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Items: 32

1.

Evidence for Chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate estrogen metabolism in ACI rats.

Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Cancer Prev Res (Phila). 2018 Oct 4. pii: canprevres.0178.2018. doi: 10.1158/1940-6207.CAPR-18-0178. [Epub ahead of print]

PMID:
30287522
2.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2018 Jul 13. doi: 10.1039/c7np00064b. [Epub ahead of print] Review.

PMID:
30003207
3.

Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.

Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen SN, Pauli GF, Dietz BM, Bolton JL.

J Nat Prod. 2018 Apr 27;81(4):966-975. doi: 10.1021/acs.jnatprod.7b01070. Epub 2018 Apr 11.

4.

Integrated analytical assets aid botanical authenticity and adulteration management.

Simmler C, Graham JG, Chen SN, Pauli GF.

Fitoterapia. 2018 Sep;129:401-414. doi: 10.1016/j.fitote.2017.11.017. Epub 2017 Nov 22. Review.

PMID:
29175549
5.

Structural Sequencing of Oligopeptides Aided by 1H Iterative Full-Spin Analysis.

Gao W, McAlpine JB, Choules MP, Napolitano JG, Lankin DC, Simmler C, Ho NA, Lee H, Suh JW, Burton IW, Cho S, Franzblau SG, Chen SN, Pauli GF.

J Nat Prod. 2017 Oct 27;80(10):2630-2643. doi: 10.1021/acs.jnatprod.7b00207. Epub 2017 Oct 16.

PMID:
29035048
6.

Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract.

Jaja-Chimedza A, Graf BL, Simmler C, Kim Y, Kuhn P, Pauli GF, Raskin I.

PLoS One. 2017 Aug 8;12(8):e0182658. doi: 10.1371/journal.pone.0182658. eCollection 2017.

7.

Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.

Li G, Simmler C, Chen L, Nikolic D, Chen SN, Pauli GF, van Breemen RB.

Eur J Pharm Sci. 2017 Nov 15;109:182-190. doi: 10.1016/j.ejps.2017.07.034. Epub 2017 Jul 31.

PMID:
28774812
8.

Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A.

Simmler C, Lankin DC, Nikolić D, van Breemen RB, Pauli GF.

Fitoterapia. 2017 Sep;121:6-15. doi: 10.1016/j.fitote.2017.06.017. Epub 2017 Jun 21.

9.

Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract.

Phansalkar RS, Simmler C, Bisson J, Chen SN, Lankin DC, McAlpine JB, Niemitz M, Pauli GF.

J Nat Prod. 2017 Mar 24;80(3):634-647. doi: 10.1021/acs.jnatprod.6b00923. Epub 2017 Jan 9.

10.

Dissemination of original NMR data enhances reproducibility and integrity in chemical research.

Bisson J, Simmler C, Chen SN, Friesen JB, Lankin DC, McAlpine JB, Pauli GF.

Nat Prod Rep. 2016 Aug 25;33(9):1028-33. doi: 10.1039/c6np00022c.

11.

Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products.

Simmler C, Kulakowski D, Lankin DC, McAlpine JB, Chen SN, Pauli GF.

Adv Nutr. 2016 Jan;7(1):179-89. Review.

12.

Botanical Integrity: Part 2: Traditional and Modern Analytical Approaches.

Simmler C, Chen SN, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF.

HerbalGram. 2016 Spring;109:60-64.

13.

Correction to Importance of Purity Evaluation and the Potential of Quantitative (1)H NMR as a Purity Assay.

Pauli GF, Chen SN, Simmler C, Lankin DC, Gödecke T, Jaki BU, Friesen JB, McAlpine JB, Napolitano JG.

J Med Chem. 2015 Nov 25;58(22):9061. doi: 10.1021/acs.jmedchem.5b01667. Epub 2015 Nov 17. No abstract available.

14.

Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolić D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Nov 16;28(11):2130-41. doi: 10.1021/acs.chemrestox.5b00310. Epub 2015 Nov 5.

15.

Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.

Simmler C, Anderson JR, Gauthier L, Lankin DC, McAlpine JB, Chen SN, Pauli GF.

J Nat Prod. 2015 Aug 28;78(8):2007-22. doi: 10.1021/acs.jnatprod.5b00342. Epub 2015 Aug 5.

16.

Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Aug 17;28(8):1584-94. doi: 10.1021/acs.chemrestox.5b00157. Epub 2015 Jul 16.

17.

Botanical Integrity: The Importance of the Integration of Chemical, Biological, and Botanical Analyses, and the Role of DNA Barcoding.

