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Items: 1 to 50 of 975

1.

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro.

Vodovotz Y, Simmons RL, Barclay D, Yin J, Jefferson BS, Zamora R.

Ann Transl Med. 2019 Aug;7(16):371. doi: 10.21037/atm.2019.07.09.

2.

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.

Yazdani HO, Roy E, Comerci AJ, van der Windt DJ, Zhang H, Huang H, Loughran P, Shiva S, Geller DA, Bartlett DL, Tsung A, Sheng T, Simmons RL, Tohme S.

Cancer Res. 2019 Nov 1;79(21):5626-5639. doi: 10.1158/0008-5472.CAN-19-0800. Epub 2019 Sep 13.

PMID:
31519688
3.

Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits.

Ruggiu F, Yang S, Simmons RL, Casarez A, Jones AK, Li C, Jansen JM, Moser HE, Dean CR, Reck F, Lindvall M.

ACS Infect Dis. 2019 Oct 11;5(10):1688-1692. doi: 10.1021/acsinfecdis.9b00256. Epub 2019 Sep 3.

PMID:
31478369
4.

Morphological Deconvolution of Beta-Lactam Polyspecificity in E. coli.

Godinez WJ, Chan H, Hossain I, Li C, Ranjitkar S, Rasper D, Simmons RL, Zhang X, Feng BY.

ACS Chem Biol. 2019 Jun 21;14(6):1217-1226. doi: 10.1021/acschembio.9b00141. Epub 2019 Jun 11.

PMID:
31184469
5.

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.

Zamora R, Barclay D, Yin J, Alonso EM, Leonis MA, Mi Q, Billiar TR, Simmons RL, Squires RH, Vodovotz Y.

Sci Rep. 2019 Apr 12;9(1):5971. doi: 10.1038/s41598-019-42564-5.

6.

IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor.

Reck F, Bermingham A, Blais J, Casarez A, Colvin R, Dean CR, Furegati M, Gamboa L, Growcott E, Li C, Lopez S, Metzger L, Nocito S, Ossola F, Phizackerley K, Rasper D, Shaul J, Shen X, Simmons RL, Tang D, Tashiro K, Yue Q.

ACS Infect Dis. 2019 Jul 12;5(7):1045-1051. doi: 10.1021/acsinfecdis.9b00031. Epub 2019 Mar 27.

PMID:
30861342
7.

Development and Optimization of a Higher-Throughput Bacterial Compound Accumulation Assay.

Widya M, Pasutti WD, Sachdeva M, Simmons RL, Tamrakar P, Krucker T, Six DA.

ACS Infect Dis. 2019 Mar 8;5(3):394-405. doi: 10.1021/acsinfecdis.8b00299. Epub 2019 Jan 30.

PMID:
30624052
8.

Computational Analysis Supports IL-17A as a Central Driver of Neutrophil Extracellular Trap-Mediated Injury in Liver Ischemia Reperfusion.

Tohme S, Yazdani HO, Sud V, Loughran P, Huang H, Zamora R, Simmons RL, Vodovotz Y, Tsung A.

J Immunol. 2019 Jan 1;202(1):268-277. doi: 10.4049/jimmunol.1800454. Epub 2018 Nov 30.

PMID:
30504418
9.

Can post-hoc video review of robotic pancreaticoduodenectomy predict portal/superior mesenteric vein margin status in pancreatic adenocarcinoma?

Jung JP, Zenati MS, Hamad A, Hogg ME, Simmons RL, Zureikat AH, Zeh HJ, Boone BA.

HPB (Oxford). 2019 Jun;21(6):679-686. doi: 10.1016/j.hpb.2018.10.012. Epub 2018 Nov 28.

PMID:
30501987
10.

Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

Growcott EJ, Cariaga TA, Morris L, Zang X, Lopez S, Ansaldi DA, Gold J, Gamboa L, Roth T, Simmons RL, Osborne CS.

J Antimicrob Chemother. 2019 Jan 1;74(1):280. doi: 10.1093/jac/dky478. No abstract available.

PMID:
30412250
11.

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice.

Zamora R, Korff S, Mi Q, Barclay D, Schimunek L, Zucca R, Arsiwalla XD, Simmons RL, Verschure P, Billiar TR, Vodovotz Y.

PLoS Comput Biol. 2018 Nov 6;14(11):e1006582. doi: 10.1371/journal.pcbi.1006582. eCollection 2018 Nov.

12.

Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

Growcott EJ, Cariaga TA, Morris L, Zang X, Lopez S, Ansaldi DA, Gold J, Gamboa L, Roth T, Simmons RL, Osborne CS.

