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Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex.

Simms J, Uddin R, Sakmar TP, Gingell JJ, Garelja ML, Hay DL, Brimble MA, Harris PWR, Reynolds CA, Poyner DR.

Biochemistry. 2018 Jul 13. doi: 10.1021/acs.biochem.8b00502. [Epub ahead of print]


The Structure of the CGRP and Related Receptors.

Simms J, Routledge S, Uddin R, Poyner D.

Handb Exp Pharmacol. 2018 May 25. doi: 10.1007/164_2018_132. [Epub ahead of print]


Social Justice and Mobility in Coastal Louisiana, USA.

Colten CE, Simms JRZ, Grismore AA, Hemmerling SA.

Reg Environ Change. 2018 Feb;18(2):371-383. doi: 10.1007/s10113-017-1115-7. Epub 2017 Feb 21.


Functional characterisation of G protein-coupled receptors.

Uddin R, Simms J, Poyner D.

Methods. 2018 Mar 3. pii: S1046-2023(17)30375-4. doi: 10.1016/j.ymeth.2018.02.018. [Epub ahead of print] Review.


Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.

Coudrat T, Simms J, Christopoulos A, Wootten D, Sexton PM.

PLoS Comput Biol. 2017 Nov 13;13(11):e1005819. doi: 10.1371/journal.pcbi.1005819. eCollection 2017 Nov.


Istradefylline reduces memory deficits in aging mice with amyloid pathology.

Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L.

Neurobiol Dis. 2018 Feb;110:29-36. doi: 10.1016/j.nbd.2017.10.014. Epub 2017 Oct 31.


The Cultural Functions and Social Potential of Queer Monuments: A Preliminary Inventory and Analysis.

Orangias J, Simms J, French S.

J Homosex. 2017 Aug 4:1-22. doi: 10.1080/00918369.2017.1364106. [Epub ahead of print]


Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.

Woolley MJ, Reynolds CA, Simms J, Walker CS, Mobarec JC, Garelja ML, Conner AC, Poyner DR, Hay DL.

Biochem Pharmacol. 2017 Oct 15;142:96-110. doi: 10.1016/j.bcp.2017.07.005. Epub 2017 Jul 11.


Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP8-37): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.

Woolley MJ, Simms J, Uddin S, Poyner DR, Conner AC.

Biochemistry. 2017 Aug 1;56(30):3877-3880. doi: 10.1021/acs.biochem.7b00077. Epub 2017 Jul 18.


Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.

Woolley MJ, Simms J, Mobarec JC, Reynolds CA, Poyner DR, Conner AC.

Mol Cell Endocrinol. 2017 Oct 15;454:39-49. doi: 10.1016/j.mce.2017.05.034. Epub 2017 May 30.


Career planning for the non-clinical workforce - an opportunity to develop a sustainable workforce in primary care.

Tavabie JA, Simms JM.

Educ Prim Care. 2017 Mar;28(2):94-101. doi: 10.1080/14739879.2016.1262216. Epub 2016 Dec 16.


Defining the role of corticotropin releasing factor binding protein in alcohol consumption.

Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L.

Transl Psychiatry. 2016 Nov 15;6(11):e953. doi: 10.1038/tp.2016.208.


A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice.

Lei K, Wegner SA, Yu JH, Simms JA, Hopf FW.

Alcohol. 2016 Sep;55:9-16. doi: 10.1016/j.alcohol.2016.07.008. Epub 2016 Aug 20.


Erratum: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology.

Gingell JJ, Simms J, Barwell J, Poyner DR, Watkins HA, Pioszak AA, Sexton PM, Hay DL.

Cell Discov. 2016 Jun 21;2:16020. doi: 10.1038/celldisc.2016.20. eCollection 2016.


An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology.

J Gingell J, Simms J, Barwell J, Poyner DR, Watkins HA, Pioszak AA, Sexton PM, Hay DL.

Cell Discov. 2016 May 17;2:16012. doi: 10.1038/celldisc.2016.12. eCollection 2016. Erratum in: Cell Discov. 2016;2:16020.


The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.

Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SGB, Liu M, Thompson PE, Miller LJ, Christopoulos A, Sexton PM.

Cell. 2016 Jun 16;165(7):1632-1643. doi: 10.1016/j.cell.2016.05.023.


