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Associations between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Liver Cancer Among Post-Menopausal Women.

Petrick JL, Florio AA, Zhang X, Zeleniuch-Jacquotte A, Wactawski-Wende J, Van Den Eeden SK, Stanczyk FZ, Simon TG, Sinha R, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Purdue MP, Palmer JR, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Kirsh VA, Hofmann JN, Guillemette C, Graubard BI, Giovannucci E, Gaziano JM, Gapster SM, Freedman ND, Engel LS, Chong DQ, Chen Y, Chan AT, Caron P, Buring JE, Bradwin G, Beane Freeman LE, Campbell PT, McGlynn KA.

Hepatology. 2019 Dec 5. doi: 10.1002/hep.31057. [Epub ahead of print]


Manufacturing of plasma-derived C1-inhibitor concentrate for treatment of patients with hereditary angioedema.

Simon TL, Kalina U, Laske R, Mycroft S, Widmer E, Roth NJ.

Allergy Asthma Proc. 2019 Dec 3. doi: 10.2500/aap.2020.41.190021. [Epub ahead of print]


Safety of Abatacept Versus Placebo in Rheumatoid Arthritis: Integrated Data Analysis of Nine Clinical Trials.

Simon TA, Soule BP, Hochberg M, Fleming D, Torbeyns A, Banerjee S, Boers M.

ACR Open Rheumatol. 2019 May 29;1(4):251-257. doi: 10.1002/acr2.1034. eCollection 2019 Jun.


In-hospital outcomes and 5-year mortality following an acute myocardial infarction in patients with a history of cancer: Results from the French registry on Acute ST-elevation or non-ST-elevation myocardial infarction (FAST-MI) 2005 cohort.

Ederhy S, Cohen A, Boccara F, Puymirat E, Aissaoui N, Elbaz M, Bonnefoy-Cudraz E, Druelles P, Andrieu S, Angoulvant D, Furber A, Ferrières J, Schiele F, Cottin Y, Simon T, Danchin N; FAST-MI investigators.

Arch Cardiovasc Dis. 2019 Nov;112(11):657-669. doi: 10.1016/j.acvd.2019.06.012. Epub 2019 Nov 21.


Seeing Eye to Eye With Threat: Atypical Threat Bias in Children With 22q11.2 Deletion Syndrome.

Popa AM, Cruz JR, Wong LM, Harvey DJ, Angkustsiri K, Leckliter IN, Perez-Edgar K, Simon TJ.

Am J Intellect Dev Disabil. 2019 Nov;124(6):549-567. doi: 10.1352/1944-7558-124.6.549.


Cysteamine-capped gold-copper nanoclusters for fluorometric determination and imaging of chromium(VI) and dopamine.

Shellaiah M, Simon T, Thirumalaivasan N, Sun KW, Ko FH, Wu SP.

Mikrochim Acta. 2019 Nov 15;186(12):788. doi: 10.1007/s00604-019-3974-8.


Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.

Pocock SJ, Brieger D, Gregson J, Chen JY, Cohen MG, Goodman SG, Granger CB, Grieve R, Nicolau JC, Simon T, Westermann D, Yasuda S, Hedman K, Rennie KL, Sundell KA; TIGRIS Study Investigators.

Clin Cardiol. 2019 Nov 12. doi: 10.1002/clc.23283. [Epub ahead of print]


Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes.

Guyot M, Simon T, Ceppo F, Panzolini C, Guyon A, Lavergne J, Murris E, Daoudlarian D, Brusini R, Zarif H, Abélanet S, Hugues-Ascery S, Divoux JL, Lewis SJ, Sridhar A, Glaichenhaus N, Blancou P.

Nat Biotechnol. 2019 Dec;37(12):1446-1451. doi: 10.1038/s41587-019-0295-8. Epub 2019 Nov 11.


High-quality cooperative research: studies that represent a triumph in the rheumatology community.

Simon TA.

Arthritis Res Ther. 2019 Nov 11;21(1):232. doi: 10.1186/s13075-019-2024-6.


Comparative risk of malignancies and infections in patients with rheumatoid arthritis initiating abatacept versus other biologics: a multi-database real-world study.

Simon TA, Boers M, Hochberg M, Baker N, Skovron ML, Ray N, Singhal S, Suissa S, Gomez-Caminero A.