Simmler C, Chen SN, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF.

HerbalGram. 2015 Summer;106:58-60.

18.

Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.

Simmler C, Jones T, Anderson JR, Nikolić DC, van Breemen RB, Soejarto DD, Chen SN, Pauli GF.

Phytochem Anal. 2014 Jul-Aug;25(4):378-88. doi: 10.1002/pca.2472. Epub 2013 Nov 13.

19.

Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.

Napolitano JG, Simmler C, McAlpine JB, Lankin DC, Chen SN, Pauli GF.

J Nat Prod. 2015 Apr 24;78(4):658-65. doi: 10.1021/np5008203. Epub 2015 Feb 25.

20.

K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).

Ramos Alvarenga RF, Friesen JB, Nikolić D, Simmler C, Napolitano JG, van Breemen R, Lankin DC, McAlpine JB, Pauli GF, Chen SN.

J Nat Prod. 2014 Dec 26;77(12):2595-604. doi: 10.1021/np500376g. Epub 2014 Dec 1.

21.

Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.

Pauli GF, Chen SN, Simmler C, Lankin DC, Gödecke T, Jaki BU, Friesen JB, McAlpine JB, Napolitano JG.

J Med Chem. 2014 Nov 26;57(22):9220-31. doi: 10.1021/jm500734a. Epub 2014 Oct 8. Review. Erratum in: J Med Chem. 2015 Nov 25;58(22):9061.

22.

Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.

Simmler C, Nikolić D, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF.

J Nat Prod. 2014 Aug 22;77(8):1806-16. doi: 10.1021/np5001945. Epub 2014 Jul 31.

23.

Universal quantitative NMR analysis of complex natural samples.

Simmler C, Napolitano JG, McAlpine JB, Chen SN, Pauli GF.

Curr Opin Biotechnol. 2014 Feb;25:51-9. doi: 10.1016/j.copbio.2013.08.004. Epub 2013 Sep 14. Review.

24.

New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.

Elkington BG, Sydara K, Newsome A, Hwang CH, Lankin DC, Simmler C, Napolitano JG, Ree R, Graham JG, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli GF, Franzblau SG, Soejarto DD.

J Ethnopharmacol. 2014 Feb 3;151(2):903-11. doi: 10.1016/j.jep.2013.11.057. Epub 2013 Dec 11.

25.

Absolute configuration of naturally occurring glabridin.

Simmler C, Fronczek FR, Pauli GF, Santarsiero BD.

Acta Crystallogr C. 2013 Nov;69(Pt 11):1212-6. doi: 10.1107/S0108270113018842. Epub 2013 Oct 9.

26.

Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.

Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL.

PLoS One. 2013 Jul 12;8(7):e67947. doi: 10.1371/journal.pone.0067947. Print 2013.

27.

Phytochemistry and biological properties of glabridin.

Simmler C, Pauli GF, Chen SN.

Fitoterapia. 2013 Oct;90:160-84. doi: 10.1016/j.fitote.2013.07.003. Epub 2013 Jul 10. Review.

28.

Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.

Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen SN, Pauli GF.

J Agric Food Chem. 2013 Mar 6;61(9):2146-57. doi: 10.1021/jf304445p. Epub 2013 Feb 22.

29.

Diarylheptanoids from Dioscorea villosa (Wild Yam).

Dong SH, Nikolić D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen SN.

J Nat Prod. 2012 Dec 28;75(12):2168-77. doi: 10.1021/np300603z. Epub 2012 Dec 17. Erratum in: J Nat Prod. 2013 Oct 25;76(10):2005-7.

30.

[Action of an extract of Vanda coerulea on the senescence of skin fibroblasts].

Bonté F, Simmler C, Lobstein A, Pellicier F, Cauchard JH.

Ann Pharm Fr. 2011 May;69(3):177-81. doi: 10.1016/j.pharma.2011.02.001. Epub 2011 Apr 22. French.

PMID:
21570542
31.

Glucosyloxybenzyl eucomate derivatives from Vanda teres stimulate HaCaT cytochrome c oxidase.

Simmler C, Antheaume C, André P, Bonté F, Lobstein A.

J Nat Prod. 2011 May 27;74(5):949-55. doi: 10.1021/np1006636. Epub 2011 Apr 21.

PMID:
21510636
32.

Antioxidant biomarkers from Vanda coerulea stems reduce irradiated HaCaT PGE-2 production as a result of COX-2 inhibition.

Simmler C, Antheaume C, Lobstein A.

PLoS One. 2010 Oct 28;5(10):e13713. doi: 10.1371/journal.pone.0013713.

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