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Items: 8


Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro.

Robinson MK, Hodge KM, Horak E, Sundberg AL, Russeva M, Shaller CC, von Mehren M, Shchaveleva I, Simmons HH, Marks JD, Adams GP.

Br J Cancer. 2008 Nov 4;99(9):1415-25. doi: 10.1038/sj.bjc.6604700. Epub 2008 Oct 7.


Isolation of anti-MISIIR scFv molecules from a phage display library by cell sorter biopanning.

Yuan QA, Robinson MK, Simmons HH, Russeva M, Adams GP.

Cancer Immunol Immunother. 2008 Mar;57(3):367-78. Epub 2007 Aug 4.


Isolation of scFvs to in vitro produced extracellular domains of EGFR family members.

Horak E, Heitner T, Robinson MK, Simmons HH, Garrison J, Russeva M, Furmanova P, Lou J, Zhou Y, Yuan QA, Weiner LM, Adams GP, Marks JD.

Cancer Biother Radiopharm. 2005 Dec;20(6):603-13.


A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.

Adams GP, Shaller CC, Dadachova E, Simmons HH, Horak EM, Tesfaye A, Klein-Szanto AJ, Marks JD, Brechbiel MW, Weiner LM.

Cancer Res. 2004 Sep 1;64(17):6200-6.


High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

Adams GP, Schier R, McCall AM, Simmons HH, Horak EM, Alpaugh RK, Marks JD, Weiner LM.

Cancer Res. 2001 Jun 15;61(12):4750-5.


Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity.

McCall AM, Shahied L, Amoroso AR, Horak EM, Simmons HH, Nielson U, Adams GP, Schier R, Marks JD, Weiner LM.

J Immunol. 2001 May 15;166(10):6112-7.


Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.

Adams GP, Shaller CC, Chappell LL, Wu C, Horak EM, Simmons HH, Litwin S, Marks JD, Weiner LM, Brechbiel MW.

Nucl Med Biol. 2000 May;27(4):339-46.


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