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Preventive antibiotic treatment of calves: emergence of dysbiosis causing propagation of obese state-associated and mobile multidrug resistance-carrying bacteria.

Dobrzanska DA, Lamaudière MTF, Rollason J, Acton L, Duncan M, Compton S, Simms J, Weedall GD, Morozov IY.

Microb Biotechnol. 2019 Oct 30. doi: 10.1111/1751-7915.13496. [Epub ahead of print]


TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.

Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY.

Elife. 2019 Sep 4;8. pii: e47106. doi: 10.7554/eLife.47106.


TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.

Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY.

J Neurosci. 2019 Sep 4;39(36):7102-7117. doi: 10.1523/JNEUROSCI.3137-18.2019. Epub 2019 Jul 18.


Taking Stock of Dietary Supplements' Harmful Effects on Children, Adolescents, and Young Adults.

Or F, Kim Y, Simms J, Austin SB.

J Adolesc Health. 2019 Oct;65(4):455-461. doi: 10.1016/j.jadohealth.2019.03.005. Epub 2019 Jun 5.


Community paramedic point of care testing: validity and usability of two commercially available devices.

Blanchard IE, Kozicky R, Dalgarno D, Simms J, Goulder S, Williamson TS, Biesbroek S, Page L, Leaman K, Snozyk S, Redman L, Spackman K, Doig CJ, Lang ES, Lazarenko G.

BMC Emerg Med. 2019 May 2;19(1):30. doi: 10.1186/s12873-019-0243-4.


Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.

Bailey S, Harris M, Barkan K, Winfield I, Harper MT, Simms J, Ladds G, Wheatley M, Poyner D.

Biochim Biophys Acta Biomembr. 2019 May 1;1861(5):997-1003. doi: 10.1016/j.bbamem.2019.02.008. Epub 2019 Feb 28.


Contraceptive care for Canadian youth.

Di Meglio G, Crowther C, Simms J.

Paediatr Child Health. 2018 Jul;23(4):271-277. doi: 10.1093/pch/pxx192. Epub 2018 Jun 12. Review. English, French.


hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.

Mackie DI, Al Mutairi F, Davis RB, Kechele DO, Nielsen NR, Snyder JC, Caron MG, Kliman HJ, Berg JS, Simms J, Poyner DR, Caron KM.

J Exp Med. 2018 Sep 3;215(9):2339-2353. doi: 10.1084/jem.20180528. Epub 2018 Aug 16.


Eastern Canadian Colorectal Cancer Consensus Conference 2017.

McGee SF, AlGhareeb W, Ahmad CH, Armstrong D, Babak S, Berry S, Biagi J, Booth C, Bossé D, Champion P, Colwell B, Finn N, Goel R, Gray S, Green J, Harb M, Hyde A, Jeyakumar A, Jonker D, Kanagaratnam S, Kavan P, MacMillan A, Muinuddin A, Patil N, Porter G, Powell E, Ramjeesingh R, Raza M, Rorke S, Seal M, Servidio-Italiano F, Siddiqui J, Simms J, Smithson L, Snow S, St-Hilaire E, Stuckless T, Tate A, Tehfe M, Thirlwell M, Tsvetkova E, Valdes M, Vickers M, Virik K, Welch S, Marginean C, Asmis T.

Curr Oncol. 2018 Aug;25(4):262-274. doi: 10.3747/co.25.4083. Epub 2018 Aug 14.


Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex.

Simms J, Uddin R, Sakmar TP, Gingell JJ, Garelja ML, Hay DL, Brimble MA, Harris PW, Reynolds CA, Poyner DR.

Biochemistry. 2018 Aug 14;57(32):4915-4922. doi: 10.1021/acs.biochem.8b00502. Epub 2018 Jul 25.


The Structure of the CGRP and Related Receptors.

Simms J, Routledge S, Uddin R, Poyner D.

Handb Exp Pharmacol. 2019;255:23-36. doi: 10.1007/164_2018_132.


Social Justice and Mobility in Coastal Louisiana, USA.

Colten CE, Simms JRZ, Grismore AA, Hemmerling SA.

Reg Environ Change. 2018 Feb;18(2):371-383. doi: 10.1007/s10113-017-1115-7. Epub 2017 Feb 21.


Functional characterisation of G protein-coupled receptors.

Uddin R, Simms J, Poyner D.

Methods. 2018 Sep 1;147:213-220. doi: 10.1016/j.ymeth.2018.02.018. Epub 2018 Mar 3. Review.


Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.

Coudrat T, Simms J, Christopoulos A, Wootten D, Sexton PM.

PLoS Comput Biol. 2017 Nov 13;13(11):e1005819. doi: 10.1371/journal.pcbi.1005819. eCollection 2017 Nov.


Istradefylline reduces memory deficits in aging mice with amyloid pathology.

Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L.

Neurobiol Dis. 2018 Feb;110:29-36. doi: 10.1016/j.nbd.2017.10.014. Epub 2017 Oct 31.


The Cultural Functions and Social Potential of Queer Monuments: A Preliminary Inventory and Analysis.

Orangias J, Simms J, French S.

J Homosex. 2017 Aug 4:1-22. doi: 10.1080/00918369.2017.1364106. [Epub ahead of print]


Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.

Woolley MJ, Reynolds CA, Simms J, Walker CS, Mobarec JC, Garelja ML, Conner AC, Poyner DR, Hay DL.

Biochem Pharmacol. 2017 Oct 15;142:96-110. doi: 10.1016/j.bcp.2017.07.005. Epub 2017 Jul 11.


Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP8-37): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.

Woolley MJ, Simms J, Uddin S, Poyner DR, Conner AC.

Biochemistry. 2017 Aug 1;56(30):3877-3880. doi: 10.1021/acs.biochem.7b00077. Epub 2017 Jul 18.


Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.

Woolley MJ, Simms J, Mobarec JC, Reynolds CA, Poyner DR, Conner AC.

Mol Cell Endocrinol. 2017 Oct 15;454:39-49. doi: 10.1016/j.mce.2017.05.034. Epub 2017 May 30.


Career planning for the non-clinical workforce - an opportunity to develop a sustainable workforce in primary care.

Tavabie JA, Simms JM.

Educ Prim Care. 2017 Mar;28(2):94-101. doi: 10.1080/14739879.2016.1262216. Epub 2016 Dec 16.


Defining the role of corticotropin releasing factor binding protein in alcohol consumption.

Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L.

Transl Psychiatry. 2016 Nov 15;6(11):e953. doi: 10.1038/tp.2016.208.


A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice.

Lei K, Wegner SA, Yu JH, Simms JA, Hopf FW.

Alcohol. 2016 Sep;55:9-16. doi: 10.1016/j.alcohol.2016.07.008. Epub 2016 Aug 20.


Erratum: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology.

Gingell JJ, Simms J, Barwell J, Poyner DR, Watkins HA, Pioszak AA, Sexton PM, Hay DL.

Cell Discov. 2016 Jun 21;2:16020. doi: 10.1038/celldisc.2016.20. eCollection 2016.


An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology.

J Gingell J, Simms J, Barwell J, Poyner DR, Watkins HA, Pioszak AA, Sexton PM, Hay DL.

Cell Discov. 2016 May 17;2:16012. doi: 10.1038/celldisc.2016.12. eCollection 2016. Erratum in: Cell Discov. 2016;2:16020.


The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.

Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SGB, Liu M, Thompson PE, Miller LJ, Christopoulos A, Sexton PM.

Cell. 2016 Jun 16;165(7):1632-1643. doi: 10.1016/j.cell.2016.05.023.


A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

Wootten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopoulos A, Sexton PM.

Mol Pharmacol. 2016 Mar;89(3):335-47. doi: 10.1124/mol.115.101246. Epub 2015 Dec 23.


Single session walk-in therapy.

Harper-Jaques S, Simms J.

Can Nurse. 2015 Jan;111(1):12-3. No abstract available.


Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.

Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA.

Mol Cell. 2015 Jun 18;58(6):1040-52. doi: 10.1016/j.molcel.2015.04.018. Epub 2015 May 14.


Simultaneous optimization method for absorption spectroscopy postprocessing.

Simms JM, An X, Brittelle MS, Ramesh V, Ghandhi JB, Sanders ST.

Appl Opt. 2015 May 10;54(14):4403-10. doi: 10.1364/AO.54.004403.


D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats.

Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW.

Neuropsychopharmacology. 2015 Sep;40(10):2357-67. doi: 10.1038/npp.2015.84. Epub 2015 Mar 24.


Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.

Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

J Pharmacol Exp Ther. 2015 Apr;353(1):52-63. doi: 10.1124/jpet.114.220913. Epub 2015 Jan 28.


Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens.

Feduccia AA, Simms JA, Mill D, Yi HY, Bartlett SE.