A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

Wootten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopoulos A, Sexton PM.

Mol Pharmacol. 2016 Mar;89(3):335-47. doi: 10.1124/mol.115.101246. Epub 2015 Dec 23.


Single session walk-in therapy.

Harper-Jaques S, Simms J.

Can Nurse. 2015 Jan;111(1):12-3. No abstract available.


Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.

Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA.

Mol Cell. 2015 Jun 18;58(6):1040-52. doi: 10.1016/j.molcel.2015.04.018. Epub 2015 May 14.


Simultaneous optimization method for absorption spectroscopy postprocessing.

Simms JM, An X, Brittelle MS, Ramesh V, Ghandhi JB, Sanders ST.

Appl Opt. 2015 May 10;54(14):4403-10. doi: 10.1364/AO.54.004403.


D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats.

Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW.

Neuropsychopharmacology. 2015 Sep;40(10):2357-67. doi: 10.1038/npp.2015.84. Epub 2015 Mar 24.


Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.

Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

J Pharmacol Exp Ther. 2015 Apr;353(1):52-63. doi: 10.1124/jpet.114.220913. Epub 2015 Jan 28.


Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens.

Feduccia AA, Simms JA, Mill D, Yi HY, Bartlett SE.

Br J Pharmacol. 2014 Jul;171(14):3420-31. doi: 10.1111/bph.12690.


Relative domain folding and stability of a membrane transport protein.

Harris NJ, Findlay HE, Simms J, Liu X, Booth PJ.

J Mol Biol. 2014 Apr 17;426(8):1812-25. doi: 10.1016/j.jmb.2014.01.012. Epub 2014 Feb 14.


Membrane proteins by accident or design.

Simms J, Booth PJ.

Curr Opin Chem Biol. 2013 Dec;17(6):976-81. Review.


Improving collaborative care in managing eating disorders: a pilot study.

Heath O, English D, Simms J, Ward P, Hollett A, Dominic A.

J Contin Educ Health Prof. 2013 Fall;33(4):235-43. doi: 10.1002/chp.21187.


Fischer rats consume 20% ethanol in a long-term intermittent-access two-bottle-choice paradigm.

Mill DJ, Bito-Onon JJ, Simms JA, Li R, Bartlett SE.

PLoS One. 2013 Nov 14;8(11):e79824. doi: 10.1371/journal.pone.0079824. eCollection 2013.


Characterization of Giardia lamblia genotypes in dogs from Tucson, Arizona using SSU-rRNA and β-giardin sequences.

Johansen KM, Castro NS, Lancaster KE, Madrid E, Havas A, Simms J, Sterling CR.

Parasitol Res. 2014 Jan;113(1):387-90.


Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.

Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW.

Nat Neurosci. 2013 Aug;16(8):1094-100. doi: 10.1038/nn.3445. Epub 2013 Jun 30.


Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations.

Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5211-6. doi: 10.1073/pnas.1221585110. Epub 2013 Mar 11.


At the 'heart' of the matter: an exploration of the psychological impact of living with congenital heart disease in adulthood.

Cornett L, Simms J.

J Health Psychol. 2014 Mar;19(3):393-406. doi: 10.1177/1359105312471569. Epub 2013 Feb 13.


Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395.

Simms JA, Nielsen CK, Li R, Bartlett SE.

Addict Biol. 2014 Jul;19(4):606-11. doi: 10.1111/adb.12024. Epub 2013 Jan 30.


The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration.

Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE.

PLoS One. 2012;7(9):e44726. doi: 10.1371/journal.pone.0044726. Epub 2012 Sep 21.


Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.

Feduccia AA, Wang Y, Simms JA, Yi HY, Li R, Bjeldanes L, Ye C, Bartlett SE.

Pharmacol Biochem Behav. 2012 Aug;102(2):241-8. doi: 10.1016/j.pbb.2012.04.014. Epub 2012 May 9.


Post-coital haemoperitoneum: a downside to intercourse.

Toquero L, Gadd R, Owers CE, Simms JM.

Ann R Coll Surg Engl. 2012 Jan;94(1):e26-7. doi: 10.1308/003588412X13171221499586.


