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Items: 38

1.

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.

Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, Jones TK, Fraser IP, Grice CA, Ezekowitz RAB, O'Neill GP, Blankman JL.

J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296. doi: 10.1124/jpet.118.252296. [Epub ahead of print]

2.

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.

Cisar JS, Weber OD, Clapper JR, Blankman JL, Henry CL, Simon GM, Alexander JP, Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA.

J Med Chem. 2018 Oct 25;61(20):9062-9084. doi: 10.1021/acs.jmedchem.8b00951. Epub 2018 Aug 23.

PMID:
30067909
3.

Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.

Whitby LR, Obach RS, Simon GM, Hayward MM, Cravatt BF.

ACS Chem Biol. 2017 Aug 18;12(8):2040-2050. doi: 10.1021/acschembio.7b00346. Epub 2017 Jun 21.

4.

ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.

Lee HC, Simon GM, Cravatt BF.

Biochemistry. 2015 Apr 21;54(15):2539-49. doi: 10.1021/acs.biochem.5b00207. Epub 2015 Apr 8.

5.

Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome.

Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RA, Kleschevnikov AM.

PLoS One. 2014 Dec 4;9(12):e114521. doi: 10.1371/journal.pone.0114521. eCollection 2014.

6.

Bacteria from diverse habitats colonize and compete in the mouse gut.

Seedorf H, Griffin NW, Ridaura VK, Reyes A, Cheng J, Rey FE, Smith MI, Simon GM, Scheffrahn RH, Woebken D, Spormann AM, Van Treuren W, Ursell LK, Pirrung M, Robbins-Pianka A, Cantarel BL, Lombard V, Henrissat B, Knight R, Gordon JI.

Cell. 2014 Oct 9;159(2):253-66. doi: 10.1016/j.cell.2014.09.008. Epub 2014 Oct 2.

7.

Global identification of caspase substrates using PROTOMAP (protein topography and migration analysis platform).

Dix MM, Simon GM, Cravatt BF.

Methods Mol Biol. 2014;1133:61-70. doi: 10.1007/978-1-4939-0357-3_3.

PMID:
24567094
8.

Determining target engagement in living systems.

Simon GM, Niphakis MJ, Cravatt BF.

Nat Chem Biol. 2013 Apr;9(4):200-5. doi: 10.1038/nchembio.1211. No abstract available.

9.

Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer.

McNulty SN, Abubucker S, Simon GM, Mitreva M, McNulty NP, Fischer K, Curtis KC, Brattig NW, Weil GJ, Fischer PU.

PLoS One. 2012;7(9):e45777. doi: 10.1371/journal.pone.0045777. Epub 2012 Sep 26.

10.

Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome.

Dix MM, Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF.

Cell. 2012 Jul 20;150(2):426-40. doi: 10.1016/j.cell.2012.05.040.

11.

The role of the therapist: what effective therapists do.

Simon GM.

J Marital Fam Ther. 2012 Jun;38 Suppl 1:8-12. doi: 10.1111/j.1752-0606.2009.00136.x. Epub 2011 Sep 29.

PMID:
22765319
12.

The role of the therapist in common factors: continuing the dialogue.

Simon GM.

J Marital Fam Ther. 2012 Jun;38 Suppl 1:1-7. doi: 10.1111/j.1752-0606.2009.00135.x. Epub 2011 Sep 28.

PMID:
22765318
13.

Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.

Simon GM, Cheng J, Gordon JI.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. doi: 10.1073/pnas.1208669109. Epub 2012 Jun 25.

14.

Quantitative reactivity profiling predicts functional cysteines in proteomes.

Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF.

Nature. 2010 Dec 9;468(7325):790-5. doi: 10.1038/nature09472. Epub 2010 Nov 17.

15.

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening.

Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6. doi: 10.1073/pnas.1011663107. Epub 2010 Nov 17.

16.

Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte.

Bowyer PW, Simon GM, Cravatt BF, Bogyo M.