Arthritis Res Ther. 2019 Nov 8;21(1):228. doi: 10.1186/s13075-019-1992-x.


Vital Signs: Estimated Proportion of Adult Health Problems Attributable to Adverse Childhood Experiences and Implications for Prevention - 25 States, 2015-2017.

Merrick MT, Ford DC, Ports KA, Guinn AS, Chen J, Klevens J, Metzler M, Jones CM, Simon TR, Daniel VM, Ottley P, Mercy JA.

MMWR Morb Mortal Wkly Rep. 2019 Nov 8;68(44):999-1005. doi: 10.15585/mmwr.mm6844e1.


The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35.

Liu PY, Tee AE, Milazzo G, Hannan KM, Maag J, Mondal S, Atmadibrata B, Bartonicek N, Peng H, Ho N, Mayoh C, Ciaccio R, Sun Y, Henderson MJ, Gao J, Everaert C, Hulme AJ, Wong M, Lan Q, Cheung BB, Shi L, Wang JY, Simon T, Fischer M, Zhang XD, Marshall GM, Norris MD, Haber M, Vandesompele J, Li J, Mestdagh P, Hannan RD, Dinger ME, Perini G, Liu T.

Nat Commun. 2019 Nov 5;10(1):5026. doi: 10.1038/s41467-019-12971-3.


Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women.

Luo X, Sui J, Yang W, Sun Q, Ma Y, Simon TG, Liang G, Meyerhardt JA, Chan AT, Giovannucci EL, Zhang X.

Am J Gastroenterol. 2019 Dec;114(12):1870-1877. doi: 10.14309/ajg.0000000000000450.


Abdominal and Gluteofemoral Size and Risk of Liver Cancer: The Liver Cancer Pooling Project.

Florio AA, Campbell PT, Zhang X, Zeleniuch-Jacquotte A, Wactawski-Wende J, Smith-Warner SA, Sinha R, Simon TG, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Robien K, Renehan AG, Purdue MP, Poynter JN, Palmer JR, Newton CC, Lu Y, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Kirsh VA, Hofmann JN, Graubard BI, Giovannucci E, Gaziano JM, Gapstur SM, Freedman ND, Demuth J, Chong DQ, Chan AT, Buring JE, Bradshaw PT, Beane Freeman LE, McGlynn KA, Petrick JL.

Int J Cancer. 2019 Nov 2. doi: 10.1002/ijc.32760. [Epub ahead of print]


Development of Chronic Pseudomonas aeruginosa-Positive Respiratory Cultures in Children with Tracheostomy.

Russell CJ, Simon TD, Neely MN.

Lung. 2019 Dec;197(6):811-817. doi: 10.1007/s00408-019-00285-6. Epub 2019 Oct 31.


Does A Longer Waiting Period After Neoadjuvant Radio-chemotherapy Improve the Oncological Prognosis of Rectal Cancer?: Three Years' Follow-up Results of the Greccar-6 Randomized Multicenter Trial.

Lefèvre JH, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C, Meunier B, Mehrdad J, Cotte E, Desrame J, Karoui M, Benoist S, Kirzin S, Berger A, Panis Y, Piessen G, Saudemont A, Prudhomme M, Peschaud F, Dubois A, Loriau J, Tuech JJ, Meurette G, Lupinacci R, Goasguen N, Creavin B, Simon T, Parc Y; The French Research Group of Rectal Cancer Surgery (GRECCAR).

Ann Surg. 2019 Nov;270(5):747-754. doi: 10.1097/SLA.0000000000003530.


A new risk score for patients after first recurrence of stage 4 neuroblastoma aged ≥18 months at first diagnosis.

Kreitz K, Ernst A, Schmidt R, Simon T, Fischer M, Volland R, Hero B, Berthold F.

Cancer Med. 2019 Dec;8(17):7236-7243. doi: 10.1002/cam4.2562. Epub 2019 Oct 20.


Vaccination Status and Resource Use During Hospital Visits for Respiratory Illnesses.

Bryan MA, Hofstetter AM, deHart MP, Simon TD, Opel DJ.

Pediatrics. 2019 Nov;144(5). pii: e20190585. doi: 10.1542/peds.2019-0585. Epub 2019 Oct 17.


