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Items: 1 to 50 of 98

1.

Whole Gene Sequencing of CFTR Reveals a High Prevalence of the Intronic Variant c.3874-4522A>G in Cystic Fibrosis.

Morris-Rosendahl DJ, Edwards M, McDonnell MJ, John S, Alton EW, Davies JC, Simmonds NJ.

Am J Respir Crit Care Med. 2020 Feb 4. doi: 10.1164/rccm.201908-1541LE. [Epub ahead of print] No abstract available.

PMID:
32017858
2.

Fair selection of participants in clinical trials: The challenge to push the envelope further.

Davies JC, Scott S, Dobra R, Brendell R, Brownlee K, Carr SB, Cosgriff R, Simmonds NJ; London Network of Clinical Trials Accelerator Platform sites, Jahan R, Jones A, Matthews J, Brown S, Galono K, Miles K, Pao C, Shafi N, Watson D, Orchard C, Davies G, Pike K, Shah S, Bossley CJ, Fong T, Macedo P, Ruiz G, Waller M, Baker L.

J Cyst Fibros. 2019 Sep;18(5):e48-e50. doi: 10.1016/j.jcf.2019.07.004. Epub 2019 Aug 9. No abstract available.

PMID:
31405729
3.

Nasal potential difference in suspected cystic fibrosis patients with 5T polymorphism.

Aalbers BL, Yaakov Y, Derichs N, Simmonds NJ, De Wachter E, Melotti P, De Boeck K, Leal T, Tümmler B, Wilschanski M, Bronsveld I.

J Cyst Fibros. 2019 Jul 19. pii: S1569-1993(19)30822-7. doi: 10.1016/j.jcf.2019.07.001. [Epub ahead of print]

PMID:
31331863
4.

Reduced exercise ventilatory efficiency in adults with cystic fibrosis and normal to moderately impaired lung function.

Di Paolo M, Teopompi E, Savi D, Crisafulli E, Longo C, Tzani P, Longo F, Ielpo A, Pisi G, Cimino G, Simmonds NJ, Neder JA, Chetta A, Palange P.

J Appl Physiol (1985). 2019 Aug 1;127(2):501-512. doi: 10.1152/japplphysiol.00030.2019. Epub 2019 Jun 20.

PMID:
31219769
5.

Randomised cross-over trial evaluating the short-term effects of non-invasive ventilation as an adjunct to airway clearance techniques in adults with cystic fibrosis.

Stanford G, Parrott H, Bilton D, Agent P, Banya W, Simmonds N.

BMJ Open Respir Res. 2019 Apr 14;6(1):e000399. doi: 10.1136/bmjresp-2018-000399. eCollection 2019.

6.

Who and why; sharing our experiences of developing a standard operating procedure (SOP) to allocate screening slots for highly competitive cystic fibrosis trials.

Dobra R, Scott S, Davies JC, Simmonds NJ.

J Cyst Fibros. 2019 Sep;18(5):e45-e46. doi: 10.1016/j.jcf.2019.04.008. Epub 2019 May 3. No abstract available.

PMID:
31060801
7.

"Fortunate are those who take the first steps"? The psychosocial impact of novel drug development.

Dobra R, Madge S, Martin I, Weldon P, Simmonds N, Davies JC.

Paediatr Respir Rev. 2019 Aug;31:9-11. doi: 10.1016/j.prrv.2019.02.005. Epub 2019 Feb 27. Review.

8.

Is it cystic fibrosis? The challenges of diagnosing cystic fibrosis.

Simmonds NJ.

Paediatr Respir Rev. 2019 Aug;31:6-8. doi: 10.1016/j.prrv.2019.02.004. Epub 2019 Feb 28. Review.

PMID:
30967347
9.

The emerging burden of liver disease in cystic fibrosis patients: A UK nationwide study.

Toledano MB, Mukherjee SK, Howell J, Westaby D, Khan SA, Bilton D, Simmonds NJ.

PLoS One. 2019 Apr 4;14(4):e0212779. doi: 10.1371/journal.pone.0212779. eCollection 2019.

10.

