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Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation.

Simmons DA, Lartey FM, Schüler E, Rafat M, King G, Kim A, Ko R, Semaan S, Gonzalez S, Jenkins M, Pradhan P, Shih Z, Wang J, von Eyben R, Graves EE, Maxim PG, Longo FM, Loo BW Jr.

Radiother Oncol. 2019 Oct;139:4-10. doi: 10.1016/j.radonc.2019.06.006. Epub 2019 Jun 25.


TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.

Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM.

Hum Mol Genet. 2018 Aug 15;27(16):2893-2912. doi: 10.1093/hmg/ddy202.


Accuracy Beyond ISO: Introducing a New Method for Distinguishing Differences Between Blood Glucose Monitoring Systems Meeting ISO 15197:2013 Accuracy Requirements.

Pardo S, Shaginian RM, Simmons DA.

J Diabetes Sci Technol. 2018 May;12(3):650-656. doi: 10.1177/1932296818762509. Epub 2018 Mar 15.


Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.

Simmons DA.

J Huntingtons Dis. 2017;6(4):303-325. doi: 10.3233/JHD-170275. Review.


Using Radar Plots to Demonstrate the Accuracy and Precision of 6 Blood Glucose Monitoring Systems.

Pardo S, Dunne N, Simmons DA.

J Diabetes Sci Technol. 2017 Sep;11(5):966-969. doi: 10.1177/1932296817713026. Epub 2017 Jun 12.


Bolus Insulin Dose Error Distributions Based on Results From Two Clinical Trials Comparing Blood Glucose Monitoring Systems.

Pardo S, Dunne N, Simmons DA.

J Diabetes Sci Technol. 2017 Sep;11(5):970-974. doi: 10.1177/1932296817713025. Epub 2017 Jun 12.


A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM.

Hum Mol Genet. 2016 Nov 15;25(22):4920-4938. doi: 10.1093/hmg/ddw316.


Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.

Simmons DA, Longo FM, Massa SM.

CNS Neurol Disord Drug Targets. 2017;16(3):291-302. doi: 10.2174/1871527315666161107093047. Review.


A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.

Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM.

Neuropharmacology. 2016 Nov;110(Pt A):343-361. doi: 10.1016/j.neuropharm.2016.06.015. Epub 2016 Jun 19.


Fundamental Importance of Reference Glucose Analyzer Accuracy for Evaluating the Performance of Blood Glucose Monitoring Systems (BGMSs).

Bailey TS, Klaff LJ, Wallace JF, Greene C, Pardo S, Harrison B, Simmons DA.

J Diabetes Sci Technol. 2016 Jun 28;10(4):872-5. doi: 10.1177/1932296816634356. Print 2016 Jul.


How Should Blood Glucose Meter System Analytical Performance Be Assessed?

Simmons DA.

J Diabetes Sci Technol. 2015 Aug 31;10(1):178-84. doi: 10.1177/1932296815598599.


Analytic characteristics of three Bayer contour blood glucose monitoring systems in neonates.

Dietzen DJ, Nenninger DA, Simmons DA, Pardo S, Pandya M, Fullam J.

J Diabetes Sci Technol. 2015 Mar;9(2):257-61. doi: 10.1177/1932296814557669. Epub 2014 Nov 4.


A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.

PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.


Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.

Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.


A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM.

J Neurosci. 2013 Nov 27;33(48):18712-27. doi: 10.1523/JNEUROSCI.1310-13.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.


A new test strip technology platform for self-monitoring of blood glucose.

Bernstein R, Parkes JL, Goldy A, Brown D, Harrison B, Chu A, Pflug BK, Simmons DA, Pardo S, Bailey TS.

J Diabetes Sci Technol. 2013 Sep 1;7(5):1386-99.


Accuracy evaluation of five blood glucose monitoring systems: the North American comparator trial.

Halldorsdottir S, Warchal-Windham ME, Wallace JF, Pardo S, Parkes JL, Simmons DA.

J Diabetes Sci Technol. 2013 Sep 1;7(5):1294-304.


Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.

Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.


Performance of a new blood glucose monitoring system in the hands of intended users.

Bailey TS, Wallace JF, Parkes JL, Pardo S, Yu J, Schachner HC, Simmons DA, Chu A.

Diabetes Technol Ther. 2012 Sep;14(9):783-9. doi: 10.1089/dia.2012.0046. Epub 2012 Jun 29.


Multitaxonomic diversity patterns along a desert riparian-upland gradient.

Soykan CU, Brand LA, Ries L, Stromberg JC, Hass C, Simmons DA Jr, Patterson WJ, Sabo JL.

PLoS One. 2012;7(1):e28235. doi: 10.1371/journal.pone.0028235. Epub 2012 Jan 17.


Evaluation of a novel continuous glucose measurement device in patients with diabetes mellitus across the glycemic range.

Morrow L, Hompesch M, Tideman AM, Matson J, Dunne N, Pardo S, Parkes JL, Schachner HC, Simmons DA.

J Diabetes Sci Technol. 2011 Jul 1;5(4):853-9.


Evaluation of an over-the-counter glycated hemoglobin (A1C) test kit.

Chang A, Frank J, Knaebel J, Fullam J, Pardo S, Simmons DA.

