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Items: 1 to 50 of 264

1.

An atlas of genetic influences on osteoporosis in humans and mice.

Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG; 23andMe Research Team, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB.

Nat Genet. 2018 Dec 31. doi: 10.1038/s41588-018-0302-x. [Epub ahead of print]

PMID:
30598549
2.

Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function.

Findlay AS, Carter RN, Starbuck B, McKie L, Nováková K, Budd PS, Keighren MA, Marsh JA, Cross SH, Simon MM, Potter PK, Morton NM, Jackson IJ.

Dis Model Mech. 2018 Dec 18;11(12). pii: dmm036426. doi: 10.1242/dmm.036426.

3.

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice.

Gorvin CM, Ahmad BN, Stechman MJ, Loh NY, Hough TA, Leo P, Marshall M, Sethi S, Bentley L, Piret SE, Reed A, Jeyabalan J, Christie PT, Wells S, Simon MM, Mallon AM, Schulz H, Huebner N, Brown MA, Cox RD, Brown SD, Thakker RV.

J Bone Miner Res. 2018 Nov 5. doi: 10.1002/jbmr.3624. [Epub ahead of print]

PMID:
30395686
4.

An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion.

Esapa CT, Piret SE, Nesbit MA, Thomas GP, Coulton LA, Gallagher OM, Simon MM, Kumar S, Mallon AM, Bellantuono I, Brown MA, Croucher PI, Potter PK, Brown SD, Cox RD, Thakker RV.

JBMR Plus. 2018 Mar 8;2(3):154-163. doi: 10.1002/jbm4.10033. eCollection 2018 May.

5.

Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Vinuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI.

Nat Genet. 2018 Sep;50(9):1342. doi: 10.1038/s41588-018-0180-2.

PMID:
30087441
6.

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants.

Codner GF, Mianné J, Caulder A, Loeffler J, Fell R, King R, Allan AJ, Mackenzie M, Pike FJ, McCabe CV, Christou S, Joynson S, Hutchison M, Stewart ME, Kumar S, Simon MM, Agius L, Anstee QM, Volynski KE, Kullmann DM, Wells S, Teboul L.

BMC Biol. 2018 Jun 21;16(1):70. doi: 10.1186/s12915-018-0530-7.

7.

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI.

Nat Genet. 2018 Apr;50(4):572-580. doi: 10.1038/s41588-018-0088-x. Epub 2018 Apr 9. Erratum in: Nat Genet. 2018 Sep;50(9):1342.

8.

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L; International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM.

Nat Commun. 2017 Oct 12;8(1):886. doi: 10.1038/s41467-017-00595-4.

9.

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

Crompton M, Purnell T, Tyrer HE, Parker A, Ball G, Hardisty-Hughes RE, Gale R, Williams D, Dean CH, Simon MM, Mallon AM, Wells S, Bhutta MF, Burton MJ, Tateossian H, Brown SDM.

PLoS Genet. 2017 Aug 14;13(8):e1006969. doi: 10.1371/journal.pgen.1006969. eCollection 2017 Aug.

10.

A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.

Banks G, Lassi G, Hoerder-Suabedissen A, Tinarelli F, Simon MM, Wilcox A, Lau P, Lawson TN, Johnson S, Rutman A, Sweeting M, Chesham JE, Barnard AR, Horner N, Westerberg H, Smith LB, Molnár Z, Hastings MH, Hirst RA, Tucci V, Nolan PM.

Mol Psychiatry. 2018 Mar;23(3):713-722. doi: 10.1038/mp.2017.54. Epub 2017 Apr 4.

11.

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Cheung WA, Shao X, Morin A, Siroux V, Kwan T, Ge B, Aïssi D, Chen L, Vasquez L, Allum F, Guénard F, Bouzigon E, Simon MM, Boulier E, Redensek A, Watt S, Datta A, Clarke L, Flicek P, Mead D, Paul DS, Beck S, Bourque G, Lathrop M, Tchernof A, Vohl MC, Demenais F, Pin I, Downes K, Stunnenberg HG, Soranzo N, Pastinen T, Grundberg E.