Effects of Lumacaftor/Ivacaftor on physical activity and exercise tolerance in three adults with cystic fibrosis.

Savi D, Schiavetto S, Simmonds NJ, Righelli D, Palange P.

J Cyst Fibros. 2019 May;18(3):420-424. doi: 10.1016/j.jcf.2019.03.001. Epub 2019 Mar 14.

PMID:
30879989
11.

Chronic histological changes in deceased donor kidneys at implantation do not predict graft survival: a single-centre retrospective analysis.

Phillips BL, Kassimatis T, Atalar K, Wilkinson H, Kessaris N, Simmonds N, Hilton R, Horsfield C, Callaghan CJ.

Transpl Int. 2019 May;32(5):523-534. doi: 10.1111/tri.13398. Epub 2019 Feb 8.

PMID:
30636065
12.

Non-invasive ventilation and clinical outcomes in cystic fibrosis: Findings from the UK CF registry.

Archangelidi O, Carr SB, Simmonds NJ, Bilton D, Banya W, Cullinan P; CF-EpiNet.

J Cyst Fibros. 2019 Sep;18(5):665-670. doi: 10.1016/j.jcf.2018.11.006. Epub 2018 Nov 28.

13.

A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology.

Roufosse C, Simmonds N, Clahsen-van Groningen M, Haas M, Henriksen KJ, Horsfield C, Loupy A, Mengel M, Perkowska-Ptasińska A, Rabant M, Racusen LC, Solez K, Becker JU.

Transplantation. 2018 Nov;102(11):1795-1814. doi: 10.1097/TP.0000000000002366. Review. Erratum in: Transplantation. 2018 Dec;102(12):e497.

14.

Use of a rare disease patient registry in long-term post-authorisation drug studies: a model for collaboration with industry.

Bilton D, Caine N, Cunningham S, Simmonds NJ, Cosgriff R, Carr SB.

Lancet Respir Med. 2018 Jul;6(7):495-496. doi: 10.1016/S2213-2600(18)30192-9. Epub 2018 May 4. Review. No abstract available.

PMID:
29735358
15.

Airway persistence by the emerging multi-azole-resistant Rasamsonia argillacea complex in cystic fibrosis.

Abdolrasouli A, Bercusson AC, Rhodes JL, Hagen F, Buil JB, Tang AYY, de Boer LL, Shah A, Milburn AJ, Elborn JS, Jones AL, Meis JF, Fisher MC, Schelenz S, Simmonds NJ, Armstrong-James D.

Mycoses. 2018 Sep;61(9):665-673. doi: 10.1111/myc.12789. Epub 2018 Jun 20.

16.

Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?

Savi D, Di Paolo M, Simmonds NJ, Pascucci C, Quattrucci S, Palange P.

BMC Pulm Med. 2018 Apr 19;18(1):60. doi: 10.1186/s12890-018-0623-7.

17.

Improvement in Exophiala dermatitidis airway persistence and respiratory decline in response to interferon-gamma therapy in a patient with cystic fibrosis.

Eades CP, Armstrong-James DPH, Periselneris J, Jones A, Simmonds N, Kelleher P, Shah A.

J Cyst Fibros. 2018 May;17(3):e32-e34. doi: 10.1016/j.jcf.2018.02.002. Epub 2018 Feb 15. No abstract available.

18.

The Man in the Paper Mask: One (Mask) for All and All for . . . Cystic Fibrosis?

Simmonds NJ, Bush A.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):281-283. doi: 10.1164/rccm.201710-2001ED. No abstract available.

19.

Burkholderia cepacia complex and limited cutaneous vasculitis in patients with cystic fibrosis: a case series.

Kayria M, Chris O, Dhasmana DJ, Nilesh M, Hodson ME, Khin G, Diana B, Simmonds NJ.

JRSM Open. 2017 Apr 3;8(4):2054270417692732. doi: 10.1177/2054270417692732. eCollection 2017 Apr.

20.

Clostridium difficile and cystic fibrosis: management strategies and the role of faecal transplantation.

Dunwoody R, Steel A, Landy J, Simmonds N.

