Jan 4;22(1):119-127.e3. doi: 10.1016/j.stem.2017.11.009. Epub 2017 Dec 14.


A Unifying Theory of Branching Morphogenesis.

Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD.

Cell. 2017 Sep 21;171(1):242-255.e27. doi: 10.1016/j.cell.2017.08.026.


Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, Luu B, Carles A, Moksa M, Rastegar N, Head R, Dolma S, Prinos P, Cusimano MD, Das S, Bernstein M, Arrowsmith CH, Mungall AJ, Moore RA, Ma Y, Gallo M, Lupien M, Pugh TJ, Taylor MD, Hirst M, Eaves CJ, Simons BD, Dirks PB.

Nature. 2017 Sep 14;549(7671):227-232. doi: 10.1038/nature23666. Epub 2017 Aug 30.


Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates.

Moad M, Hannezo E, Buczacki SJ, Wilson L, El-Sherif A, Sims D, Pickard R, Wright NA, Williamson SC, Turnbull DM, Taylor RW, Greaves L, Robson CN, Simons BD, Heer R.

Cell Rep. 2017 Aug 15;20(7):1609-1622. doi: 10.1016/j.celrep.2017.07.061.


Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A.

Dev Cell. 2017 May 8;41(3):274-286.e5. doi: 10.1016/j.devcel.2017.04.004. Epub 2017 Apr 27.


Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium.

Turco MY, Gardner L, Hughes J, Cindrova-Davies T, Gomez MJ, Farrell L, Hollinshead M, Marsh SGE, Brosens JJ, Critchley HO, Simons BD, Hemberger M, Koo BK, Moffett A, Burton GJ.

Nat Cell Biol. 2017 May;19(5):568-577. doi: 10.1038/ncb3516. Epub 2017 Apr 10.


Defining stem cell dynamics and migration during wound healing in mouse skin epidermis.

Aragona M, Dekoninck S, Rulands S, Lenglez S, Mascré G, Simons BD, Blanpain C.

Nat Commun. 2017 Mar 1;8:14684. doi: 10.1038/ncomms14684.


Identity and dynamics of mammary stem cells during branching morphogenesis.

Scheele CL, Hannezo E, Muraro MJ, Zomer A, Langedijk NS, van Oudenaarden A, Simons BD, van Rheenen J.

Nature. 2017 Feb 16;542(7641):313-317. doi: 10.1038/nature21046. Epub 2017 Jan 30.


Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models.

Chappell J, Harman JL, Narasimhan VM, Yu H, Foote K, Simons BD, Bennett MR, Jørgensen HF.

Circ Res. 2016 Dec 9;119(12):1313-1323. Epub 2016 Sep 28.


A single dividing cell population with imbalanced fate drives oesophageal tumour growth.

Frede J, Greulich P, Nagy T, Simons BD, Jones PH.

Nat Cell Biol. 2016 Sep;18(9):967-78. doi: 10.1038/ncb3400. Epub 2016 Aug 22.


Tracing cellular dynamics in tissue development, maintenance and disease.

Rulands S, Simons BD.

Curr Opin Cell Biol. 2016 Dec;43:38-45. doi: 10.1016/ Epub 2016 Jul 27. Review.


Defining the clonal dynamics leading to mouse skin tumour initiation.

Sánchez-Danés A, Hannezo E, Larsimont JC, Liagre M, Youssef KK, Simons BD, Blanpain C.

Nature. 2016 Aug 18;536(7616):298-303. Epub 2016 Jul 8.


Dynamic heterogeneity as a strategy of stem cell self-renewal.

Greulich P, Simons BD.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7509-14. doi: 10.1073/pnas.1602779113. Epub 2016 Jun 16.


Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.

Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR.

Development. 2016 Jul 15;143(14):2522-35. doi: 10.1242/dev.131797. Epub 2016 Jun 10.


Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells.

Wuidart A, Ousset M, Rulands S, Simons BD, Van Keymeulen A, Blanpain C.

Genes Dev. 2016 Jun 1;30(11):1261-77. doi: 10.1101/gad.280057.116. Epub 2016 Jun 9.


2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.

Otani T, Marchetto MC, Gage FH, Simons BD, Livesey FJ.