Genome Biol. 2017 Mar 10;18(1):50. doi: 10.1186/s13059-017-1173-7.

12.

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.

Paul DS, Teschendorff AE, Dang MA, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S, Fouts AR, Ramelius A, Burden F, Farrow S, Rowlston S, Rehnstrom K, Frontini M, Downes K, Busche S, Cheung WA, Ge B, Simon MM, Bujold D, Kwan T, Bourque G, Datta A, Lowy E, Clarke L, Flicek P, Libertini E, Heath S, Gut M, Gut IG, Ouwehand WH, Pastinen T, Soranzo N, Hofer SE, Karges B, Meissner T, Boehm BO, Cilio C, Elding Larsson H, Lernmark Å, Steck AK, Rakyan VK, Beck S, Leslie RD.

Nat Commun. 2016 Nov 29;7:13555. doi: 10.1038/ncomms13555.

13.

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

Chen L, Ge B, Casale FP, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yan Y, Kundu K, Ecker S, Datta A, Richardson D, Burden F, Mead D, Mann AL, Fernandez JM, Rowlston S, Wilder SP, Farrow S, Shao X, Lambourne JJ, Redensek A, Albers CA, Amstislavskiy V, Ashford S, Berentsen K, Bomba L, Bourque G, Bujold D, Busche S, Caron M, Chen SH, Cheung W, Delaneau O, Dermitzakis ET, Elding H, Colgiu I, Bagger FO, Flicek P, Habibi E, Iotchkova V, Janssen-Megens E, Kim B, Lehrach H, Lowy E, Mandoli A, Matarese F, Maurano MT, Morris JA, Pancaldi V, Pourfarzad F, Rehnstrom K, Rendon A, Risch T, Sharifi N, Simon MM, Sultan M, Valencia A, Walter K, Wang SY, Frontini M, Antonarakis SE, Clarke L, Yaspo ML, Beck S, Guigo R, Rico D, Martens JHA, Ouwehand WH, Kuijpers TW, Paul DS, Stunnenberg HG, Stegle O, Downes K, Pastinen T, Soranzo N.

Cell. 2016 Nov 17;167(5):1398-1414.e24. doi: 10.1016/j.cell.2016.10.026.

14.

Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis.

Santiago L, Menaa C, Arias M, Martin P, Jaime-Sánchez P, Metkar S, Comas L, Erill N, Gonzalez-Rumayor V, Esser E, Galvez EM, Raja S, Simon MM, Sprague SM, Gabay C, Martinez-Lostao L, Pardo J, Froelich CJ.

Arthritis Rheumatol. 2017 Feb;69(2):320-334. doi: 10.1002/art.39857.

15.

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

Potter PK, Bowl MR, Jeyarajan P, Wisby L, Blease A, Goldsworthy ME, Simon MM, Greenaway S, Michel V, Barnard A, Aguilar C, Agnew T, Banks G, Blake A, Chessum L, Dorning J, Falcone S, Goosey L, Harris S, Haynes A, Heise I, Hillier R, Hough T, Hoslin A, Hutchison M, King R, Kumar S, Lad HV, Law G, MacLaren RE, Morse S, Nicol T, Parker A, Pickford K, Sethi S, Starbuck B, Stelma F, Cheeseman M, Cross SH, Foster RG, Jackson IJ, Peirson SN, Thakker RV, Vincent T, Scudamore C, Wells S, El-Amraoui A, Petit C, Acevedo-Arozena A, Nolan PM, Cox R, Mallon AM, Brown SD.

Nat Commun. 2016 Aug 18;7:12444. doi: 10.1038/ncomms12444.

16.

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair.

Mianné J, Chessum L, Kumar S, Aguilar C, Codner G, Hutchison M, Parker A, Mallon AM, Wells S, Simon MM, Teboul L, Brown SD, Bowl MR.