Paediatr Respir Rev. 2018 Mar;26:16-18. doi: 10.1016/j.prrv.2017.03.003. Epub 2017 Mar 14. Review.

PMID:
28411069
21.

Evaluating the success of a marine protected area: A systematic review approach.

Gallacher J, Simmonds N, Fellowes H, Brown N, Gill N, Clark W, Biggs C, Rodwell LD.

J Environ Manage. 2016 Dec 1;183:280-293. doi: 10.1016/j.jenvman.2016.08.029. Epub 2016 Sep 3. Review.

PMID:
27600332
22.

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis.

Alton EWFW, Armstrong DK, Ashby D, Bayfield KJ, Bilton D, Bloomfield EV, Boyd AC, Brand J, Buchan R, Calcedo R, Carvelli P, Chan M, Cheng SH, Collie DS, Cunningham S, Davidson HE, Davies G, Davies JC, Davies LA, Dewar MH, Doherty A, Donovan J, Dwyer NS, Elgmati HI, Featherstone RF, Gavino J, Gea-Sorli S, Geddes DM, Gibson JSR, Gill DR, Greening AP, Griesenbach U, Hansell DM, Harman K, Higgins TE, Hodges SL, Hyde SC, Hyndman L, Innes JA, Jacob J, Jones N, Keogh BF, Limberis MP, Lloyd-Evans P, Maclean AW, Manvell MC, McCormick D, McGovern M, McLachlan G, Meng C, Montero MA, Milligan H, Moyce LJ, Murray GD, Nicholson AG, Osadolor T, Parra-Leiton J, Porteous DJ, Pringle IA, Punch EK, Pytel KM, Quittner AL, Rivellini G, Saunders CJ, Scheule RK, Sheard S, Simmonds NJ, Smith K, Smith SN, Soussi N, Soussi S, Spearing EJ, Stevenson BJ, Sumner-Jones SG, Turkkila M, Ureta RP, Waller MD, Wasowicz MY, Wilson JM, Wolstenholme-Hogg P; on behalf of the UK Cystic Fibrosis Gene Therapy Consortium.

Southampton (UK): NIHR Journals Library; 2016 Jul.

23.

Phenotypic variability of R117H-CFTR expression within monozygotic twins.

Waller MD, Simmonds NJ.

Paediatr Respir Rev. 2016 Aug;20 Suppl:21-3. doi: 10.1016/j.prrv.2016.06.009. Epub 2016 Jun 15. Review.

PMID:
27364092
24.

Aminoglycosides: old friend…new foe?

Simmonds NJ, Thomson AH.

J Cyst Fibros. 2016 Jul;15(4):411-2. doi: 10.1016/j.jcf.2016.05.011. Epub 2016 Jun 2. No abstract available.

25.

Clinical Trials of Novel Treatments for Cystic Fibrosis.

Hippolyte S, Pabary R, Waller M, Jones A, Simmonds N, Davies JC.

Am J Respir Crit Care Med. 2016 Mar 1;193(5):569-71. doi: 10.1164/rccm.201509-1734RR. No abstract available.

PMID:
26765316
26.

Response to Letter to the Editor: HbA1c as a screening tool for cystic fibrosis related diabetes: Response to letters by Widger et al. and Schnyder et al.

Burgess JC, Bridges N, Winston B, Gyi KM, Hodson ME, Bilton D, Simmonds NJ.

J Cyst Fibros. 2016 Mar;15(2):265-6. doi: 10.1016/j.jcf.2015.12.001. Epub 2015 Dec 23. No abstract available.

27.

Relationship between pulmonary exacerbations and daily physical activity in adults with cystic fibrosis.

Savi D, Simmonds N, Di Paolo M, Quattrucci S, Palange P, Banya W, Hopkinson NS, Bilton D.

BMC Pulm Med. 2015 Dec 1;15:151. doi: 10.1186/s12890-015-0151-7.

28.

An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis.

Geake JB, Reid DW, Currie BJ, Bell SC; MelioidCF Investigators, Bright-Thomas R, Dewar J, Holden S, Simmonds N, Gyi K, Kenna D, Waters V, Jackson M, O'Sullivan B, Taccetti G, Kolbe J, O'Carroll M, Campbell D, Jaksic M, Radhakrishna N, Kidd TJ, Flight W.

