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Items: 1 to 50 of 134

1.

Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.

Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, Swanson S, Catlow J, Witkin JM, Zwart R, Sher E, Choong KC, Wall TM, Schober D, Felder CC, Kato AS, Bredt DS, Nisenbaum ES.

J Pharmacol Exp Ther. 2019 Jun;369(3):345-363. doi: 10.1124/jpet.118.250126. Epub 2019 Mar 25.

PMID:
30910921
2.

Conditioned media from the renal cell carcinoma cell line 786.O drives human blood monocytes to a monocytic myeloid-derived suppressor cell phenotype.

Okada SL, Simmons RM, Franke-Welch S, Nguyen TH, Korman AJ, Dillon SR, Gilbertson DG.

Cell Immunol. 2018 Jan;323:49-58. doi: 10.1016/j.cellimm.2017.10.014. Epub 2017 Oct 31.

PMID:
29103587
3.

Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models.

Johnson MP, Muhlhauser MA, Nisenbaum ES, Simmons RM, Forster BM, Knopp KL, Yang L, Morrow D, Li DL, Kennedy JD, Swanson S, Monn JA.

Br J Pharmacol. 2017 May;174(9):822-835. doi: 10.1111/bph.13740. Epub 2017 Mar 13.

4.

A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072.

Simmons RM, Ballman KV, Cox C, Carp N, Sabol J, Hwang RF, Attai D, Sabel M, Nathanson D, Kenler A, Gold L, Kaufman C, Han L, Bleznak A, Stanley Smith J, Holmes D, Fornage B, Le-Petross C, Hoda S, McCall L, Hunt KK; ACOSOG investigators.

Ann Surg Oncol. 2016 Aug;23(8):2438-45. doi: 10.1245/s10434-016-5275-3. Epub 2016 May 24.

5.

Advocating Nonsurgical Management of Patients With Small, Incidental Radial Scars at the Time of Needle Core Biopsy: A Study of 77 Cases.

Matrai C, D'Alfonso TM, Pharmer L, Drotman MB, Simmons RM, Shin SJ.

Arch Pathol Lab Med. 2015 Sep;139(9):1137-42. doi: 10.5858/arpa.2014-0550-OA. Epub 2015 Jan 21.

PMID:
25607999
6.

Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.

Monn JA, Prieto L, Taboada L, Pedregal C, Hao J, Reinhard MR, Henry SS, Goldsmith PJ, Beadle CD, Walton L, Man T, Rudyk H, Clark B, Tupper D, Baker SR, Lamas C, Montero C, Marcos A, Blanco J, Bures M, Clawson DK, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang X, Carter JH, Xiang C, Catlow JT, Swanson S, Sanger H, Broad LM, Johnson MP, Knopp KL, Simmons RM, Johnson BG, Shaw DB, McKinzie DL.

J Med Chem. 2015 Feb 26;58(4):1776-94. doi: 10.1021/jm501612y. Epub 2015 Feb 5.

PMID:
25602126
7.

A method to enhance the magnitude of tactile hypersensitivity following spinal nerve ligation in rats.

Simmons RM, Forster B, Guo W, Knopp KL.

J Neurosci Methods. 2014 Aug 15;233:50-3. doi: 10.1016/j.jneumeth.2014.06.001. Epub 2014 Jun 10.

PMID:
24928434
8.

Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.

Dreyfus N, Myers JK, Badescu VO, de Frutos O, de la Puente ML, Ding C, Filla SA, Fynboe K, Gernert DL, Heinz BA, Hemrick-Luecke SK, Johnson KW, Johnson MP, López P, Love PL, Martin LJ, Masquelin T, McCoy MJ, Mendiola J, Morrow D, Muhlhauser M, Pascual G, Perun TJ, Pfeifer LA, Phebus LA, Richards SJ, Rincón JA, Seest EP, Shah J, Shaojuan J, Simmons RM, Stephenson GA, Tromiczak EG, Thompson LK, Walter MW, Weber WW, Zarrinmayeh H, Thomas CE, Joshi E, Iyengar S, Johansson AM.

ACS Med Chem Lett. 2013 May 7;4(6):560-4. doi: 10.1021/ml400049p. eCollection 2013 Jun 13.

9.

An unusual breast lesion: granular cell tumor of the breast with extensive chest wall invasion.

Coates SJ, Mitchell K, Olorunnipa OB, DeSimone RA, Otterburn DM, Simmons RM.

J Surg Oncol. 2014 Sep;110(3):345-7. doi: 10.1002/jso.23640. Epub 2014 May 26.

PMID:
24863566
10.

A randomized prospective study of lumpectomy margin assessment with use of MarginProbe in patients with nonpalpable breast malignancies.

Schnabel F, Boolbol SK, Gittleman M, Karni T, Tafra L, Feldman S, Police A, Friedman NB, Karlan S, Holmes D, Willey SC, Carmon M, Fernandez K, Akbari S, Harness J, Guerra L, Frazier T, Lane K, Simmons RM, Estabrook A, Allweis T.