Genome Med. 2016 Feb 15;8(1):16. doi: 10.1186/s13073-016-0273-4.

17.

Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation.

Busche S, Shao X, Caron M, Kwan T, Allum F, Cheung WA, Ge B, Westfall S, Simon MM; Multiple Tissue Human Expression Resource, Barrett A, Bell JT, McCarthy MI, Deloukas P, Blanchette M, Bourque G, Spector TD, Lathrop M, Pastinen T, Grundberg E.

Genome Biol. 2015 Dec 23;16:290. doi: 10.1186/s13059-015-0856-1.

18.

In memoriam: Prof Christopher J Froelich (1951-2015).

Metkar SS, Pardo J, Anderluh G, Salvesen G, Trapani JA, Simon MM.

Cell Death Differ. 2016 Jan;23(1):3-4. doi: 10.1038/cdd.2015.141. No abstract available.

19.

Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.

Tateossian H, Morse S, Simon MM, Dean CH, Brown SD.

Dis Model Mech. 2015 Dec;8(12):1531-42. doi: 10.1242/dmm.022426. Epub 2015 Oct 15.

20.

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.

Simon MM, Moresco EM, Bull KR, Kumar S, Mallon AM, Beutler B, Potter PK.

Mamm Genome. 2015 Oct;26(9-10):486-500. doi: 10.1007/s00335-015-9603-x. Epub 2015 Oct 8. Review.

21.

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Parsons MJ, Brancaccio M, Sethi S, Maywood ES, Satija R, Edwards JK, Jagannath A, Couch Y, Finelli MJ, Smyllie NJ, Esapa C, Butler R, Barnard AR, Chesham JE, Saito S, Joynson G, Wells S, Foster RG, Oliver PL, Simon MM, Mallon AM, Hastings MH, Nolan PM.

Cell. 2015 Jul 30;162(3):607-21. doi: 10.1016/j.cell.2015.06.060.

22.

Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Allum F, Shao X, Guénard F, Simon MM, Busche S, Caron M, Lambourne J, Lessard J, Tandre K, Hedman ÅK, Kwan T, Ge B; Multiple Tissue Human Expression Resource Consortium, Rönnblom L, McCarthy MI, Deloukas P, Richmond T, Burgess D, Spector TD, Tchernof A, Marceau S, Lathrop M, Vohl MC, Pastinen T, Grundberg E.

Nat Commun. 2015 Jul 29;6:8016. doi: 10.1038/ncomms9016. No abstract available.

PMID:
26219997
23.

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Allum F, Shao X, Guénard F, Simon MM, Busche S, Caron M, Lambourne J, Lessard J, Tandre K, Hedman ÅK, Kwan T, Ge B; Multiple Tissue Human Expression Resource Consortium, Rönnblom L, McCarthy MI, Deloukas P, Richmond T, Burgess D, Spector TD, Tchernof A, Marceau S, Lathrop M, Vohl MC, Pastinen T, Grundberg E.

Nat Commun. 2015 May 29;6:7211. doi: 10.1038/ncomms8211. Erratum in: Nat Commun. 2015;6:8016.

24.

Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.

Catalán E, Jaime-Sánchez P, Aguiló N, Simon MM, Froelich CJ, Pardo J.

J Biol Chem. 2015 Mar 13;290(11):6868-77. doi: 10.1074/jbc.M114.631564. Epub 2015 Jan 20.

25.

Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.

Arias MA, Jiménez de Bagües MP, Aguiló N, Menao S, Hervás-Stubbs S, de Martino A, Alcaraz A, Simon MM, Froelich CJ, Pardo J.

Cell Rep. 2014 Jul 24;8(2):420-9. doi: 10.1016/j.celrep.2014.06.012. Epub 2014 Jul 10.

26.

Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner.

Zorn CN, Pardo J, Martin P, Kuhny M, Simon MM, Huber M.

