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Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial.

Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M.

Am J Clin Nutr. 2019 Nov 1;110(5):1098-1107. doi: 10.1093/ajcn/nqz191.


BACH1 Orchestrates Lung Cancer Metastasis.

Anderson NM, Simon MC.

Cell. 2019 Oct 17;179(3):800. doi: 10.1016/j.cell.2019.09.032. No abstract available.


Even Cancer Cells Watch Their Cholesterol!

Riscal R, Skuli N, Simon MC.

Mol Cell. 2019 Oct 17;76(2):220-231. doi: 10.1016/j.molcel.2019.09.008. Epub 2019 Oct 2. Review.


Microbial Metabolites of Flavan-3-Ols and Their Biological Activity.

Márquez Campos E, Stehle P, Simon MC.

Nutrients. 2019 Sep 20;11(10). pii: E2260. doi: 10.3390/nu11102260. Review.


Applying Data Analytics to Address Social Determinants of Health in Practice.

Wallace JW, Decosimo KP, Simon MC.

N C Med J. 2019 Jul-Aug;80(4):244-248. doi: 10.18043/ncm.80.4.244.


BACH1 Orchestrates Lung Cancer Metastasis.

Anderson NM, Simon MC.

Cell. 2019 Jul 11;178(2):265-267. doi: 10.1016/j.cell.2019.06.020. Epub 2019 Jun 27. Erratum in: Cell. 2019 Oct 17;179(3):800.


Gamma-Glutamyltransferase 1 Promotes Clear Cell Renal Cell Carcinoma Initiation and Progression.

Bansal A, Sanchez DJ, Nimgaonkar V, Sanchez D, Riscal R, Skuli N, Simon MC.

Mol Cancer Res. 2019 Sep;17(9):1881-1892. doi: 10.1158/1541-7786.MCR-18-1204. Epub 2019 May 31.


Comparison of the diagnostic accuracy of the current guidelines for detecting insulinoma.

Dauben L, Simon MC, Strassburger K, Burkart V, Weber KS, Schinner S, Roden M, Müssig K.

Eur J Endocrinol. 2019 Jun 1;180(6):381-386. doi: 10.1530/EJE-18-0879.


Correlates of Insulin-Stimulated Glucose Disposal in Recent-Onset Type 1 and Type 2 Diabetes.

Simon MC, Möller-Horigome A, Strassburger K, Nowotny B, Knebel B, Müssig K, Herder C, Szendroedi J, Roden MW; German Diabetes Study Group.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2295-2304. doi: 10.1210/jc.2018-02057.


Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature.

Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon MC, Semenza GL, Nicolls MR.

Circulation. 2019 Jan 22;139(4):502-517. doi: 10.1161/CIRCULATIONAHA.118.036157.


Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Lin N, Shay JES, Xie H, Lee DSM, Skuli N, Tang Q, Zhou Z, Azzam A, Meng H, Wang H, FitzGerald GA, Simon MC.

Front Immunol. 2018 Nov 5;9:2565. doi: 10.3389/fimmu.2018.02565. eCollection 2018.


Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus.

Bódis K, Kahl S, Simon MC, Zhou Z, Sell H, Knebel B, Tura A, Strassburger K, Burkart V, Müssig K, Markgraf D, Al-Hasani H, Szendroedi J, Roden M; GDS Study Group.

Nutr Diabetes. 2018 Sep 7;8(1):49. doi: 10.1038/s41387-018-0054-9.


Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation.

Ackerman D, Tumanov S, Qiu B, Michalopoulou E, Spata M, Azzam A, Xie H, Simon MC, Kamphorst JJ.

Cell Rep. 2018 Sep 4;24(10):2596-2605.e5. doi: 10.1016/j.celrep.2018.08.015.


Perseverance when the going gets tough.

Simon MC.

Nat Cell Biol. 2018 Sep;20(9):1008. doi: 10.1038/s41556-018-0172-6. No abstract available.


Transcriptional control of kidney cancer.

Sanchez DJ, Simon MC.

Science. 2018 Jul 20;361(6399):226-227. doi: 10.1126/science.aau4385. No abstract available.


Hidden features: exploring the non-canonical functions of metabolic enzymes.

Huangyang P, Simon MC.

Dis Model Mech. 2018 Jul 6;11(8). pii: dmm033365. doi: 10.1242/dmm.033365. Review.


Genetic and metabolic hallmarks of clear cell renal cell carcinoma.

Sanchez DJ, Simon MC.

Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):23-31. doi: 10.1016/j.bbcan.2018.06.003. Epub 2018 Jun 28. Review.


Hif1α Deletion Limits Tissue Regeneration via Aberrant B Cell Accumulation in Experimental Pancreatitis.

Lee KE, Spata M, Maduka R, Vonderheide RH, Simon MC.

Cell Rep. 2018 Jun 19;23(12):3457-3464. doi: 10.1016/j.celrep.2018.05.071.


Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas.

Chang KK, Yoon C, Yi BC, Tap WD, Simon MC, Yoon SS.

Oncogenesis. 2018 Jun 19;7(6):47. doi: 10.1038/s41389-018-0059-1.


Glutathione metabolism in cancer progression and treatment resistance.

Bansal A, Simon MC.

J Cell Biol. 2018 Jul 2;217(7):2291-2298. doi: 10.1083/jcb.201804161. Epub 2018 Jun 18. Review.


Habitual Fructose Intake Relates to Insulin Sensitivity and Fatty Liver Index in Recent-Onset Type 2 Diabetes Patients and Individuals without Diabetes.

Weber KS, Simon MC, Strassburger K, Markgraf DF, Buyken AE, Szendroedi J, Müssig K, Roden M; GDS Group.

Nutrients. 2018 Jun 15;10(6). pii: E774. doi: 10.3390/nu10060774.


PPARγ is dispensable for clear cell renal cell carcinoma progression.

Sanchez DJ, Steger DJ, Skuli N, Bansal A, Simon MC.

Mol Metab. 2018 Aug;14:139-149. doi: 10.1016/j.molmet.2018.05.013. Epub 2018 May 21.


Combining Measurements from Mobile Monitoring and a Reference Site To Develop Models of Ambient Ultrafine Particle Number Concentration at Residences.

Simon MC, Patton AP, Naumova EN, Levy JI, Kumar P, Brugge D, Durant JL.

Environ Sci Technol. 2018 Jun 19;52(12):6985-6995. doi: 10.1021/acs.est.8b00292. Epub 2018 May 25.


Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC.

Cell Metab. 2018 Jun 5;27(6):1263-1280.e6. doi: 10.1016/j.cmet.2018.04.009. Epub 2018 May 10.


Longitudinal associations of long-term exposure to ultrafine particles with blood pressure and systemic inflammation in Puerto Rican adults.

Corlin L, Woodin M, Hart JE, Simon MC, Gute DM, Stowell J, Tucker KL, Durant JL, Brugge D.

Environ Health. 2018 Apr 5;17(1):33. doi: 10.1186/s12940-018-0379-9.


The ASACUSA antihydrogen and hydrogen program: results and prospects.

Malbrunot C, Amsler C, Arguedas Cuendis S, Breuker H, Dupre P, Fleck M, Higaki H, Kanai Y, Kolbinger B, Kuroda N, Leali M, Mäckel V, Mascagna V, Massiczek O, Matsuda Y, Nagata Y, Simon MC, Spitzer H, Tajima M, Ulmer S, Venturelli L, Widmann E, Wiesinger M, Yamazaki Y, Zmeskal J.

Philos Trans A Math Phys Eng Sci. 2018 Mar 28;376(2116). pii: 20170273. doi: 10.1098/rsta.2017.0273.


Aviation-Related Impacts on Ultrafine Particle Number Concentrations Outside and Inside Residences near an Airport.

Hudda N, Simon MC, Zamore W, Durant JL.

Environ Sci Technol. 2018 Feb 20;52(4):1765-1772. doi: 10.1021/acs.est.7b05593. Epub 2018 Feb 7.


Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations.

Brugge D, Simon MC, Hudda N, Zellmer M, Corlin L, Cleland S, Lu EY, Rivera S, Byrne M, Chung M, Durant JL.

Build Environ. 2017 Dec;126:266-275. doi: 10.1016/j.buildenv.2017.10.007. Epub 2017 Oct 6.


IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.

Xie H, Tang CH, Song JH, Mancuso A, Del Valle JR, Cao J, Xiang Y, Dang CV, Lan R, Sanchez DJ, Keith B, Hu CC, Simon MC.

J Clin Invest. 2018 Apr 2;128(4):1300-1316. doi: 10.1172/JCI95864. Epub 2018 Feb 26.


Comparisons of Traffic-Related Ultrafine Particle Number Concentrations Measured in Two Urban Areas by Central, Residential, and Mobile Monitoring.

Simon MC, Hudda N, Naumova EN, Levy JI, Brugge D, Durant JL.

Atmos Environ (1994). 2017 Nov;169:113-127. doi: 10.1016/j.atmosenv.2017.09.003. Epub 2017 Sep 4.


Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues.

Li F, Lee KE, Simon MC.

Methods Mol Biol. 2018;1742:277-282. doi: 10.1007/978-1-4939-7665-2_24.


Microbial Regulation of Glucose Metabolism and Insulin Resistance.

Crommen S, Simon MC.

Genes (Basel). 2017 Dec 29;9(1). pii: E10. doi: 10.3390/genes9010010. Review.


Oxygen availability and metabolic reprogramming in cancer.

Xie H, Simon MC.

J Biol Chem. 2017 Oct 13;292(41):16825-16832. doi: 10.1074/jbc.R117.799973. Epub 2017 Aug 24. Review.