Ann Surg Oncol. 2014 May;21(5):1589-95. doi: 10.1245/s10434-014-3602-0. Epub 2014 Mar 5.

11.

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity.

Stromnes IM, Brockenbrough JS, Izeradjene K, Carlson MA, Cuevas C, Simmons RM, Greenberg PD, Hingorani SR.

Gut. 2014 Nov;63(11):1769-81. doi: 10.1136/gutjnl-2013-306271. Epub 2014 Feb 20.

12.

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24.

PMID:
24140446
13.

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6459-62. doi: 10.1016/j.bmcl.2013.09.046. Epub 2013 Sep 25.

PMID:
24119554
14.

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

Hao J, Dehlinger V, Fivush AM, Rudyk HC, Britton TC, Hollinshead SP, Vokits BP, Clark BP, Henry SS, Massey SM, Peng L, Dressman BA, Heinz BA, Roberts EF, Bracey-Walker MR, Swanson S, Catlow JT, Love PL, Tepool AD, Peters SC, Simmons RM, Iyengar S, McKinzie DL, Monn JA.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1249-52. doi: 10.1016/j.bmcl.2013.01.009. Epub 2013 Jan 12.

PMID:
23374867
15.

3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.

Fisher MJ, Backer RT, Barth VN, Garbison KE, Gruber JM, Heinz BA, Iyengar S, Hollinshead SP, Kingston A, Kuklish SL, Li L, Nisenbaum ES, Peters SC, Phebus L, Simmons RM, van der Aar E.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2514-7. doi: 10.1016/j.bmcl.2012.02.003. Epub 2012 Feb 9.

PMID:
22386665
16.

HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau.

Simmons RM, Satterfield MC, Welsh TH Jr, Bazer FW, Spencer TE.

Biol Reprod. 2010 Jan;82(1):35-43. doi: 10.1095/biolreprod.109.079608. Epub 2009 Aug 19.

PMID:
19696010
17.

Discovery of candidate genes and pathways in the endometrium regulating ovine blastocyst growth and conceptus elongation.

Satterfield MC, Song G, Kochan KJ, Riggs PK, Simmons RM, Elsik CG, Adelson DL, Bazer FW, Zhou H, Spencer TE.

Physiol Genomics. 2009 Oct 7;39(2):85-99. doi: 10.1152/physiolgenomics.00001.2009. Epub 2009 Aug 18.

PMID:
19690047
18.

Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.

Simmons RM, Erikson DW, Kim J, Burghardt RC, Bazer FW, Johnson GA, Spencer TE.

Endocrinology. 2009 Sep;150(9):4295-305. doi: 10.1210/en.2009-0060. Epub 2009 Jun 4.

PMID:
19497977
19.

Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer.

Arora N, Martins D, Ruggerio D, Tousimis E, Swistel AJ, Osborne MP, Simmons RM.

Am J Surg. 2008 Oct;196(4):523-6. doi: 10.1016/j.amjsurg.2008.06.015.

PMID:
18809055
20.

Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation.

Gilchrist M, Henderson WR Jr, Clark AE, Simmons RM, Ye X, Smith KD, Aderem A.

J Exp Med. 2008 Sep 29;205(10):2349-57. doi: 10.1084/jem.20072254. Epub 2008 Sep 15.

21.

Sentinel node positivity rates with and without frozen section for breast cancer.

Arora N, Martins D, Huston TL, Christos P, Hoda S, Osborne MP, Swistel AJ, Tousimis E, Pressman PI, Simmons RM.

Ann Surg Oncol. 2008 Jan;15(1):256-61. Epub 2007 Sep 19.

PMID:
17879116
22.

AMPA receptor potentiation can prevent ethanol-induced intoxication.

Jones N, Messenger MJ, O'Neill MJ, Oldershaw A, Gilmour G, Simmons RM, Iyengar S, Libri V, Tricklebank M, Williams SC.

Neuropsychopharmacology. 2008 Jun;33(7):1713-23. Epub 2007 Sep 12.

23.
24.

Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.

Jones CK, Alt A, Ogden AM, Bleakman D, Simmons RM, Iyengar S, Dominguez E, Ornstein PL, Shannon HE.

J Pharmacol Exp Ther. 2006 Oct;319(1):396-404. Epub 2006 Jul 12.

PMID:
16837561
25.

Intraoperative intraductal injection of methylene blue dye to assist in major duct excision.

Sharma N, Huston TL, Simmons RM.

Am J Surg. 2006 Apr;191(4):553-4.

PMID:
16531154
26.

Kinetics of force recovery following length changes in active skinned single fibres from rabbit psoas muscle: analysis and modelling of the late recovery phase.

Burton K, Simmons RM, Sleep J, Simmons RM, Burton K, Smith DA.

J Physiol. 2006 Jun 1;573(Pt 2):305-28. Epub 2006 Feb 23.

27.

Identification of a high-affinity binding site involved in the transport of endocannabinoids.

Moore SA, Nomikos GG, Dickason-Chesterfield AK, Schober DA, Schaus JM, Ying BP, Xu YC, Phebus L, Simmons RM, Li D, Iyengar S, Felder CC.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17852-7. Epub 2005 Nov 28.