Eur J Immunol. 2013 Dec;43(12):3209-18. doi: 10.1002/eji.201343941.

27.

A chronological expression profile of gene activity during embryonic mouse brain development.

Goggolidou P, Soneji S, Powles-Glover N, Williams D, Sethi S, Baban D, Simon MM, Ragoussis I, Norris DP.

Mamm Genome. 2013 Dec;24(11-12):459-72. doi: 10.1007/s00335-013-9486-7. Epub 2013 Nov 19.

28.

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.

Simon MM, Greenaway S, White JK, Fuchs H, Gailus-Durner V, Wells S, Sorg T, Wong K, Bedu E, Cartwright EJ, Dacquin R, Djebali S, Estabel J, Graw J, Ingham NJ, Jackson IJ, Lengeling A, Mandillo S, Marvel J, Meziane H, Preitner F, Puk O, Roux M, Adams DJ, Atkins S, Ayadi A, Becker L, Blake A, Brooker D, Cater H, Champy MF, Combe R, Danecek P, di Fenza A, Gates H, Gerdin AK, Golini E, Hancock JM, Hans W, Hölter SM, Hough T, Jurdic P, Keane TM, Morgan H, Müller W, Neff F, Nicholson G, Pasche B, Roberson LA, Rozman J, Sanderson M, Santos L, Selloum M, Shannon C, Southwell A, Tocchini-Valentini GP, Vancollie VE, Westerberg H, Wurst W, Zi M, Yalcin B, Ramirez-Solis R, Steel KP, Mallon AM, de Angelis MH, Herault Y, Brown SD.

Genome Biol. 2013 Jul 31;14(7):R82. doi: 10.1186/gb-2013-14-7-r82.

29.

Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK.

Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C.

Cell Death Differ. 2013 Oct;20(10):1317-29. doi: 10.1038/cdd.2013.78. Epub 2013 Jul 5.

30.

Mapping the ligand-binding region of Borrelia hermsii fibronectin-binding protein.

Brenner C, Bomans K, Habicht J, Simon MM, Wallich R.

PLoS One. 2013 May 2;8(5):e63437. doi: 10.1371/journal.pone.0063437. Print 2013.

31.

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ.

PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31.

32.

Viscum album agglutinin-I (VAA-I) increases cell surface expression of cytoskeletal proteins in apoptotic human neutrophils: moesin and ezrin are two novel targets of VAA-I.

Simon MM, Simard JC, Girard D.

Hum Exp Toxicol. 2013 Oct;32(10):1097-106. doi: 10.1177/0960327112468910. Epub 2012 Dec 21.

PMID:
23263853
33.

High throughput sequencing approaches to mutation discovery in the mouse.

Simon MM, Mallon AM, Howell GR, Reinholdt LG.

Mamm Genome. 2012 Oct;23(9-10):499-513. doi: 10.1007/s00335-012-9424-0. Epub 2012 Sep 19. Review.

34.

Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.

Joeckel LT, Wallich R, Metkar SS, Froelich CJ, Simon MM, Borner C.

J Virol. 2012 Aug;86(16):8713-9. doi: 10.1128/JVI.00682-12. Epub 2012 Jun 6.

35.

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis.

Ivanova S, Gregorc U, Vidergar N, Javier R, Bredt DS, Vandenabeele P, Pardo J, Simon MM, Turk V, Banks L, Turk B.

Cell Death Dis. 2011 Jan 20;2:e116. doi: 10.1038/cddis.2010.92.

36.

Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.

Simard JC, Simon MM, Tessier PA, Girard D.

J Immunol. 2011 Mar 15;186(6):3622-31. doi: 10.4049/jimmunol.1002956. Epub 2011 Feb 16.

37.

Mouse granzyme K has pro-inflammatory potential.

Joeckel LT, Wallich R, Martin P, Sanchez-Martinez D, Weber FC, Martin SF, Borner C, Pardo J, Froelich C, Simon MM.