Cell Stem Cell. 2016 Apr 7;18(4):467-80. doi: 10.1016/j.stem.2016.03.003. Epub 2016 Mar 31.


The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue.

Wan Y, Almeida AD, Rulands S, Chalour N, Muresan L, Wu Y, Simons BD, He J, Harris WA.

Development. 2016 Apr 1;143(7):1099-107. doi: 10.1242/dev.133314. Epub 2016 Feb 18.


Reply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking.

Simons BD.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1130-1. doi: 10.1073/pnas.1601045113. Epub 2016 Feb 16. No abstract available.


Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis.

Chabab S, Lescroart F, Rulands S, Mathiah N, Simons BD, Blanpain C.

Cell Rep. 2016 Jan 5;14(1):1-10. doi: 10.1016/j.celrep.2015.12.013. Epub 2015 Dec 24.


Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis.

Simons BD.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):128-33. doi: 10.1073/pnas.1516123113. Epub 2015 Dec 22.


Human keratinocytes have two interconvertible modes of proliferation.

Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V, Jones PH.

Nat Cell Biol. 2016 Feb;18(2):145-56. doi: 10.1038/ncb3282. Epub 2015 Dec 7.


Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.

Füllgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgård R, Kasper M.

Stem Cell Reports. 2015 Nov 10;5(5):843-855. doi: 10.1016/j.stemcr.2015.09.013.


Stem and progenitor cell division kinetics during postnatal mouse mammary gland development.

Giraddi RR, Shehata M, Gallardo M, Blasco MA, Simons BD, Stingl J.

Nat Commun. 2015 Oct 29;6:8487. doi: 10.1038/ncomms9487.


The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina.

Boije H, Rulands S, Dudczig S, Simons BD, Harris WA.

Dev Cell. 2015 Sep 14;34(5):532-43. doi: 10.1016/j.devcel.2015.08.011. Epub 2015 Sep 3.


Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner.

Kolahgar G, Suijkerbuijk SJ, Kucinski I, Poirier EZ, Mansour S, Simons BD, Piddini E.

Dev Cell. 2015 Aug 10;34(3):297-309. doi: 10.1016/j.devcel.2015.06.010. Epub 2015 Jul 23.


Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.

Watson JK, Rulands S, Wilkinson AC, Wuidart A, Ousset M, Van Keymeulen A, Göttgens B, Blanpain C, Simons BD, Rawlins EL.

Cell Rep. 2015 Jul 7;12(1):90-101. doi: 10.1016/j.celrep.2015.06.011. Epub 2015 Jun 25.


Dynamic stem cell heterogeneity.

Krieger T, Simons BD.

Development. 2015 Apr 15;142(8):1396-406. doi: 10.1242/dev.101063. Review.


Deterministic progenitor behavior and unitary production of neurons in the neocortex.

Gao P, Postiglione MP, Krieger TG, Hernandez L, Wang C, Han Z, Streicher C, Papusheva E, Insolera R, Chugh K, Kodish O, Huang K, Simons BD, Luo L, Hippenmeyer S, Shi SH.

Cell. 2014 Nov 6;159(4):775-88. doi: 10.1016/j.cell.2014.10.027.


Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.

Lescroart F, Chabab S, Lin X, Rulands S, Paulissen C, Rodolosse A, Auer H, Achouri Y, Dubois C, Bondue A, Simons BD, Blanpain C.

Nat Cell Biol. 2014 Sep;16(9):829-40. doi: 10.1038/ncb3024. Epub 2014 Aug 24.


Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina.

Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J.

Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892. Epub 2014 Aug 19.


Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SA, Wright NA, Simons BD, Jansen M, Graham TA.

Cell Rep. 2014 Aug 21;8(4):940-7. doi: 10.1016/j.celrep.2014.07.019. Epub 2014 Aug 7.


Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo.

Amoyel M, Simons BD, Bach EA.

EMBO J. 2014 Oct 16;33(20):2295-313. doi: 10.15252/embj.201387500. Epub 2014 Aug 4.


Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.

Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD, Jones PH.

Nat Cell Biol. 2014 Jun;16(6):615-22. doi: 10.1038/ncb2963. Epub 2014 May 11.

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