J Antimicrob Chemother. 2019 Jan 1;74(1):108-116. doi: 10.1093/jac/dky404. Erratum in: J Antimicrob Chemother. 2019 Jan 1;74(1):280.

PMID:
30325447
13.

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

Lee PS, Lapointe G, Madera AM, Simmons RL, Xu W, Yifru A, Tjandra M, Karur S, Rico A, Thompson K, Bojkovic J, Xie L, Uehara K, Liu A, Shu W, Bellamacina C, McKenney D, Morris L, Tonn GR, Osborne C, Benton BM, McDowell L, Fu J, Sweeney ZK.

J Med Chem. 2018 Oct 25;61(20):9360-9370. doi: 10.1021/acs.jmedchem.8b01287. Epub 2018 Oct 3.

PMID:
30226381
14.

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.

Dean CR, Barkan DT, Bermingham A, Blais J, Casey F, Casarez A, Colvin R, Fuller J, Jones AK, Li C, Lopez S, Metzger LE 4th, Mostafavi M, Prathapam R, Rasper D, Reck F, Ruzin A, Shaul J, Shen X, Simmons RL, Skewes-Cox P, Takeoka KT, Tamrakar P, Uehara T, Wei JR.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01200-18. doi: 10.1128/AAC.01200-18. Print 2018 Oct.

15.

In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-Resistant Enterobacteriaceae.

Blais J, Lopez S, Li C, Ruzin A, Ranjitkar S, Dean CR, Leeds JA, Casarez A, Simmons RL, Reck F.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00552-18. doi: 10.1128/AAC.00552-18. Print 2018 Oct.

16.

Use of Video Review to Investigate Technical Factors That May Be Associated With Delayed Gastric Emptying After Pancreaticoduodenectomy.

Jung JP, Zenati MS, Dhir M, Zureikat AH, Zeh HJ, Simmons RL, Hogg ME.

JAMA Surg. 2018 Oct 1;153(10):918-927. doi: 10.1001/jamasurg.2018.2089.

17.

IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies.

Sud V, Abboud A, Tohme S, Vodovotz Y, Simmons RL, Tsung A.

Cytokine. 2018 Jun 25. pii: S1043-4666(18)30116-9. doi: 10.1016/j.cyto.2018.03.030. [Epub ahead of print] Review.

PMID:
29954675
18.

Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis.

van der Windt DJ, Sud V, Zhang H, Varley PR, Goswami J, Yazdani HO, Tohme S, Loughran P, O'Doherty RM, Minervini MI, Huang H, Simmons RL, Tsung A.

Hepatology. 2018 Oct;68(4):1347-1360. doi: 10.1002/hep.29914. Epub 2018 Jul 16.

19.

Suppressed networks of inflammatory mediators characterize chronic venous insufficiency.

Sachdev U, Vodovotz L, Bitner J, Barclay D, Zamora R, Yin J, Simmons RL, Vodovotz Y.

J Vasc Surg Venous Lymphat Disord. 2018 May;6(3):358-366. doi: 10.1016/j.jvsv.2017.11.009. Epub 2018 Feb 10.

PMID:
29439934
20.

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA.

Dyer MR, Chen Q, Haldeman S, Yazdani H, Hoffman R, Loughran P, Tsung A, Zuckerbraun BS, Simmons RL, Neal MD.

Sci Rep. 2018 Feb 1;8(1):2068. doi: 10.1038/s41598-018-20479-x.

21.

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.

Reck F, Bermingham A, Blais J, Capka V, Cariaga T, Casarez A, Colvin R, Dean CR, Fekete A, Gong W, Growcott E, Guo H, Jones AK, Li C, Li F, Lin X, Lindvall M, Lopez S, McKenney D, Metzger L, Moser HE, Prathapam R, Rasper D, Rudewicz P, Sethuraman V, Shen X, Shaul J, Simmons RL, Tashiro K, Tang D, Tjandra M, Turner N, Uehara T, Vitt C, Whitebread S, Yifru A, Zang X, Zhu Q.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755. doi: 10.1016/j.bmcl.2018.01.006. Epub 2018 Jan 4.

PMID:
29336873
22.

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress.

Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R.

Front Physiol. 2017 Dec 22;8:1104. doi: 10.3389/fphys.2017.01104. eCollection 2017.

23.

Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion.

Tohme S, Kameneva MV, Yazdani HO, Sud V, Goswami J, Loughran P, Huang H, Simmons RL, Tsung A.

