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Items: 1 to 50 of 301

1.

BODY MASS INDEX AND ALBUMIN LEVELS ARE ASSOCIATED WITH PULMONARY FUNCTION PARAMETERS IN PEDIATRIC SUBJECTS WITH CYSTIC FIBROSIS.

Simon MISDS, Paulo GCF, Marostica JC.

Rev Paul Pediatr. 2019 May 9. pii: S0103-05822019005008108. doi: 10.1590/1984-0462/;2019;37;4;00016. [Epub ahead of print] English, Portuguese.

2.

The role of neonatal screening in nutritional evolution in the first 12 months after diagnosis of cystic fibrosis.

Martins JP, Forte GC, Simon MISDS, Epifanio M, Pinto LA, Marostica PJC.

Rev Assoc Med Bras (1992). 2018 Nov;64(11):1032-1037. doi: 10.1590/1806-9282.64.11.1032.

3.

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.

Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN.

EMBO Mol Med. 2013 Jun;5(6):904-18. doi: 10.1002/emmm.201201429. Epub 2013 May 24.

4.

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5422-7. doi: 10.1073/pnas.1303360110. Epub 2013 Mar 19.

5.

Anthropometric and dietary intake indicators as predictors of pulmonary function in cystic fibrosis patients.

Forte GC, Pereira JS, Drehmer M, Simon MI.

J Bras Pneumol. 2012 Jul-Aug;38(4):470-6. English, Portuguese.

6.

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.

Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D.

Nat Cell Biol. 2012 May 20;14(7):686-96. doi: 10.1038/ncb2507.

7.

Melanopsin signalling in mammalian iris and retina.

Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW.

Nature. 2011 Nov 2;479(7371):67-73. doi: 10.1038/nature10567.

8.

Intracellular signaling and the origins of the sensations of itch and pain.

Han SK, Simon MI.

Sci Signal. 2011 Aug 23;4(187):er3.

PMID:
21972468
9.

Intracellular signaling and the origins of the sensations of itch and pain.

Han SK, Simon MI.

Sci Signal. 2011 Aug 2;4(185):pe38. doi: 10.1126/scisignal.2002353. Review.

PMID:
21868356
10.

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons.

Kim SJ, Park GH, Kim D, Lee J, Min H, Wall E, Lee CJ, Simon MI, Lee SJ, Han SK.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3371-6. doi: 10.1073/pnas.1019755108. Epub 2011 Feb 7.

11.

Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.

Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE.

J Biol Chem. 2011 Jan 14;286(2):942-51. doi: 10.1074/jbc.M110.198200. Epub 2010 Oct 29.

12.

Variability in G-protein-coupled signaling studied with microfluidic devices.

Bao XR, Fraser ID, Wall EA, Quake SR, Simon MI.

Biophys J. 2010 Oct 20;99(8):2414-22. doi: 10.1016/j.bpj.2010.08.043.

13.

NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.

Kim D, You B, Jo EK, Han SK, Simon MI, Lee SJ.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14851-6. doi: 10.1073/pnas.1009926107. Epub 2010 Aug 2.

14.

Association between nutritional status and dietary intake in patients with cystic fibrosis.

Simon MI, Drehmer M, Menna-Barreto SS.

J Bras Pneumol. 2009 Oct;35(10):966-72. English, Portuguese.

15.

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.

Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11330-5. doi: 10.1073/pnas.0905605106. Epub 2009 Jun 29.

16.

Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.

Wall EA, Zavzavadjian JR, Chang MS, Randhawa B, Zhu X, Hsueh RC, Liu J, Driver A, Bao XR, Sternweis PC, Simon MI, Fraser ID.

Sci Signal. 2009 Jun 16;2(75):ra28. doi: 10.1126/scisignal.2000202.

17.

Deciphering signaling outcomes from a system of complex networks.

Hsueh RC, Natarajan M, Fraser I, Pond B, Liu J, Mumby S, Han H, Jiang LI, Simon MI, Taussig R, Sternweis PC.

Sci Signal. 2009 May 19;2(71):ra22. doi: 10.1126/scisignal.2000054.

18.

Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation.

Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6243-8. doi: 10.1073/pnas.0801569105. Epub 2008 Apr 23.

19.

Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.

Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE.

J Biol Chem. 2008 Jun 20;283(25):17351-61. doi: 10.1074/jbc.M800907200. Epub 2008 Apr 14.

20.

A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs.

Zhu X, Santat LA, Chang MS, Liu J, Zavzavadjian JR, Wall EA, Kivork C, Simon MI, Fraser ID.

BMC Mol Biol. 2007 Oct 30;8:98.

21.

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.

Shi G, Partida-Sánchez S, Misra RS, Tighe M, Borchers MT, Lee JJ, Simon MI, Lund FE.

J Exp Med. 2007 Oct 29;204(11):2705-18. Epub 2007 Oct 15.

22.

Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.

Pero RS, Borchers MT, Spicher K, Ochkur SI, Sikora L, Rao SP, Abdala-Valencia H, O'Neill KR, Shen H, McGarry MP, Lee NA, Cook-Mills JM, Sriramarao P, Simon MI, Birnbaumer L, Lee JJ.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4371-6. Epub 2007 Mar 7.

23.

The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.

