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Items: 1 to 50 of 195

1.

Retrons and their applications in genome engineering.

Simon AJ, Ellington AD, Finkelstein IJ.

Nucleic Acids Res. 2019 Oct 10. pii: gkz865. doi: 10.1093/nar/gkz865. [Epub ahead of print]

PMID:
31598685
2.

CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis.

Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K.

Blood. 2019 Sep 9. pii: blood.2019000644. doi: 10.1182/blood.2019000644. [Epub ahead of print]

PMID:
31501153
3.

Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors.

Meinke JL, Simon AJ, Wagner DT, Morrow BR, You S, Ellington AD, Keatinge-Clay AT.

ACS Synth Biol. 2019 Sep 20;8(9):2017-2024. doi: 10.1021/acssynbio.9b00047. Epub 2019 Sep 12.

PMID:
31469555
4.

Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation.

Lev A, Simon AJ, Barel O, Eyal E, Glick-Saar E, Nayshool O, Birk O, Stauber T, Hochberg A, Broides A, Almashanu S, Hendel A, Lee YN, Somech R.

Front Immunol. 2019 Jul 17;10:1672. doi: 10.3389/fimmu.2019.01672. eCollection 2019.

5.

Fetuin-A deficiency is associated with infantile cortical hyperostosis (Caffey disease).

Merdler-Rabinowicz R, Grinberg A, Jacobson JM, Somekh I, Klein C, Lev A, Ihsan S, Habib A, Somech R, Simon AJ.

Pediatr Res. 2019 Jul 9. doi: 10.1038/s41390-019-0499-0. [Epub ahead of print]

PMID:
31288248
6.

Immune reconstitution after HSCT in SCID-a cohort of conditioned and unconditioned patients.

Manor U, Lev A, Simon AJ, Hutt D, Toren A, Bielorai B, Goldberg L, Stauber T, Somech R.

Immunol Res. 2019 Jun;67(2-3):166-175. doi: 10.1007/s12026-019-09081-z.

PMID:
31222511
7.

Synthetic evolution.

Simon AJ, d'Oelsnitz S, Ellington AD.

Nat Biotechnol. 2019 Jul;37(7):730-743. doi: 10.1038/s41587-019-0157-4. Epub 2019 Jun 17. Review.

PMID:
31209374
8.

Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion.

Devilbiss DM, Etnoyer-Slaski JL, Dunn E, Dussourd CR, Kothare MV, Martino SJ, Simon AJ.

J Healthc Eng. 2019 Apr 30;2019:4794637. doi: 10.1155/2019/4794637. eCollection 2019.

9.

Closed-loop digital meditation improves sustained attention in young adults.

Ziegler DA, Simon AJ, Gallen CL, Skinner S, Janowich JR, Volponi JJ, Rolle CE, Mishra J, Kornfield J, Anguera JA, Gazzaley A.

Nat Hum Behav. 2019 Jul;3(7):746-757. doi: 10.1038/s41562-019-0611-9. Epub 2019 Jun 3.

PMID:
31160812
10.

Novel MALT1 Mutation Linked to Immunodeficiency, Immune Dysregulation, and an Abnormal T Cell Receptor Repertoire.

Frizinsky S, Rechavi E, Barel O, Najeeb RH, Greenberger S, Lee YN, Simon AJ, Lev A, Ma CA, Sun G, Blackstone SA, Milner JD, Somech R, Stauber T.

J Clin Immunol. 2019 May;39(4):401-413. doi: 10.1007/s10875-019-00629-0. Epub 2019 Apr 29.

PMID:
31037583
11.

Disentangling expectation from selective attention during perceptual decision making.

Simon AJ, Schachtner JN, Gallen CL.

J Neurophysiol. 2019 Jun 1;121(6):1977-1980. doi: 10.1152/jn.00639.2018. Epub 2019 Mar 13.

PMID:
30864895
12.

Neutrophil Functions in Immunodeficiency Due to DOCK8 Deficiency.

Mandola AB, Levy J, Nahum A, Hadad N, Levy R, Rylova A, Simon AJ, Lev A, Somech R, Broides A.

Immunol Invest. 2019 May;48(4):431-439. doi: 10.1080/08820139.2019.1567533. Epub 2019 Jan 28.

PMID:
30689480
13.

Supercharging enables organized assembly of synthetic biomolecules.

Simon AJ, Zhou Y, Ramasubramani V, Glaser J, Pothukuchy A, Gollihar J, Gerberich JC, Leggere JC, Morrow BR, Jung C, Glotzer SC, Taylor DW, Ellington AD.