Prevalence of pulmonary embolism in emergency department patients with isolated syncope: a prospective cohort study.

Raynal PA, Cachanado M, Truchot J, Damas-Perrichet C, Feral-Pierssens AL, Goulet H, Deltour S, Boussouar S, Donciu V, Simon T, Freund Y, Philippon AL.

Eur J Emerg Med. 2019 Dec;26(6):458-461. doi: 10.1097/MEJ.0000000000000625.


When less is more: dosing simvastatin in decompensated cirrhosis.

Simon TG.

Lancet Gastroenterol Hepatol. 2020 Jan;5(1):3-5. doi: 10.1016/S2468-1253(19)30321-8. Epub 2019 Oct 10. No abstract available.


Correction: Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation.

Berthold F, Ernst A, Hero B, Klingebiel T, Kremens B, Schilling FH, Simon T.

Br J Cancer. 2019 Nov;121(10):894-895. doi: 10.1038/s41416-019-0592-5.


[Nurses' participation in clinical research projects: a cross-sectional study in five hospitals].

Martin M, Bérard L, Simon T, Leblanc J.

Soins. 2019 Sep;64(838):13-19. doi: 10.1016/j.soin.2019.07.003. Review. French.


High-intensity lipid lowering regimens in patients with stable coronary artery disease: the intriguing question of all-cause mortality.

Danchin N, Simon T.

Eur Heart J Cardiovasc Pharmacother. 2019 Sep 20. pii: pvz049. doi: 10.1093/ehjcvp/pvz049. [Epub ahead of print] No abstract available.


Five-year outcomes following timely primary percutaneous intervention, late primary percutaneous intervention, or a pharmaco-invasive strategy in ST-segment elevation myocardial infarction: the FAST-MI programme.

Danchin N, Popovic B, Puymirat E, Goldstein P, Belle L, Cayla G, Roubille F, Lemesle G, Ferrières J, Schiele F, Simon T; FAST-MI Investigators.

Eur Heart J. 2019 Sep 20. pii: ehz665. doi: 10.1093/eurheartj/ehz665. [Epub ahead of print]


Comparative safety of biologic versus conventional synthetic DMARDs in rheumatoid arthritis with COPD: a real-world population study.

Hudson M, Dell'Aniello S, Shen S, Simon TA, Ernst P, Suissa S.

Rheumatology (Oxford). 2019 Sep 3. pii: kez359. doi: 10.1093/rheumatology/kez359. [Epub ahead of print]


Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial.

Bhatt DL, Steg PG, Mehta SR, Leiter LA, Simon T, Fox K, Held C, Andersson M, Himmelmann A, Ridderstråle W, Chen J, Song Y, Diaz R, Goto S, James SK, Ray KK, Parkhomenko AN, Kosiborod MN, McGuire DK, Harrington RA; THEMIS Steering Committee and Investigators.

Lancet. 2019 Sep 28;394(10204):1169-1180. doi: 10.1016/S0140-6736(19)31887-2. Epub 2019 Sep 1.


Implementation of Nurse-Driven HIV Screening Targeting Key Populations in Emergency Departments: A Multilevel Analysis From the DICI-VIH Trial.

Leblanc J, Côté J, Pagé MG, Piquet H, Simon T, Crémieux AC; DICI-VIH (Dépistage Infirmier CIblé du VIH) Group.

Worldviews Evid Based Nurs. 2019 Dec;16(6):444-453. doi: 10.1111/wvn.12393. Epub 2019 Sep 2.


Ticagrelor in Patients with Stable Coronary Disease and Diabetes.

Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, Held C, Andersson M, Himmelmann A, Ridderstråle W, Leonsson-Zachrisson M, Liu Y, Opolski G, Zateyshchikov D, Ge J, Nicolau JC, Corbalán R, Cornel JH, Widimský P, Leiter LA; THEMIS Steering Committee and Investigators.

N Engl J Med. 2019 Oct 3;381(14):1309-1320. doi: 10.1056/NEJMoa1908077. Epub 2019 Sep 1.


In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis.

Gorlier C, Sellam J, Laurans L, Simon T, Giurgea I, Bastard JP, Fellahi S, Deshayes S, Grateau G, Ait Oufella H, Georgin-Lavialle S.