Oncotarget. 2017 May 31;8(35):59854-59866. doi: 10.18632/oncotarget.18322. eCollection 2017 Aug 29.

24.

Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency.

Fu J, Becker C, Cao L, Capparelli M, Denay R, Fujimoto R, Gai Y, Gao Z, Guenat C, Karur S, Kim H, Li W, Li X, Li W, Lochmann T, Lu A, Lu P, Luneau A, Meier N, Mergo W, Ng S, Parker D, Peng Y, Riss B, Rivkin A, Roggo S, Schroeder H, Schuerch F, Simmons RL, Sun F, Sweeney ZK, Tjandra M, Wang M, Wang R, Weiss AH, Wenger N, Wu Q, Xiong X, Xu S, Xu W, Yifru A, Zhao J, Zhou J, Zürcher C, Gallou F.

Bioorg Med Chem. 2018 Feb 15;26(4):957-969. doi: 10.1016/j.bmc.2017.09.008. Epub 2017 Sep 7.

PMID:
28919180
25.

Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction.

Tohme S, Yazdani HO, Liu Y, Loughran P, van der Windt DJ, Huang H, Simmons RL, Shiva S, Tai S, Tsung A.

Hepatology. 2017 Jul;66(1):182-197. doi: 10.1002/hep.29184. Epub 2017 May 22.

26.

Surgery for Cancer: A Trigger for Metastases.

Tohme S, Simmons RL, Tsung A.

Cancer Res. 2017 Apr 1;77(7):1548-1552. doi: 10.1158/0008-5472.CAN-16-1536. Epub 2017 Mar 22. Review.

27.

Emergency Surgical Airways Following Activation of a Difficult Airway Management Team in Hospitalized Critically Ill Patients: A Case Series.

Darby JM, Halenda G, Chou C, Quinlan JJ, Alarcon LH, Simmons RL.

J Intensive Care Med. 2018 Sep;33(9):517-526. doi: 10.1177/0885066616680594. Epub 2016 Nov 30.

PMID:
27899469
28.

Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality.

Abboud A, Namas RA, Ramadan M, Mi Q, Almahmoud K, Abdul-Malak O, Azhar N, Zaaqoq A, Namas R, Barclay DA, Yin J, Sperry J, Peitzman A, Zamora R, Simmons RL, Billiar TR, Vodovotz Y.

Crit Care Med. 2016 Nov;44(11):e1074-e1081.

29.

Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment.

Vergidis P, Clancy CJ, Shields RK, Park SY, Wildfeuer BN, Simmons RL, Nguyen MH.

PLoS One. 2016 Apr 28;11(4):e0153247. doi: 10.1371/journal.pone.0153247. eCollection 2016.

30.

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress.

Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Loughran P, Mowen K, Wang Y, Simmons RL, Huang H, Tsung A.

Cancer Res. 2016 Mar 15;76(6):1367-80. doi: 10.1158/0008-5472.CAN-15-1591. Epub 2016 Jan 12.

31.

Prior inpatient admission increases the risk of post-operative infection in hepatobiliary and pancreatic surgery.

Dong ZM, Chidi AP, Goswami J, Han K, Simmons RL, Rosengart MR, Tsung A.

HPB (Oxford). 2015 Dec;17(12):1105-12. doi: 10.1111/hpb.12499. Epub 2015 Sep 3.

32.

Do Written Disclosures of Serious Events Increase Risk of Malpractice Claims? One Health Care System's Experience.

Painter LM, Kidwell KM, Kidwell RP, Janov C, Voinchet RG Jr, Simmons RL, Wu AW.

J Patient Saf. 2018 Jun;14(2):87-94. doi: 10.1097/PTS.0000000000000178.

33.

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK.

J Med Chem. 2014 Oct 23;57(20):8503-16. doi: 10.1021/jm500862r. Epub 2014 Oct 13.

PMID:
25310383
34.

A retrospective review of crisis events in diagnostic radiology: an analysis of frequency, demographics, etiologies, and outcomes.

Tindel MS, Darby JM, Simmons RL.

J Patient Saf. 2014 Jun;10(2):111-6. doi: 10.1097/PTS.0000000000000113.

PMID:
24840191
35.

Addressing Patient Safety in Rapid Response Activations for Nonhospitalized Persons.

Lakshminarayana PH, Darby JM, Simmons RL.

J Patient Saf. 2017 Mar;13(1):14-19. doi: 10.1097/PTS.0000000000000098.

PMID:
24717529
36.

Innate immune activation after transfusion of stored red blood cells.