Nat Chem. 2019 Mar;11(3):204-212. doi: 10.1038/s41557-018-0196-3. Epub 2019 Jan 14.

PMID:
30643229
14.

The Duffy antigen receptor for chemokines, ACKR1,- 'Jeanne DARC' of benign neutropenia.

Rappoport N, Simon AJ, Amariglio N, Rechavi G.

Br J Haematol. 2019 Feb;184(4):497-507. doi: 10.1111/bjh.15730. Epub 2018 Dec 27. Review.

PMID:
30592023
15.

Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction.

Kain D, Simon AJ, Greenberg A, Ben Zvi D, Gilburd B, Schneiderman J.

PLoS One. 2018 Oct 12;13(10):e0203902. doi: 10.1371/journal.pone.0203902. eCollection 2018.

16.

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.

Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz D.

Gastroenterology. 2019 Jan;156(1):275-278. doi: 10.1053/j.gastro.2018.09.041. Epub 2018 Sep 26. No abstract available.

PMID:
30267714
17.

Retroelement-Based Genome Editing and Evolution.

Simon AJ, Morrow BR, Ellington AD.

ACS Synth Biol. 2018 Nov 16;7(11):2600-2611. doi: 10.1021/acssynbio.8b00273. Epub 2018 Oct 26.

PMID:
30256621
18.

Correction to: Novel Mutations in RASGRP1 Are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.

Somekh I, Marquardt B, Liu Y, Rohlfs M, Hollizeck S, Karakukcu M, Unal E, Yilmaz E, Patiroglu T, Cansever M, Frizinsky S, Vishnvenskia-Dai V, Rechavi E, Stauber T, Simon AJ, Lev A, Klein C, Kotlarz D, Somech R.

J Clin Immunol. 2018 Aug;38(6):711. doi: 10.1007/s10875-018-0541-8.

PMID:
30099695
19.

MHC II deficient infant identified by newborn screening program for SCID.

Marcus N, Stauber T, Lev A, Simon AJ, Stein J, Broides A, Somekh I, Almashanu S, Somech R.

Immunol Res. 2018 Aug;66(4):537-542. doi: 10.1007/s12026-018-9019-2.

PMID:
30084052
20.

Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.

Somekh I, Marquardt B, Liu Y, Rohlfs M, Hollizeck S, Karakukcu M, Unal E, Yilmaz E, Patiroglu T, Cansever M, Frizinsky S, Vishnvenska-Dai V, Rechavi E, Stauber T, Simon AJ, Lev A, Klein C, Kotlarz D, Somech R.

J Clin Immunol. 2018 Aug;38(6):699-710. doi: 10.1007/s10875-018-0533-8. Epub 2018 Jul 20. Erratum in: J Clin Immunol. 2018 Aug 11;:.

PMID:
30030704
21.

Co-appearance of OPV and BCG vaccine-derived complications in two infants with severe combined immunodeficiency.

Heiman S, Weil M, Shulman LM, Simon AJ, Lev A, Somech R, Stauber T.

Immunol Res. 2018 Jun;66(3):437-443. doi: 10.1007/s12026-018-9007-6.

PMID:
29804197
22.

Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel.

Simon AJ, Walls-Smith LT, Plaxco KW.

Analyst. 2018 May 29;143(11):2531-2538. doi: 10.1039/c8an00337h.

PMID:
29713702
23.

Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders.

Jacob-Hirsch J, Eyal E, Knisbacher BA, Roth J, Cesarkas K, Dor C, Farage-Barhom S, Kunik V, Simon AJ, Gal M, Yalon M, Moshitch-Moshkovitz S, Tearle R, Constantini S, Levanon EY, Amariglio N, Rechavi G.

Cell Res. 2018 Feb;28(2):187-203. doi: 10.1038/cr.2018.8. Epub 2018 Jan 12.

24.

First Year of Israeli Newborn Screening for Severe Combined Immunodeficiency-Clinical Achievements and Insights.

Rechavi E, Lev A, Simon AJ, Stauber T, Daas S, Saraf-Levy T, Broides A, Nahum A, Marcus N, Hanna S, Stepensky P, Toker O, Dalal I, Etzioni A, Almashanu S, Somech R.

Front Immunol. 2017 Nov 6;8:1448. doi: 10.3389/fimmu.2017.01448. eCollection 2017.

25.

Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.

Somech R, Lev A, Lee YN, Simon AJ, Barel O, Schiby G, Avivi C, Barshack I, Rhodes M, Yin J, Wang M, Yang Y, Rhodes J, Marcus N, Garty BZ, Stein J, Amariglio N, Rechavi G, Wiest DL, Zhang Y.