Distribution and habitat associations of billfish and swordfish larvae across mesoscale features in the Gulf of Mexico.

Rooker JR, Simms JR, Wells RJ, Holt SA, Holt GJ, Graves JE, Furey NB.

PLoS One. 2012;7(4):e34180. doi: 10.1371/journal.pone.0034180. Epub 2012 Apr 11.


δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats.

Nielsen CK, Simms JA, Li R, Mill D, Yi H, Feduccia AA, Santos N, Bartlett SE.

J Neurosci. 2012 Mar 28;32(13):4540-52. doi: 10.1523/JNEUROSCI.5345-11.2012.


RAMPs as drug targets.

Sexton PM, Poyner DR, Simms J, Christopoulos A, Hay DL.

Adv Exp Med Biol. 2012;744:61-74. doi: 10.1007/978-1-4614-2364-5_6. Review.


RAMPs and CGRP receptors.

Barwell J, Wootten D, Simms J, Hay DL, Poyner DR.

Adv Exp Med Biol. 2012;744:13-24. doi: 10.1007/978-1-4614-2364-5_2. Review.


Structure-function studies of muscarinic acetylcholine receptors.

Leach K, Simms J, Sexton PM, Christopoulos A.

Handb Exp Pharmacol. 2012;(208):29-48. doi: 10.1007/978-3-642-23274-9_2. Review.


Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.

Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

J Biol Chem. 2012 Feb 3;287(6):3642-58. doi: 10.1074/jbc.M111.309328. Epub 2011 Dec 6.


Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.

Koole C, Wootten D, Simms J, Savage EE, Miller LJ, Christopoulos A, Sexton PM.

J Biol Chem. 2012 Feb 3;287(6):3659-73. doi: 10.1074/jbc.M111.309369. Epub 2011 Dec 6.


Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking.

Simms JA, Haass-Koffler CL, Bito-Onon J, Li R, Bartlett SE.

Neuropsychopharmacology. 2012 Mar;37(4):906-18. doi: 10.1038/npp.2011.268. Epub 2011 Nov 2.


Lifting the lid on GPCRs: the role of extracellular loops.

Wheatley M, Wootten D, Conner MT, Simms J, Kendrick R, Logan RT, Poyner DR, Barwell J.

Br J Pharmacol. 2012 Mar;165(6):1688-1703. doi: 10.1111/j.1476-5381.2011.01629.x. Review.


Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the α-2 adrenoreceptor antagonist yohimbine.

Simms JA, Richards JK, Mill D, Kanholm I, Holgate JY, Bartlett SE.

Psychopharmacology (Berl). 2011 Nov;218(1):101-10. doi: 10.1007/s00213-011-2451-9. Epub 2011 Aug 24.


Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

Koole C, Wootten D, Simms J, Valant C, Miller LJ, Christopoulos A, Sexton PM.

Mol Pharmacol. 2011 Sep;80(3):486-97. doi: 10.1124/mol.111.072884. Epub 2011 May 26. Erratum in: Mol Pharmacol. 2012 Jul;82(1):142.


Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability.

Vivekananda U, Manjalay ZR, Ganesalingam J, Simms J, Shaw CE, Leigh PN, Turner MR, Al-Chalabi A.

J Neurol Neurosurg Psychiatry. 2011 Jun;82(6):635-7. doi: 10.1136/jnnp.2010.237412.


The ghrelin signalling system is involved in the consumption of sweets.

Landgren S, Simms JA, Thelle DS, Strandhagen E, Bartlett SE, Engel JA, Jerlhag E.

PLoS One. 2011 Mar 23;6(3):e18170. doi: 10.1371/journal.pone.0018170. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/69c18638-12de-4f08-9a3c-f8c7bf3a0cc6.


Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats.

Bito-Onon JJ, Simms JA, Chatterjee S, Holgate J, Bartlett SE.

Addict Biol. 2011 Jul;16(3):440-9. doi: 10.1111/j.1369-1600.2010.00309.x. Epub 2011 Mar 11.


The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking.

Nielsen CK, Simms JA, Bito-Onon JJ, Li R, Ananthan S, Bartlett SE.

Addict Biol. 2012 Mar;17(2):224-34. doi: 10.1111/j.1369-1600.2010.00295.x. Epub 2011 Feb 11.

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