Innate Immun. 2019 Nov;25(8):487-490. doi: 10.1177/1753425919870847. Epub 2019 Aug 31. No abstract available.


Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping.

Lane R, Simon T, Vintu M, Solkin B, Koch B, Stewart N, Benstead-Hume G, Pearl FMG, Critchley G, Stebbing J, Giamas G.

Commun Biol. 2019 Aug 19;2:315. doi: 10.1038/s42003-019-0560-x. eCollection 2019.


Interrelationship Between Cognitive Control, Anxiety, and Restricted and Repetitive Behaviors in Children with 22q11.2 Deletion Syndrome.

Uljarević M, McCabe KL, Angkustsiri K, Simon TJ, Hardan AY.

Autism Res. 2019 Dec;12(12):1737-1744. doi: 10.1002/aur.2194. Epub 2019 Aug 21.


Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.

Desch AK, Hartung K, Botzen A, Brobeil A, Rummel M, Kurch L, Georgi T, Jox T, Bielack S, Burdach S, Classen CF, Claviez A, Debatin KM, Ebinger M, Eggert A, Faber J, Flotho C, Frühwald M, Graf N, Jorch N, Kontny U, Kramm C, Kulozik A, Kühr J, Sykora KW, Metzler M, Müller HL, Nathrath M, Nüßlein T, Paulussen M, Pekrun A, Reinhardt D, Reinhard H, Rössig C, Sauerbrey A, Schlegel PG, Schneider DT, Scheurlen W, Schweigerer L, Simon T, Suttorp M, Vorwerk P, Schmitz R, Kluge R, Mauz-Körholz C, Körholz D, Gattenlöhner S, Bräuninger A.

Leukemia. 2019 Aug 20. doi: 10.1038/s41375-019-0541-6. [Epub ahead of print]


Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population.

Simon TG, Duberg AS, Aleman S, Hagstrom H, Nguyen LH, Khalili H, Chung RT, Ludvigsson JF.

Ann Intern Med. 2019 Sep 3;171(5):318-327. doi: 10.7326/M18-2753. Epub 2019 Aug 20.


Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.

Villalón-Reina JE, Martínez K, Qu X, Ching CRK, Nir TM, Kothapalli D, Corbin C, Sun D, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Emanuel B, McDonald-McGinn DM, Vorstman JAS, Fiksinski AM, Koops S, Ruparel K, Roalf D, Gur RE, Eric Schmitt J, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Doherty JL, Cunningham AC, van den Bree M, Linden DEJ, Owen M, Moss H, Kelly S, Donohoe G, Murphy KC, Arango C, Jahanshad N, Thompson PM, Bearden CE.

Mol Psychiatry. 2019 Jul 29. doi: 10.1038/s41380-019-0450-0. [Epub ahead of print]



Simon TG, Corey KE.

Clin Gastroenterol Hepatol. 2019 Jul 25. pii: S1542-3565(19)30785-2. doi: 10.1016/j.cgh.2019.07.041. [Epub ahead of print] No abstract available.


Pediatric Respiratory Illness Measurement System (PRIMES) Scores and Outcomes.

Mangione-Smith R, Zhou C, Williams DJ, Johnson DP, Kenyon CC, Tyler A, Quinonez R, Vachani J, McGalliard J, Tieder JS, Simon TD, Wilson KM; Pediatric Research in Inpatient Settings (PRIS) Network .

Pediatrics. 2019 Aug;144(2). pii: e20190242. doi: 10.1542/peds.2019-0242.


Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.

Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS.

Transplantation. 2019 Oct;103(10):2075-2089. doi: 10.1097/TP.0000000000002774.


OpenPose: Realtime Multi-Person 2D Pose Estimation using Part Affinity Fields.

Cao Z, Hidalgo Martinez G, Simon T, Wei SE, Sheikh YA.

IEEE Trans Pattern Anal Mach Intell. 2019 Jul 17. doi: 10.1109/TPAMI.2019.2929257. [Epub ahead of print]


Serum level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a biomarker of synovitis in rheumatoid arthritis.

Gorlier C, Gottenberg JE, Laurans L, Simon T, Ait-Oufella H, Sellam J.