J Immunol. 2017 Dec 15;199(12):4036-4045. doi: 10.4049/jimmunol.1700460. Epub 2017 Nov 10.

26.

Accelerating Innovation that Enhances Resource Recovery in the Wastewater Sector: Advancing a National Testbed Network.

Mihelcic JR, Ren ZJ, Cornejo PK, Fisher A, Simon AJ, Snyder SW, Zhang Q, Rosso D, Huggins TM, Cooper W, Moeller J, Rose B, Schottel BL, Turgeon J.

Environ Sci Technol. 2017 Jul 18;51(14):7749-7758. doi: 10.1021/acs.est.6b05917. Epub 2017 Jun 13.

PMID:
28534608
27.

T and B cell clonal expansion in Ras-associated lymphoproliferative disease (RALD) as revealed by next-generation sequencing.

Levy-Mendelovich S, Lev A, Rechavi E, Barel O, Golan H, Bielorai B, Neumann Y, Simon AJ, Somech R.

Clin Exp Immunol. 2017 Sep;189(3):310-317. doi: 10.1111/cei.12986. Epub 2017 Jun 5.

28.

Simultaneous Measurement of the Dissolution Kinetics of Responsive DNA Hydrogels at Multiple Length Scales.

Simon AJ, Walls-Smith LT, Freddi MJ, Fong FY, Gubala V, Plaxco KW.

ACS Nano. 2017 Jan 24;11(1):461-468. doi: 10.1021/acsnano.6b06414. Epub 2017 Jan 3.

PMID:
28006092
29.

A Novel Mutation in a Critical Region for the Methyl Donor Binding in DNMT3B Causes Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome (ICF).

Rechavi E, Lev A, Eyal E, Barel O, Kol N, Barhom SF, Pode-Shakked B, Anikster Y, Somech R, Simon AJ.

J Clin Immunol. 2016 Nov;36(8):801-809. Epub 2016 Oct 12.

PMID:
27734333
30.

Recent advances in synthetic biosafety.

Simon AJ, Ellington AD.

F1000Res. 2016 Aug 31;5. pii: F1000 Faculty Rev-2118. doi: 10.12688/f1000research.8365.1. eCollection 2016. Review.

31.

Using Nature's "Tricks" To Rationally Tune the Binding Properties of Biomolecular Receptors.

Ricci F, Vallée-Bélisle A, Simon AJ, Porchetta A, Plaxco KW.

Acc Chem Res. 2016 Sep 20;49(9):1884-92. doi: 10.1021/acs.accounts.6b00276. Epub 2016 Aug 26. Review.

32.

Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems.

Toren A, Pismenyuk T, Yalon M, Freedman S, Simon AJ, Fisher T, Moshe I, Reichardt JK, Constantini S, Mardor Y, Last D, Guez D, Daniels D, Assoulin M, Mehrian-Shai R.

Oncotarget. 2016 Nov 15;7(46):74860-74871. doi: 10.18632/oncotarget.11382.

33.

Training Working Memory: Anatomy Matters.

Simon AJ, Skinner SN, Ziegler DA.

J Neurosci. 2016 Jul 27;36(30):7805-6. doi: 10.1523/JNEUROSCI.1513-16.2016. Review. No abstract available.

34.

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Barel O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R.

J Exp Med. 2016 Jul 25;213(8):1429-40. doi: 10.1084/jem.20151618. Epub 2016 Jul 18.

35.

Combined immunodeficiency in a patient with mosaic monosomy 21.

Rechavi E, Levy-Mendelovich S, Stauber T, Shamash J, Reinstein S, Vernitsky H, Adam D, Simon AJ, Lev A, Raas-Rothschild A, Somech R.

Immunol Res. 2016 Aug;64(4):841-7. doi: 10.1007/s12026-016-8803-0.

PMID:
27216863
36.

Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure.

Mao X, Simon AJ, Pei H, Shi J, Li J, Huang Q, Plaxco KW, Fan C.

Chem Sci. 2016 Feb 1;7(2):1200-1204. doi: 10.1039/c5sc03705k. Epub 2015 Oct 26.

37.

High metallothionein predicts poor survival in glioblastoma multiforme.

Mehrian-Shai R, Yalon M, Simon AJ, Eyal E, Pismenyuk T, Moshe I, Constantini S, Toren A.

BMC Med Genomics. 2015 Oct 22;8:68. doi: 10.1186/s12920-015-0137-6.

38.

Highlighting the problematic reliance on CD18 for diagnosing leukocyte adhesion deficiency type 1.