Neal MD, Raval JS, Triulzi DJ, Simmons RL.

Transfus Med Rev. 2013 Apr;27(2):113-8. doi: 10.1016/j.tmrv.2013.01.001. Epub 2013 Feb 21. Review.

PMID:
23434246
37.

The role of acute care surgery in the treatment of severe, complicated Clostridium difficile-associated disease.

Carchman EH, Peitzman AB, Simmons RL, Zuckerbraun BS.

J Trauma Acute Care Surg. 2012 Oct;73(4):789-800. doi: 10.1097/TA.0b013e318265d19f. Review.

PMID:
23026914
38.

Novel management strategies in the treatment of severe Clostridium difficile infection.

Nassour I, Carchman EH, Simmons RL, Zuckerbraun BS.

Adv Surg. 2012;46:111-35. Review.

PMID:
22873036
39.

Storable arylpalladium(II) reagents for alkene labeling in aqueous media.

Simmons RL, Yu RT, Myers AG.

J Am Chem Soc. 2011 Oct 12;133(40):15870-3. doi: 10.1021/ja206339s. Epub 2011 Sep 15.

40.

Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease.

Neal MD, Alverdy JC, Hall DE, Simmons RL, Zuckerbraun BS.

Ann Surg. 2011 Sep;254(3):423-7; discussion 427-9. doi: 10.1097/SLA.0b013e31822ade48.

PMID:
21865943
41.

Extracellular nucleotides affect pericyte-mediated regulation of rat in situ vasa recta diameter.

Crawford C, Kennedy-Lydon TM, Callaghan H, Sprott C, Simmons RL, Sawbridge L, Syme HM, Unwin RJ, Wildman SS, Peppiatt-Wildman CM.

Acta Physiol (Oxf). 2011 Jul;202(3):241-51. doi: 10.1111/j.1748-1716.2011.02310.x. Epub 2011 May 28.

PMID:
21624094
42.

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L.

Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17.

PMID:
21459573
43.

The nurse's role in the causation of compensable injury.

Painter LM, Dudjak LA, Kidwell KM, Simmons RL, Kidwell RP.

J Nurs Care Qual. 2011 Oct-Dec;26(4):311-9. doi: 10.1097/NCQ.0b013e31820f9576.

PMID:
21386717
44.

A 5-year analysis of rapid response system activation at an in-hospital haemodialysis unit.

Galhotra S, Devita MA, Dew MA, Simmons RL.

Qual Saf Health Care. 2010 Dec;19(6):e38. doi: 10.1136/qshc.2008.031666. Epub 2010 Jun 16.

PMID:
20554573
45.

Analysis of major complications associated with arterial catheterisation.

Salmon AA, Galhotra S, Rao V, DeVita MA, Darby J, Hilmi I, Simmons RL.

Qual Saf Health Care. 2010 Jun;19(3):208-12. doi: 10.1136/qshc.2008.028597. Epub 2010 Mar 1.

PMID:
20194221
46.

Patient safety on the otolaryngology service: the role of an established rapid response system.

Oliver CL, Devita MA, Dunwoody CJ, Johnson JT, Sok JC, Simmons RL.

Qual Saf Health Care. 2009 Dec;18(6):496-9. doi: 10.1136/qshc.2007.024810.

PMID:
19955464
47.

Acute mesenteric ischemia: the importance of early surgical consultation.

Eltarawy IG, Etman YM, Zenati M, Simmons RL, Rosengart MR.

Am Surg. 2009 Mar;75(3):212-9.

PMID:
19350855
48.

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.

Cancilla MT, He MM, Viswanathan N, Simmons RL, Taylor M, Fung AD, Cao K, Erlanson DA.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3978-81. doi: 10.1016/j.bmcl.2008.06.011. Epub 2008 Jun 10.

PMID:
18579375
49.

Migration of the Günther Tulip inferior vena cava filter to the chest.

Galhotra S, Amesur NB, Zajko AB, Simmons RL.

J Vasc Interv Radiol. 2007 Dec;18(12):1581-5. Review.

PMID:
18057295
50.

Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach.

Muto CA, Blank MK, Marsh JW, Vergis EN, O'Leary MM, Shutt KA, Pasculle AW, Pokrywka M, Garcia JG, Posey K, Roberts TL, Potoski BA, Blank GE, Simmons RL, Veldkamp P, Harrison LH, Paterson DL.

Clin Infect Dis. 2007 Nov 15;45(10):1266-73. Epub 2007 Oct 9.

PMID:
17968819

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