Br J Pharmacol. 2014 Jul;171(14):3420-31. doi: 10.1111/bph.12690.


Relative domain folding and stability of a membrane transport protein.

Harris NJ, Findlay HE, Simms J, Liu X, Booth PJ.

J Mol Biol. 2014 Apr 17;426(8):1812-25. doi: 10.1016/j.jmb.2014.01.012. Epub 2014 Feb 14.


Membrane proteins by accident or design.

Simms J, Booth PJ.

Curr Opin Chem Biol. 2013 Dec;17(6):976-81. Review.


Improving collaborative care in managing eating disorders: a pilot study.

Heath O, English D, Simms J, Ward P, Hollett A, Dominic A.

J Contin Educ Health Prof. 2013 Fall;33(4):235-43. doi: 10.1002/chp.21187.


Fischer rats consume 20% ethanol in a long-term intermittent-access two-bottle-choice paradigm.

Mill DJ, Bito-Onon JJ, Simms JA, Li R, Bartlett SE.

PLoS One. 2013 Nov 14;8(11):e79824. doi: 10.1371/journal.pone.0079824. eCollection 2013.


Characterization of Giardia lamblia genotypes in dogs from Tucson, Arizona using SSU-rRNA and β-giardin sequences.

Johansen KM, Castro NS, Lancaster KE, Madrid E, Havas A, Simms J, Sterling CR.

Parasitol Res. 2014 Jan;113(1):387-90.


Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.

Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW.

Nat Neurosci. 2013 Aug;16(8):1094-100. doi: 10.1038/nn.3445. Epub 2013 Jun 30.


Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations.

Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5211-6. doi: 10.1073/pnas.1221585110. Epub 2013 Mar 11.


At the 'heart' of the matter: an exploration of the psychological impact of living with congenital heart disease in adulthood.

Cornett L, Simms J.

J Health Psychol. 2014 Mar;19(3):393-406. doi: 10.1177/1359105312471569. Epub 2013 Feb 13.


Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395.

Simms JA, Nielsen CK, Li R, Bartlett SE.

Addict Biol. 2014 Jul;19(4):606-11. doi: 10.1111/adb.12024. Epub 2013 Jan 30.


The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration.

Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE.

PLoS One. 2012;7(9):e44726. doi: 10.1371/journal.pone.0044726. Epub 2012 Sep 21.


Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.

Feduccia AA, Wang Y, Simms JA, Yi HY, Li R, Bjeldanes L, Ye C, Bartlett SE.

Pharmacol Biochem Behav. 2012 Aug;102(2):241-8. doi: 10.1016/j.pbb.2012.04.014. Epub 2012 May 9.


Post-coital haemoperitoneum: a downside to intercourse.

Toquero L, Gadd R, Owers CE, Simms JM.

Ann R Coll Surg Engl. 2012 Jan;94(1):e26-7. doi: 10.1308/003588412X13171221499586.


Distribution and habitat associations of billfish and swordfish larvae across mesoscale features in the Gulf of Mexico.

Rooker JR, Simms JR, Wells RJ, Holt SA, Holt GJ, Graves JE, Furey NB.

PLoS One. 2012;7(4):e34180. doi: 10.1371/journal.pone.0034180. Epub 2012 Apr 11.


δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats.

Nielsen CK, Simms JA, Li R, Mill D, Yi H, Feduccia AA, Santos N, Bartlett SE.

J Neurosci. 2012 Mar 28;32(13):4540-52. doi: 10.1523/JNEUROSCI.5345-11.2012.


RAMPs as drug targets.

Sexton PM, Poyner DR, Simms J, Christopoulos A, Hay DL.

Adv Exp Med Biol. 2012;744:61-74. doi: 10.1007/978-1-4614-2364-5_6. Review.


RAMPs and CGRP receptors.

Barwell J, Wootten D, Simms J, Hay DL, Poyner DR.

Adv Exp Med Biol. 2012;744:13-24. doi: 10.1007/978-1-4614-2364-5_2. Review.


Structure-function studies of muscarinic acetylcholine receptors.

Leach K, Simms J, Sexton PM, Christopoulos A.

Handb Exp Pharmacol. 2012;(208):29-48. doi: 10.1007/978-3-642-23274-9_2. Review.


Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.

Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

J Biol Chem. 2012 Feb 3;287(6):3642-58. doi: 10.1074/jbc.M111.309328. Epub 2011 Dec 6.

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