Levy-Mendelovich S, Rechavi E, Abuzaitoun O, Vernitsky H, Simon AJ, Lev A, Somech R.

Immunol Res. 2016 Apr;64(2):476-82. doi: 10.1007/s12026-015-8706-5.

PMID:
26434744
39.

Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype.

Patrizi A, Picard N, Simon AJ, Gunner G, Centofante E, Andrews NA, Fagiolini M.

Biol Psychiatry. 2016 May 1;79(9):755-764. doi: 10.1016/j.biopsych.2015.08.018. Epub 2015 Aug 24.

40.

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.

Egbertson M, McGaughey GB, Pitzenberger SM, Stauffer SR, Coburn CA, Stachel SJ, Yang W, Barrow JC, Neilson LA, McWherter M, Perlow D, Fahr B, Munshi S, Allison TJ, Holloway K, Selnick HG, Yang Z, Swestock J, Simon AJ, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Pietrak B, Haugabook S, Jin L, Chen IW, Holahan M, Stranieri-Michener M, Cook JJ, Vacca J, Graham SL.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4812-4819. doi: 10.1016/j.bmcl.2015.06.082. Epub 2015 Jun 29.

PMID:
26195137
41.

Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions.

Watkins HM, Simon AJ, Sosnick TR, Lipman EA, Hjelm RP, Plaxco KW.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6631-6. doi: 10.1073/pnas.1418673112. Epub 2015 May 11.

42.

Exploration of EEG features of Alzheimer's disease using continuous wavelet transform.

Ghorbanian P, Devilbiss DM, Hess T, Bernstein A, Simon AJ, Ashrafiuon H.

Med Biol Eng Comput. 2015 Sep;53(9):843-55. doi: 10.1007/s11517-015-1298-3. Epub 2015 Apr 12.

PMID:
25863694
43.

Correlation between 'ACKR1/DARC null' polymorphism and benign neutropenia in Yemenite Jews.

Rappoport N, Simon AJ, Lev A, Yacobi M, Kaplinsky C, Weingarten M, Somech R, Amariglio N, Rechavi G.

Br J Haematol. 2015 Sep;170(6):892-5. doi: 10.1111/bjh.13345. Epub 2015 Mar 26. No abstract available.

PMID:
25817587
44.

Timely and spatially regulated maturation of B and T cell repertoire during human fetal development.

Rechavi E, Lev A, Lee YN, Simon AJ, Yinon Y, Lipitz S, Amariglio N, Weisz B, Notarangelo LD, Somech R.

Sci Transl Med. 2015 Feb 25;7(276):276ra25. doi: 10.1126/scitranslmed.aaa0072.

PMID:
25717098
45.

Thymic and bone marrow output in individuals with 22q11.2 deletion syndrome.

Dar N, Gothelf D, Korn D, Frisch A, Weizman A, Michaelovsky E, Carmel M, Yeshayahu Y, Dubnov-Raz G, Pessach IM, Simon AJ, Lev A, Somech R.

Pediatr Res. 2015 Apr;77(4):579-85. doi: 10.1038/pr.2015.14. Epub 2015 Jan 12.

PMID:
25580739
46.

Intravascular leiomyomatosis: A case report and review of the literature.

Simon AJ, Parry-Smith WR, Redman CW, Kodampur M, Todd R, Satur C, Morgan R.

J Obstet Gynaecol. 2015;35(5):539-40. doi: 10.3109/01443615.2014.978847. Review. No abstract available.

PMID:
25409202
47.

Use of vacuum bagging for fabricating thermoplastic microfluidic devices.

Cassano CL, Simon AJ, Liu W, Fredrickson C, Fan ZH.

Lab Chip. 2015 Jan 7;15(1):62-6. doi: 10.1039/c4lc00927d.

48.

Insight into normal thymic activity by assessment of peripheral blood samples.

Machnes-Maayan D, Lev A, Katz U, Mishali D, Vardi A, Simon AJ, Somech R.

Immunol Res. 2015 Mar;61(3):198-205. doi: 10.1007/s12026-014-8558-4.

PMID:
25294167
49.

Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors.

Simon AJ, Vallée-Bélisle A, Ricci F, Plaxco KW.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15048-53. doi: 10.1073/pnas.1410796111. Epub 2014 Oct 6.

50.

Using the population-shift mechanism to rationally introduce "Hill-type" cooperativity into a normally non-cooperative receptor.

Simon AJ, Vallée-Bélisle A, Ricci F, Watkins HM, Plaxco KW.

Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9471-5. doi: 10.1002/anie.201403777. Epub 2014 Jul 11.

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