In-beam measurement of the hydrogen hyperfine splitting and prospects for antihydrogen spectroscopy.

Diermaier M, Jepsen CB, Kolbinger B, Malbrunot C, Massiczek O, Sauerzopf C, Simon MC, Zmeskal J, Widmann E.

Nat Commun. 2017 Jun 12;8:15749. doi: 10.1038/ncomms15749.


BODIPY 493/503 Staining of Neutral Lipid Droplets for Microscopy and Quantification by Flow Cytometry.

Qiu B, Simon MC.

Bio Protoc. 2016 Sep 5;6(17). pii: e1912. doi: 10.21769/BioProtoc.1912.


Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma.

Gade TPF, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC.

Radiology. 2017 Jun;283(3):702-710. doi: 10.1148/radiol.2017160728. Epub 2017 Mar 2.


Oxygen availability and metabolic adaptations.

Nakazawa MS, Keith B, Simon MC.

Nat Rev Cancer. 2016 Sep 23;16(10):663-73. doi: 10.1038/nrc.2016.84. Review.


The Hypoxia Response Pathways - Hats Off!

Simon MC.

N Engl J Med. 2016 Oct 27;375(17):1687-1689. Epub 2016 Sep 13. No abstract available.


Hypoxia-inducible factors: key regulators of myeloid cells during inflammation.

Lin N, Simon MC.

J Clin Invest. 2016 Oct 3;126(10):3661-3671. doi: 10.1172/JCI84426. Epub 2016 Sep 6. Review.


Aviation Emissions Impact Ambient Ultrafine Particle Concentrations in the Greater Boston Area.

Hudda N, Simon MC, Zamore W, Brugge D, Durant JL.

Environ Sci Technol. 2016 Aug 16;50(16):8514-21. doi: 10.1021/acs.est.6b01815. Epub 2016 Aug 4.


Intratumoral oxygen gradients mediate sarcoma cell invasion.

Lewis DM, Park KM, Tang V, Xu Y, Pak K, Eisinger-Mathason TS, Simon MC, Gerecht S.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9292-7. doi: 10.1073/pnas.1605317113. Epub 2016 Aug 2.


Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.

Yoon C, Chang KK, Lee JH, Tap WD, Hart CP, Simon MC, Yoon SS.

Oncotarget. 2016 Jul 12;7(28):42844-42858. doi: 10.18632/oncotarget.10212.


The Impact of Dietary Factors on Glycemic Control, Insulin Sensitivity and Secretion in the First Years after Diagnosis of Diabetes.

Weber KS, Buyken AE, Nowotny B, Strassburger K, Simon MC, Pacini G, Szendroedi J, Müssig K, Roden M; GDS Group.

Exp Clin Endocrinol Diabetes. 2016 Apr;124(4):230-8. doi: 10.1055/s-0035-1569354. Epub 2016 Apr 28.


E2A Antagonizes PU.1 Activity through Inhibition of DNA Binding.

Rogers JH, Owens KS, Kurkewich J, Klopfenstein N, Iyer SR, Simon MC, Dahl R.

Biomed Res Int. 2016;2016:3983686. doi: 10.1155/2016/3983686. Epub 2016 Jan 28.


Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.

Nakazawa MS, Eisinger-Mathason TS, Sadri N, Ochocki JD, Gade TP, Amin RK, Simon MC.

Nat Commun. 2016 Feb 3;7:10539. doi: 10.1038/ncomms10539.


Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.

Lee KE, Spata M, Bayne LJ, Buza EL, Durham AC, Allman D, Vonderheide RH, Simon MC.

Cancer Discov. 2016 Mar;6(3):256-69. doi: 10.1158/2159-8290.CD-15-0822. Epub 2015 Dec 29.


On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.

Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, Tremblay C, Le Gall JM, Cua E, Pasquet A, Raffi F, Pintado C, Chidiac C, Chas J, Charbonneau P, Delaugerre C, Suzan-Monti M, Loze B, Fonsart J, Peytavin G, Cheret A, Timsit J, Girard G, Lorente N, Préau M, Rooney JF, Wainberg MA, Thompson D, Rozenbaum W, Doré V, Marchand L, Simon MC, Etien N, Aboulker JP, Meyer L, Delfraissy JF; ANRS IPERGAY Study Group.

N Engl J Med. 2015 Dec 3;373(23):2237-46. doi: 10.1056/NEJMoa1506273. Epub 2015 Dec 1.


SnapShot: Hypoxia-Inducible Factors.

Lee KE, Simon MC.

Cell. 2015 Nov 19;163(5):1288-1288.e1. doi: 10.1016/j.cell.2015.11.011.


MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.

Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17.


Oncogenes strike a balance between cellular growth and homeostasis.

Qiu B, Simon MC.

Semin Cell Dev Biol. 2015 Jul;43:3-10. doi: 10.1016/j.semcdb.2015.08.005. Epub 2015 Aug 13. Review.

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