Int J Rheum Dis. 2019 Sep;22(9):1616-1618. doi: 10.1111/1756-185X.13656. Epub 2019 Jul 16. No abstract available.


Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men.

Ma Y, Yang W, Li T, Liu Y, Simon TG, Sui J, Wu K, Giovannucci EL, Chan AT, Zhang X.

Int J Epidemiol. 2019 Jul 13. pii: dyz146. doi: 10.1093/ije/dyz146. [Epub ahead of print]


The development of resilience among rheumatoid arthritis patients: a qualitative study.

Shaw Y, Bradley M, Zhang C, Dominique A, Michaud K, McDonald D, Simon TA.

Arthritis Care Res (Hoboken). 2019 Jul 8. doi: 10.1002/acr.24024. [Epub ahead of print]


Author Correction: Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling.

Piao W, Xiong Y, Famulski K, Brinkman CC, Li L, Toney N, Wagner C, Saxena V, Simon T, Bromberg JS.

Nat Commun. 2019 Jun 27;10(1):2927. doi: 10.1038/s41467-019-10952-0.


Twenty-year trends in profile, management and outcomes of patients with ST-segment elevation myocardial infarction according to use of reperfusion therapy: Data from the FAST-MI program 1995-2015.

Puymirat E, Cayla G, Cottin Y, Elbaz M, Henry P, Gerbaud E, Lemesle G, Popovic B, Labèque JN, Roubille F, Andrieu S, Farah B, Schiele F, Ferrières J, Simon T, Danchin N.

Am Heart J. 2019 Aug;214:97-106. doi: 10.1016/j.ahj.2019.05.007. Epub 2019 May 16.


Randomized clinical trial of open suture repair versus totally extraperitoneal repair for treatment of sportsman's hernia.

Sheen AJ, Montgomery A, Simon T, Ilves I, Paajanen H.

Br J Surg. 2019 Jun;106(7):837-844. doi: 10.1002/bjs.11226.


Predictors of success for combined endoscopic third ventriculostomy and choroid plexus cauterization in a North American setting: a Hydrocephalus Clinical Research Network study.

Riva-Cambrin J, Kestle JRW, Rozzelle CJ, Naftel RP, Alvey JS, Reeder RW, Holubkov R, Browd SR, Cochrane DD, Limbrick DD, Shannon CN, Simon TD, Tamber MS, Wellons JC, Whitehead WE, Kulkarni AV; Hydrocephalus Clinical Research Network.

J Neurosurg Pediatr. 2019 May 31:1-11. doi: 10.3171/2019.3.PEDS18532. [Epub ahead of print]


Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies.

McGee EE, Jackson SS, Petrick JL, Van Dyke AL, Adami HO, Albanes D, Andreotti G, Beane-Freeman LE, de Gonzalez AB, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, Zhu B, McGlynn KA, Campbell PT, Koshiol J.

J Natl Cancer Inst. 2019 May 24. pii: djz103. doi: 10.1093/jnci/djz103. [Epub ahead of print]


Outcome associated with prescription of cardiac rehabilitation according to predicted risk after acute myocardial infarction: Insights from the FAST-MI registries.

Puymirat E, Bonaca M, Iliou MC, Tea V, Ducrocq G, Douard H, Labrunee M, Plastaras P, Chevallereau P, Taldir G, Bataille V, Ferrières J, Schiele F, Simon T, Danchin N; FAST-MI investigators.

Arch Cardiovasc Dis. 2019 Aug - Sep;112(8-9):459-468. doi: 10.1016/j.acvd.2019.04.002. Epub 2019 May 22.


A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women.

Yang W, Sui J, Ma Y, Simon TG, Chong D, Meyerhardt JA, Willett WC, Giovannucci EL, Chan AT, Zhang X.

Int J Cancer. 2019 May 22. doi: 10.1002/ijc.32423. [Epub ahead of print]


Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project.

Jackson SS, Van Dyke AL, Zhu B, Pfeiffer RM, Petrick JL, Adami HO, Albanes D, Andreotti G, Beane Freeman LE, Berrington de González A, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, McGee EE, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon RZ, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, McGlynn KA, Campbell PT, Koshiol J.

Cancer Res. 2019 Aug 1;79(15):3973-3982. doi: 10.1158/0008-5472.CAN-19-0459. Epub 2019 May 21.


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