BMC Pulm Med. 2015 Oct 9;15:116. doi: 10.1186/s12890-015-0109-9.

29.

The Effect of Salinity on Egg Development and Viability of Schistocephalus solidus (Cestoda: Diphyllobothriidea).

Simmonds NE, Barber I.

J Parasitol. 2016 Feb;102(1):42-6. doi: 10.1645/14-701. Epub 2015 Sep 29.

PMID:
26418088
30.

Cystic Fibrosis Papers of the Year, 2013-2014.

Simmonds NJ.

Paediatr Respir Rev. 2015 Oct;16 Suppl 1:9-11. doi: 10.1016/j.prrv.2015.07.008. Epub 2015 Sep 26. Review.

PMID:
26410284
32.

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

Alton EWFW, Armstrong DK, Ashby D, Bayfield KJ, Bilton D, Bloomfield EV, Boyd AC, Brand J, Buchan R, Calcedo R, Carvelli P, Chan M, Cheng SH, Collie DDS, Cunningham S, Davidson HE, Davies G, Davies JC, Davies LA, Dewar MH, Doherty A, Donovan J, Dwyer NS, Elgmati HI, Featherstone RF, Gavino J, Gea-Sorli S, Geddes DM, Gibson JSR, Gill DR, Greening AP, Griesenbach U, Hansell DM, Harman K, Higgins TE, Hodges SL, Hyde SC, Hyndman L, Innes JA, Jacob J, Jones N, Keogh BF, Limberis MP, Lloyd-Evans P, Maclean AW, Manvell MC, McCormick D, McGovern M, McLachlan G, Meng C, Montero MA, Milligan H, Moyce LJ, Murray GD, Nicholson AG, Osadolor T, Parra-Leiton J, Porteous DJ, Pringle IA, Punch EK, Pytel KM, Quittner AL, Rivellini G, Saunders CJ, Scheule RK, Sheard S, Simmonds NJ, Smith K, Smith SN, Soussi N, Soussi S, Spearing EJ, Stevenson BJ, Sumner-Jones SG, Turkkila M, Ureta RP, Waller MD, Wasowicz MY, Wilson JM, Wolstenholme-Hogg P; UK Cystic Fibrosis Gene Therapy Consortium.

Lancet Respir Med. 2015 Sep;3(9):684-691. doi: 10.1016/S2213-2600(15)00245-3. Epub 2015 Jul 3. Erratum in: Lancet Respir Med. 2015 Sep;3(9):e33.

33.

Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis.

Savi D, Di Paolo M, Simmonds N, Onorati P, Internullo M, Quattrucci S, Winston B, Laveneziana P, Palange P.

BMC Pulm Med. 2015 May 9;15:59. doi: 10.1186/s12890-015-0036-9.

34.

Effective strategies for managing new Pseudomonas cultures in adults with cystic fibrosis.

Ali H, Orchard C, Mariveles M, Scott S, Alshafi K, Bilton D, Simmonds N.

Eur Respir J. 2015 Sep;46(3):862-5. doi: 10.1183/09031936.00225914. Epub 2015 Apr 16. No abstract available.

35.

HbA1c as a screening tool for cystic fibrosis related diabetes.

Burgess JC, Bridges N, Banya W, Gyi KM, Hodson ME, Bilton D, Simmonds NJ.

J Cyst Fibros. 2016 Mar;15(2):251-7. doi: 10.1016/j.jcf.2015.03.013. Epub 2015 Apr 11.

36.

Eradication of respiratory tract MRSA at a large adult cystic fibrosis centre.

Hall H, Gadhok R, Alshafi K, Bilton D, Simmonds NJ.

Respir Med. 2015 Mar;109(3):357-63. doi: 10.1016/j.rmed.2015.01.013. Epub 2015 Feb 3.

37.
38.

Aspergillus and cystic fibrosis: old disease - new classifications.

Felton IC, Simmonds NJ.