Cell Death Differ. 2011 Jul;18(7):1112-9. doi: 10.1038/cdd.2011.5. Epub 2011 Feb 11.

38.

Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity.

Weber FC, Esser PR, Müller T, Ganesan J, Pellegatti P, Simon MM, Zeiser R, Idzko M, Jakob T, Martin SF.

J Exp Med. 2010 Nov 22;207(12):2609-19. doi: 10.1084/jem.20092489. Epub 2010 Nov 8.

39.

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis.

Grosskinsky S, Schott M, Brenner C, Cutler SJ, Simon MM, Wallich R.

PLoS Negl Trop Dis. 2010 Jun 1;4(6):e698. doi: 10.1371/journal.pntd.0000698.

40.

Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.

Martin P, Pardo J, Schill N, Jöckel L, Berg M, Froelich CJ, Wallich R, Simon MM.

J Biol Chem. 2010 Jun 11;285(24):18918-27. doi: 10.1074/jbc.M109.056028. Epub 2010 Apr 15.

41.

Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.

Aguiló JI, Anel A, Catalán E, Sebastián A, Acín-Pérez R, Naval J, Wallich R, Simon MM, Pardo J.

Immunol Cell Biol. 2010 Jul;88(5):545-54. doi: 10.1038/icb.2010.5. Epub 2010 Feb 2.

PMID:
20125115
42.

Granzyme A is a proinflammatory protease.

Pardo J, Simon MM, Froelich CJ.

Blood. 2009 Oct 29;114(18):3968; author reply 3969-70. doi: 10.1182/blood-2009-07-231027. No abstract available.

43.

Caspase-dependent inhibition of mousepox replication by gzmB.

Pardo J, Gálvez EM, Koskinen A, Simon MM, Lobigs M, Regner M, Müllbacher A.

PLoS One. 2009 Oct 19;4(10):e7512. doi: 10.1371/journal.pone.0007512.

44.

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Krönke M, Simon MM, Utermöhlen O.

Nat Immunol. 2009 Jul;10(7):761-8. doi: 10.1038/ni.1757. Epub 2009 Jun 14.

PMID:
19525969
45.

EMBO workshop on cytotoxicity, cell death and the immune system.

Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Müllbacher A, Pardo J, Simon MM, Trapani JA.

Cell Death Differ. 2009 May;16(5):790-3. doi: 10.1038/cdd.2009.4. No abstract available.

46.

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity.

Grosskinsky S, Schott M, Brenner C, Cutler SJ, Kraiczy P, Zipfel PF, Simon MM, Wallich R.

PLoS One. 2009;4(3):e4858. doi: 10.1371/journal.pone.0004858. Epub 2009 Mar 24.

47.

The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation.

Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM.

Microbes Infect. 2009 Apr;11(4):452-9. doi: 10.1016/j.micinf.2009.02.004. Epub 2009 Feb 26. Review.

PMID:
19249384
48.

Granule-associated serine proteases: granzymes might not just be killer proteases.

Froelich CJ, Pardo J, Simon MM.

Trends Immunol. 2009 Mar;30(3):117-23. doi: 10.1016/j.it.2009.01.002. Epub 2009 Feb 13.

PMID:
19217825
49.

Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes.

Kudryashev M, Cyrklaff M, Baumeister W, Simon MM, Wallich R, Frischknecht F.

Mol Microbiol. 2009 Mar;71(6):1415-34. doi: 10.1111/j.1365-2958.2009.06613.x. Epub 2009 Feb 4.

50.

Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H.

Kraiczy P, Hanssen-Hübner C, Kitiratschky V, Brenner C, Besier S, Brade V, Simon MM, Skerka C, Roversi P, Lea SM, Stevenson B, Wallich R, Zipfel PF.

Int J Med Microbiol. 2009 Apr;299(4):255-68. doi: 10.1016/j.ijmm.2008.09.002. Epub 2009 Jan 9.

PMID:
19138559

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