Zavzavadjian JR, Couture S, Park WS, Whalen J, Lyon S, Lee G, Fung E, Mi Q, Liu J, Wall E, Santat L, Dhandapani K, Kivork C, Driver A, Zhu X, Chang MS, Randhawa B, Gehrig E, Bryan H, Verghese M, Maer A, Saunders B, Ning Y, Subramaniam S, Meyer T, Simon MI, O'Rourke N, Chandy G, Fraser ID.

Mol Cell Proteomics. 2007 Mar;6(3):413-24. Epub 2006 Dec 27.

25.

Dual ligand stimulation of RAW 264.7 cells uncovers feedback mechanisms that regulate TLR-mediated gene expression.

Zhu X, Chang MS, Hsueh RC, Taussig R, Smith KD, Simon MI, Choi S.

J Immunol. 2006 Oct 1;177(7):4299-310.

26.

A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression.

Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13759-64. Epub 2006 Aug 31.

27.

Identification of small molecule antagonists of the human mas-related gene-X1 receptor.

Kunapuli P, Lee S, Zheng W, Alberts M, Kornienko O, Mull R, Kreamer A, Hwang JI, Simon MI, Strulovici B.

Anal Biochem. 2006 Apr 1;351(1):50-61. Epub 2006 Feb 3.

PMID:
16510108
28.

Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.

Burns ME, Mendez A, Chen CK, Almuete A, Quillinan N, Simon MI, Baylor DA, Chen J.

J Neurosci. 2006 Jan 18;26(3):1036-44.

29.

Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA.

Quezada CM, Hamel DJ, Gradinaru C, Bilwes AM, Dahlquist FW, Crane BR, Simon MI.

J Biol Chem. 2005 Aug 26;280(34):30581-5. Epub 2005 Jun 30.

30.

Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins.

Hwang JI, Choi S, Fraser ID, Chang MS, Simon MI.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9493-8. Epub 2005 Jun 27.

31.

An open letter to Elias Zerhouni.

Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N.

Science. 2005 Mar 4;307(5714):1409-10. No abstract available.

PMID:
15746409
32.

D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.

Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J.

J Neurosci. 2005 Feb 23;25(8):2157-65.

33.

Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands.

Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S.

J Immunol. 2004 Dec 15;173(12):7141-9.

34.

Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration.

Roca A, Shin KJ, Liu X, Simon MI, Chen J.

Neuroscience. 2004;129(3):779-90.

PMID:
15541899
35.

Helical shifts generate two distinct conformers in the atomic resolution structure of the CheA phosphotransferase domain from Thermotoga maritima.

Quezada CM, Gradinaru C, Simon MI, Bilwes AM, Crane BR.

J Mol Biol. 2004 Aug 27;341(5):1283-94.

PMID:
15321722
36.

In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved.

Park SY, Beel BD, Simon MI, Bilwes AM, Crane BR.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11646-51. Epub 2004 Aug 2.

37.

Recoverin regulates light-dependent phosphodiesterase activity in retinal rods.

Makino CL, Dodd RL, Chen J, Burns ME, Roca A, Simon MI, Baylor DA.

J Gen Physiol. 2004 Jun;123(6):729-41. Erratum in: J Gen Physiol. 2005 Jul;126(1):81.

39.

Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA.

Hwang JI, Fraser ID, Choi S, Qin XF, Simon MI.

Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):488-93. Epub 2003 Dec 29.

40.

Novel form of adaptation in mouse retinal rods speeds recovery of phototransduction.

Krispel CM, Chen CK, Simon MI, Burns ME.

J Gen Physiol. 2003 Dec;122(6):703-12. Epub 2003 Nov 10.

41.

G13 is an essential mediator of platelet activation in hemostasis and thrombosis.

Moers A, Nieswandt B, Massberg S, Wettschureck N, Grüner S, Konrad I, Schulte V, Aktas B, Gratacap MP, Simon MI, Gawaz M, Offermanns S.

Nat Med. 2003 Nov;9(11):1418-22. Epub 2003 Oct 5.

PMID:
14528298
42.

A quantitative characterization of the yeast heterotrimeric G protein cycle.

Yi TM, Kitano H, Simon MI.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10764-9. Epub 2003 Sep 5.

43.

Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.

Marinissen MJ, Servitja JM, Offermanns S, Simon MI, Gutkind JS.

J Biol Chem. 2003 Nov 21;278(47):46814-25. Epub 2003 Sep 3.

44.

Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.

Krispel CM, Chen CK, Simon MI, Burns ME.

J Neurosci. 2003 Aug 6;23(18):6965-71.

45.

RGS9 modulates dopamine signaling in the basal ganglia.

Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI, Nestler EJ.

Neuron. 2003 Jun 19;38(6):941-52.

46.

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5.

Chen CK, Eversole-Cire P, Zhang H, Mancino V, Chen YJ, He W, Wensel TG, Simon MI.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6604-9. Epub 2003 May 8.

47.

Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling.

Borchers MT, Biechele T, Justice JP, Ansay T, Cormier S, Mancino V, Wilkie TM, Simon MI, Lee NA, Lee JJ.

Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L114-20. Epub 2003 Feb 28.

48.
49.

Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.

50.

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.

Han SK, Dong X, Hwang JI, Zylka MJ, Anderson DJ, Simon MI.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14740-5. Epub 2002 Oct 23.

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