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Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer.

von Loga K, Woolston A, Punta M, Barber LJ, Griffiths B, Semiannikova M, Spain G, Challoner B, Fenwick K, Simon R, Marx A, Sauter G, Lise S, Matthews N, Gerlinger M.

Nat Commun. 2020 Jan 16;11(1):139. doi: 10.1038/s41467-019-13915-7.


High homogeneity of MMR deficiency in ovarian cancer.

Fraune C, Rosebrock J, Simon R, Hube-Magg C, Makrypidi-Fraune G, Kluth M, Büscheck F, Höflmayer D, Schmalfeldt B, Müller V, Wölber L, Witzel I, Paluchowski P, Wilke C, Heilenkötter U, von Leffern I, Clauditz TS, Wilczak W, Sauter G, Steurer S, Burandt E.

Gynecol Oncol. 2020 Jan 7. pii: S0090-8258(19)31861-X. doi: 10.1016/j.ygyno.2019.12.031. [Epub ahead of print]


Bioinspired sonar reflectors as guiding beacons for autonomous navigation.

Simon R, Rupitsch S, Baumann M, Wu H, Peremans H, Steckel J.

Proc Natl Acad Sci U S A. 2020 Jan 6. pii: 201909890. doi: 10.1073/pnas.1909890117. [Epub ahead of print]


Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion.

Steurer S, Schwemmer L, Hube-Magg C, Büscheck F, Höflmayer D, Tsourlakis MC, Clauditz TS, Luebke AM, Simon R, Sauter G, Izbicki J, Schroeder C, Schlomm T, Huland H, Heinzer H, Haese A, Graefen M, Göbel C, Weidemann S, Lebok P, Dum D, Fraune C, Minner S, Meiners J.

Oncotarget. 2019 Dec 24;10(67):7096-7111. doi: 10.18632/oncotarget.27270. eCollection 2019 Dec 24.


Loss of cytoplasmic survivin expression is an independent predictor of poor prognosis in radically operated prostate cancer patients.

Büscheck F, Sulimankhil M, Melling N, Höflmayer D, Hube-Magg C, Simon R, Göbel C, Hinsch A, Weidemann S, Izbicki JR, Jacobsen F, Mandelkow T, Blessin NC, Möller-Koop C, Lutz F, Viehweger F, Möller K, Sauter G, Lennartz M, Burandt E, Lebok P, Minner S, Bonk S, Huland H, Graefen M, Schlomm T, Fraune C.

Cancer Med. 2020 Jan 1. doi: 10.1002/cam4.2773. [Epub ahead of print]


Teleost IgD+IgM- B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles.

Perdiguero P, Martín-Martín A, Benedicenti O, Díaz-Rosales P, Morel E, Muñoz-Atienza E, García-Flores M, Simón R, Soleto I, Cerutti A, Tafalla C.

Cell Rep. 2019 Dec 24;29(13):4223-4235.e5. doi: 10.1016/j.celrep.2019.11.101.


Over the rainbow: A practical guide for fluorescent protein selection in plant FRET experiments.

Denay G, Schultz P, Hänsch S, Weidtkamp-Peters S, Simon R.

Plant Direct. 2019 Dec 6;3(12):e00189. doi: 10.1002/pld3.189. eCollection 2019 Dec.


High-grade intratumoral tumor budding is a predictor for lymphovascular invasion and adverse outcome in stage II colorectal cancer.

Marx AH, Mickler C, Sauter G, Simon R, Terracciano LM, Izbicki JR, Clauditz TS.

Int J Colorectal Dis. 2020 Feb;35(2):259-268. doi: 10.1007/s00384-019-03478-w. Epub 2019 Dec 14.


High homogeneity of mismatch repair deficiency in advanced prostate cancer.

Fraune C, Simon R, Höflmayer D, Möller K, Dum D, Büscheck F, Hube-Magg C, Makrypidi-Fraune G, Kluth M, Hinsch A, Burandt E, Clauditz TS, Wilczak W, Sauter G, Steurer S.

Virchows Arch. 2019 Dec 6. doi: 10.1007/s00428-019-02701-x. [Epub ahead of print]


CLE40 signalling regulates the fate of root stem cells in Arabidopsis.

Berckmans B, Kirschner G, Gerlitz N, Stadler R, Simon R.

Plant Physiol. 2019 Dec 5. pii: pp.00914.2019. doi: 10.1104/pp.19.00914. [Epub ahead of print]


Bronchoscopic delivery of aminocaproic acid as a treatment for pulmonary bleeding: A case series.

Simon RP, Oromendia C, Sanso LM, Ramos LG, Rajwani K.