Curr Opin Pulm Med. 2014 Nov;20(6):632-8. doi: 10.1097/MCP.0000000000000106. Review.

PMID:
25229669
39.

Paneth cell metaplasia in newly diagnosed inflammatory bowel disease in children.

Simmonds N, Furman M, Karanika E, Phillips A, Bates AW.

BMC Gastroenterol. 2014 May 15;14:93. doi: 10.1186/1471-230X-14-93.

40.

Effects of ivacaftor in patients with cystic fibrosis who carry the G551D mutation and have severe lung disease.

Barry PJ, Plant BJ, Nair A, Bicknell S, Simmonds NJ, Bell NJ, Shafi NT, Daniels T, Shelmerdine S, Felton I, Gunaratnam C, Jones AM, Horsley AR.

Chest. 2014 Jul;146(1):152-158. doi: 10.1378/chest.13-2397.

PMID:
24522694
41.

Burkholderia pyrrocinia in cystic fibrosis lung transplantation: a case report.

Savi D, De Biase RV, Amaddeo A, Anile M, Venuta F, Ruberto F, Simmonds N, Cimino G, Quattrucci S.

Transplant Proc. 2014 Jan-Feb;46(1):295-7. doi: 10.1016/j.transproceed.2013.08.108.

PMID:
24507071
42.

A molecular comparison of microbial communities in bronchiectasis and cystic fibrosis.

Duff RM, Simmonds NJ, Davies JC, Wilson R, Alton EW, Pantelidis P, Cox MJ, Cookson WO, Bilton D, Moffatt MF.

Eur Respir J. 2013 Apr;41(4):991-3. doi: 10.1183/09031936.00052712. No abstract available.

43.

The destructive combination of Scediosporium apiosperum lung disease and exuberant inflammation in cystic fibrosis.

Russell GK, Gadhok R, Simmonds NJ.

Paediatr Respir Rev. 2013 May;14 Suppl 1:22-5. doi: 10.1016/j.prrv.2013.02.004. Epub 2013 Mar 18.

PMID:
23518310
44.

Ageing in cystic fibrosis and long-term survival.

Simmonds NJ.

Paediatr Respir Rev. 2013 May;14 Suppl 1:6-9. doi: 10.1016/j.prrv.2013.01.007. Epub 2013 Feb 24. Review.

PMID:
23497942
45.

Cystic fibrosis: management of haemoptysis.

Hurt K, Simmonds NJ.

Paediatr Respir Rev. 2012 Dec;13(4):200-5. doi: 10.1016/j.prrv.2012.01.003. Epub 2012 Feb 28. Review.

PMID:
23069116
46.

Diagnosing cystic fibrosis: what are we sweating about?

Simmonds NJ, Bush A.

Thorax. 2012 Jul;67(7):571-3. doi: 10.1136/thoraxjnl-2012-201758. Epub 2012 Apr 17. No abstract available.

PMID:
22511297
47.

Hot off the breath: 'I've a cost for'--the 64 million dollar question.

Bush A, Simmonds NJ.

Thorax. 2012 May;67(5):382-4. doi: 10.1136/thoraxjnl-2012-201798. Epub 2012 Mar 10. No abstract available.

PMID:
22407889
48.

A theoretical framework for the role of fascia in manual therapy.

Simmonds N, Miller P, Gemmell H.

J Bodyw Mov Ther. 2012 Jan;16(1):83-93. doi: 10.1016/j.jbmt.2010.08.001. Epub 2010 Sep 27. Review.

PMID:
22196432
49.

The prevalence of "risky behaviour" in adults with cystic fibrosis.

Mc Ewan FA, Hodson ME, Simmonds NJ.

J Cyst Fibros. 2012 Jan;11(1):56-8. doi: 10.1016/j.jcf.2011.09.002. Epub 2011 Oct 2.

50.

Improved survival at low lung function in cystic fibrosis: cohort study from 1990 to 2007.

George PM, Banya W, Pareek N, Bilton D, Cullinan P, Hodson ME, Simmonds NJ.

BMJ. 2011 Feb 28;342:d1008. doi: 10.1136/bmj.d1008.

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