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Items: 45


Pharmacological modulation of the ER stress response ameliorates oculopharyngeal muscular dystrophy.

Malerba A, Roth F, Harish P, Dhiab J, Lu-Nguyen N, Cappellari O, Jarmin S, Mahoudeau A, Ythier V, Lainé J, Negroni E, Abgueguen E, Simonelig M, Guedat P, Mouly V, Butler-Browne G, Voisset C, Dickson G, Trollet C.

Hum Mol Genet. 2019 May 15;28(10):1694-1708. doi: 10.1093/hmg/ddz007.


piRNAs and PIWI proteins: regulators of gene expression in development and stem cells.

Rojas-Ríos P, Simonelig M.

Development. 2018 Sep 7;145(17). pii: dev161786. doi: 10.1242/dev.161786. Review.


Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.

Coll O, Guitart T, Villalba A, Papin C, Simonelig M, Gebauer F.

RNA. 2018 Apr;24(4):529-539. doi: 10.1261/rna.065417.117. Epub 2018 Jan 9.


iCLIP of the PIWI Protein Aubergine in Drosophila Embryos.

Barckmann B, Dufourt J, Simonelig M.

Methods Mol Biol. 2018;1720:89-110. doi: 10.1007/978-1-4939-7540-2_7.


piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm.

Dufourt J, Bontonou G, Chartier A, Jahan C, Meunier AC, Pierson S, Harrison PF, Papin C, Beilharz TH, Simonelig M.

Nat Commun. 2017 Nov 3;8(1):1305. doi: 10.1038/s41467-017-01431-5.


Aubergine and piRNAs promote germline stem cell self-renewal by repressing the proto-oncogene Cbl.

Rojas-Ríos P, Chartier A, Pierson S, Simonelig M.

EMBO J. 2017 Nov 2;36(21):3194-3211. doi: 10.15252/embj.201797259. Epub 2017 Oct 13.


Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch.

Götze M, Dufourt J, Ihling C, Rammelt C, Pierson S, Sambrani N, Temme C, Sinz A, Simonelig M, Wahle E.

RNA. 2017 Oct;23(10):1552-1568. doi: 10.1261/rna.062208.117. Epub 2017 Jul 12.


Measurement of mRNA Poly(A) Tail Lengths in Drosophila Female Germ Cells and Germ-Line Stem Cells.

Chartier A, Joly W, Simonelig M.

Methods Mol Biol. 2017;1463:93-102.


Translational Control of Autophagy by Orb in the Drosophila Germline.

Rojas-Ríos P, Chartier A, Pierson S, Séverac D, Dantec C, Busseau I, Simonelig M.

Dev Cell. 2015 Dec 7;35(5):622-631. doi: 10.1016/j.devcel.2015.11.003. Epub 2015 Nov 25.


Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo.

Barckmann B, Pierson S, Dufourt J, Papin C, Armenise C, Port F, Grentzinger T, Chambeyron S, Baronian G, Desvignes JP, Curk T, Simonelig M.

Cell Rep. 2015 Aug 18;12(7):1205-16. doi: 10.1016/j.celrep.2015.07.030. Epub 2015 Aug 6.


Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis.

Chartier A, Klein P, Pierson S, Barbezier N, Gidaro T, Casas F, Carberry S, Dowling P, Maynadier L, Bellec M, Oloko M, Jardel C, Moritz B, Dickson G, Mouly V, Ohlendieck K, Butler-Browne G, Trollet C, Simonelig M.

PLoS Genet. 2015 Mar 27;11(3):e1005092. doi: 10.1371/journal.pgen.1005092. eCollection 2015 Mar.


piRNAs, master regulators of gene expression.

Simonelig M.

Cell Res. 2014 Jul;24(7):779-80. doi: 10.1038/cr.2014.78. Epub 2014 Jun 20.


Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects.

Temme C, Simonelig M, Wahle E.

Front Genet. 2014 May 26;5:143. doi: 10.3389/fgene.2014.00143. eCollection 2014. Review.


The CCR4 deadenylase acts with Nanos and Pumilio in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal.

Joly W, Chartier A, Rojas-Rios P, Busseau I, Simonelig M.

Stem Cell Reports. 2013 Nov 7;1(5):411-24. doi: 10.1016/j.stemcr.2013.09.007. eCollection 2013.


Animal models in therapeutic drug discovery for oculopharyngeal muscular dystrophy.

Chartier A, Simonelig M.

Drug Discov Today Technol. 2013 Spring;10(1):e103-8. doi: 10.1016/j.ddtec.2012.07.002. Review.


Control of maternal mRNA stability in germ cells and early embryos.