Pulm Pharmacol Ther. 2019 Nov 26;60:101871. doi: 10.1016/j.pupt.2019.101871. [Epub ahead of print]


Infectious Trigger for Autoimmune Encephalitis: A Case Report and Literature Review.

Sahar N, Nurre AM, Simon RQ.

Case Rep Infect Dis. 2019 Nov 6;2019:5731969. doi: 10.1155/2019/5731969. eCollection 2019.


Rare Variants in 48 Genes Account for 42% of Cases of Epilepsy With or Without Neurodevelopmental Delay in 246 Pediatric Patients.

Fernández-Marmiesse A, Roca I, Díaz-Flores F, Cantarín V, Pérez-Poyato MS, Fontalba A, Laranjeira F, Quintans S, Moldovan O, Felgueroso B, Rodríguez-Pedreira M, Simón R, Camacho A, Quijada P, Ibanez-Mico S, Domingno MR, Benito C, Calvo R, Pérez-Cejas A, Carrasco ML, Ramos F, Couce ML, Ruiz-Falcó ML, Gutierrez-Solana L, Martínez-Atienza M.

Front Neurosci. 2019 Nov 8;13:1135. doi: 10.3389/fnins.2019.01135. eCollection 2019.


Brucella melitensis Rev.1 vaccination generates a higher shedding risk of the vaccine strain in Alpine ibex (Capra ibex) compared to the domestic goat (Capra hircus).

Ponsart C, Riou M, Locatelli Y, Jacques I, Fadeau A, Jay M, Simon R, Perrot L, Freddi L, Breton S, Chaumeil T, Blanc B, Ortiz K, Vion C, Rioult D, Quéméré E, Sarradin P, Chollet JY, Garin-Bastuji B, Rossi S.

Vet Res. 2019 Nov 27;50(1):100. doi: 10.1186/s13567-019-0717-0.


Hepatic Complications in Preeclampsia.

Chandrasekaran S, Simon R.

Clin Obstet Gynecol. 2019 Nov 25. doi: 10.1097/GRF.0000000000000501. [Epub ahead of print]


Automated Knee Osteoarthritis Assessment Increases Physicians' Agreement Rate and Accuracy: Data from the Osteoarthritis Initiative.

Nehrer S, Ljuhar R, Steindl P, Simon R, Maurer D, Ljuhar D, Bertalan Z, Dimai HP, Goetz C, Paixao T.

Cartilage. 2019 Nov 24:1947603519888793. doi: 10.1177/1947603519888793. [Epub ahead of print]


8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival.

Eichenauer T, Bannenberg DC, Kluth M, Wittmer C, Büscheck F, Möller K, Dum D, Fraune C, Hube-Magg C, Möller-Koop C, Dahlem R, Fisch M, Rink M, Riechardt S, Tsourlakis MC, Bernreuther C, Minner S, Simon R, Sauter G, Wilczak W, Clauditz TS.

Urol Oncol. 2020 Feb;38(2):43.e13-43.e20. doi: 10.1016/j.urolonc.2019.09.024. Epub 2019 Nov 19.


A novel approach to assess real-world efficacy of cancer therapy in metastatic prostate cancer. Analysis of national data on Veterans treated with abiraterone and enzalutamide.

Leuva H, Sigel K, Zhou M, Wilkerson J, Aggen DH, Park YA, Anderson CB, Hsu TM, Langhoff E, McWilliams G, Drake CG, Simon R, Bates SE, Fojo T.

Semin Oncol. 2019 Aug - Oct;46(4-5):351-361. doi: 10.1053/j.seminoncol.2019.11.004. Epub 2019 Nov 16. Review.


Patient experiences with a transitional, low-threshold clinic for the treatment of substance use disorder: A qualitative study of a bridge clinic.

Snow RL, Simon RE, Jack HE, Oller D, Kehoe L, Wakeman SE.

J Subst Abuse Treat. 2019 Dec;107:1-7. doi: 10.1016/j.jsat.2019.09.003. Epub 2019 Sep 10.


Claudin-1 upregulation is associated with favorable tumor features and a reduced risk for biochemical recurrence in ERG-positive prostate cancer.

Kind S, Büscheck F, Höflmayer D, Hube-Magg C, Kluth M, Tsourlakis MC, Steurer S, Clauditz TS, Luebke AM, Burandt E, Wilczak W, Hinsch A, Dum D, Weidemann S, Fraune C, Beyer B, Steuber T, Huland H, Graefen M, Fisch M, Simon R, Sauter G, Schlomm T, Minner S, Eichenauer T.