J Diabetes Sci Technol. 2010 Nov 1;4(6):1495-503.


A forebrain-retrorubral pathway involved in male sex behavior is GABAergic and activated with mating in gerbils.

Simmons DA, Hoffman NW, Yahr P.

Neuroscience. 2011 Feb 23;175:162-8. doi: 10.1016/j.neuroscience.2010.11.048. Epub 2010 Nov 29.


Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice.

Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G.

Neurobiol Dis. 2011 Feb;41(2):436-44. doi: 10.1016/j.nbd.2010.10.015. Epub 2010 Oct 23.


BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats.

Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G.

Neurobiol Aging. 2012 Apr;33(4):708-19. doi: 10.1016/j.neurobiolaging.2010.06.008. Epub 2010 Jul 31.


Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy.

Benesch JL, Ruotolo BT, Simmons DA, Barrera NP, Morgner N, Wang L, Saibil HR, Robinson CV.

J Struct Biol. 2010 Nov;172(2):161-8. doi: 10.1016/j.jsb.2010.03.004. Epub 2010 Mar 15.


Re-evaluating a standard approach to assessing glucose monitor performance.

Baum JM, Pardo SA, Schachner HC, Parkes JL, Simmons DA.

Diabetes Technol Ther. 2009 May;11(5):323-5; author reply 327. doi: 10.1089/dia.2008.0084. No abstract available.


Functional interaction between the basolateral amygdala and the nucleus accumbens underlies incentive motivation for food reward on a fixed ratio schedule.

Simmons DA, Neill DB.

Neuroscience. 2009 Apr 10;159(4):1264-73. doi: 10.1016/j.neuroscience.2009.01.026. Epub 2009 Jan 20.


Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice.

Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4906-11. doi: 10.1073/pnas.0811228106. Epub 2009 Mar 5.


Comments on evaluation of five glucose meters by Thomas et al.

Simmons DA.

Diabetes Technol Ther. 2008 Oct;10(5):415; author reply 417. doi: 10.1089/dia.2008.0056. No abstract available.


CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.

Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM.

Mol Cell Neurosci. 2008 Sep;39(1):8-20. doi: 10.1016/j.mcn.2008.04.007. Epub 2008 Apr 24.


Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.

Conforti P, Ramos C, Apostol BL, Simmons DA, Nguyen HP, Riess O, Thompson LM, Zuccato C, Cattaneo E.

Mol Cell Neurosci. 2008 Sep;39(1):1-7. doi: 10.1016/j.mcn.2008.04.012. Epub 2008 May 10.


Evidence that long-term potentiation occurs within individual hippocampal synapses during learning.

Fedulov V, Rex CS, Simmons DA, Palmer L, Gall CM, Lynch G.

J Neurosci. 2007 Jul 25;27(30):8031-9.


Protein complexes in the gas phase: technology for structural genomics and proteomics.

Benesch JL, Ruotolo BT, Simmons DA, Robinson CV.

Chem Rev. 2007 Aug;107(8):3544-67. Epub 2007 Jul 25. Review. No abstract available.


Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease.

Simmons DA, Casale M, Alcon B, Pham N, Narayan N, Lynch G.

Glia. 2007 Aug 1;55(10):1074-84.


GABAergic inactivation of basolateral amygdala alters behavioral processes other than primary reward of ventral tegmental self-stimulation.

Simmons DA, Brooks BM, Neill DB.

Behav Brain Res. 2007 Jul 19;181(1):110-7. Epub 2007 Apr 5.


Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease.

Lynch G, Kramar EA, Rex CS, Jia Y, Chappas D, Gall CM, Simmons DA.

J Neurosci. 2007 Apr 18;27(16):4424-34.


Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring.

van Duijn E, Simmons DA, van den Heuvel RH, Bakkes PJ, van Heerikhuizen H, Heeren RM, Robinson CV, van der Vies SM, Heck AJ.

J Am Chem Soc. 2006 Apr 12;128(14):4694-702.


Mass spectrometry-based approaches to protein-ligand interactions.

Schermann SM, Simmons DA, Konermann L.

Expert Rev Proteomics. 2005 Aug;2(4):475-85. Review.


Cytokines, stressors, and clinical depression: augmented adaptation responses underlie depression pathogenesis.

Simmons DA, Broderick PA.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):793-807. Review.


Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry.

Simmons DA, Wilson DJ, Lajoie GA, Doherty-Kirby A, Konermann L.

Biochemistry. 2004 Nov 23;43(46):14792-801.


Protein-folding kinetics and mechanisms studied by pulse-labeling and mass spectrometry.

Konermann L, Simmons DA.

Mass Spectrom Rev. 2003 Jan-Feb;22(1):1-26. Review.


Conformational dynamics of partially denatured myoglobin studied by time-resolved electrospray mass spectrometry with online hydrogen-deuterium exchange.

Simmons DA, Dunn SD, Konermann L.

Biochemistry. 2003 May 20;42(19):5896-905. Erratum in: Biochemistry. 2003 Aug 5;42(30):9248.


Stopped-flow electrospray ionization mass spectrometry: a new method for studying chemical reaction kinetics in solution.

Kolakowski BM, Simmons DA, Konermann L.

Rapid Commun Mass Spectrom. 2000;14(9):772-6.


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