Mol Cell Proteomics. 2011 May;10(5):M110.001636. doi: 10.1074/mcp.M110.001636. Epub 2010 Oct 12.

17.

The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice.

Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF.

Chem Biol. 2010 Aug 27;17(8):831-40. doi: 10.1016/j.chembiol.2010.06.009.

19.

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study.

Simon GM, Cravatt BF.

J Biol Chem. 2010 Apr 9;285(15):11051-5. doi: 10.1074/jbc.R109.097600. Epub 2010 Feb 10. Review.

20.

Biomarkers of endocannabinoid system activation in severe obesity.

Sipe JC, Scott TM, Murray S, Harismendy O, Simon GM, Cravatt BF, Waalen J.

PLoS One. 2010 Jan 20;5(1):e8792. doi: 10.1371/journal.pone.0008792.

21.

Comparative assessment of large-scale proteomic studies of apoptotic proteolysis.

Simon GM, Dix MM, Cravatt BF.

ACS Chem Biol. 2009 Jun 19;4(6):401-8. doi: 10.1021/cb900082q.

22.

Challenges for the 'chemical-systems' biologist.

Simon GM, Cravatt BF.

Nat Chem Biol. 2008 Nov;4(11):639-42. doi: 10.1038/nchembio1108-639. No abstract available.

PMID:
18936742
23.

Global mapping of the topography and magnitude of proteolytic events in apoptosis.

Dix MM, Simon GM, Cravatt BF.

Cell. 2008 Aug 22;134(4):679-91. doi: 10.1016/j.cell.2008.06.038.

24.

Disparate proteome reactivity profiles of carbon electrophiles.

Weerapana E, Simon GM, Cravatt BF.

Nat Chem Biol. 2008 Jul;4(7):405-7. doi: 10.1038/nchembio.91. Epub 2008 May 18. Erratum in: Nat Chem Biol. 2008 Jul;4(7):following 407.

25.

Activation of the endocannabinoid system by organophosphorus nerve agents.

Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE.

Nat Chem Biol. 2008 Jun;4(6):373-8. doi: 10.1038/nchembio.86. Epub 2008 Apr 27.

26.

Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.

Simon GM, Cravatt BF.

J Biol Chem. 2008 Apr 4;283(14):9341-9. doi: 10.1074/jbc.M707807200. Epub 2008 Jan 27.

27.
28.

The biological impact of mass-spectrometry-based proteomics.

Cravatt BF, Simon GM, Yates JR 3rd.

Nature. 2007 Dec 13;450(7172):991-1000. Review.

PMID:
18075578
29.
30.

Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes.

Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong CH.

J Am Chem Soc. 2007 Jun 13;129(23):7266-7. Epub 2007 May 17. No abstract available.

32.
33.
34.

Cell-specific regulatory modules control expression of genes in vascular and visceral smooth muscle tissues.

Hoggatt AM, Simon GM, Herring BP.

Circ Res. 2002 Dec 13;91(12):1151-9.

PMID:
12480816
35.

The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.

Sterner DE, Wang X, Bloom MH, Simon GM, Berger SL.

J Biol Chem. 2002 Mar 8;277(10):8178-86. Epub 2002 Jan 2.

36.

Hierarchy again: on accepting limitations.

Simon GM.

Fam Process. 1994 Mar;33(1):101-3. No abstract available.

PMID:
8039564
37.

Revisiting the notion of hierarchy.

Simon GM.

Fam Process. 1993 Jun;32(2):147-55.

PMID:
8405348
38.

Use of magnesium hydroxide and low magnesium dialysate does not permit reduction of aluminum hydroxide during continuous ambulatory peritoneal dialysis.

Jennings AE, Bodvarsson M, Galicka-Piskorska G, Diefendorf AS, Simon GM, Levey AS.

Am J Kidney Dis. 1986 Sep;8(3):192-5.

PMID:
3752074

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