World J Urol. 2019 Nov 19. doi: 10.1007/s00345-019-03017-w. [Epub ahead of print]


Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer.

Höflmayer D, Steinhoff A, Hube-Magg C, Kluth M, Simon R, Burandt E, Tsourlakis MC, Minner S, Sauter G, Büscheck F, Wilczak W, Steurer S, Huland H, Graefen M, Haese A, Heinzer H, Schlomm T, Jacobsen F, Hinsch A, Poos AM, Oswald M, Rippe K, König R, Schroeder C.

Mol Oncol. 2020 Jan;14(1):129-138. doi: 10.1002/1878-0261.12597. Epub 2019 Nov 29.


Preclinical safety evaluation of triacylglycerol lipase QLM from Burkholderia ubonensis.

Mak A, Simon RR.

Regul Toxicol Pharmacol. 2020 Feb;110:104523. doi: 10.1016/j.yrtph.2019.104523. Epub 2019 Nov 11.


Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain.

Foucault G, Duval GT, Simon R, Beauchet O, Dinomais M, Annweiler C; SOCOS group.

Curr Alzheimer Res. 2019;16(11):1063-1071. doi: 10.2174/1567205016666191113124356.


Midwifery leadership in maternity emergencies: a video analysis.

Janssens S, Simon R, Barwick S, Clipperton S, Beckmann M, Marshall S.

J Interprof Care. 2019 Nov 7:1-7. doi: 10.1080/13561820.2019.1675611. [Epub ahead of print]


High RSF1 protein expression is an independent prognostic feature in prostate cancer.

Höflmayer D, Hamuda M, Schroeder C, Hube-Magg C, Simon R, Göbel C, Hinsch A, Weidemann S, Möller K, Izbicki JR, Jacobsen F, Mandelkow T, Blessin NC, Lutz F, Viehweger F, Sauter G, Burandt E, Lebok P, Lennartz M, Fraune C, Minner S, Bonk S, Huland H, Graefen M, Schlomm T, Büscheck F.

Acta Oncol. 2019 Nov 5:1-6. doi: 10.1080/0284186X.2019.1686537. [Epub ahead of print]


Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.

Luskin KT, Bosso JV, Simon RA.

J Allergy Clin Immunol Pract. 2019 Oct 31. pii: S2213-2198(19)30895-5. doi: 10.1016/j.jaip.2019.10.006. [Epub ahead of print] No abstract available.


Random forest-based modelling to detect biomarkers for prostate cancer progression.

Toth R, Schiffmann H, Hube-Magg C, Büscheck F, Höflmayer D, Weidemann S, Lebok P, Fraune C, Minner S, Schlomm T, Sauter G, Plass C, Assenov Y, Simon R, Meiners J, Gerhäuser C.

Clin Epigenetics. 2019 Oct 22;11(1):148. doi: 10.1186/s13148-019-0736-8.


Understanding why patients with substance use disorders leave the hospital against medical advice: A qualitative study.

Simon R, Snow R, Wakeman S.

Subst Abus. 2019 Oct 22:1-7. doi: 10.1080/08897077.2019.1671942. [Epub ahead of print]


Upregulation of SPDEF is associated with poor prognosis in prostate cancer.

Meiners J, Schulz K, Möller K, Höflmayer D, Burdelski C, Hube-Magg C, Simon R, Göbel C, Hinsch A, Reiswich V, Weidemann S, Izbicki JR, Sauter G, Jacobsen F, Möller-Koop C, Mandelkow T, Blessin NC, Lutz F, Viehweger F, Lennartz M, Fraune C, Heinzer H, Minner S, Bonk S, Huland H, Graefen M, Schlomm T, Büscheck F.

Oncol Lett. 2019 Nov;18(5):5107-5118. doi: 10.3892/ol.2019.10885. Epub 2019 Sep 19.


High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer.

Weidemann SA, Sauer C, Luebke AM, Möller-Koop C, Steurer S, Hube-Magg C, Büscheck F, Höflmayer D, Tsourlakis MC, Clauditz TS, Simon R, Sauter G, Göbel C, Lebok P, Dum D, Fraune C, Kind S, Minner S, Izbicki J, Schlomm T, Huland H, Heinzer H, Burandt E, Haese A, Graefen M, Heumann A.

BMC Cancer. 2019 Oct 12;19(1):944. doi: 10.1186/s12885-019-6182-3.


Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.

Tezil T, Chamoli M, Ng CP, Simon RP, Butler VJ, Jung M, Andersen J, Kao AW, Verdin E.

NPJ Aging Mech Dis. 2019 Oct 2;5:7. doi: 10.1038/s41514-019-0037-7. eCollection 2019.


MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS.