Barckmann B, Simonelig M.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):714-24. doi: 10.1016/j.bbagrm.2012.12.011. Epub 2013 Jan 5. Review.


PABPN1 shuts down alternative poly(A) sites.

Simonelig M.

Cell Res. 2012 Oct;22(10):1419-21. doi: 10.1038/cr.2012.86. Epub 2012 May 29.


Maternal-to-zygotic transition: soma versus germline.

Simonelig M.

Genome Biol. 2012 Feb 22;13(2):145. doi: 10.1186/gb-2012-13-2-145.


[Embryonic development is controlled by small non-coding RNAs derived from transposable elements].

Papin C, Simonelig M.

Med Sci (Paris). 2011 Dec;27(12):1050-2. doi: 10.1051/medsci/20112712004. Epub 2011 Dec 23. Review. French. No abstract available.


Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients.

Anvar SY, 't Hoen PA, Venema A, van der Sluijs B, van Engelen B, Snoeck M, Vissing J, Trollet C, Dickson G, Chartier A, Simonelig M, van Ommen GJ, van der Maarel SM, Raz V.

Skelet Muscle. 2011 Apr 4;1(1):15. doi: 10.1186/2044-5040-1-15.


Developmental functions of piRNAs and transposable elements: a Drosophila point-of-view.

Simonelig M.

RNA Biol. 2011 Sep-Oct;8(5):754-9. doi: 10.4161/rna.8.5.16042. Epub 2011 Jul 19.


Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy.

Barbezier N, Chartier A, Bidet Y, Buttstedt A, Voisset C, Galons H, Blondel M, Schwarz E, Simonelig M.

EMBO Mol Med. 2011 Jan;3(1):35-49. doi: 10.1002/emmm.201000109.


Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.

Rouget C, Papin C, Boureux A, Meunier AC, Franco B, Robine N, Lai EC, Pelisson A, Simonelig M.

Nature. 2010 Oct 28;467(7319):1128-32. doi: 10.1038/nature09465. Epub 2010 Oct 17.


Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.

Temme C, Zhang L, Kremmer E, Ihling C, Chartier A, Sinz A, Simonelig M, Wahle E.

RNA. 2010 Jul;16(7):1356-70. doi: 10.1261/rna.2145110. Epub 2010 May 26.


Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo.

Chartier A, Raz V, Sterrenburg E, Verrips CT, van der Maarel SM, Simonelig M.

Hum Mol Genet. 2009 May 15;18(10):1849-59. doi: 10.1093/hmg/ddp101. Epub 2009 Mar 3.


PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila.

Benoit P, Papin C, Kwak JE, Wickens M, Simonelig M.

Development. 2008 Jun;135(11):1969-79. doi: 10.1242/dev.021444. Epub 2008 Apr 23.


Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.

Chicoine J, Benoit P, Gamberi C, Paliouras M, Simonelig M, Lasko P.

Dev Cell. 2007 Nov;13(5):691-704.


Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4.

Zaessinger S, Busseau I, Simonelig M.

Development. 2006 Nov;133(22):4573-83. Epub 2006 Oct 18.


A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1.

Chartier A, Benoit B, Simonelig M.

EMBO J. 2006 May 17;25(10):2253-62. Epub 2006 Apr 27.


An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila.

Benoit B, Mitou G, Chartier A, Temme C, Zaessinger S, Wahle E, Busseau I, Simonelig M.

Dev Cell. 2005 Oct;9(4):511-22.


A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila.

Temme C, Zaessinger S, Meyer S, Simonelig M, Wahle E.

EMBO J. 2004 Jul 21;23(14):2862-71. Epub 2004 Jun 24.


Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila.

Juge F, Zaessinger S, Temme C, Wahle E, Simonelig M.

EMBO J. 2002 Dec 2;21(23):6603-13.


Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.

Benoit B, Juge F, Iral F, Audibert A, Simonelig M.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10593-8. Epub 2002 Jul 29.


Detection of mitotic spindles in third-instar imaginal discs of Drosophila melanogaster.

Audibert A, Debec A, Simonelig M.

Trends Genet. 1996 Nov;12(11):452-3. No abstract available.


Drosophila P element: transposition, regulation and evolution.

Coen D, Lemaitre B, Delattre M, Quesneville H, Ronsseray S, Simonelig M, Higuet D, Lehmann M, Montchamp C, Nouaud D, et al.

Genetica. 1994;93(1-3):61-78. Review. No abstract available.


I elements and the Drosophila genome.

Bucheton A, Vaury C, Chaboissier MC, Abad P, Pélisson A, Simonelig M.

Genetica. 1992;86(1-3):175-90. Review.


A P element of Scaptomyza pallida is active in Drosophila melanogaster.

Simonelig M, Anxolabéhère D.

Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6102-6.

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