28.

Inflammatory local recurrence after breast-conservation therapy for noninflammatory breast cancer.

Huston TL, Simmons RM.

Am J Clin Oncol. 2005 Aug;28(4):431-2.

PMID:
16062091
29.

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

Dominguez E, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Buckmaster JL, Castano AM, Del Prado M, Escribano A, Filla SA, Ho KH, Hudziak KJ, Jones CK, Martinez-Perez JA, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

J Med Chem. 2005 Jun 30;48(13):4200-3.

PMID:
15974569
30.

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.

Underhill DM, Rossnagle E, Lowell CA, Simmons RM.

Blood. 2005 Oct 1;106(7):2543-50. Epub 2005 Jun 14.

31.

Ablative therapies for the treatment of malignant diseases of the breast.

Huston TL, Simmons RM.

Am J Surg. 2005 Jun;189(6):694-701. Review.

PMID:
15910722
32.

Multiple re-excisions versus mastectomy in patients with persistent residual disease following breast conservation surgery.

Cellini C, Huston TL, Martins D, Christos P, Carson J, Kemper S, Simmons RM.

Am J Surg. 2005 Jun;189(6):662-6.

PMID:
15910716
33.

Do bone marrow micrometastases correlate with sentinel lymph node metastases in breast cancer patients?

Trocciola SM, Hoda S, Osborne MP, Christos PJ, Levin H, Martins D, Carson J, Daly J, Simmons RM.

J Am Coll Surg. 2005 May;200(5):720-5; discussion 725-6.

PMID:
15848362
34.

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.

Gantner BN, Simmons RM, Underhill DM.

EMBO J. 2005 Mar 23;24(6):1277-86. Epub 2005 Feb 24.

35.
36.

Locally recurrent breast cancer after conservation therapy.

Huston TL, Simmons RM.

Am J Surg. 2005 Feb;189(2):229-35. Review.

PMID:
15720997
37.

Postgraduate training in breast surgery.

Simmons RM.

Breast Dis. 2001;12:141-4.

PMID:
15687614
38.

Two-year follow-up of areola-sparing mastectomy with immediate reconstruction.

Simmons RM, Hollenbeck ST, Latrenta GS.

Am J Surg. 2004 Oct;188(4):403-6.

PMID:
15474435
39.

Amphiphysin IIm is required for survival of Chlamydia pneumoniae in macrophages.

Gold ES, Simmons RM, Petersen TW, Campbell LA, Kuo CC, Aderem A.

J Exp Med. 2004 Sep 6;200(5):581-6. Epub 2004 Aug 30.

40.

Ductal carcinoma in situ in a 27-year-old woman with McCune-Albright syndrome.

Huston TL, Simmons RM.

Breast J. 2004 Sep-Oct;10(5):440-2.

PMID:
15327499
41.

The elasticity of single titin molecules using a two-bead optical tweezers assay.

Leake MC, Wilson D, Gautel M, Simmons RM.

Biophys J. 2004 Aug;87(2):1112-35.

42.

Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.

Iyengar S, Webster AA, Hemrick-Luecke SK, Xu JY, Simmons RM.

J Pharmacol Exp Ther. 2004 Nov;311(2):576-84. Epub 2004 Jul 13.

PMID:
15254142
43.

Bone marrow micrometastases and adjuvant treatment of breast cancer.

Yu JJ, Brennan M, Christos P, Osborne MP, Hoda S, Simmons RM.

Breast J. 2004 May-Jun;10(3):181-5.

PMID:
15125741
44.

Breast cancer in patients with residual invasive carcinoma is more accurately staged with additive tumor size assessment.

Hollenbeck ST, Cellini C, Christos P, Varnado-Rhodes Y, Martins D, Nussbaum M, Osborne MP, Simmons RM.

Ann Surg Oncol. 2004 Jan;11(1):59-64.

PMID:
14699035
45.

Areola-sparing mastectomy with immediate breast reconstruction.

Simmons RM, Hollenbeck ST, Latrenta GS.

Ann Plast Surg. 2003 Dec;51(6):547-51.

PMID:
14646645
46.

Freezing breast cancers to enhance complete resection.

Simmons RM.

Ann Surg Oncol. 2003 Nov;10(9):999. No abstract available.

PMID:
14597433
47.

Ablative techniques in the treatment of benign and malignant breast disease.

Simmons RM.

J Am Coll Surg. 2003 Aug;197(2):334-8. Review. No abstract available.

PMID:
12892821
48.

Ductal carcinoma in situ with microinvasion.

Adamovich TL, Simmons RM.

Am J Surg. 2003 Aug;186(2):112-6. Review.

PMID:
12885600
49.

Skin-sparing mastectomy.

Simmons RM, Adamovich TL.

Surg Clin North Am. 2003 Aug;83(4):885-99. Review.

PMID:
12875600
50.

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.

Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM.

J Exp Med. 2003 May 5;197(9):1107-17. Epub 2003 Apr 28.

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