Simon RP, Winter M, Kleiner C, Ries R, Schnapp G, Heimann A, Li J, Zuvela-Jelaska L, Bretschneider T, Luippold AH, Reindl W, Bischoff D, Büttner FH.

SLAS Discov. 2019 Oct 4:2472555219880185. doi: 10.1177/2472555219880185. [Epub ahead of print]


Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer.

Steurer S, Hager B, Büscheck F, Höflmayer D, Tsourlakis MC, Minner S, Clauditz TS, Hube-Magg C, Luebke AM, Simon R, Izbicki JR, Burandt E, Sauter G, Fraune C, Weidemann S, Schlomm T, Heinzer H, Haese A, Graefen M, Huland H, Heumann A.

Aging (Albany NY). 2019 Sep 25;11(18):7859-7879. doi: 10.18632/aging.102294. Epub 2019 Sep 25.


Maternal Antibodies Elicited by Immunization With an O- Polysaccharide Glycoconjugate Vaccine Protect Infant Mice Against Lethal Salmonella Typhimurium Infection.

Baliban SM, Curtis B, Amin MN, Levine MM, Pasetti MF, Simon R.

Front Immunol. 2019 Sep 6;10:2124. doi: 10.3389/fimmu.2019.02124. eCollection 2019.


A shift from membranous and stromal syndecan-1 (CD138) expression to cytoplasmic CD138 expression is associated with poor prognosis in breast cancer.

Kind S, Jaretzke A, Büscheck F, Möller K, Dum D, Höflmayer D, Hinsch A, Weidemann S, Fraune C, Möller-Koop C, Hube-Magg C, Simon R, Wilczak W, Lebok P, Witzel I, Müller V, Schmalfeldt B, Paluchowski P, Wilke C, Heilenkötter U, von Leffern I, Krech T, Krech RH, von der Assen A, Bawahab AA, Burandt E.

Mol Carcinog. 2019 Dec;58(12):2306-2315. doi: 10.1002/mc.23119. Epub 2019 Sep 23.


Lessons from the 2018 International Symposium on Alternatives Assessment: Advances and Reflections on Practice and Ongoing Needs to Build the Field.

Tickner J, Simon R, Jacobs M, Rudisill C, Tanir J, Heine L, Spencer P, Fantke P, Malloy T, Edwards S, Zhou X.

Integr Environ Assess Manag. 2019 Nov;15(6):909-916. doi: 10.1002/ieam.4213.


Prognostic and diagnostic role of PSA immunohistochemistry: A tissue microarray study on 21,000 normal and cancerous tissues.

Bonk S, Kluth M, Hube-Magg C, Polonski A, Soekeland G, Makropidi-Fraune G, Möller-Koop C, Witt M, Luebke AM, Hinsch A, Burandt E, Steurer S, Clauditz TS, Schlomm T, Perez D, Graefen M, Heinzer H, Huland H, Izbicki JR, Wilczak W, Minner S, Sauter G, Simon R.

Oncotarget. 2019 Sep 10;10(52):5439-5453. doi: 10.18632/oncotarget.27145. eCollection 2019 Sep 10.


Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer.

Lebok P, von Hassel A, Meiners J, Hube-Magg C, Simon R, Höflmayer D, Hinsch A, Dum D, Fraune C, Göbel C, Möller K, Sauter G, Jacobsen F, Büscheck F, Prien K, Krech T, Krech RH, von der Assen A, Wölber L, Witzel I, Schmalfeldt B, Geist S, Paluchoswski P, Wilke C, Heilenkötter U, Terracciano L, Müller V, Wilczak W, Burandt EC.

Aging (Albany NY). 2019 Sep 18;11(18):7796-7804. doi: 10.18632/aging.102287. Epub 2019 Sep 18.


Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers.

Luebke AM, Attarchi-Tehrani A, Meiners J, Hube-Magg C, Lang DS, Kluth M, Tsourlakis MC, Minner S, Simon R, Sauter G, Büscheck F, Jacobsen F, Hinsch A, Steurer S, Schlomm T, Huland H, Graefen M, Haese A, Heinzer H, Clauditz TS, Burandt E, Wilczak W, Höflmayer D.

Cancer Biol Med. 2019 May;16(2):319-330. doi: 10.20892/j.issn.2095-3941.2018.0384.


Comparison of pancreas-sparing duodenectomy (PSD) and pancreatoduodenectomy (PD) for the management of duodenal polyposis syndromes.

Walsh RM, Augustin T, Aleassa EM, Simon R, El-Hayek KM, Moslim MA, Burke CA, Church JM, Morris-Stiff G.

Surgery. 2019 Oct;166(4):496-502. doi: 10.1016/j.surg.2019.05.060. Epub 2019 Aug 29.


Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy.

Schroeder C, Navid-Hill E, Meiners J, Hube-Magg C, Kluth M, Makrypidi-Fraune G, Simon R, Büscheck F, Luebke AM, Goebel C, Lang DS, Weidemann S, Neubauer E, Hinsch A, Jacobsen F, Lebok P, Michl U, Pehrke D, Huland H, Graefen M, Schlomm T, Sauter G, Höflmayer D.

Oncotarget. 2019 Aug 13;10(48):4973-4986. doi: 10.18632/oncotarget.27132. eCollection 2019 Aug 13.


Expression of the immune checkpoint receptor TIGIT in seminoma.

Hinsch A, Blessin NC, Simon R, Kluth M, Fischer K, Hube-Magg C, Li W, Makrypidi-Fraune G, Wellge B, Mandelkow T, Debatin NF, Höflmayer D, Lennartz M, Sauter G, Izbicki JR, Minner S, Büscheck F, Uhlig R, Dum D, Krech T, Luebke AM, Wittmer C, Jacobsen F, Burandt E, Steurer S, Wilczak W.

Oncol Lett. 2019 Aug;18(2):1497-1502. doi: 10.3892/ol.2019.10428. Epub 2019 May 31.


Getting It Right for Our Patients: The Importance of Collaborative Leadership in the ICU.

Savel RH, Shiloh AL, Simon RJ, Kupfer Y.

Crit Care Med. 2019 Sep;47(9):1279-1281. doi: 10.1097/CCM.0000000000003880. No abstract available.


Measures of Cystic Fibrosis Airway Microbiota during Periods of Clinical Stability.

Caverly LJ, Lu J, Carmody LA, Kalikin LM, Shedden K, Opron K, Azar M, Cahalan S, Foster B, VanDevanter DR, Simon RH, LiPuma JJ.

Ann Am Thorac Soc. 2019 Dec;16(12):1534-1542. doi: 10.1513/AnnalsATS.201903-270OC.


Down-Regulation of S100A8 is an Independent Predictor of PSA Recurrence in Prostate Cancer Treated by Radical Prostatectomy.

Minner S, Hager D, Steurer S, Höflmayer D, Tsourlakis MC, Möller-Koop C, Clauditz TS, Hube-Magg C, Luebke AM, Simon R, Sauter G, Göbel C, Weidemann S, Lebok P, Dum D, Fraune C, Izbicki J, Burandt E, Schlomm T, Huland H, Heinzer H, Haese A, Graefen M, Heumann A.

Neoplasia. 2019 Sep;21(9):872-881. doi: 10.1016/j.neo.2019.07.003. Epub 2019 Aug 2.


Bats Actively Use Leaves as Specular Reflectors to Detect Acoustically Camouflaged Prey.

Geipel I, Steckel J, Tschapka M, Vanderelst D, Schnitzler HU, Kalko EKV, Peremans H, Simon R.

Curr Biol. 2019 Aug 19;29(16):2731-2736.e3. doi: 10.1016/j.cub.2019.06.076. Epub 2019 Aug 1.


Identification of pharmacodynamic biomarkers and common molecular mechanisms of response to genotoxic agents in cancer cell lines.

Min DJ, Zhao Y, Monks A, Palmisano A, Hose C, Teicher BA, Doroshow JH, Simon RM.

Cancer Chemother Pharmacol. 2019 Oct;84(4):771-780. doi: 10.1007/s00280-019-03898-z. Epub 2019 Jul 31.


Visual Analysis for Understanding Irritable Bowel Syndrome.

Jönsson D, Bergström A, Algström I, Simon R, Engström M, Walter S, Hotz I.

Adv Exp Med Biol. 2019;1156:111-122. doi: 10.1007/978-3-030-19385-0_8.


A Cellular Insulator against CLE45 Peptide Signaling.

Breda AS, Hazak O, Schultz P, Anne P, Graeff M, Simon R, Hardtke CS.

Curr Biol. 2019 Aug 5;29(15):2501-2508.e3. doi: 10.1016/j.cub.2019.06.037. Epub 2019 Jul 18.


On Functional Connectivity and Symptom Relief After Gut-directed Hypnotherapy in Irritable Bowel Syndrome: A Preliminary Study.

Simon RA, Engström M, Icenhour A, Lowén M, Ström M, Tillisch K, Mayer E, Elsenbruch S, Walter S.

J Neurogastroenterol Motil. 2019 Jul 1;25(3):478-479. doi: 10.5056/jnm19069. No abstract available.

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